Click here to switch to the map view.

The map label for this gene is prpC [H]

Identifier: 238025478

GI number: 238025478

Start: 2694807

End: 2695976

Strand: Reverse

Name: prpC [H]

Synonym: bglu_2g21700

Alternate gene names: 238025478

Gene position: 2695976-2694807 (Counterclockwise)

Preceding gene: 238025479

Following gene: 238025477

Centisome position: 95.35

GC content: 67.26

Gene sequence:

>1170_bases
ATGAGCGAGACGAAAGACGCGGCACCGGCCGCGGCCGGTGGCTTCAAGCCGAAGAAATCGGTTGCGCTGTCGGGCGTCGC
GGCCGGCAACACCGCGCTGTGCACGGTCGGCCGCACCGGCAACGACCTGCATTACCGCGGTTACGACATCCTCGACTTTG
CCCAGGCCTGCGAATTCGAGGAGATCGCCTATCTGCTCGTCCACGAGAAGCTGCCCACCCGGGCCGAACTGAGCGCCTAC
AAGACCAAGCTGCGCGCGCTGCGCGGGCTGCCCGCCGCCGTGAAGGCGGCGCTCGAGGCGGTGCCGGCTTCCGCGCATCC
GATGGACGTGATGCGCACCGGCGTGTCGGTGCTCGGCACCGTGCTGCCCGAGAAGGACGACCACAACCTGCCCGGCGCGC
GCGACATCGCCGACCGCCTGATGGCCTCGCTCGGCTCGATGCTGCTGTACTGGTACCACTGGTCCCACAACGGCCGCCGC
ATCGAGGTGGAGACCGACGACGATTCGATCGGCGGCCATTTCCTGCACCTGCTGCACGGCAAGGCACCGTCGCAGGCGTG
GGTCGAGGCGATGCATACCTCGCTGATCCTCTACGCCGAGCACGAGTTCAACGCCTCGACCTTCACCGGCCGCGTGATCG
CGGGCACCGGGTCCGACATCTACTCGGCGATCACCGGCGCGATCGGTGCGCTGCGCGGGCCGAAGCACGGCGGCGCGAAC
GAGGTGGCGTTCGAGATCCAGAGCCGCTACCGCAACGCCGACGAGGCCGAGGCCGACATCCGCCGCCGCGTCGGCAACAA
GGAGGTGGTGATCGGCTTCGGCCATCCCGTCTACACGATCTCGGACCCGCGCAACAAGGTGATCAAGGAAGTCGCCCGCA
AGCTCTCGAAAGAGGCCGGCGACACGCAGCTGTTCGAGATCGCCGAGCGGCTGGAGGCGGTGATGTGGGACGCGAAGAAG
ATGTTCCCCAACCTCGACTGGTTCAGCGCCGTGTCGTACCGGATGATGGGCGTGCCGACCGCGATGTTCACGCCGCTGTT
CGTGATCGCGCGCACCTCCGGCTGGAGCGCGCACATCATCGAGCAGCGCATCGACAACAAGATCATCCGCCCGAGCGCGA
ACTACACCGGGCCGGAAGATCTCACCTTCGTGCCGATCGAGAAGCGCTGA

Upstream 100 bases:

>100_bases
CGGCGGATCGGTTCAGAATCCCGAATCACGGCCGGCGCCGACCGGAAACGGACCCGAAGACGGCCGAACGAACCCGAAGA
ACGACCAGGAGAACATCACG

Downstream 100 bases:

>100_bases
GCGAAAGCGGCGCGGCGGCCGGCGGCTTCGGTCCGCCGCCGGCCGCGCCGTGCCCGCCGTTGACTTTCCCCGCATGCCCC
AGAACATGAATACCGCCCAT

Product: methylcitrate synthase

Products: NA

Alternate protein names: Citrate synthase 2; Methylcitrate synthase [H]

Number of amino acids: Translated: 389; Mature: 388

Protein sequence:

>389_residues
MSETKDAAPAAAGGFKPKKSVALSGVAAGNTALCTVGRTGNDLHYRGYDILDFAQACEFEEIAYLLVHEKLPTRAELSAY
KTKLRALRGLPAAVKAALEAVPASAHPMDVMRTGVSVLGTVLPEKDDHNLPGARDIADRLMASLGSMLLYWYHWSHNGRR
IEVETDDDSIGGHFLHLLHGKAPSQAWVEAMHTSLILYAEHEFNASTFTGRVIAGTGSDIYSAITGAIGALRGPKHGGAN
EVAFEIQSRYRNADEAEADIRRRVGNKEVVIGFGHPVYTISDPRNKVIKEVARKLSKEAGDTQLFEIAERLEAVMWDAKK
MFPNLDWFSAVSYRMMGVPTAMFTPLFVIARTSGWSAHIIEQRIDNKIIRPSANYTGPEDLTFVPIEKR

Sequences:

>Translated_389_residues
MSETKDAAPAAAGGFKPKKSVALSGVAAGNTALCTVGRTGNDLHYRGYDILDFAQACEFEEIAYLLVHEKLPTRAELSAY
KTKLRALRGLPAAVKAALEAVPASAHPMDVMRTGVSVLGTVLPEKDDHNLPGARDIADRLMASLGSMLLYWYHWSHNGRR
IEVETDDDSIGGHFLHLLHGKAPSQAWVEAMHTSLILYAEHEFNASTFTGRVIAGTGSDIYSAITGAIGALRGPKHGGAN
EVAFEIQSRYRNADEAEADIRRRVGNKEVVIGFGHPVYTISDPRNKVIKEVARKLSKEAGDTQLFEIAERLEAVMWDAKK
MFPNLDWFSAVSYRMMGVPTAMFTPLFVIARTSGWSAHIIEQRIDNKIIRPSANYTGPEDLTFVPIEKR
>Mature_388_residues
SETKDAAPAAAGGFKPKKSVALSGVAAGNTALCTVGRTGNDLHYRGYDILDFAQACEFEEIAYLLVHEKLPTRAELSAYK
TKLRALRGLPAAVKAALEAVPASAHPMDVMRTGVSVLGTVLPEKDDHNLPGARDIADRLMASLGSMLLYWYHWSHNGRRI
EVETDDDSIGGHFLHLLHGKAPSQAWVEAMHTSLILYAEHEFNASTFTGRVIAGTGSDIYSAITGAIGALRGPKHGGANE
VAFEIQSRYRNADEAEADIRRRVGNKEVVIGFGHPVYTISDPRNKVIKEVARKLSKEAGDTQLFEIAERLEAVMWDAKKM
FPNLDWFSAVSYRMMGVPTAMFTPLFVIARTSGWSAHIIEQRIDNKIIRPSANYTGPEDLTFVPIEKR

Specific function: Catalyzes the synthesis of 2-methylcitrate from propionyl-CoA and oxaloacetate. Also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower specificity [H]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Escherichia coli, GI1786527, Length=375, Percent_Identity=77.3333333333333, Blast_Score=612, Evalue=1e-176,
Organism=Escherichia coli, GI1786939, Length=363, Percent_Identity=32.5068870523416, Blast_Score=174, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI17555174, Length=362, Percent_Identity=24.585635359116, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24640124, Length=330, Percent_Identity=23.3333333333333, Blast_Score=69, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24640126, Length=330, Percent_Identity=23.3333333333333, Blast_Score=68, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011278
- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.5 [H]

Molecular weight: Translated: 42690; Mature: 42559

Theoretical pI: Translated: 7.24; Mature: 7.24

Prosite motif: PS00480 CITRATE_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSETKDAAPAAAGGFKPKKSVALSGVAAGNTALCTVGRTGNDLHYRGYDILDFAQACEFE
CCCCCCCCCCCCCCCCCCHHHEEECEECCCEEEEEECCCCCCCEECCCHHHHHHHHCCHH
EIAYLLVHEKLPTRAELSAYKTKLRALRGLPAAVKAALEAVPASAHPMDVMRTGVSVLGT
HHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
VLPEKDDHNLPGARDIADRLMASLGSMLLYWYHWSHNGRRIEVETDDDSIGGHFLHLLHG
HCCCCCCCCCCCHHHHHHHHHHHHHHHEEEEEEECCCCEEEEEECCCCCCCHHHHHHHCC
KAPSQAWVEAMHTSLILYAEHEFNASTFTGRVIAGTGSDIYSAITGAIGALRGPKHGGAN
CCCHHHHHHHHHHEEEEEEECCCCCCEECCEEEECCCHHHHHHHHHHHHHCCCCCCCCCC
EVAFEIQSRYRNADEAEADIRRRVGNKEVVIGFGHPVYTISDPRNKVIKEVARKLSKEAG
HHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEECCCEEEEECCHHHHHHHHHHHHHHHCCC
DTQLFEIAERLEAVMWDAKKMFPNLDWFSAVSYRMMGVPTAMFTPLFVIARTSGWSAHII
CHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHEEEEEECCCCHHHHH
EQRIDNKIIRPSANYTGPEDLTFVPIEKR
HHHHCCCEECCCCCCCCCCCCEEEECCCC
>Mature Secondary Structure 
SETKDAAPAAAGGFKPKKSVALSGVAAGNTALCTVGRTGNDLHYRGYDILDFAQACEFE
CCCCCCCCCCCCCCCCCHHHEEECEECCCEEEEEECCCCCCCEECCCHHHHHHHHCCHH
EIAYLLVHEKLPTRAELSAYKTKLRALRGLPAAVKAALEAVPASAHPMDVMRTGVSVLGT
HHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
VLPEKDDHNLPGARDIADRLMASLGSMLLYWYHWSHNGRRIEVETDDDSIGGHFLHLLHG
HCCCCCCCCCCCHHHHHHHHHHHHHHHEEEEEEECCCCEEEEEECCCCCCCHHHHHHHCC
KAPSQAWVEAMHTSLILYAEHEFNASTFTGRVIAGTGSDIYSAITGAIGALRGPKHGGAN
CCCHHHHHHHHHHEEEEEEECCCCCCEECCEEEECCCHHHHHHHHHHHHHCCCCCCCCCC
EVAFEIQSRYRNADEAEADIRRRVGNKEVVIGFGHPVYTISDPRNKVIKEVARKLSKEAG
HHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEECCCEEEEECCHHHHHHHHHHHHHHHCCC
DTQLFEIAERLEAVMWDAKKMFPNLDWFSAVSYRMMGVPTAMFTPLFVIARTSGWSAHII
CHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHEEEEEECCCCHHHHH
EQRIDNKIIRPSANYTGPEDLTFVPIEKR
HHHHCCCEECCCCCCCCCCCCEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503; 8508809; 9325432 [H]