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The map label for this gene is adhA [H]

Identifier: 238025372

GI number: 238025372

Start: 2534812

End: 2535840

Strand: Reverse

Name: adhA [H]

Synonym: bglu_2g20480

Alternate gene names: 238025372

Gene position: 2535840-2534812 (Counterclockwise)

Preceding gene: 238025373

Following gene: 238025370

Centisome position: 89.69

GC content: 66.47

Gene sequence:

>1029_bases
ATGTCCAAGACGATGAAGGCCGCAGTGGTGCGTGAATTCGGCAAACCGCTCGCGATCGAGGAAGTGCCCGTACCGGTGCC
GGGGCCCGGCCAGATCCTGGTGAGGATCGCGGCCACCGGCGTGTGCCATACCGATCTGCACGCCGCCGAGGGCGACTGGC
CGGTCAAGCCGAAGCCGCCGTTCATTCCCGGCCACGAGGGCGTCGGCCACGTCGTCGGCGTGGGCGCGGGCGTCAGGCAT
GTGCGCGAGGGCGACCGCGTCGGCGTGCCGTGGCTCTACGCCACCTGCGGCCACTGCGTACACTGCCTCGGCGGCTGGGA
AACCTTGTGCGAATCCCAGCAGAACACCGGTTATTCGGTGAACGGCAGCTTCGCGGAATACGTGGTCGCCGATCCGAACT
TCGTCGGGCACCTTCCGGCCAACCTGCCCTTCGTCGACGTCGCGCCGATCCTGTGTGCCGGCGTGACCGTCTACAAAGGA
TTGAAGGTCACCGACACCAAGCCGGACGATTGGGTGGTGATCTCCGGAATCGGCGGCCTGGGGCATCTCGCGGTGCAATA
CGCCAGGGCGATGGGCCTGAACGTCATCGCGGTCGACATCGACGACGAGAAGCTCGAGCTGGCGAAACGGCTTGGCGCCG
CCCTGGCCGTCAATGCCAAGCGCGAGGACCCCGTGCAGTTCGTGCGGTCCGCCGTGGGCGGCGCGCGCGGCGTGCTCGTC
ACCGCGGTCTCGCGATCCGCGTTTGCCCAGGCGATGGGGATGGTCGGCCGAGGCGGCACGGTGTCGTTGAATGGTCTGCC
GCCCGGCGATTTCCCCCTGTCCATCTTCGATACCGTGCTCAACGGCGTGACCGTTCGCGGCTCGATTGTGGGGACGCGCC
TGGACCTTCAGGAGGCGCTCAACTTTGCCGGAGAAGGCAAGGTGGCGGCGACGGTCAGCACCGCGAAGCTCGAGGATATC
AACGACATCTTCTCGAAGATGCATCAGGGCGATATCCAGGGCCGCATGGTGATCGACTTTTCCGCCTGA

Upstream 100 bases:

>100_bases
CCGCGGCGGCCCAGGCCGGGGACGGCCGCCGCAGCACTGAACGCGGTCGTGCCCATGACGCGACGAAGCATGGCCGCCCA
TTTATGCTAAGGAGCGTTTC

Downstream 100 bases:

>100_bases
GTCACCGCGCGCACGAGCGGCCGATTCCCGATGAATCGGCGTCAATGGGGCGGTCGAGCGGATCCGGCACCGCTCGAGCG
GCCCGCGCGAGTTCGGCGTG

Product: zinc-containing alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 342; Mature: 341

Protein sequence:

>342_residues
MSKTMKAAVVREFGKPLAIEEVPVPVPGPGQILVRIAATGVCHTDLHAAEGDWPVKPKPPFIPGHEGVGHVVGVGAGVRH
VREGDRVGVPWLYATCGHCVHCLGGWETLCESQQNTGYSVNGSFAEYVVADPNFVGHLPANLPFVDVAPILCAGVTVYKG
LKVTDTKPDDWVVISGIGGLGHLAVQYARAMGLNVIAVDIDDEKLELAKRLGAALAVNAKREDPVQFVRSAVGGARGVLV
TAVSRSAFAQAMGMVGRGGTVSLNGLPPGDFPLSIFDTVLNGVTVRGSIVGTRLDLQEALNFAGEGKVAATVSTAKLEDI
NDIFSKMHQGDIQGRMVIDFSA

Sequences:

>Translated_342_residues
MSKTMKAAVVREFGKPLAIEEVPVPVPGPGQILVRIAATGVCHTDLHAAEGDWPVKPKPPFIPGHEGVGHVVGVGAGVRH
VREGDRVGVPWLYATCGHCVHCLGGWETLCESQQNTGYSVNGSFAEYVVADPNFVGHLPANLPFVDVAPILCAGVTVYKG
LKVTDTKPDDWVVISGIGGLGHLAVQYARAMGLNVIAVDIDDEKLELAKRLGAALAVNAKREDPVQFVRSAVGGARGVLV
TAVSRSAFAQAMGMVGRGGTVSLNGLPPGDFPLSIFDTVLNGVTVRGSIVGTRLDLQEALNFAGEGKVAATVSTAKLEDI
NDIFSKMHQGDIQGRMVIDFSA
>Mature_341_residues
SKTMKAAVVREFGKPLAIEEVPVPVPGPGQILVRIAATGVCHTDLHAAEGDWPVKPKPPFIPGHEGVGHVVGVGAGVRHV
REGDRVGVPWLYATCGHCVHCLGGWETLCESQQNTGYSVNGSFAEYVVADPNFVGHLPANLPFVDVAPILCAGVTVYKGL
KVTDTKPDDWVVISGIGGLGHLAVQYARAMGLNVIAVDIDDEKLELAKRLGAALAVNAKREDPVQFVRSAVGGARGVLVT
AVSRSAFAQAMGMVGRGGTVSLNGLPPGDFPLSIFDTVLNGVTVRGSIVGTRLDLQEALNFAGEGKVAATVSTAKLEDIN
DIFSKMHQGDIQGRMVIDFSA

Specific function: Preferred Specificity Is Towards 1-Propanol. [C]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI34577061, Length=370, Percent_Identity=30.2702702702703, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI4501933, Length=314, Percent_Identity=31.2101910828025, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI4501929, Length=314, Percent_Identity=31.2101910828025, Blast_Score=108, Evalue=8e-24,
Organism=Homo sapiens, GI71565154, Length=249, Percent_Identity=33.3333333333333, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI71743840, Length=252, Percent_Identity=30.5555555555556, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI262073058, Length=252, Percent_Identity=30.5555555555556, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI71565152, Length=366, Percent_Identity=28.4153005464481, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI156523966, Length=246, Percent_Identity=29.2682926829268, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI4501939, Length=246, Percent_Identity=29.2682926829268, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI194239674, Length=300, Percent_Identity=25.3333333333333, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI13236495, Length=300, Percent_Identity=25.3333333333333, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI194239676, Length=243, Percent_Identity=27.1604938271605, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI87081918, Length=312, Percent_Identity=47.1153846153846, Blast_Score=249, Evalue=2e-67,
Organism=Escherichia coli, GI1786518, Length=336, Percent_Identity=32.1428571428571, Blast_Score=155, Evalue=4e-39,
Organism=Escherichia coli, GI1790045, Length=290, Percent_Identity=32.4137931034483, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI87082401, Length=341, Percent_Identity=29.9120234604106, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1788073, Length=284, Percent_Identity=31.6901408450704, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI87082125, Length=220, Percent_Identity=35.4545454545455, Blast_Score=115, Evalue=6e-27,
Organism=Escherichia coli, GI1786552, Length=366, Percent_Identity=32.2404371584699, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI226510992, Length=310, Percent_Identity=27.4193548387097, Blast_Score=91, Evalue=9e-20,
Organism=Escherichia coli, GI1787863, Length=294, Percent_Identity=28.9115646258503, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1788407, Length=221, Percent_Identity=33.4841628959276, Blast_Score=88, Evalue=8e-19,
Organism=Escherichia coli, GI1790485, Length=322, Percent_Identity=27.0186335403727, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1786825, Length=312, Percent_Identity=29.8076923076923, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1788075, Length=324, Percent_Identity=26.8518518518519, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790718, Length=338, Percent_Identity=27.2189349112426, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17562584, Length=342, Percent_Identity=38.8888888888889, Blast_Score=226, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI71988145, Length=342, Percent_Identity=35.9649122807018, Blast_Score=223, Evalue=9e-59,
Organism=Caenorhabditis elegans, GI17562582, Length=347, Percent_Identity=38.9048991354467, Blast_Score=208, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI17562876, Length=338, Percent_Identity=30.4733727810651, Blast_Score=123, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17562878, Length=227, Percent_Identity=35.2422907488987, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI25146526, Length=239, Percent_Identity=31.3807531380753, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71997431, Length=241, Percent_Identity=31.5352697095436, Blast_Score=78, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17507255, Length=266, Percent_Identity=27.0676691729323, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17565904, Length=212, Percent_Identity=29.2452830188679, Blast_Score=66, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6319621, Length=345, Percent_Identity=40.5797101449275, Blast_Score=258, Evalue=8e-70,
Organism=Saccharomyces cerevisiae, GI6323961, Length=343, Percent_Identity=40.5247813411079, Blast_Score=255, Evalue=7e-69,
Organism=Saccharomyces cerevisiae, GI6323729, Length=343, Percent_Identity=40.5247813411079, Blast_Score=251, Evalue=1e-67,
Organism=Saccharomyces cerevisiae, GI6324486, Length=343, Percent_Identity=39.3586005830904, Blast_Score=249, Evalue=6e-67,
Organism=Saccharomyces cerevisiae, GI6319949, Length=339, Percent_Identity=28.6135693215339, Blast_Score=110, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6323980, Length=325, Percent_Identity=28.3076923076923, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6320033, Length=242, Percent_Identity=33.4710743801653, Blast_Score=97, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6319955, Length=325, Percent_Identity=28.9230769230769, Blast_Score=87, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6322619, Length=325, Percent_Identity=28.9230769230769, Blast_Score=87, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6319257, Length=321, Percent_Identity=25.5451713395639, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI17737895, Length=241, Percent_Identity=31.1203319502075, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17137530, Length=234, Percent_Identity=29.0598290598291, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI17737897, Length=220, Percent_Identity=27.2727272727273, Blast_Score=68, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 35828; Mature: 35696

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKTMKAAVVREFGKPLAIEEVPVPVPGPGQILVRIAATGVCHTDLHAAEGDWPVKPKPP
CCCHHHHHHHHHHCCCCEECCCCCCCCCCCCEEEEEECCCCEECCCCCCCCCCCCCCCCC
FIPGHEGVGHVVGVGAGVRHVREGDRVGVPWLYATCGHCVHCLGGWETLCESQQNTGYSV
CCCCCCCCCCEEECCHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCHHHHHCCCCCCCEEE
NGSFAEYVVADPNFVGHLPANLPFVDVAPILCAGVTVYKGLKVTDTKPDDWVVISGIGGL
CCCEEEEEEECCCEEECCCCCCCHHHHHHHHHHHHHHHCCEEEECCCCCCEEEEECCCCH
GHLAVQYARAMGLNVIAVDIDDEKLELAKRLGAALAVNAKREDPVQFVRSAVGGARGVLV
HHHHHHHHHHCCCEEEEEECCHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHCCCCCEEE
TAVSRSAFAQAMGMVGRGGTVSLNGLPPGDFPLSIFDTVLNGVTVRGSIVGTRLDLQEAL
EHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCHHHHHHHHCCEEEEEEEEECEECHHHHH
NFAGEGKVAATVSTAKLEDINDIFSKMHQGDIQGRMVIDFSA
CCCCCCCEEEEEEHHHHHHHHHHHHHHHCCCCCCEEEEEECC
>Mature Secondary Structure 
SKTMKAAVVREFGKPLAIEEVPVPVPGPGQILVRIAATGVCHTDLHAAEGDWPVKPKPP
CCHHHHHHHHHHCCCCEECCCCCCCCCCCCEEEEEECCCCEECCCCCCCCCCCCCCCCC
FIPGHEGVGHVVGVGAGVRHVREGDRVGVPWLYATCGHCVHCLGGWETLCESQQNTGYSV
CCCCCCCCCCEEECCHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCHHHHHCCCCCCCEEE
NGSFAEYVVADPNFVGHLPANLPFVDVAPILCAGVTVYKGLKVTDTKPDDWVVISGIGGL
CCCEEEEEEECCCEEECCCCCCCHHHHHHHHHHHHHHHCCEEEECCCCCCEEEEECCCCH
GHLAVQYARAMGLNVIAVDIDDEKLELAKRLGAALAVNAKREDPVQFVRSAVGGARGVLV
HHHHHHHHHHCCCEEEEEECCHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHCCCCCEEE
TAVSRSAFAQAMGMVGRGGTVSLNGLPPGDFPLSIFDTVLNGVTVRGSIVGTRLDLQEAL
EHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCHHHHHHHHCCEEEEEEEEECEECHHHHH
NFAGEGKVAATVSTAKLEDINDIFSKMHQGDIQGRMVIDFSA
CCCCCCCEEEEEEHHHHHHHHHHHHHHHCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9659380; 11481432 [H]