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The map label for this gene is lrp [H]

Identifier: 238025281

GI number: 238025281

Start: 2429576

End: 2430058

Strand: Reverse

Name: lrp [H]

Synonym: bglu_2g19550

Alternate gene names: 238025281

Gene position: 2430058-2429576 (Counterclockwise)

Preceding gene: 238025283

Following gene: 238025277

Centisome position: 85.95

GC content: 64.8

Gene sequence:

>483_bases
ATGAAGAAAGCCAGTCCGCGCGTCGAGATCGACGCGACCGATATGAAAATCCTGCAGATCGTGCAGGACAAGGGCAGGCT
CAGCAACGCCGAGCTGGCCGAGCAGGTTTCCCTGTCGCCCTCGCCGTGCTGGAAGCGCCTGCGGCGGCTTGAATCGAGCG
GCGTGATCCGCGGCTACCGGGCCGAGCTCGACCGGCACGTGCTCGGTTTCAACGTCGTCGCGTTCGTCAGCATCTCGCTC
GACAGTCACACGCAGAAAGTGTGCCGCGCCTTCGAGGCCGGCGTGATGGCGATGTCCGAGGTGGTGGCCTGCCACAACAC
CACGGGCGCGCACGACTACCTGCTGCAGATCCTCGTCGAGGACTTCGAGCGCTATTCCGAGTTCGTGCTGGACCGCCTGC
GCACGCTGCCCGGCGTGAAGGAGATGCTGAGCACGGTGTCGATGCGCGAGCTGAAATCGTCGAGCAAGCTCGCGCTGCGC
TAG

Upstream 100 bases:

>100_bases
GCATCGCCAGTCAGTGTAGAGTTGCCCGGCCAGAATATTCGTTCCTTTTCGTTCCGGCAAATCCTATAATTTAGAACGAT
CTTTCCCGTCAGGCCCCCCG

Downstream 100 bases:

>100_bases
GCGGCGCGTTCGTTGCTACTGCGGTAATGATGCGATCACGGCGGCCGGCGCCTTGCCAGGGGCGCTGCGCGCCGCGGTCG
CTTGCTCAGCCCGGTCGAGA

Product: AsnC family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 160; Mature: 160

Protein sequence:

>160_residues
MKKASPRVEIDATDMKILQIVQDKGRLSNAELAEQVSLSPSPCWKRLRRLESSGVIRGYRAELDRHVLGFNVVAFVSISL
DSHTQKVCRAFEAGVMAMSEVVACHNTTGAHDYLLQILVEDFERYSEFVLDRLRTLPGVKEMLSTVSMRELKSSSKLALR

Sequences:

>Translated_160_residues
MKKASPRVEIDATDMKILQIVQDKGRLSNAELAEQVSLSPSPCWKRLRRLESSGVIRGYRAELDRHVLGFNVVAFVSISL
DSHTQKVCRAFEAGVMAMSEVVACHNTTGAHDYLLQILVEDFERYSEFVLDRLRTLPGVKEMLSTVSMRELKSSSKLALR
>Mature_160_residues
MKKASPRVEIDATDMKILQIVQDKGRLSNAELAEQVSLSPSPCWKRLRRLESSGVIRGYRAELDRHVLGFNVVAFVSISL
DSHTQKVCRAFEAGVMAMSEVVACHNTTGAHDYLLQILVEDFERYSEFVLDRLRTLPGVKEMLSTVSMRELKSSSKLALR

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes [H]

COG id: COG1522

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=158, Percent_Identity=38.6075949367089, Blast_Score=121, Evalue=2e-29,
Organism=Escherichia coli, GI87081742, Length=150, Percent_Identity=35.3333333333333, Blast_Score=104, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 18011; Mature: 18011

Theoretical pI: Translated: 8.87; Mature: 8.87

Prosite motif: PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKASPRVEIDATDMKILQIVQDKGRLSNAELAEQVSLSPSPCWKRLRRLESSGVIRGYR
CCCCCCCEEECHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHH
AELDRHVLGFNVVAFVSISLDSHTQKVCRAFEAGVMAMSEVVACHNTTGAHDYLLQILVE
HHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
DFERYSEFVLDRLRTLPGVKEMLSTVSMRELKSSSKLALR
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MKKASPRVEIDATDMKILQIVQDKGRLSNAELAEQVSLSPSPCWKRLRRLESSGVIRGYR
CCCCCCCEEECHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHH
AELDRHVLGFNVVAFVSISLDSHTQKVCRAFEAGVMAMSEVVACHNTTGAHDYLLQILVE
HHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
DFERYSEFVLDRLRTLPGVKEMLSTVSMRELKSSSKLALR
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]