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The map label for this gene is envZ [H]

Identifier: 238025050

GI number: 238025050

Start: 2141730

End: 2142977

Strand: Reverse

Name: envZ [H]

Synonym: bglu_2g17070

Alternate gene names: 238025050

Gene position: 2142977-2141730 (Counterclockwise)

Preceding gene: 238025051

Following gene: 238025049

Centisome position: 75.79

GC content: 72.04

Gene sequence:

>1248_bases
ATGAAACGCCGCTTTGATACGCTGTTCGTCCGGCTGGCGTTGATGGCCATCGGCCTCGTGCTGGTGGTCCACGCGATCGG
CCTGGTGCTGCTCGACCGCGAGCGGCTGCGCCTGGAAGTCGAGCAGACGCGCCGCGTGATCGCGCTGTCCACGCAGGCGC
AGGCGAGCGGCAGCGCGCTCGGCCTCGCGGTCAGCGCGATGCTCGGCACGTCGTTCGTCGACGTGAAGGATGCCTTGGCG
TTCGGCTGCCCGCCGCCGTGCGTCGATACCTATGGCCCGTTCGAGCGCCATCTGCGCGAGGCGATGCCGCCCGGCACGCA
CGTGGTCGGTGACGGCCGCTCGCGCACCATCTGGGCACGCTATCCGGGCGCGCGCTACTGGGTGACGCTGCCCTCGACGA
TGCCGTCGGTCACGCGCTTCATCGGCGCCTCGTCGCTGACGATGCTGATCGGCATCGGCCTGGCGATCTTCGGCGCCTGG
CGCATCCAGCGCCCGCTGCGGCGGCTCGCGCAGGCGGTGCGCGATTTCCGGCTCGGCAACCGGCAGGCGGCGGTGCCGGT
CGGCGGCCCGCGCGAGGTCAAGGACGTGATCGCGAACTTCAACGAGATGGTGAGCGAGCTGGCGCAGGGCGAGCAGGAGC
GCGCGATGATGCTGGCTGGCCTCGCGCACGACCTGCGCGCGCCGATCACGCGCATGCAGGTGCGCGCCGACCTGCTGCCC
GACCAGGCCACCCGCGACGGCTTCCTGCGCGATGCCGAGGCGCTTTCGCGGATCGTCACGCAGTTCCTCGATTTCGCGGG
CGAAGGCGCGGCGCCGTCGCCGACCGCGAGCGTCGACGCGCATTGCCGCCAGCACTACGGGGGCGAGCTCGACGACGCGC
TCGTTACCACCGACCTGCGCGCCGGCGAGGGTTTCCGGCTGCCGCTCGTCGATCTCGACCGGATTCTGTCGAACCTGATC
GAGAACGCGATGACCTACGGCGAGCCGCCCGTCGAGATCTCCACGGCGGCGCTCGCGCAGGGCTACCGGCTGGTGGTGCG
CGACCACGGGCCGGGCATTCCCGAGGCCGAGCTCGAACGCGCGCAGCGGCCGTTCGTGCGGCTCGACGCGGCGCGCGGCG
GCGACGCGCACTGCGGGCTCGGGCTCGCGATCGTCAAGCGGCTGGTGCACCAGCGGCGCGGCAGCTTCGTCGCCTCGAAC
GCCGACGACGGCGGCTTCGTCGTCACCATGACGTTCCCGCCCGCCTGA

Upstream 100 bases:

>100_bases
TGGCGCCTGCGCCGCCTGCTGGAAGACGACCCCGCCCGGCCGCGCTACGTGCAGACGATGCGCGGCGTCGGCTACATGTT
CGTGCCTGGCGGCGATGCCG

Downstream 100 bases:

>100_bases
GGCCCGCCGCCGCTTGCGGGCCGCTCGTGCTTGCGTGTTGGCGCGCGAGCCCCGAGAATCGTCGTTCCTTTCAACCGAAC
CCAGACGACGAGCGACCTCA

Product: Periplasmic sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 415; Mature: 415

Protein sequence:

>415_residues
MKRRFDTLFVRLALMAIGLVLVVHAIGLVLLDRERLRLEVEQTRRVIALSTQAQASGSALGLAVSAMLGTSFVDVKDALA
FGCPPPCVDTYGPFERHLREAMPPGTHVVGDGRSRTIWARYPGARYWVTLPSTMPSVTRFIGASSLTMLIGIGLAIFGAW
RIQRPLRRLAQAVRDFRLGNRQAAVPVGGPREVKDVIANFNEMVSELAQGEQERAMMLAGLAHDLRAPITRMQVRADLLP
DQATRDGFLRDAEALSRIVTQFLDFAGEGAAPSPTASVDAHCRQHYGGELDDALVTTDLRAGEGFRLPLVDLDRILSNLI
ENAMTYGEPPVEISTAALAQGYRLVVRDHGPGIPEAELERAQRPFVRLDAARGGDAHCGLGLAIVKRLVHQRRGSFVASN
ADDGGFVVTMTFPPA

Sequences:

>Translated_415_residues
MKRRFDTLFVRLALMAIGLVLVVHAIGLVLLDRERLRLEVEQTRRVIALSTQAQASGSALGLAVSAMLGTSFVDVKDALA
FGCPPPCVDTYGPFERHLREAMPPGTHVVGDGRSRTIWARYPGARYWVTLPSTMPSVTRFIGASSLTMLIGIGLAIFGAW
RIQRPLRRLAQAVRDFRLGNRQAAVPVGGPREVKDVIANFNEMVSELAQGEQERAMMLAGLAHDLRAPITRMQVRADLLP
DQATRDGFLRDAEALSRIVTQFLDFAGEGAAPSPTASVDAHCRQHYGGELDDALVTTDLRAGEGFRLPLVDLDRILSNLI
ENAMTYGEPPVEISTAALAQGYRLVVRDHGPGIPEAELERAQRPFVRLDAARGGDAHCGLGLAIVKRLVHQRRGSFVASN
ADDGGFVVTMTFPPA
>Mature_415_residues
MKRRFDTLFVRLALMAIGLVLVVHAIGLVLLDRERLRLEVEQTRRVIALSTQAQASGSALGLAVSAMLGTSFVDVKDALA
FGCPPPCVDTYGPFERHLREAMPPGTHVVGDGRSRTIWARYPGARYWVTLPSTMPSVTRFIGASSLTMLIGIGLAIFGAW
RIQRPLRRLAQAVRDFRLGNRQAAVPVGGPREVKDVIANFNEMVSELAQGEQERAMMLAGLAHDLRAPITRMQVRADLLP
DQATRDGFLRDAEALSRIVTQFLDFAGEGAAPSPTASVDAHCRQHYGGELDDALVTTDLRAGEGFRLPLVDLDRILSNLI
ENAMTYGEPPVEISTAALAQGYRLVVRDHGPGIPEAELERAQRPFVRLDAARGGDAHCGLGLAIVKRLVHQRRGSFVASN
ADDGGFVVTMTFPPA

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=328, Percent_Identity=28.9634146341463, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1790346, Length=285, Percent_Identity=28.4210526315789, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1787894, Length=289, Percent_Identity=26.643598615917, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1787374, Length=302, Percent_Identity=26.8211920529801, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1788393, Length=274, Percent_Identity=25.1824817518248, Blast_Score=74, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 45101; Mature: 45101

Theoretical pI: Translated: 8.35; Mature: 8.35

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRRFDTLFVRLALMAIGLVLVVHAIGLVLLDRERLRLEVEQTRRVIALSTQAQASGSAL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCEEEEEECCCCCCCCHH
GLAVSAMLGTSFVDVKDALAFGCPPPCVDTYGPFERHLREAMPPGTHVVGDGRSRTIWAR
HHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCEEEECCCCCEEEEE
YPGARYWVTLPSTMPSVTRFIGASSLTMLIGIGLAIFGAWRIQRPLRRLAQAVRDFRLGN
CCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
RQAAVPVGGPREVKDVIANFNEMVSELAQGEQERAMMLAGLAHDLRAPITRMQVRADLLP
CCEECCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DQATRDGFLRDAEALSRIVTQFLDFAGEGAAPSPTASVDAHCRQHYGGELDDALVTTDLR
CCHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCHHHEEECCC
AGEGFRLPLVDLDRILSNLIENAMTYGEPPVEISTAALAQGYRLVVRDHGPGIPEAELER
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCEEEEECCCCCCCHHHHHH
AQRPFVRLDAARGGDAHCGLGLAIVKRLVHQRRGSFVASNADDGGFVVTMTFPPA
HCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHCCCEEECCCCCCCEEEEEECCCC
>Mature Secondary Structure
MKRRFDTLFVRLALMAIGLVLVVHAIGLVLLDRERLRLEVEQTRRVIALSTQAQASGSAL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCEEEEEECCCCCCCCHH
GLAVSAMLGTSFVDVKDALAFGCPPPCVDTYGPFERHLREAMPPGTHVVGDGRSRTIWAR
HHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCEEEECCCCCEEEEE
YPGARYWVTLPSTMPSVTRFIGASSLTMLIGIGLAIFGAWRIQRPLRRLAQAVRDFRLGN
CCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
RQAAVPVGGPREVKDVIANFNEMVSELAQGEQERAMMLAGLAHDLRAPITRMQVRADLLP
CCEECCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DQATRDGFLRDAEALSRIVTQFLDFAGEGAAPSPTASVDAHCRQHYGGELDDALVTTDLR
CCHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCHHHEEECCC
AGEGFRLPLVDLDRILSNLIENAMTYGEPPVEISTAALAQGYRLVVRDHGPGIPEAELER
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCEEEEECCCCCCCHHHHHH
AQRPFVRLDAARGGDAHCGLGLAIVKRLVHQRRGSFVASNADDGGFVVTMTFPPA
HCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHCCCEEECCCCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]