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The map label for this gene is penA [H]

Identifier: 238024831

GI number: 238024831

Start: 1869310

End: 1871211

Strand: Direct

Name: penA [H]

Synonym: bglu_2g14710

Alternate gene names: 238024831

Gene position: 1869310-1871211 (Clockwise)

Preceding gene: 238024830

Following gene: 238024841

Centisome position: 66.12

GC content: 70.14

Gene sequence:

>1902_bases
ATGCCGCACCGAAACAAGCCGAAATCCGCCGATCCTTACGTCGCCGTCGCGCGCAGCCCGATGCTCGGGTCGAGCCTGCC
GATGTGGCGTTCGAAATTCGTCGTGATCGTCATGTTTCTCGCGTTCGCCGCGCTGATCGGGCGCGCGTTCTGGGTGCAGG
TCGCCAATCAGGATTTCTATCTCGGACAGGGCGAGAAACGCTATCAGCGCACCATCGAACTGGACGCGACGCGCGGGCGC
ATCGTCGATCGCAACGGCGCGATGCTGGCCGTGAGCCTCGCCACCTACGAAATCTGGGCCAATCCGAAGCAGGTCGATCC
GGCCGCCTACGGCCCGCTCGCGAAGCTGCTCGACATGCCGCACGCCGAACTCGCGCGGCGCCTGACGGCAGACAAGAGCT
TCGTGCTGCTGAAGCGGCAGATCGATCCCGACACTGCCGCGAAGATCGGCAAGCTCGACCTCGAAGGCATCACGCAGATC
GCCGATTCGAAGCGCTTCTATCCCGAAGGCGAATCGGCCGCGCACGTGGTGGGCTTCACCAACATCGAGGACCGCGGCCA
GGAAGGCGTCGAGCTGGCCGCCGACGGCCGGCTGCTCGGCACCGCCGGGCAGCGCGAGGTGATCCGCGACCGGCTCGGCC
GCATCATCTCCGACACGCGCCCGCTGGTGCCCGCGCAGCACGGCGCCACCGTCGAGCTGACGATCGACCGCCGCGTGCAG
CAGCTCGCCTACGCGCAACTGAAGGCCGCCGTGCTGGCCAACCATGCGAAGGCGGGCAGCGTGGTGGTGCTCGAGGCGCG
CTCGGGCGAGATCCTCGCGCTCGCCAATTACCCGACCTTCGACCCGAACGACCGCAGCCGCCTGACCGGCGCGCAATTGC
GCAACCGCGCCGTGATCGACACGTTCGAGCCCGGCTCGACCGTCAAGCCGCTCGTCGTGGCGCTGTCGATCGACGAGGGC
AAGGTCGGGCCGCAGACGCTCGTCAACACCTCGCCCGGCACCTGGAAGATCGGGCCGGCGGTGATCCACGACACCTCGAA
CCACGGCGTGATGACGGTCGCGCAGGCGCTGCAGAAGTCGAGCAACGTCGCGCTCGCGAAGCTGGCGCTGAACCTGCCCG
CGCAGACGATCTGGGACAAGTATCAGGAATACGGCATCGGCCACGCGCCGGATCTGACGTTTCCCGGCGTCGCCTCGGGC
CGGCTGCGCCCCTACCAGCGCTGGCGGCCGATCGAGCAGGCCACCATGGCTTACGGCTATGGGCTGTCGATGTCGCTGCT
GCAGATCGCGCAGATGTACACCGCCTATGCCGGCGACGGCACGCTCCACCCGGTCTCGCTGCTGCGCGACGGCAGCGATG
CCGGCCGCCAGGGCCATCGCGTGACACGGCCCGAGACCGCCGCCGCGATCCGCTCGATGCTGGAGATGGCCGTCAGCGAG
GGCGGCACCGGGCGCGCGGCGCGCGTGGACGGCTACCGGATCGGCGGCAAGACCGGCACCGCGCGCAAGCAGGAAGGCGG
CGGCTACGCCAAGGGCAAGTACCGCGCCCTGTTCGCCGGCATGGCGCCGATGAGCGACCCGCGCGTGATCGTCGCCGTGA
TGATCGACGAGCCGGGCGGGCGCGGCTACTACGGCGGCACGGTGGCTGGCCCGGTGTTTTCGTCGGTGATGGGCGGCACG
CTGCAGTTGCTGGCGGTGCCGCCCGATGCGCCGGTCAAGCCCGATGCAGTGAAGCCGGCGTCGGCCGCGGCCGCCGGGGT
GCCGGCGCAAACGGCCGCGCGCGCCGCCCCGACTGCACCGGCAACCAGGCCGGCACGGCCGCGCGCGATGGTCCAGATGC
AGGCCAATGCAAAGCCCAATGCACCGGCCGACGCGGGCAGCCCGAGCGCGGCGCGCTCCTGA

Upstream 100 bases:

>100_bases
GCCCTGCGCCGGCACCGGCGCGGGCCAGATTCGCATCGACAATCATTGCAAATCGCCTTAATATTTCTTTCAAATAAACC
AGCGCCTTCCCGCCGCCCTC

Downstream 100 bases:

>100_bases
CGACGTGACGTGATACCGGCGCGAGCGAGCGCCTCCGGCGGGCGCCGTCCGGCCTGCCGCGTCGGCGCGTCCCGCGGGTA
CGCCGCCGGCAGACCGCGCC

Product: Penicillin-binding protein

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 633; Mature: 632

Protein sequence:

>633_residues
MPHRNKPKSADPYVAVARSPMLGSSLPMWRSKFVVIVMFLAFAALIGRAFWVQVANQDFYLGQGEKRYQRTIELDATRGR
IVDRNGAMLAVSLATYEIWANPKQVDPAAYGPLAKLLDMPHAELARRLTADKSFVLLKRQIDPDTAAKIGKLDLEGITQI
ADSKRFYPEGESAAHVVGFTNIEDRGQEGVELAADGRLLGTAGQREVIRDRLGRIISDTRPLVPAQHGATVELTIDRRVQ
QLAYAQLKAAVLANHAKAGSVVVLEARSGEILALANYPTFDPNDRSRLTGAQLRNRAVIDTFEPGSTVKPLVVALSIDEG
KVGPQTLVNTSPGTWKIGPAVIHDTSNHGVMTVAQALQKSSNVALAKLALNLPAQTIWDKYQEYGIGHAPDLTFPGVASG
RLRPYQRWRPIEQATMAYGYGLSMSLLQIAQMYTAYAGDGTLHPVSLLRDGSDAGRQGHRVTRPETAAAIRSMLEMAVSE
GGTGRAARVDGYRIGGKTGTARKQEGGGYAKGKYRALFAGMAPMSDPRVIVAVMIDEPGGRGYYGGTVAGPVFSSVMGGT
LQLLAVPPDAPVKPDAVKPASAAAAGVPAQTAARAAPTAPATRPARPRAMVQMQANAKPNAPADAGSPSAARS

Sequences:

>Translated_633_residues
MPHRNKPKSADPYVAVARSPMLGSSLPMWRSKFVVIVMFLAFAALIGRAFWVQVANQDFYLGQGEKRYQRTIELDATRGR
IVDRNGAMLAVSLATYEIWANPKQVDPAAYGPLAKLLDMPHAELARRLTADKSFVLLKRQIDPDTAAKIGKLDLEGITQI
ADSKRFYPEGESAAHVVGFTNIEDRGQEGVELAADGRLLGTAGQREVIRDRLGRIISDTRPLVPAQHGATVELTIDRRVQ
QLAYAQLKAAVLANHAKAGSVVVLEARSGEILALANYPTFDPNDRSRLTGAQLRNRAVIDTFEPGSTVKPLVVALSIDEG
KVGPQTLVNTSPGTWKIGPAVIHDTSNHGVMTVAQALQKSSNVALAKLALNLPAQTIWDKYQEYGIGHAPDLTFPGVASG
RLRPYQRWRPIEQATMAYGYGLSMSLLQIAQMYTAYAGDGTLHPVSLLRDGSDAGRQGHRVTRPETAAAIRSMLEMAVSE
GGTGRAARVDGYRIGGKTGTARKQEGGGYAKGKYRALFAGMAPMSDPRVIVAVMIDEPGGRGYYGGTVAGPVFSSVMGGT
LQLLAVPPDAPVKPDAVKPASAAAAGVPAQTAARAAPTAPATRPARPRAMVQMQANAKPNAPADAGSPSAARS
>Mature_632_residues
PHRNKPKSADPYVAVARSPMLGSSLPMWRSKFVVIVMFLAFAALIGRAFWVQVANQDFYLGQGEKRYQRTIELDATRGRI
VDRNGAMLAVSLATYEIWANPKQVDPAAYGPLAKLLDMPHAELARRLTADKSFVLLKRQIDPDTAAKIGKLDLEGITQIA
DSKRFYPEGESAAHVVGFTNIEDRGQEGVELAADGRLLGTAGQREVIRDRLGRIISDTRPLVPAQHGATVELTIDRRVQQ
LAYAQLKAAVLANHAKAGSVVVLEARSGEILALANYPTFDPNDRSRLTGAQLRNRAVIDTFEPGSTVKPLVVALSIDEGK
VGPQTLVNTSPGTWKIGPAVIHDTSNHGVMTVAQALQKSSNVALAKLALNLPAQTIWDKYQEYGIGHAPDLTFPGVASGR
LRPYQRWRPIEQATMAYGYGLSMSLLQIAQMYTAYAGDGTLHPVSLLRDGSDAGRQGHRVTRPETAAAIRSMLEMAVSEG
GTGRAARVDGYRIGGKTGTARKQEGGGYAKGKYRALFAGMAPMSDPRVIVAVMIDEPGGRGYYGGTVAGPVFSSVMGGTL
QLLAVPPDAPVKPDAVKPASAAAAGVPAQTAARAAPTAPATRPARPRAMVQMQANAKPNAPADAGSPSAARS

Specific function: Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=551, Percent_Identity=39.7459165154265, Blast_Score=393, Evalue=1e-110,
Organism=Escherichia coli, GI1786854, Length=614, Percent_Identity=24.9185667752443, Blast_Score=124, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 67443; Mature: 67312

Theoretical pI: Translated: 10.26; Mature: 10.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPHRNKPKSADPYVAVARSPMLGSSLPMWRSKFVVIVMFLAFAALIGRAFWVQVANQDFY
CCCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCEE
LGQGEKRYQRTIELDATRGRIVDRNGAMLAVSLATYEIWANPKQVDPAAYGPLAKLLDMP
ECCCHHHHHHEEEEECCCCEEEECCCCEEEEEEEEEEEECCCCCCCCHHHHHHHHHHCCC
HAELARRLTADKSFVLLKRQIDPDTAAKIGKLDLEGITQIADSKRFYPEGESAAHVVGFT
HHHHHHHHHCCCCEEEEEECCCCHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEC
NIEDRGQEGVELAADGRLLGTAGQREVIRDRLGRIISDTRPLVPAQHGATVELTIDRRVQ
CCHHCCCCCCEEEECCEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEHHHHHH
QLAYAQLKAAVLANHAKAGSVVVLEARSGEILALANYPTFDPNDRSRLTGAQLRNRAVID
HHHHHHHHHHHHHCCCCCCCEEEEEECCCCEEEEECCCCCCCCCCHHCCHHHHCCCEEEE
TFEPGSTVKPLVVALSIDEGKVGPQTLVNTSPGTWKIGPAVIHDTSNHGVMTVAQALQKS
ECCCCCCCCEEEEEEEECCCCCCCHHEEECCCCCEEECCEEEEECCCCCHHHHHHHHHHC
SNVALAKLALNLPAQTIWDKYQEYGIGHAPDLTFPGVASGRLRPYQRWRPIEQATMAYGY
CCEEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHCCCHHHHHHHHCC
GLSMSLLQIAQMYTAYAGDGTLHPVSLLRDGSDAGRQGHRVTRPETAAAIRSMLEMAVSE
CCHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHC
GGTGRAARVDGYRIGGKTGTARKQEGGGYAKGKYRALFAGMAPMSDPRVIVAVMIDEPGG
CCCCCEEEECCEEECCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEEEECCCC
RGYYGGTVAGPVFSSVMGGTLQLLAVPPDAPVKPDAVKPASAAAAGVPAQTAARAAPTAP
CCCCCCCHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCHHHHCCCCHHHHHHCCCCCC
ATRPARPRAMVQMQANAKPNAPADAGSPSAARS
CCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PHRNKPKSADPYVAVARSPMLGSSLPMWRSKFVVIVMFLAFAALIGRAFWVQVANQDFY
CCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCEE
LGQGEKRYQRTIELDATRGRIVDRNGAMLAVSLATYEIWANPKQVDPAAYGPLAKLLDMP
ECCCHHHHHHEEEEECCCCEEEECCCCEEEEEEEEEEEECCCCCCCCHHHHHHHHHHCCC
HAELARRLTADKSFVLLKRQIDPDTAAKIGKLDLEGITQIADSKRFYPEGESAAHVVGFT
HHHHHHHHHCCCCEEEEEECCCCHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEC
NIEDRGQEGVELAADGRLLGTAGQREVIRDRLGRIISDTRPLVPAQHGATVELTIDRRVQ
CCHHCCCCCCEEEECCEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEHHHHHH
QLAYAQLKAAVLANHAKAGSVVVLEARSGEILALANYPTFDPNDRSRLTGAQLRNRAVID
HHHHHHHHHHHHHCCCCCCCEEEEEECCCCEEEEECCCCCCCCCCHHCCHHHHCCCEEEE
TFEPGSTVKPLVVALSIDEGKVGPQTLVNTSPGTWKIGPAVIHDTSNHGVMTVAQALQKS
ECCCCCCCCEEEEEEEECCCCCCCHHEEECCCCCEEECCEEEEECCCCCHHHHHHHHHHC
SNVALAKLALNLPAQTIWDKYQEYGIGHAPDLTFPGVASGRLRPYQRWRPIEQATMAYGY
CCEEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHCCCHHHHHHHHCC
GLSMSLLQIAQMYTAYAGDGTLHPVSLLRDGSDAGRQGHRVTRPETAAAIRSMLEMAVSE
CCHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHC
GGTGRAARVDGYRIGGKTGTARKQEGGGYAKGKYRALFAGMAPMSDPRVIVAVMIDEPGG
CCCCCEEEECCEEECCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEEEECCCC
RGYYGGTVAGPVFSSVMGGTLQLLAVPPDAPVKPDAVKPASAAAAGVPAQTAARAAPTAP
CCCCCCCHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCHHHHCCCCHHHHHHCCCCCC
ATRPARPRAMVQMQANAKPNAPADAGSPSAARS
CCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3126399 [H]