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The map label for this gene is kipI [H]

Identifier: 238024680

GI number: 238024680

Start: 1685573

End: 1686448

Strand: Direct

Name: kipI [H]

Synonym: bglu_2g13090

Alternate gene names: 238024680

Gene position: 1685573-1686448 (Clockwise)

Preceding gene: 238024679

Following gene: 238024681

Centisome position: 59.62

GC content: 64.84

Gene sequence:

>876_bases
GTGACGATCCGTTATACGTTCGGCGGCGACGAGTTCGTGTTCGCCGAGATCAGCGAGGCGATGTCGCTCGATGCCTTCTT
CGAGGGCGCGGCGATCACGCGCGAATTGCAGCGGCGTTCAGTGCCGGGCATCACCGAGATCTGCCCGGCGAACGCGTCCT
ACCAGGTGCGCTACGACCCGGACGTGATCGAGCCCGACACGCTCATCGCGCTGCTCAAAGCGATCGAGGCCGAGGTCGGC
GACGCGCCGCTCGAACTCGACACGCGCATCGTCGAGGTGCCGGTGCTGTACAACGACCCGTGGACGCACGAGACGTTGAT
GCGGTTTCGCGAGCGTCACCAGGACCCGTCGTCGACCGATCTCGAATATGCGGCGCGGGTCAACGACAAGCGCGACGTCG
ACGATTTCATCGCCGCACACTCGGGCTCGCCGTGGTTCGTGTCGATGGTCGGCTTCGTCGCCGGCCTGCCGTTCATGTAT
CAGATGGTCGAGCGCGCTCGCCAGCTCGAAGTGCCGAAATACTTGCGACCGCGTACCGATACGCCGAAGCTGACGGTCGG
CCACGGCGGCTGCTTCGGCTGTATCTATTCGGTGCGCGGCGCGGGCGGCTACCAGATGTTCGGCGTGACGCCGGCACCGA
TCTTCGATCCCGCACAACGGCTCGACTACCTGCGCGACTTCATGGTGTTCTTCCGGCCCGGCGACATCGTGAAGTTCCAG
CCGATCGATCGCGATGCCTACGACGCGGCCGTAGCGGCGGTCGAAGCGGGCACGTTCTCGCTGCGCGTGCGCCCCGTGAA
ATTCTCGCTCGACGCGTTCCTGCGTGATCCCGATGCGTACAACCGTTCTCTCGTCGAGGTGCTGCATGCAAGCTGA

Upstream 100 bases:

>100_bases
CGAATTTTCTCGAAGCTTGGATGCTGCGATGGCGCGAGGCCGCAACGGCCGCCGCCCGGCAGCATGAAACCGCGGACGCC
GCGCGCGTCGGGGAGGCACT

Downstream 100 bases:

>100_bases
CGCGCACAACCTAATGGAGGTCGTGAAACCCGGCCTCGCGACGTCGGTCCAGGATACGGGTCGGCAAGGCTACTACCACG
TCGGCATCCCGCCGTCGGGC

Product: allophanate hydrolase subunit 1

Products: NA

Alternate protein names: Sporulation inhibitor kipI [H]

Number of amino acids: Translated: 291; Mature: 290

Protein sequence:

>291_residues
MTIRYTFGGDEFVFAEISEAMSLDAFFEGAAITRELQRRSVPGITEICPANASYQVRYDPDVIEPDTLIALLKAIEAEVG
DAPLELDTRIVEVPVLYNDPWTHETLMRFRERHQDPSSTDLEYAARVNDKRDVDDFIAAHSGSPWFVSMVGFVAGLPFMY
QMVERARQLEVPKYLRPRTDTPKLTVGHGGCFGCIYSVRGAGGYQMFGVTPAPIFDPAQRLDYLRDFMVFFRPGDIVKFQ
PIDRDAYDAAVAAVEAGTFSLRVRPVKFSLDAFLRDPDAYNRSLVEVLHAS

Sequences:

>Translated_291_residues
MTIRYTFGGDEFVFAEISEAMSLDAFFEGAAITRELQRRSVPGITEICPANASYQVRYDPDVIEPDTLIALLKAIEAEVG
DAPLELDTRIVEVPVLYNDPWTHETLMRFRERHQDPSSTDLEYAARVNDKRDVDDFIAAHSGSPWFVSMVGFVAGLPFMY
QMVERARQLEVPKYLRPRTDTPKLTVGHGGCFGCIYSVRGAGGYQMFGVTPAPIFDPAQRLDYLRDFMVFFRPGDIVKFQ
PIDRDAYDAAVAAVEAGTFSLRVRPVKFSLDAFLRDPDAYNRSLVEVLHAS
>Mature_290_residues
TIRYTFGGDEFVFAEISEAMSLDAFFEGAAITRELQRRSVPGITEICPANASYQVRYDPDVIEPDTLIALLKAIEAEVGD
APLELDTRIVEVPVLYNDPWTHETLMRFRERHQDPSSTDLEYAARVNDKRDVDDFIAAHSGSPWFVSMVGFVAGLPFMYQ
MVERARQLEVPKYLRPRTDTPKLTVGHGGCFGCIYSVRGAGGYQMFGVTPAPIFDPAQRLDYLRDFMVFFRPGDIVKFQP
IDRDAYDAAVAAVEAGTFSLRVRPVKFSLDAFLRDPDAYNRSLVEVLHAS

Specific function: Is a potent inhibitor of the autophosphorylation reaction of kinase A and its reverse reaction, but does not inhibit phosphate transfer to the Spo0F response regulator once kinase A is phosphorylated. KipI is an inhibitor of the catalytic domain of kinase

COG id: COG2049

COG function: function code E; Allophanate hydrolase subunit 1

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786929, Length=202, Percent_Identity=27.2277227722772, Blast_Score=66, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6319685, Length=288, Percent_Identity=23.6111111111111, Blast_Score=73, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003833
- InterPro:   IPR020899
- InterPro:   IPR010016
- InterPro:   IPR002130 [H]

Pfam domain/function: PF02682 AHS1 [H]

EC number: NA

Molecular weight: Translated: 32740; Mature: 32609

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIRYTFGGDEFVFAEISEAMSLDAFFEGAAITRELQRRSVPGITEICPANASYQVRYDP
CEEEEECCCCEEEHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHCCCCCCEEEEECC
DVIEPDTLIALLKAIEAEVGDAPLELDTRIVEVPVLYNDPWTHETLMRFRERHQDPSSTD
CCCCHHHHHHHHHHHHHHCCCCCCEECCEEEEEEEEECCCCCHHHHHHHHHHCCCCCCCC
LEYAARVNDKRDVDDFIAAHSGSPWFVSMVGFVAGLPFMYQMVERARQLEVPKYLRPRTD
HHHHHHCCCCCCHHHHHHHCCCCCHHHHHHHHHHCHHHHHHHHHHHHHCCCCHHHCCCCC
TPKLTVGHGGCFGCIYSVRGAGGYQMFGVTPAPIFDPAQRLDYLRDFMVFFRPGDIVKFQ
CCEEEECCCCHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEE
PIDRDAYDAAVAAVEAGTFSLRVRPVKFSLDAFLRDPDAYNRSLVEVLHAS
CCCCCHHHHHHHHHCCCEEEEEEEEEEEEHHHHHCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
TIRYTFGGDEFVFAEISEAMSLDAFFEGAAITRELQRRSVPGITEICPANASYQVRYDP
EEEEECCCCEEEHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHCCCCCCEEEEECC
DVIEPDTLIALLKAIEAEVGDAPLELDTRIVEVPVLYNDPWTHETLMRFRERHQDPSSTD
CCCCHHHHHHHHHHHHHHCCCCCCEECCEEEEEEEEECCCCCHHHHHHHHHHCCCCCCCC
LEYAARVNDKRDVDDFIAAHSGSPWFVSMVGFVAGLPFMYQMVERARQLEVPKYLRPRTD
HHHHHHCCCCCCHHHHHHHCCCCCHHHHHHHHHHCHHHHHHHHHHHHHCCCCHHHCCCCC
TPKLTVGHGGCFGCIYSVRGAGGYQMFGVTPAPIFDPAQRLDYLRDFMVFFRPGDIVKFQ
CCEEEECCCCHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEE
PIDRDAYDAAVAAVEAGTFSLRVRPVKFSLDAFLRDPDAYNRSLVEVLHAS
CCCCCHHHHHHHHHCCCEEEEEEEEEEEEHHHHHCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377; 10568751 [H]