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The map label for this gene is clcA [H]

Identifier: 238024621

GI number: 238024621

Start: 1574289

End: 1576085

Strand: Direct

Name: clcA [H]

Synonym: bglu_2g12360

Alternate gene names: 238024621

Gene position: 1574289-1576085 (Clockwise)

Preceding gene: 238024620

Following gene: 238024622

Centisome position: 55.68

GC content: 73.4

Gene sequence:

>1797_bases
ATGCATGCCACTGCGCCGCACCAGCGCGATTTCGCGCCGAACCTCCGCCTGCCCCGCATCGCCATGCTCGCCGCCGCGAT
CGGCGTGACCAGCACGCTCGCGGCAGTCGCGCTGCTGAACCTGATCCACCTGTTCACGAACCTGTTCTTCTTCGGGCGCT
GGTCGCTGGTCGGCCGCTCCCCGGCCGGCCACGCGCTCGGCGCCTGGGTGATCGCGGTGCCGGTGATCGGTGGCCTGATC
GTGGGGCTGATCGCGCGCTTCGGCTCGGAGAAGATTCGCGGCCACGGCATTCCCGAGGCGATCGAGGCGATCCTGTTCGG
CAAGAGCCGCATGTCGCCGAAGGTGGCGGTGCTCAAGCCGCTCTCGTCGGGCATCGTGATCGGCAGCGGCGGACCGTTCG
GCGCCGAGGGGCCGATCATCATGACGGGCGGGGCGCTCGGCTCGCTGCTCGCGCAATGCTTCAAGGTCACGGCCGCCGAG
CGCAAGACGCTGCTGGTGGCGGGCGCCACGGCCGGCATGACCGCCGTGTTCGGCACGCCGGTCGCCGCGGTGCTGCTGGC
CGTCGAGCTGCTGCTGTTCGAATGGCGCCCACGCAGCTTCCTGCCGGTGGCGCTGGCCTGCGCGGTGGCCGGCTTCGCGC
GCGCGCTCTGCTTCGGCAGCGCGCCGCTGTTTCCGTTGACGACGGCCGCGCCCTCCACGTCCGCGCTGTGGGTCTGCCTG
CTGGCCGGGCTGCTCTCGGGCGCGCTCGCCAGCGGCCTGTCGGCCGCGCTCTACCGCACCGAGGATGCGTTCGGCAGGCT
GCCGCTGCACTGGATGTGGTGGCCGGCGCTCGGCGGCGTCGTGGTGGGCATCGGCGGCTGGCTCGAACCGCGCGCGTTCG
GGGTCGGCTACGACGTGATCGGCGATCTGCTGCATGGGCAGCTCGCGCTGCACGCCGTGCTCGCGCTGCTCGCGGTCAAG
GCGGTGATCTGGGTGGTGGCGCTCGGCTCCGGCACCTCGGGCGGCGTGCTGGCACCGCTGCTGATGCTGGGCGCCGGACT
CGGCACGCTGCTGGGCGCCGCGCTGCCGGGCAGCGATCCCGCGCTGTGGCCGCTCGTCTGCATGGCCGCCACGCTCGGCG
CCACGCTCGGCGCGCCGCTCACGGCGGTGGTGTTCGCGTTCGGCCTGACCCACGACGCCACCGCCCTGCTGCCGCTGCTC
GCGGCCACGCTGGTCGCGCACGGCTTCTCGTCGGTGGTGATGCGGCGCTCGATCATGACCGAGAAGATCGCGCGGCGCGG
CTATCACATCTATCGCGAGTACGGTGTCGATCCGCTCGAGCGGCACGAGGTGGCCGAGGTGATGACGCGCGAGGCGATCA
CGATCGACGCGGCCACGCCGCTTGCCGAGGTACGGCGTGCCTACTTCGGCGCGGACCAGAAGCATCGCGCGTACCCGGTG
GTGCGCGACGGCGCGCTCGTGACGATGCTCGACCGCGCCGCGCTCGAAGGGCTCGAGGCCGCGCACGGCCCGCACGCGCG
CCTCGCCGATGCGCTGCACGGTGCCTCGCGCGGCGCCTGGGCGCTGCCGCACGAAACCTGCCGGCTGGTCGCGACGCGGC
TCGCCGTGCATGGGCTCGAACGGCTGCCGGTGATCGCCGGCGATGCCTCGCCGCAGCTGGTGGGCGTGGTCGCGCGCAGC
GATCTGGTCAAGCCCGCACTGCGCCACTTCGACGAGGAGCACAAGCGCGAGCGCTTCCACGGCATGCGGCTGCCGCGCGC
CGCGCGCGCGCGGCGGCGCATCGCGCGCACCGGCTGA

Upstream 100 bases:

>100_bases
CCGCGCTGCATCGCGCCGAACTCAAATCGCTGCGCGGCGCGTTCCAGGTGCCGCAAATCGACTACTAGCCCCATTTTCCC
GCTCCCCGTTCCCCACCATC

Downstream 100 bases:

>100_bases
CGGCGCCACGGCCTCGCGAGGGCCGCGGCCGCGCTAGCCGAGCGGCACGGATCGCGCGCCGCCGTTGTCACAAACCGTCA
CGAATTTAAATCTGCTTAAC

Product: chloride transporter, ClC family

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 598; Mature: 598

Protein sequence:

>598_residues
MHATAPHQRDFAPNLRLPRIAMLAAAIGVTSTLAAVALLNLIHLFTNLFFFGRWSLVGRSPAGHALGAWVIAVPVIGGLI
VGLIARFGSEKIRGHGIPEAIEAILFGKSRMSPKVAVLKPLSSGIVIGSGGPFGAEGPIIMTGGALGSLLAQCFKVTAAE
RKTLLVAGATAGMTAVFGTPVAAVLLAVELLLFEWRPRSFLPVALACAVAGFARALCFGSAPLFPLTTAAPSTSALWVCL
LAGLLSGALASGLSAALYRTEDAFGRLPLHWMWWPALGGVVVGIGGWLEPRAFGVGYDVIGDLLHGQLALHAVLALLAVK
AVIWVVALGSGTSGGVLAPLLMLGAGLGTLLGAALPGSDPALWPLVCMAATLGATLGAPLTAVVFAFGLTHDATALLPLL
AATLVAHGFSSVVMRRSIMTEKIARRGYHIYREYGVDPLERHEVAEVMTREAITIDAATPLAEVRRAYFGADQKHRAYPV
VRDGALVTMLDRAALEGLEAAHGPHARLADALHGASRGAWALPHETCRLVATRLAVHGLERLPVIAGDASPQLVGVVARS
DLVKPALRHFDEEHKRERFHGMRLPRAARARRRIARTG

Sequences:

>Translated_598_residues
MHATAPHQRDFAPNLRLPRIAMLAAAIGVTSTLAAVALLNLIHLFTNLFFFGRWSLVGRSPAGHALGAWVIAVPVIGGLI
VGLIARFGSEKIRGHGIPEAIEAILFGKSRMSPKVAVLKPLSSGIVIGSGGPFGAEGPIIMTGGALGSLLAQCFKVTAAE
RKTLLVAGATAGMTAVFGTPVAAVLLAVELLLFEWRPRSFLPVALACAVAGFARALCFGSAPLFPLTTAAPSTSALWVCL
LAGLLSGALASGLSAALYRTEDAFGRLPLHWMWWPALGGVVVGIGGWLEPRAFGVGYDVIGDLLHGQLALHAVLALLAVK
AVIWVVALGSGTSGGVLAPLLMLGAGLGTLLGAALPGSDPALWPLVCMAATLGATLGAPLTAVVFAFGLTHDATALLPLL
AATLVAHGFSSVVMRRSIMTEKIARRGYHIYREYGVDPLERHEVAEVMTREAITIDAATPLAEVRRAYFGADQKHRAYPV
VRDGALVTMLDRAALEGLEAAHGPHARLADALHGASRGAWALPHETCRLVATRLAVHGLERLPVIAGDASPQLVGVVARS
DLVKPALRHFDEEHKRERFHGMRLPRAARARRRIARTG
>Mature_598_residues
MHATAPHQRDFAPNLRLPRIAMLAAAIGVTSTLAAVALLNLIHLFTNLFFFGRWSLVGRSPAGHALGAWVIAVPVIGGLI
VGLIARFGSEKIRGHGIPEAIEAILFGKSRMSPKVAVLKPLSSGIVIGSGGPFGAEGPIIMTGGALGSLLAQCFKVTAAE
RKTLLVAGATAGMTAVFGTPVAAVLLAVELLLFEWRPRSFLPVALACAVAGFARALCFGSAPLFPLTTAAPSTSALWVCL
LAGLLSGALASGLSAALYRTEDAFGRLPLHWMWWPALGGVVVGIGGWLEPRAFGVGYDVIGDLLHGQLALHAVLALLAVK
AVIWVVALGSGTSGGVLAPLLMLGAGLGTLLGAALPGSDPALWPLVCMAATLGATLGAPLTAVVFAFGLTHDATALLPLL
AATLVAHGFSSVVMRRSIMTEKIARRGYHIYREYGVDPLERHEVAEVMTREAITIDAATPLAEVRRAYFGADQKHRAYPV
VRDGALVTMLDRAALEGLEAAHGPHARLADALHGASRGAWALPHETCRLVATRLAVHGLERLPVIAGDASPQLVGVVARS
DLVKPALRHFDEEHKRERFHGMRLPRAARARRRIARTG

Specific function: Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme

COG id: COG0038

COG function: function code P; Chloride channel protein EriC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClcA subfamily [H]

Homologues:

Organism=Escherichia coli, GI87081943, Length=342, Percent_Identity=28.3625730994152, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1786350, Length=313, Percent_Identity=24.6006389776358, Blast_Score=67, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014743
- InterPro:   IPR001807 [H]

Pfam domain/function: PF00654 Voltage_CLC [H]

EC number: NA

Molecular weight: Translated: 62650; Mature: 62650

Theoretical pI: Translated: 10.50; Mature: 10.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHATAPHQRDFAPNLRLPRIAMLAAAIGVTSTLAAVALLNLIHLFTNLFFFGRWSLVGRS
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PAGHALGAWVIAVPVIGGLIVGLIARFGSEKIRGHGIPEAIEAILFGKSRMSPKVAVLKP
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCHHHHHHHHHCCCCCCCCCEEEEE
LSSGIVIGSGGPFGAEGPIIMTGGALGSLLAQCFKVTAAERKTLLVAGATAGMTAVFGTP
CCCCEEEECCCCCCCCCCEEEECCHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHCCH
VAAVLLAVELLLFEWRPRSFLPVALACAVAGFARALCFGSAPLFPLTTAAPSTSALWVCL
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHH
LAGLLSGALASGLSAALYRTEDAFGRLPLHWMWWPALGGVVVGIGGWLEPRAFGVGYDVI
HHHHHHHHHHHHHHHHHHHCHHHHCCCCCCEEEHHHHCCEEEECCCCCCCHHHCCCHHHH
GDLLHGQLALHAVLALLAVKAVIWVVALGSGTSGGVLAPLLMLGAGLGTLLGAALPGSDP
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCHHHHHHHCCCCCCC
ALWPLVCMAATLGATLGAPLTAVVFAFGLTHDATALLPLLAATLVAHGFSSVVMRRSIMT
HHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EKIARRGYHIYREYGVDPLERHEVAEVMTREAITIDAATPLAEVRRAYFGADQKHRAYPV
HHHHHCCHHHHHHHCCCHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHCCCCCCCCCCE
VRDGALVTMLDRAALEGLEAAHGPHARLADALHGASRGAWALPHETCRLVATRLAVHGLE
EECCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
RLPVIAGDASPQLVGVVARSDLVKPALRHFDEEHKRERFHGMRLPRAARARRRIARTG
HCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MHATAPHQRDFAPNLRLPRIAMLAAAIGVTSTLAAVALLNLIHLFTNLFFFGRWSLVGRS
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PAGHALGAWVIAVPVIGGLIVGLIARFGSEKIRGHGIPEAIEAILFGKSRMSPKVAVLKP
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCHHHHHHHHHCCCCCCCCCEEEEE
LSSGIVIGSGGPFGAEGPIIMTGGALGSLLAQCFKVTAAERKTLLVAGATAGMTAVFGTP
CCCCEEEECCCCCCCCCCEEEECCHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHCCH
VAAVLLAVELLLFEWRPRSFLPVALACAVAGFARALCFGSAPLFPLTTAAPSTSALWVCL
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHH
LAGLLSGALASGLSAALYRTEDAFGRLPLHWMWWPALGGVVVGIGGWLEPRAFGVGYDVI
HHHHHHHHHHHHHHHHHHHCHHHHCCCCCCEEEHHHHCCEEEECCCCCCCHHHCCCHHHH
GDLLHGQLALHAVLALLAVKAVIWVVALGSGTSGGVLAPLLMLGAGLGTLLGAALPGSDP
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCHHHHHHHCCCCCCC
ALWPLVCMAATLGATLGAPLTAVVFAFGLTHDATALLPLLAATLVAHGFSSVVMRRSIMT
HHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EKIARRGYHIYREYGVDPLERHEVAEVMTREAITIDAATPLAEVRRAYFGADQKHRAYPV
HHHHHCCHHHHHHHCCCHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHCCCCCCCCCCE
VRDGALVTMLDRAALEGLEAAHGPHARLADALHGASRGAWALPHETCRLVATRLAVHGLE
EECCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
RLPVIAGDASPQLVGVVARSDLVKPALRHFDEEHKRERFHGMRLPRAARARRRIARTG
HCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA