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The map label for this gene is clpX

Identifier: 229918353

GI number: 229918353

Start: 2602765

End: 2604033

Strand: Direct

Name: clpX

Synonym: EAT1b_2638

Alternate gene names: 229918353

Gene position: 2602765-2604033 (Clockwise)

Preceding gene: 229918352

Following gene: 229918354

Centisome position: 86.76

GC content: 48.86

Gene sequence:

>1269_bases
ATGTTCAAATTTAACGAGGAAAAGGGGCAACTCAAGTGCTCGTTTTGCGGAAAATCGCAAGAACAAGTTCGTAAGTTAGT
CGCCGGTCCTGGCGTATACATTTGCGATGAATGTATCGAACTTTGCAATGAAATTGTTGAGGAAGAGCTCGGTGTAGAGG
AAGAAGTCGAATTCAAAGACATTCCAAAACCACAAGAGATTCGTAACATCCTAGACGATTATGTCATTGGTCAAGACCGC
GCCAAACGTGCGCTTTCAGTAGCTGTCTATAACCACTATAAACGCATCAACGCCGGCGGTCGTTCAGATGATGTCGAACT
TGCGAAGTCGAACATCGTCATGATTGGACCAACGGGTAGCGGGAAGACGCTTCTCGCTCAGACGATGGCTCGCGTCTTGA
ACGTCCCATTCGCAATCGCAGATGCGACGAGCTTGACGGAAGCAGGTTACGTCGGAGAAGACGTTGAGAATATCTTGCTC
AAATTGATTCAATCGGCTGACTATGATGTCGAGAAAGCTGAAAAAGGGATCATCTACATCGATGAGATCGATAAGATTGC
CCGTAAGTCTGAAAACCCATCGATTACGCGTGATGTATCCGGTGAAGGCGTTCAGCAGGCGCTCCTTAAAATTCTTGAAG
GCACGACAGCGAGCGTACCACCACAAGGTGGACGGAAGCATCCGCATCAAGAATTTATCCAAATCGACACGACAAACATT
CTCTTCATTGTCGGTGGCGCATTCGCCGGCATCGAATCGGTCGTCAAACGCCGCATCGGGAAGAAAGTCATCGGTTTCGG
AAACGATCAAGAGAATCGCGAGTTGACGCAAGAAGACTTGCTCGCCCGCGCACTCCCTGAAGACCTTCAAAAATTCGGTT
TGATTCCTGAGTTCATCGGACGTTTGCCAGTCATGGCGACGCTCACGACACTCGATGAGGAAGCACTCGTTGAAATCTTG
ACGAAGCCGAAAAATGCACTCGTCCGTCAGTACGAGAAAATGCTCGAGCTTGACGATGTCGAATTGACGTTCACAGACGA
AGCATTGATCGAAATCGCCAAACTTGCGATCAAACGTAAGACTGGCGCGCGCGGTCTCCGCTCGATTATCGAAGAAATGA
TGCTCGATGTGATGTTCACCGTCCCATCGCGTGACGATATCGAGAAAGTCATCATCACGGATGAAACGATTACGGGTCTT
GCCGGTCCGAAATACGTCCTTCGTGACGGTACTGTCGAACAGACAGGGGACAACAAAGAGACAGCATAA

Upstream 100 bases:

>100_bases
CAGAGATGTAAAATGTCTTTTCGCGGTGCATCGCACCAGAAAATTCAAATCGCGATTTATCGCACTTACATCCATTTTCA
CCACAGAAGGGGTGTATCGA

Downstream 100 bases:

>100_bases
TTTGTTAACGAAGAAGGCTCAAACACTCGGCACATCCGAGTTTTGGGCCTTTTTGCACAGGAGGCGTTGTATATGGAAAA
ATTACCAATCCTTCCTTTGC

Product: ATP-dependent protease ATP-binding subunit ClpX

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MFKFNEEKGQLKCSFCGKSQEQVRKLVAGPGVYICDECIELCNEIVEEELGVEEEVEFKDIPKPQEIRNILDDYVIGQDR
AKRALSVAVYNHYKRINAGGRSDDVELAKSNIVMIGPTGSGKTLLAQTMARVLNVPFAIADATSLTEAGYVGEDVENILL
KLIQSADYDVEKAEKGIIYIDEIDKIARKSENPSITRDVSGEGVQQALLKILEGTTASVPPQGGRKHPHQEFIQIDTTNI
LFIVGGAFAGIESVVKRRIGKKVIGFGNDQENRELTQEDLLARALPEDLQKFGLIPEFIGRLPVMATLTTLDEEALVEIL
TKPKNALVRQYEKMLELDDVELTFTDEALIEIAKLAIKRKTGARGLRSIIEEMMLDVMFTVPSRDDIEKVIITDETITGL
AGPKYVLRDGTVEQTGDNKETA

Sequences:

>Translated_422_residues
MFKFNEEKGQLKCSFCGKSQEQVRKLVAGPGVYICDECIELCNEIVEEELGVEEEVEFKDIPKPQEIRNILDDYVIGQDR
AKRALSVAVYNHYKRINAGGRSDDVELAKSNIVMIGPTGSGKTLLAQTMARVLNVPFAIADATSLTEAGYVGEDVENILL
KLIQSADYDVEKAEKGIIYIDEIDKIARKSENPSITRDVSGEGVQQALLKILEGTTASVPPQGGRKHPHQEFIQIDTTNI
LFIVGGAFAGIESVVKRRIGKKVIGFGNDQENRELTQEDLLARALPEDLQKFGLIPEFIGRLPVMATLTTLDEEALVEIL
TKPKNALVRQYEKMLELDDVELTFTDEALIEIAKLAIKRKTGARGLRSIIEEMMLDVMFTVPSRDDIEKVIITDETITGL
AGPKYVLRDGTVEQTGDNKETA
>Mature_422_residues
MFKFNEEKGQLKCSFCGKSQEQVRKLVAGPGVYICDECIELCNEIVEEELGVEEEVEFKDIPKPQEIRNILDDYVIGQDR
AKRALSVAVYNHYKRINAGGRSDDVELAKSNIVMIGPTGSGKTLLAQTMARVLNVPFAIADATSLTEAGYVGEDVENILL
KLIQSADYDVEKAEKGIIYIDEIDKIARKSENPSITRDVSGEGVQQALLKILEGTTASVPPQGGRKHPHQEFIQIDTTNI
LFIVGGAFAGIESVVKRRIGKKVIGFGNDQENRELTQEDLLARALPEDLQKFGLIPEFIGRLPVMATLTTLDEEALVEIL
TKPKNALVRQYEKMLELDDVELTFTDEALIEIAKLAIKRKTGARGLRSIIEEMMLDVMFTVPSRDDIEKVIITDETITGL
AGPKYVLRDGTVEQTGDNKETA

Specific function: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP

COG id: COG1219

COG function: function code O; ATP-dependent protease Clp, ATPase subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family

Homologues:

Organism=Homo sapiens, GI7242140, Length=329, Percent_Identity=49.5440729483283, Blast_Score=310, Evalue=2e-84,
Organism=Escherichia coli, GI1786642, Length=397, Percent_Identity=64.2317380352645, Blast_Score=527, Evalue=1e-151,
Organism=Escherichia coli, GI1790366, Length=105, Percent_Identity=43.8095238095238, Blast_Score=91, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71982908, Length=326, Percent_Identity=46.319018404908, Blast_Score=291, Evalue=6e-79,
Organism=Caenorhabditis elegans, GI71982905, Length=326, Percent_Identity=46.319018404908, Blast_Score=290, Evalue=7e-79,
Organism=Caenorhabditis elegans, GI71988663, Length=412, Percent_Identity=37.621359223301, Blast_Score=250, Evalue=1e-66,
Organism=Caenorhabditis elegans, GI71988660, Length=260, Percent_Identity=38.4615384615385, Blast_Score=169, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6319704, Length=437, Percent_Identity=38.2151029748284, Blast_Score=271, Evalue=2e-73,
Organism=Drosophila melanogaster, GI24648291, Length=338, Percent_Identity=49.112426035503, Blast_Score=318, Evalue=7e-87,
Organism=Drosophila melanogaster, GI24648289, Length=338, Percent_Identity=49.112426035503, Blast_Score=317, Evalue=9e-87,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPX_EXISA (C4L4J1)

Other databases:

- EMBL:   CP001615
- RefSeq:   YP_002886999.1
- GeneID:   7869651
- GenomeReviews:   CP001615_GR
- KEGG:   eat:EAT1b_2638
- OMA:   CGKSQEQ
- ProtClustDB:   PRK05342
- HAMAP:   MF_00175
- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR019489
- InterPro:   IPR004487
- InterPro:   IPR010603
- PANTHER:   PTHR11262:SF4
- SMART:   SM00382
- TIGRFAMs:   TIGR00382

Pfam domain/function: PF07724 AAA_2; PF10431 ClpB_D2-small; PF06689 zf-C4_ClpX

EC number: 3.4.21.-

Molecular weight: Translated: 46743; Mature: 46743

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKFNEEKGQLKCSFCGKSQEQVRKLVAGPGVYICDECIELCNEIVEEELGVEEEVEFKD
CCCCCCCCCCEEEEECCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
IPKPQEIRNILDDYVIGQDRAKRALSVAVYNHYKRINAGGRSDDVELAKSNIVMIGPTGS
CCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCEEEEECCCC
GKTLLAQTMARVLNVPFAIADATSLTEAGYVGEDVENILLKLIQSADYDVEKAEKGIIYI
CHHHHHHHHHHHHCCCHHEECCHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHCCCEEEE
DEIDKIARKSENPSITRDVSGEGVQQALLKILEGTTASVPPQGGRKHPHQEFIQIDTTNI
HHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHEEECCCEE
LFIVGGAFAGIESVVKRRIGKKVIGFGNDQENRELTQEDLLARALPEDLQKFGLIPEFIG
EEEECCHHHHHHHHHHHHHCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHC
RLPVMATLTTLDEEALVEILTKPKNALVRQYEKMLELDDVELTFTDEALIEIAKLAIKRK
CCCHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHH
TGARGLRSIIEEMMLDVMFTVPSRDDIEKVIITDETITGLAGPKYVLRDGTVEQTGDNKE
CCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCHHHCCCCCCEEEECCCCCCCCCCCC
TA
CC
>Mature Secondary Structure
MFKFNEEKGQLKCSFCGKSQEQVRKLVAGPGVYICDECIELCNEIVEEELGVEEEVEFKD
CCCCCCCCCCEEEEECCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
IPKPQEIRNILDDYVIGQDRAKRALSVAVYNHYKRINAGGRSDDVELAKSNIVMIGPTGS
CCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCEEEEECCCC
GKTLLAQTMARVLNVPFAIADATSLTEAGYVGEDVENILLKLIQSADYDVEKAEKGIIYI
CHHHHHHHHHHHHCCCHHEECCHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHCCCEEEE
DEIDKIARKSENPSITRDVSGEGVQQALLKILEGTTASVPPQGGRKHPHQEFIQIDTTNI
HHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHEEECCCEE
LFIVGGAFAGIESVVKRRIGKKVIGFGNDQENRELTQEDLLARALPEDLQKFGLIPEFIG
EEEECCHHHHHHHHHHHHHCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHC
RLPVMATLTTLDEEALVEILTKPKNALVRQYEKMLELDDVELTFTDEALIEIAKLAIKRK
CCCHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHH
TGARGLRSIIEEMMLDVMFTVPSRDDIEKVIITDETITGLAGPKYVLRDGTVEQTGDNKE
CCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCHHHCCCCCCEEEECCCCCCCCCCCC
TA
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA