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The map label for this gene is pncB [H]

Identifier: 229917781

GI number: 229917781

Start: 2010737

End: 2012182

Strand: Reverse

Name: pncB [H]

Synonym: EAT1b_2059

Alternate gene names: 229917781

Gene position: 2012182-2010737 (Counterclockwise)

Preceding gene: 229917782

Following gene: 229917779

Centisome position: 67.08

GC content: 50.28

Gene sequence:

>1446_bases
ATGTTACATCGCAATTTAGCACTTCACACTGACCTTTATCTCCCACGCTGGATGTATATCTACTGGAAGCAAGGTCGCCA
TCATGAAAAAGTCGTCTTTGACCTCTACTATCGCTCGAACCCATTTAGTGGCGGTTATGTCGTCTTTGCCGGACTCGAGA
ATATCGTTCACTATTTAGAGAACGTCTCCTTTACAGAGGCGGACATCGCCTATTTGAAAGAACAACTCGGATTCGAAGAT
GAATTCGAAGACGTCTTACGGAACTTTAAGTTCACTGGTTCACTATATAGTGTCCGCGAAGGAGAAGTCATCTTCCCTCA
TGAACAAGTCGTTCGGATTGAATCGACCATCTTTGAAGCGAAGCTGTTCCAAACGGCGCTCCTCAATATCGCGAACCACG
AATCACTCATTGCCACGAAGTATGCACGTATTCGTCAGGCTGCTCCGAACGAGACACTCCTTGAAGGAGGAGCTCGTCGC
GCGCAAGGTGTCGATGCGGCGTACTACGGGACACGTGCGGCTTACATCGCTGGTTTCGACGTGACAAGTCTCGTGTCAGC
CGGTCGTGACTTTGACGTCCCGACAGGAGGGACGATGGAGCATGCTGATATTCAGTTCCACGATGATGAATTGAGCGCAT
TCCGTTCGTTCGCTGAGATGTACCCGGACAACACGAGTCTTCTCATCGATACGTATGACACACTCAAGTCTGGTCTTCCG
AACGCGATTACGGTCGCAAAAGAACTCGAGGCGAAAGGTCATCGTCTCAAGTCAGTACGACTCGACTCTGGGGACCTCGC
CTATCTGTCGAAGCGCGCCCGGAAGGCGTTGAATGAAGCGGGGCTCGACTATGTCAAAATCGTCGTCTCTGGGGATTTGG
ATGAGTACGTCATTCAAGACTTACGGATGCAAGGCGCAGAGGCCGATACGTTCCTCGTCGGGACACGCGGCATCACGGCT
TACGAGCAGCCAGCACTCGGGATGGTCTATAAACTCGTCGCGCGTGAGGATGAATCCGGAGAATTAAAACCGGTCATCAA
AGTATCTTCTTCCAAAGTGAAGACGACGACACCTCACAAGAAAGAGTTGTATCGCATCATCGACAACGAAACGAAAAAGT
TCAAAGGCGACTATATCGCCCTCGCCGATGAACCGGTCGAATCGTACACCGAGATTGACTTGATCGACGTCCGTGACCCG
GCCTTCAAGATCAAGACACGCAACTTCAACGTGAAACGCTTGTTGCAACCGATCTTCCTTGATGGGAAACGGGTATACGA
CCTGCCGAGCACAAGTGAGATTCGTGCATATCATCACGAGCAGATGAACGGACTGTGGGAAGAGTATAAGCGTCTCCGTT
TGCCGGAAGTGTATTCGGTGACGTTCAGCAAGCCACTGTGGGATTTAAAACTCGATATGATTCGCAAAACGCGAGTACCA
AAATAA

Upstream 100 bases:

>100_bases
AGCTTCAACCCGGTCGGTCATGAATGGGCGCTCGAACATTTCGTCACGACACTCGGTGCGACCGTCGTCGGAAAGTGACG
TAAAACAGAAAGGAAACCAT

Downstream 100 bases:

>100_bases
AAAAACGGTTGTGGGTGCATACCCACAACCGTTTGCTTATACTATCGTCATCTCGCCTGCTTGGCTTTGATCTTCTTTTC
TCCGAAAGTAAAGCGCCATC

Product: nicotinate phosphoribosyltransferase

Products: NA

Alternate protein names: NAPRTase [H]

Number of amino acids: Translated: 481; Mature: 481

Protein sequence:

>481_residues
MLHRNLALHTDLYLPRWMYIYWKQGRHHEKVVFDLYYRSNPFSGGYVVFAGLENIVHYLENVSFTEADIAYLKEQLGFED
EFEDVLRNFKFTGSLYSVREGEVIFPHEQVVRIESTIFEAKLFQTALLNIANHESLIATKYARIRQAAPNETLLEGGARR
AQGVDAAYYGTRAAYIAGFDVTSLVSAGRDFDVPTGGTMEHADIQFHDDELSAFRSFAEMYPDNTSLLIDTYDTLKSGLP
NAITVAKELEAKGHRLKSVRLDSGDLAYLSKRARKALNEAGLDYVKIVVSGDLDEYVIQDLRMQGAEADTFLVGTRGITA
YEQPALGMVYKLVAREDESGELKPVIKVSSSKVKTTTPHKKELYRIIDNETKKFKGDYIALADEPVESYTEIDLIDVRDP
AFKIKTRNFNVKRLLQPIFLDGKRVYDLPSTSEIRAYHHEQMNGLWEEYKRLRLPEVYSVTFSKPLWDLKLDMIRKTRVP
K

Sequences:

>Translated_481_residues
MLHRNLALHTDLYLPRWMYIYWKQGRHHEKVVFDLYYRSNPFSGGYVVFAGLENIVHYLENVSFTEADIAYLKEQLGFED
EFEDVLRNFKFTGSLYSVREGEVIFPHEQVVRIESTIFEAKLFQTALLNIANHESLIATKYARIRQAAPNETLLEGGARR
AQGVDAAYYGTRAAYIAGFDVTSLVSAGRDFDVPTGGTMEHADIQFHDDELSAFRSFAEMYPDNTSLLIDTYDTLKSGLP
NAITVAKELEAKGHRLKSVRLDSGDLAYLSKRARKALNEAGLDYVKIVVSGDLDEYVIQDLRMQGAEADTFLVGTRGITA
YEQPALGMVYKLVAREDESGELKPVIKVSSSKVKTTTPHKKELYRIIDNETKKFKGDYIALADEPVESYTEIDLIDVRDP
AFKIKTRNFNVKRLLQPIFLDGKRVYDLPSTSEIRAYHHEQMNGLWEEYKRLRLPEVYSVTFSKPLWDLKLDMIRKTRVP
K
>Mature_481_residues
MLHRNLALHTDLYLPRWMYIYWKQGRHHEKVVFDLYYRSNPFSGGYVVFAGLENIVHYLENVSFTEADIAYLKEQLGFED
EFEDVLRNFKFTGSLYSVREGEVIFPHEQVVRIESTIFEAKLFQTALLNIANHESLIATKYARIRQAAPNETLLEGGARR
AQGVDAAYYGTRAAYIAGFDVTSLVSAGRDFDVPTGGTMEHADIQFHDDELSAFRSFAEMYPDNTSLLIDTYDTLKSGLP
NAITVAKELEAKGHRLKSVRLDSGDLAYLSKRARKALNEAGLDYVKIVVSGDLDEYVIQDLRMQGAEADTFLVGTRGITA
YEQPALGMVYKLVAREDESGELKPVIKVSSSKVKTTTPHKKELYRIIDNETKKFKGDYIALADEPVESYTEIDLIDVRDP
AFKIKTRNFNVKRLLQPIFLDGKRVYDLPSTSEIRAYHHEQMNGLWEEYKRLRLPEVYSVTFSKPLWDLKLDMIRKTRVP
K

Specific function: Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN) [H]

COG id: COG1488

COG function: function code H; Nicotinic acid phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAPRTase family [H]

Homologues:

Organism=Homo sapiens, GI194394158, Length=521, Percent_Identity=30.5182341650672, Blast_Score=227, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI71997947, Length=527, Percent_Identity=34.1555977229602, Blast_Score=266, Evalue=2e-71,
Organism=Caenorhabditis elegans, GI71997952, Length=527, Percent_Identity=34.1555977229602, Blast_Score=266, Evalue=2e-71,
Organism=Caenorhabditis elegans, GI71997955, Length=201, Percent_Identity=40.7960199004975, Blast_Score=154, Evalue=7e-38,
Organism=Drosophila melanogaster, GI24581587, Length=526, Percent_Identity=33.0798479087452, Blast_Score=236, Evalue=4e-62,
Organism=Drosophila melanogaster, GI161076680, Length=275, Percent_Identity=34.9090909090909, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24581595, Length=275, Percent_Identity=34.9090909090909, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI28574709, Length=275, Percent_Identity=34.9090909090909, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24581593, Length=275, Percent_Identity=34.9090909090909, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24581591, Length=275, Percent_Identity=34.9090909090909, Blast_Score=144, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015977
- InterPro:   IPR007229
- InterPro:   IPR006405
- InterPro:   IPR002638 [H]

Pfam domain/function: PF04095 NAPRTase [H]

EC number: =2.4.2.11 [H]

Molecular weight: Translated: 55050; Mature: 55050

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLHRNLALHTDLYLPRWMYIYWKQGRHHEKVVFDLYYRSNPFSGGYVVFAGLENIVHYLE
CCCCCEEEEECCCCCCEEEEEEECCCCCCEEEEEEEECCCCCCCCEEEEECHHHHHHHHH
NVSFTEADIAYLKEQLGFEDEFEDVLRNFKFTGSLYSVREGEVIFPHEQVVRIESTIFEA
CCCCCHHHHHHHHHHCCCCHHHHHHHHCCEECCCEEEECCCCEECCHHHHHHHHHHHHHH
KLFQTALLNIANHESLIATKYARIRQAAPNETLLEGGARRAQGVDAAYYGTRAAYIAGFD
HHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHCCCCHHCCCCHHHHCCCEEEEECCC
VTSLVSAGRDFDVPTGGTMEHADIQFHDDELSAFRSFAEMYPDNTSLLIDTYDTLKSGLP
HHHHHHCCCCCCCCCCCCEECCEEEEECHHHHHHHHHHHHCCCCCEEEEECHHHHHHCCC
NAITVAKELEAKGHRLKSVRLDSGDLAYLSKRARKALNEAGLDYVKIVVSGDLDEYVIQD
CHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCEEEEEEEECCHHHHHHHH
LRMQGAEADTFLVGTRGITAYEQPALGMVYKLVAREDESGELKPVIKVSSSKVKTTTPHK
HHHCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEEECCCEEECCCCHH
KELYRIIDNETKKFKGDYIALADEPVESYTEIDLIDVRDPAFKIKTRNFNVKRLLQPIFL
HHHHHHHCCCCHHHCCCEEEEECCCCHHHCCEEEEECCCCCEEEEECCCCHHHHHHHHHC
DGKRVYDLPSTSEIRAYHHEQMNGLWEEYKRLRLPEVYSVTFSKPLWDLKLDMIRKTRVP
CCCEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHCCCC
K
C
>Mature Secondary Structure
MLHRNLALHTDLYLPRWMYIYWKQGRHHEKVVFDLYYRSNPFSGGYVVFAGLENIVHYLE
CCCCCEEEEECCCCCCEEEEEEECCCCCCEEEEEEEECCCCCCCCEEEEECHHHHHHHHH
NVSFTEADIAYLKEQLGFEDEFEDVLRNFKFTGSLYSVREGEVIFPHEQVVRIESTIFEA
CCCCCHHHHHHHHHHCCCCHHHHHHHHCCEECCCEEEECCCCEECCHHHHHHHHHHHHHH
KLFQTALLNIANHESLIATKYARIRQAAPNETLLEGGARRAQGVDAAYYGTRAAYIAGFD
HHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHCCCCHHCCCCHHHHCCCEEEEECCC
VTSLVSAGRDFDVPTGGTMEHADIQFHDDELSAFRSFAEMYPDNTSLLIDTYDTLKSGLP
HHHHHHCCCCCCCCCCCCEECCEEEEECHHHHHHHHHHHHCCCCCEEEEECHHHHHHCCC
NAITVAKELEAKGHRLKSVRLDSGDLAYLSKRARKALNEAGLDYVKIVVSGDLDEYVIQD
CHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCEEEEEEEECCHHHHHHHH
LRMQGAEADTFLVGTRGITAYEQPALGMVYKLVAREDESGELKPVIKVSSSKVKTTTPHK
HHHCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEEECCCEEECCCCHH
KELYRIIDNETKKFKGDYIALADEPVESYTEIDLIDVRDPAFKIKTRNFNVKRLLQPIFL
HHHHHHHCCCCHHHCCCEEEEECCCCHHHCCEEEEECCCCCEEEEECCCCHHHHHHHHHC
DGKRVYDLPSTSEIRAYHHEQMNGLWEEYKRLRLPEVYSVTFSKPLWDLKLDMIRKTRVP
CCCEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHCCCC
K
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]