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The map label for this gene is recQ1 [H]

Identifier: 227815669

GI number: 227815669

Start: 2812379

End: 2813908

Strand: Reverse

Name: recQ1 [H]

Synonym: BAMEG_3088

Alternate gene names: 227815669

Gene position: 2813908-2812379 (Counterclockwise)

Preceding gene: 227815670

Following gene: 227815668

Centisome position: 53.8

GC content: 35.16

Gene sequence:

>1530_bases
ATGAAACTTGAAGAATATTTATATAAGTGGTTTGGATATTCTGAATTTCGTCCAGGTCAAAAAGGAGTAATTACAGATTT
ATTAGAAGGAAAAGATGTGATAGCAATGCTTCCGACTGGAAGAGGGAAATCTATGTGCTATCAGTTTCCGGGGCTTATGC
GAGAAGGAACCGTGCTTGTTGTATCACCGTTATTATCTTTAATGGAAGATCAAGTGACACAATTAAAGTATGTTGTGAAA
GACCGAGTGATAGCATTTAATAGTTTTCGGACATTAAATGAAAAAAGAGAAGCGATGAAAAAATTATCTTCATATAAATT
TATTTTTGTTTCACCAGAGATGTTGCAGTCGGAGTTATTAATTAGGGAATTGAAGAAAATTCATATTTCATTATTTGTTG
TTGATGAGGCTCATTGTATTTCTCAATGGGGTTATGATTTTAGACCGGACTATAAAAAACTTAATGTAGTTATTGAAAAT
ATTGGTTCTCCTACAGTATTAGCATTGACAGCCACAGCGACAAAAGGGGTACTGCAGGATATCGCAGATAGTTTAAATTT
AAAGGGTGCCGCGGAACATGTATACTCTATTGATCGTCCTAATATTGCAATGGATGTGCAATTTGTAGAGACGATAGAAG
AAAAGAAAGAGGCGCTTTTAGAGCAGGTGATGTATTTACAAGGGCCGGGGATTGTTTATTGCTCAAGTAGGGCGTGGACA
GAAAGATTAACGGAATACTTGAGAGGGAAAGGTGTTACTGGTGTAGCTTTTTATCATGGTGGTATGGAACATGAAGAGCG
TATGTTAATTCAACAGCAGTTTATGAACAATCAATTGCAACTTGTAATATGCACAAGTGCATTTGGTATGGGGGTAAATA
AGGCGAATACGCGATATATTATTCATTTTCATTATCCAACTAATATAGCTTCTTACTTACAAGAAATCGGAAGAGCTGGA
AGAGATGGCGAACCGAGTATAGCTATTTTATTATGTAGTCCGTTGGATCATGATTTACCAATTTCAATCATTGAGGATGA
ACTGCCAAGTAAGTCACAAATACAATTTTTATTTTCTTTACTACAAGAAAGAATGTTTCAAACGAAAGAATTACCAATAG
AAGATGTAGAAGAAATTTGTTATAATGCAGCAAGATTTAATGAGCAATATTGGCGTTTCGTTCGTTATCATCTCGAACAG
GTTGGAATTATACAACAACGAAGATTATTATTAGAAGGTTTGTCAGATGAAATCATGAACCGATTAATAGCTGAAGTAGA
AATAAGGTTGCGTAATAAATATAGTGAGCTAGAAAATATGAAGTCATGGATACAAGTTAAAGGGTGTAGACGTGAATATG
TGCTGCAACAGTTCGGTTATAGGAAAGAGCAAGAGTTAATGAATTGCTGCGATTATTGCGGTATTACCAAAGAAGATTAT
AAAAAAAGACGAGCGCAACAATCGGATTTCGACTATAATTGGGAAACAGAGTTACAAAAGCTTTTCGGCCTAGAAAAGAT
GGAGGAATGA

Upstream 100 bases:

>100_bases
GCATTGCAAACGCGGAAGTTACGTGTTTTGAAACAAGCGGTTGGAGAAGATATCTCTTATTTTGAAGTTCGTCTTGTATT
AGCGCGGATGGAGGGTGTAA

Downstream 100 bases:

>100_bases
TGAACATTCAAAGGCATAATGTTGAAGATATGAGTCCGCAGGAAATAAGGCTGAATCTATATATAACACAGTTAATTATT
ATCGGTATTGGCTGTTTACT

Product: ATP-dependent DNA helicase RecQ

Products: NA

Alternate protein names: Recombination protein S [H]

Number of amino acids: Translated: 509; Mature: 509

Protein sequence:

>509_residues
MKLEEYLYKWFGYSEFRPGQKGVITDLLEGKDVIAMLPTGRGKSMCYQFPGLMREGTVLVVSPLLSLMEDQVTQLKYVVK
DRVIAFNSFRTLNEKREAMKKLSSYKFIFVSPEMLQSELLIRELKKIHISLFVVDEAHCISQWGYDFRPDYKKLNVVIEN
IGSPTVLALTATATKGVLQDIADSLNLKGAAEHVYSIDRPNIAMDVQFVETIEEKKEALLEQVMYLQGPGIVYCSSRAWT
ERLTEYLRGKGVTGVAFYHGGMEHEERMLIQQQFMNNQLQLVICTSAFGMGVNKANTRYIIHFHYPTNIASYLQEIGRAG
RDGEPSIAILLCSPLDHDLPISIIEDELPSKSQIQFLFSLLQERMFQTKELPIEDVEEICYNAARFNEQYWRFVRYHLEQ
VGIIQQRRLLLEGLSDEIMNRLIAEVEIRLRNKYSELENMKSWIQVKGCRREYVLQQFGYRKEQELMNCCDYCGITKEDY
KKRRAQQSDFDYNWETELQKLFGLEKMEE

Sequences:

>Translated_509_residues
MKLEEYLYKWFGYSEFRPGQKGVITDLLEGKDVIAMLPTGRGKSMCYQFPGLMREGTVLVVSPLLSLMEDQVTQLKYVVK
DRVIAFNSFRTLNEKREAMKKLSSYKFIFVSPEMLQSELLIRELKKIHISLFVVDEAHCISQWGYDFRPDYKKLNVVIEN
IGSPTVLALTATATKGVLQDIADSLNLKGAAEHVYSIDRPNIAMDVQFVETIEEKKEALLEQVMYLQGPGIVYCSSRAWT
ERLTEYLRGKGVTGVAFYHGGMEHEERMLIQQQFMNNQLQLVICTSAFGMGVNKANTRYIIHFHYPTNIASYLQEIGRAG
RDGEPSIAILLCSPLDHDLPISIIEDELPSKSQIQFLFSLLQERMFQTKELPIEDVEEICYNAARFNEQYWRFVRYHLEQ
VGIIQQRRLLLEGLSDEIMNRLIAEVEIRLRNKYSELENMKSWIQVKGCRREYVLQQFGYRKEQELMNCCDYCGITKEDY
KKRRAQQSDFDYNWETELQKLFGLEKMEE
>Mature_509_residues
MKLEEYLYKWFGYSEFRPGQKGVITDLLEGKDVIAMLPTGRGKSMCYQFPGLMREGTVLVVSPLLSLMEDQVTQLKYVVK
DRVIAFNSFRTLNEKREAMKKLSSYKFIFVSPEMLQSELLIRELKKIHISLFVVDEAHCISQWGYDFRPDYKKLNVVIEN
IGSPTVLALTATATKGVLQDIADSLNLKGAAEHVYSIDRPNIAMDVQFVETIEEKKEALLEQVMYLQGPGIVYCSSRAWT
ERLTEYLRGKGVTGVAFYHGGMEHEERMLIQQQFMNNQLQLVICTSAFGMGVNKANTRYIIHFHYPTNIASYLQEIGRAG
RDGEPSIAILLCSPLDHDLPISIIEDELPSKSQIQFLFSLLQERMFQTKELPIEDVEEICYNAARFNEQYWRFVRYHLEQ
VGIIQQRRLLLEGLSDEIMNRLIAEVEIRLRNKYSELENMKSWIQVKGCRREYVLQQFGYRKEQELMNCCDYCGITKEDY
KKRRAQQSDFDYNWETELQKLFGLEKMEE

Specific function: Probable DNA helicase. Required in synaptic and/or post- synaptic stages of recombination. Probably has overlapping function with recQ (AC O34748). It probably acts to help generate ss-DNA from ds-DNA breaks [H]

COG id: COG0514

COG function: function code L; Superfamily II DNA helicase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 helicase C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI51242947, Length=367, Percent_Identity=38.6920980926431, Blast_Score=238, Evalue=1e-62,
Organism=Homo sapiens, GI51242943, Length=367, Percent_Identity=38.6920980926431, Blast_Score=237, Evalue=2e-62,
Organism=Homo sapiens, GI148612816, Length=357, Percent_Identity=39.4957983193277, Blast_Score=235, Evalue=6e-62,
Organism=Homo sapiens, GI110735439, Length=412, Percent_Identity=35.1941747572816, Blast_Score=230, Evalue=2e-60,
Organism=Homo sapiens, GI169218196, Length=412, Percent_Identity=35.1941747572816, Blast_Score=230, Evalue=2e-60,
Organism=Homo sapiens, GI14591902, Length=340, Percent_Identity=35.8823529411765, Blast_Score=210, Evalue=2e-54,
Organism=Homo sapiens, GI14591904, Length=340, Percent_Identity=35.8823529411765, Blast_Score=210, Evalue=2e-54,
Organism=Homo sapiens, GI4557365, Length=344, Percent_Identity=36.9186046511628, Blast_Score=202, Evalue=5e-52,
Organism=Homo sapiens, GI284005309, Length=362, Percent_Identity=34.5303867403315, Blast_Score=196, Evalue=3e-50,
Organism=Homo sapiens, GI21071032, Length=347, Percent_Identity=24.7838616714697, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI222352149, Length=346, Percent_Identity=23.6994219653179, Blast_Score=73, Evalue=6e-13,
Organism=Homo sapiens, GI7661920, Length=353, Percent_Identity=21.8130311614731, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI164664518, Length=370, Percent_Identity=24.0540540540541, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI188035877, Length=338, Percent_Identity=21.301775147929, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI13514831, Length=353, Percent_Identity=22.9461756373938, Blast_Score=66, Evalue=6e-11,
Organism=Escherichia coli, GI48994977, Length=341, Percent_Identity=41.6422287390029, Blast_Score=265, Evalue=5e-72,
Organism=Escherichia coli, GI1787605, Length=338, Percent_Identity=21.5976331360947, Blast_Score=73, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI32564293, Length=339, Percent_Identity=37.4631268436578, Blast_Score=226, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI71987997, Length=371, Percent_Identity=35.3099730458221, Blast_Score=225, Evalue=5e-59,
Organism=Caenorhabditis elegans, GI71987993, Length=371, Percent_Identity=35.3099730458221, Blast_Score=224, Evalue=6e-59,
Organism=Caenorhabditis elegans, GI25145561, Length=348, Percent_Identity=35.3448275862069, Blast_Score=217, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI17552866, Length=341, Percent_Identity=32.5513196480938, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI71987143, Length=356, Percent_Identity=24.1573033707865, Blast_Score=79, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI71995724, Length=352, Percent_Identity=23.2954545454545, Blast_Score=72, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17507121, Length=352, Percent_Identity=23.0113636363636, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323844, Length=340, Percent_Identity=35.8823529411765, Blast_Score=218, Evalue=2e-57,
Organism=Saccharomyces cerevisiae, GI6324217, Length=329, Percent_Identity=24.9240121580547, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6320497, Length=378, Percent_Identity=23.5449735449735, Blast_Score=85, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6320224, Length=354, Percent_Identity=21.4689265536723, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6321360, Length=323, Percent_Identity=25.077399380805, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320041, Length=351, Percent_Identity=21.9373219373219, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24646066, Length=337, Percent_Identity=36.7952522255193, Blast_Score=216, Evalue=3e-56,
Organism=Drosophila melanogaster, GI24664226, Length=347, Percent_Identity=35.7348703170029, Blast_Score=209, Evalue=3e-54,
Organism=Drosophila melanogaster, GI62472181, Length=347, Percent_Identity=35.7348703170029, Blast_Score=209, Evalue=5e-54,
Organism=Drosophila melanogaster, GI24664230, Length=347, Percent_Identity=35.7348703170029, Blast_Score=208, Evalue=6e-54,
Organism=Drosophila melanogaster, GI21358123, Length=352, Percent_Identity=35.5113636363636, Blast_Score=194, Evalue=9e-50,
Organism=Drosophila melanogaster, GI24645031, Length=353, Percent_Identity=23.7960339943343, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24666101, Length=339, Percent_Identity=24.188790560472, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI21355075, Length=361, Percent_Identity=21.3296398891967, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI18857967, Length=377, Percent_Identity=22.5464190981432, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24583281, Length=346, Percent_Identity=21.3872832369942, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI28575014, Length=344, Percent_Identity=22.6744186046512, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24583279, Length=346, Percent_Identity=21.3872832369942, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR011545
- InterPro:   IPR002464
- InterPro:   IPR004589
- InterPro:   IPR001650
- InterPro:   IPR014021 [H]

Pfam domain/function: PF00270 DEAD; PF00271 Helicase_C [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 59299; Mature: 59299

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: PS00690 DEAH_ATP_HELICASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLEEYLYKWFGYSEFRPGQKGVITDLLEGKDVIAMLPTGRGKSMCYQFPGLMREGTVLV
CCHHHHHHHHCCCCCCCCCCCCHHHHHHCCCCEEEEECCCCCCCHHHHCCCCHHCCCCHH
VSPLLSLMEDQVTQLKYVVKDRVIAFNSFRTLNEKREAMKKLSSYKFIFVSPEMLQSELL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECHHHHHHHHH
IRELKKIHISLFVVDEAHCISQWGYDFRPDYKKLNVVIENIGSPTVLALTATATKGVLQD
HHHHHHHEEEEEEEECHHHHHHCCCCCCCCHHHHHHHHHCCCCCEEEEEECHHHHHHHHH
IADSLNLKGAAEHVYSIDRPNIAMDVQFVETIEEKKEALLEQVMYLQGPGIVYCSSRAWT
HHHHCCCCHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHH
ERLTEYLRGKGVTGVAFYHGGMEHEERMLIQQQFMNNQLQLVICTSAFGMGVNKANTRYI
HHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCEEEEEEECHHCCCCCCCCCEEE
IHFHYPTNIASYLQEIGRAGRDGEPSIAILLCSPLDHDLPISIIEDELPSKSQIQFLFSL
EEEECCCCHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCHHHHHCCCCCHHHHHHHHHH
LQERMFQTKELPIEDVEEICYNAARFNEQYWRFVRYHLEQVGIIQQRRLLLEGLSDEIMN
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHH
RLIAEVEIRLRNKYSELENMKSWIQVKGCRREYVLQQFGYRKEQELMNCCDYCGITKEDY
HHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHH
KKRRAQQSDFDYNWETELQKLFGLEKMEE
HHHHCCCCCCCCCHHHHHHHHHCHHHCCC
>Mature Secondary Structure
MKLEEYLYKWFGYSEFRPGQKGVITDLLEGKDVIAMLPTGRGKSMCYQFPGLMREGTVLV
CCHHHHHHHHCCCCCCCCCCCCHHHHHHCCCCEEEEECCCCCCCHHHHCCCCHHCCCCHH
VSPLLSLMEDQVTQLKYVVKDRVIAFNSFRTLNEKREAMKKLSSYKFIFVSPEMLQSELL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECHHHHHHHHH
IRELKKIHISLFVVDEAHCISQWGYDFRPDYKKLNVVIENIGSPTVLALTATATKGVLQD
HHHHHHHEEEEEEEECHHHHHHCCCCCCCCHHHHHHHHHCCCCCEEEEEECHHHHHHHHH
IADSLNLKGAAEHVYSIDRPNIAMDVQFVETIEEKKEALLEQVMYLQGPGIVYCSSRAWT
HHHHCCCCHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHH
ERLTEYLRGKGVTGVAFYHGGMEHEERMLIQQQFMNNQLQLVICTSAFGMGVNKANTRYI
HHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCEEEEEEECHHCCCCCCCCCEEE
IHFHYPTNIASYLQEIGRAGRDGEPSIAILLCSPLDHDLPISIIEDELPSKSQIQFLFSL
EEEECCCCHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCHHHHHCCCCCHHHHHHHHHH
LQERMFQTKELPIEDVEEICYNAARFNEQYWRFVRYHLEQVGIIQQRRLLLEGLSDEIMN
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHH
RLIAEVEIRLRNKYSELENMKSWIQVKGCRREYVLQQFGYRKEQELMNCCDYCGITKEDY
HHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHH
KKRRAQQSDFDYNWETELQKLFGLEKMEE
HHHHCCCCCCCCCHHHHHHHHHCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8760912; 9384377; 9642195 [H]