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The map label for this gene is phoR [H]

Identifier: 227815223

GI number: 227815223

Start: 2394934

End: 2395974

Strand: Reverse

Name: phoR [H]

Synonym: BAMEG_2634

Alternate gene names: 227815223

Gene position: 2395974-2394934 (Counterclockwise)

Preceding gene: 227815224

Following gene: 227815221

Centisome position: 45.81

GC content: 34.29

Gene sequence:

>1041_bases
ATGCTGAAAGTAACAGGAGCGATAATAGCACTCTTTTCTTTTCTTACTATTATTTGGTCTACAGCATTTTATGTATCATC
TAGTATATTGGATGCCCTTGCAATACATTTATCTCCTTTTGTTACTTACCTCATTAGTGACATACTCAGTTTTATATTTA
TGATTCTTGTTTGGATATTAATTGCAGTATTAATGAGACCGAAGCGAGAGGCGATGATTTGGACTATTATTGAACCGATA
CAAAAAATTGCAAAAGGGGACTTTTCGGTAAAAATACGAAATGAAGAGAAATATGATGGGGAAATTGGTGTGCTCGTAAA
AAGTATAAACGATATGACAGATGAACTGAATGCGATGGAGAAGATGCGTCAGGAATTTGTTTCGAATGTTTCTCATGAAA
TACAGTCACCATTAACTTCTATAAAAGGGTTTGCTAGAGCACTACAAGATACTAATCTTCCTGAGGAAAAAAGAAAGCAT
TATCTTACCATTATTGAAACAGAAACGACGAGATTATCTAAACTAAGTCAAAATTTACTGAAACTCACCCTATTAGAGTC
GGAAGAATATACACCAGAAAGAGTTACTTATCGATTAGATCAACAGTTAAAGCAAATTGTGTTAAATAGTGAACCGCTTT
GGGCTGAGAAAGAAATTGAATTAGACCTTGATTTAGAAAAAGTGCATATAACTGCTGACCAAGAAAGTATGAGTCAAGTT
TGGATTAATTTAATTCATAATAGTATTAAATTTACTCCAAGTAGCGGTACGATTTCAATCAAGCTAAAAGAATATGAGAC
ATTAGTAGAAGTACGTATACGTGATACGGGAAGTGGGATATCCGAAGAACAGAAGCAACATATTTTTGAGCGTTTTTATA
AAGCAGACTCTTCACGAAATCGTGCTTATGGAGGAAGTGGTTTAGGTTTAGCGATTGTGAAAAAAGTACTCGATCTTCAT
CAGGGGGAAATAAAAGTTGAGAGTGAGGAAGGGAATGGGACGGAATGTATTGTTTGTATTCCAAATTATGAAGAGAAATA
G

Upstream 100 bases:

>100_bases
AAGAAGAGAAGTCGAAATTTAGTATTAAAACAATAAGGGGTTTAGGATATCGCTTAGAGGTAAGTAAATGAGAAAAAGAG
GACGAATGAGTAAATTCAAG

Downstream 100 bases:

>100_bases
TGTTAGGAGGGAATCCTTCTAACACTATTTCTCTTTAAAAATACATTTCCCATTACTGCAGCTATACTGATAAGCTTTTC
CTTCGCTATTCATACGGTAT

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MLKVTGAIIALFSFLTIIWSTAFYVSSSILDALAIHLSPFVTYLISDILSFIFMILVWILIAVLMRPKREAMIWTIIEPI
QKIAKGDFSVKIRNEEKYDGEIGVLVKSINDMTDELNAMEKMRQEFVSNVSHEIQSPLTSIKGFARALQDTNLPEEKRKH
YLTIIETETTRLSKLSQNLLKLTLLESEEYTPERVTYRLDQQLKQIVLNSEPLWAEKEIELDLDLEKVHITADQESMSQV
WINLIHNSIKFTPSSGTISIKLKEYETLVEVRIRDTGSGISEEQKQHIFERFYKADSSRNRAYGGSGLGLAIVKKVLDLH
QGEIKVESEEGNGTECIVCIPNYEEK

Sequences:

>Translated_346_residues
MLKVTGAIIALFSFLTIIWSTAFYVSSSILDALAIHLSPFVTYLISDILSFIFMILVWILIAVLMRPKREAMIWTIIEPI
QKIAKGDFSVKIRNEEKYDGEIGVLVKSINDMTDELNAMEKMRQEFVSNVSHEIQSPLTSIKGFARALQDTNLPEEKRKH
YLTIIETETTRLSKLSQNLLKLTLLESEEYTPERVTYRLDQQLKQIVLNSEPLWAEKEIELDLDLEKVHITADQESMSQV
WINLIHNSIKFTPSSGTISIKLKEYETLVEVRIRDTGSGISEEQKQHIFERFYKADSSRNRAYGGSGLGLAIVKKVLDLH
QGEIKVESEEGNGTECIVCIPNYEEK
>Mature_346_residues
MLKVTGAIIALFSFLTIIWSTAFYVSSSILDALAIHLSPFVTYLISDILSFIFMILVWILIAVLMRPKREAMIWTIIEPI
QKIAKGDFSVKIRNEEKYDGEIGVLVKSINDMTDELNAMEKMRQEFVSNVSHEIQSPLTSIKGFARALQDTNLPEEKRKH
YLTIIETETTRLSKLSQNLLKLTLLESEEYTPERVTYRLDQQLKQIVLNSEPLWAEKEIELDLDLEKVHITADQESMSQV
WINLIHNSIKFTPSSGTISIKLKEYETLVEVRIRDTGSGISEEQKQHIFERFYKADSSRNRAYGGSGLGLAIVKKVLDLH
QGEIKVESEEGNGTECIVCIPNYEEK

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=275, Percent_Identity=28, Blast_Score=135, Evalue=6e-33,
Organism=Escherichia coli, GI1786783, Length=308, Percent_Identity=26.9480519480519, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI1786600, Length=230, Percent_Identity=28.695652173913, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI145693157, Length=240, Percent_Identity=30, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1789149, Length=222, Percent_Identity=31.981981981982, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1788549, Length=250, Percent_Identity=27.6, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1790861, Length=229, Percent_Identity=32.3144104803493, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1788713, Length=253, Percent_Identity=27.2727272727273, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1787894, Length=367, Percent_Identity=25.3405994550409, Blast_Score=94, Evalue=9e-21,
Organism=Escherichia coli, GI1790436, Length=235, Percent_Identity=27.6595744680851, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1790346, Length=241, Percent_Identity=27.3858921161826, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI48994928, Length=239, Percent_Identity=27.6150627615063, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1789403, Length=316, Percent_Identity=25.9493670886076, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI87082128, Length=303, Percent_Identity=26.0726072607261, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1788279, Length=315, Percent_Identity=26.031746031746, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1786912, Length=225, Percent_Identity=26.2222222222222, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1789808, Length=305, Percent_Identity=21.9672131147541, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1790551, Length=245, Percent_Identity=25.3061224489796, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1790300, Length=237, Percent_Identity=26.5822784810127, Blast_Score=72, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 39547; Mature: 39547

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKVTGAIIALFSFLTIIWSTAFYVSSSILDALAIHLSPFVTYLISDILSFIFMILVWIL
CEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IAVLMRPKREAMIWTIIEPIQKIAKGDFSVKIRNEEKYDGEIGVLVKSINDMTDELNAME
HHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHH
KMRQEFVSNVSHEIQSPLTSIKGFARALQDTNLPEEKRKHYLTIIETETTRLSKLSQNLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCEEEEEECCHHHHHHHHHHHH
KLTLLESEEYTPERVTYRLDQQLKQIVLNSEPLWAEKEIELDLDLEKVHITADQESMSQV
HHHEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECEEEEEEECCHHHHHHH
WINLIHNSIKFTPSSGTISIKLKEYETLVEVRIRDTGSGISEEQKQHIFERFYKADSSRN
HHHHHHHHCEEECCCCEEEEEEHHHHEEEHEEEECCCCCCCHHHHHHHHHHHHHCCCCCC
RAYGGSGLGLAIVKKVLDLHQGEIKVESEEGNGTECIVCIPNYEEK
CCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCEEEEECCCCCCC
>Mature Secondary Structure
MLKVTGAIIALFSFLTIIWSTAFYVSSSILDALAIHLSPFVTYLISDILSFIFMILVWIL
CEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IAVLMRPKREAMIWTIIEPIQKIAKGDFSVKIRNEEKYDGEIGVLVKSINDMTDELNAME
HHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHH
KMRQEFVSNVSHEIQSPLTSIKGFARALQDTNLPEEKRKHYLTIIETETTRLSKLSQNLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCEEEEEECCHHHHHHHHHHHH
KLTLLESEEYTPERVTYRLDQQLKQIVLNSEPLWAEKEIELDLDLEKVHITADQESMSQV
HHHEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECEEEEEEECCHHHHHHH
WINLIHNSIKFTPSSGTISIKLKEYETLVEVRIRDTGSGISEEQKQHIFERFYKADSSRN
HHHHHHHHCEEECCCCEEEEEEHHHHEEEHEEEECCCCCCCHHHHHHHHHHHHHCCCCCC
RAYGGSGLGLAIVKKVLDLHQGEIKVESEEGNGTECIVCIPNYEEK
CCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]