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The map label for this gene is hssR [H]

Identifier: 227815224

GI number: 227815224

Start: 2396004

End: 2396681

Strand: Reverse

Name: hssR [H]

Synonym: BAMEG_2635

Alternate gene names: 227815224

Gene position: 2396681-2396004 (Counterclockwise)

Preceding gene: 227815225

Following gene: 227815223

Centisome position: 45.82

GC content: 34.22

Gene sequence:

>678_bases
TTGATACCTAACATTTTAATAGTAGACGATGATCCGCATATTAGAGAACTCGTTTCTGTATTTTTAGAGTGTGAAGGTTT
TCAAACATATGAGGCAATTGATGGTCTAGATGCACTTCAAAAAATAAATCAAGTGAAAGTTGATATGGTTATTCTTGATA
TCATGATGCCGAATATGGATGGATTTGATGTATGTTTCGAATTAAGAAAGTACTATGATATTCCGATTTTGATATTAACT
GCTAAAGGGGAAACGTCTCAAAAAGTAAAAGGATTTCATCTTGGTACGGATGATTATCTTGTAAAACCATTTGATCCCAT
AGAACTAGTAGTGAGGGTTAAGGCGTTATTGAAACGTTACCAAATTACAGTGTCGCAATCAATTCAAGTTGGAACTGTAC
TGTTAAATCGTAAAACATTTGAAGTTACAATTGGAGAACAAACGGTTACGTTACCGTTAAAAGAATTCGAATTGCTCTTT
ACTTTAGGCTCTAAAGCGGGGAGAACTTGTTCGAGAGAGCAATTAATTGAAGATGTATGGGGATATGATTTTGAAGGGAA
TGAACGCACACTAGACGTTCATATAAATCGGTTACGTGAGAAGTTTCAAGAAGAGAAGTCGAAATTTAGTATTAAAACAA
TAAGGGGTTTAGGATATCGCTTAGAGGTAAGTAAATGA

Upstream 100 bases:

>100_bases
GCGGCATTATAAAATGAATAATCAGTGGGGATTGTACTCCACTGATTATTCATTTTTAAAAGTTTTGTTAAGGATGCTAA
TTAGAAAGGAAATGGTTTCT

Downstream 100 bases:

>100_bases
GAAAAAGAGGACGAATGAGTAAATTCAAGATGCTGAAAGTAACAGGAGCGATAATAGCACTCTTTTCTTTTCTTACTATT
ATTTGGTCTACAGCATTTTA

Product: DNA-binding response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 225; Mature: 225

Protein sequence:

>225_residues
MIPNILIVDDDPHIRELVSVFLECEGFQTYEAIDGLDALQKINQVKVDMVILDIMMPNMDGFDVCFELRKYYDIPILILT
AKGETSQKVKGFHLGTDDYLVKPFDPIELVVRVKALLKRYQITVSQSIQVGTVLLNRKTFEVTIGEQTVTLPLKEFELLF
TLGSKAGRTCSREQLIEDVWGYDFEGNERTLDVHINRLREKFQEEKSKFSIKTIRGLGYRLEVSK

Sequences:

>Translated_225_residues
MIPNILIVDDDPHIRELVSVFLECEGFQTYEAIDGLDALQKINQVKVDMVILDIMMPNMDGFDVCFELRKYYDIPILILT
AKGETSQKVKGFHLGTDDYLVKPFDPIELVVRVKALLKRYQITVSQSIQVGTVLLNRKTFEVTIGEQTVTLPLKEFELLF
TLGSKAGRTCSREQLIEDVWGYDFEGNERTLDVHINRLREKFQEEKSKFSIKTIRGLGYRLEVSK
>Mature_225_residues
MIPNILIVDDDPHIRELVSVFLECEGFQTYEAIDGLDALQKINQVKVDMVILDIMMPNMDGFDVCFELRKYYDIPILILT
AKGETSQKVKGFHLGTDDYLVKPFDPIELVVRVKALLKRYQITVSQSIQVGTVLLNRKTFEVTIGEQTVTLPLKEFELLF
TLGSKAGRTCSREQLIEDVWGYDFEGNERTLDVHINRLREKFQEEKSKFSIKTIRGLGYRLEVSK

Specific function: Member of the two-component regulatory system hssS/hssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. Phosphorylated hssR binds to a direct repeat sequence within hrtAB promoter and activates the expression of hrtAB

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786599, Length=225, Percent_Identity=37.7777777777778, Blast_Score=159, Evalue=1e-40,
Organism=Escherichia coli, GI87082012, Length=215, Percent_Identity=33.953488372093, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1788394, Length=224, Percent_Identity=33.9285714285714, Blast_Score=138, Evalue=3e-34,
Organism=Escherichia coli, GI1790552, Length=218, Percent_Identity=36.697247706422, Blast_Score=134, Evalue=6e-33,
Organism=Escherichia coli, GI2367329, Length=224, Percent_Identity=36.1607142857143, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1786784, Length=221, Percent_Identity=36.6515837104072, Blast_Score=131, Evalue=3e-32,
Organism=Escherichia coli, GI1790860, Length=222, Percent_Identity=35.1351351351351, Blast_Score=130, Evalue=6e-32,
Organism=Escherichia coli, GI1789809, Length=224, Percent_Identity=33.0357142857143, Blast_Score=128, Evalue=3e-31,
Organism=Escherichia coli, GI1789402, Length=218, Percent_Identity=36.2385321100917, Blast_Score=128, Evalue=3e-31,
Organism=Escherichia coli, GI1790863, Length=236, Percent_Identity=30.5084745762712, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI1786911, Length=222, Percent_Identity=31.5315315315315, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI145693140, Length=229, Percent_Identity=28.3842794759825, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI1787375, Length=221, Percent_Identity=30.7692307692308, Blast_Score=104, Evalue=4e-24,
Organism=Escherichia coli, GI1787229, Length=213, Percent_Identity=27.6995305164319, Blast_Score=88, Evalue=4e-19,
Organism=Escherichia coli, GI1788550, Length=177, Percent_Identity=31.0734463276836, Blast_Score=87, Evalue=7e-19,
Organism=Escherichia coli, GI1788713, Length=102, Percent_Identity=39.2156862745098, Blast_Score=72, Evalue=2e-14,
Organism=Escherichia coli, GI1790299, Length=143, Percent_Identity=30.7692307692308, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI145693157, Length=100, Percent_Identity=36, Blast_Score=67, Evalue=8e-13,
Organism=Escherichia coli, GI1788905, Length=103, Percent_Identity=36.8932038834951, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1789149, Length=169, Percent_Identity=29.585798816568, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1787487, Length=100, Percent_Identity=35, Blast_Score=64, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25911; Mature: 25911

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPNILIVDDDPHIRELVSVFLECEGFQTYEAIDGLDALQKINQVKVDMVILDIMMPNMD
CCCCEEEECCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCC
GFDVCFELRKYYDIPILILTAKGETSQKVKGFHLGTDDYLVKPFDPIELVVRVKALLKRY
HHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEECCCCCEECCCCHHHHHHHHHHHHHHH
QITVSQSIQVGTVLLNRKTFEVTIGEQTVTLPLKEFELLFTLGSKAGRTCSREQLIEDVW
HHHHCCCEEEEEEEECCEEEEEEECCEEEEEEHHHHEEEEEECCCCCCCCCHHHHHHHHC
GYDFEGNERTLDVHINRLREKFQEEKSKFSIKTIRGLGYRLEVSK
CCCCCCCCEEEEHHHHHHHHHHHHHHHHEEHHHHHCCCEEEEECC
>Mature Secondary Structure
MIPNILIVDDDPHIRELVSVFLECEGFQTYEAIDGLDALQKINQVKVDMVILDIMMPNMD
CCCCEEEECCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCC
GFDVCFELRKYYDIPILILTAKGETSQKVKGFHLGTDDYLVKPFDPIELVVRVKALLKRY
HHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEECCCCCEECCCCHHHHHHHHHHHHHHH
QITVSQSIQVGTVLLNRKTFEVTIGEQTVTLPLKEFELLFTLGSKAGRTCSREQLIEDVW
HHHHCCCEEEEEEEECCEEEEEEECCEEEEEEHHHHEEEEEECCCCCCCCCHHHHHHHHC
GYDFEGNERTLDVHINRLREKFQEEKSKFSIKTIRGLGYRLEVSK
CCCCCCCCEEEEHHHHHHHHHHHHHHHHEEHHHHHCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA