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The map label for this gene is thrB

Identifier: 227815210

GI number: 227815210

Start: 2385231

End: 2386124

Strand: Reverse

Name: thrB

Synonym: BAMEG_2621

Alternate gene names: 227815210

Gene position: 2386124-2385231 (Counterclockwise)

Preceding gene: 227815211

Following gene: 227815209

Centisome position: 45.62

GC content: 36.47

Gene sequence:

>894_bases
GTGATACCATTAAGTATTCGTGTTCCTGCTAGTACAGCGAATGTTGGACCTGGATTTGATTCAGTAGGAATAGCTTTGTC
ATTGTATTTACATGTAGTAGTAAAAGAGAAGTCTGATAAATGGCAAGTGATCCATTCCTTTGAAGATTCAATTCCGACAG
ACGATAAAAATTTAATTGTTAGCACGGCATGTAAAGTATGTCCTTCTTTATCACCCCATATAATAGAAGTTACTAGTAAC
ATCCCGCTAACAAGAGGTCTAGGAAGTAGTGCATCAGCAATTGTAGCTGGGATAGAGCTTGCGAATCAACTAGGCAAATT
GAACTTAACGATTGATCAAAAAGTTCAAATTGCTACAAATTTTGAAGGTCATCCTGATAATGTTGCTGCTTCTATATTAG
GAGGAACTGTAATCGGAGCACTTGATGGAAAAAATGTATCGGTTGTGAGAATTGAAAGTAAGGAATTAGGTGTAATTTCA
CTTATTCCAAATGAAGAGCTAAATACAGATGAAAGTCGTTCTGTATTACCAGATGTATTTCCGTTTCATGAAGCTGTTAA
GGCTAGTGCAATAAGTAATGTATTAGTAGCTGCTTTATGTCAAAAGAAATGGAAAGTTGTAGGGGAAATGATGGAAAGGG
ATCATTTTCACGAACCGTATCGTTTAGAGCTTGTACCGTTATTACCATCTATTCGTAAATGTGCAAAAGAATTCGGTGCA
TACGGTACAGCGCTAAGCGGTGCAGGACCATCTATTTTTATATTAACGCCGTATGAGAAACGTCAAGAAATTGCTGAGCA
ATTAGCGAGAGTATTTACGTCTATGAAAGTGTGTGAGCTAGAAATTGATCATAGAGGGATTACTGTAAATAAGAAAGAAC
ATATTGGATTATAA

Upstream 100 bases:

>100_bases
AAGATCCTGATATCGCAATTTCTTCTAATACATTAGATATTGCAAGTGTTTCAAATAATATAGAACAAATTAAAGAGCAT
ATTAAAGGGGTGATTATGTC

Downstream 100 bases:

>100_bases
AGAGAGCTAGCATCGCTAGCTTTCTTTATGTTGTAAATATTTTTAAGTTTGCATATAAAAGAAAAATATGAATGTATAAT
TTAGTAAAGAGTGTATTAAT

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MIPLSIRVPASTANVGPGFDSVGIALSLYLHVVVKEKSDKWQVIHSFEDSIPTDDKNLIVSTACKVCPSLSPHIIEVTSN
IPLTRGLGSSASAIVAGIELANQLGKLNLTIDQKVQIATNFEGHPDNVAASILGGTVIGALDGKNVSVVRIESKELGVIS
LIPNEELNTDESRSVLPDVFPFHEAVKASAISNVLVAALCQKKWKVVGEMMERDHFHEPYRLELVPLLPSIRKCAKEFGA
YGTALSGAGPSIFILTPYEKRQEIAEQLARVFTSMKVCELEIDHRGITVNKKEHIGL

Sequences:

>Translated_297_residues
MIPLSIRVPASTANVGPGFDSVGIALSLYLHVVVKEKSDKWQVIHSFEDSIPTDDKNLIVSTACKVCPSLSPHIIEVTSN
IPLTRGLGSSASAIVAGIELANQLGKLNLTIDQKVQIATNFEGHPDNVAASILGGTVIGALDGKNVSVVRIESKELGVIS
LIPNEELNTDESRSVLPDVFPFHEAVKASAISNVLVAALCQKKWKVVGEMMERDHFHEPYRLELVPLLPSIRKCAKEFGA
YGTALSGAGPSIFILTPYEKRQEIAEQLARVFTSMKVCELEIDHRGITVNKKEHIGL
>Mature_297_residues
MIPLSIRVPASTANVGPGFDSVGIALSLYLHVVVKEKSDKWQVIHSFEDSIPTDDKNLIVSTACKVCPSLSPHIIEVTSN
IPLTRGLGSSASAIVAGIELANQLGKLNLTIDQKVQIATNFEGHPDNVAASILGGTVIGALDGKNVSVVRIESKELGVIS
LIPNEELNTDESRSVLPDVFPFHEAVKASAISNVLVAALCQKKWKVVGEMMERDHFHEPYRLELVPLLPSIRKCAKEFGA
YGTALSGAGPSIFILTPYEKRQEIAEQLARVFTSMKVCELEIDHRGITVNKKEHIGL

Specific function: Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate

COG id: COG0083

COG function: function code E; Homoserine kinase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Homoserine kinase subfamily

Homologues:

Organism=Escherichia coli, GI1786184, Length=301, Percent_Identity=25.2491694352159, Blast_Score=94, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6321814, Length=357, Percent_Identity=29.1316526610644, Blast_Score=122, Evalue=6e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KHSE_BACAA (C3P7F5)

Other databases:

- EMBL:   CP001598
- RefSeq:   YP_002866368.1
- ProteinModelPortal:   C3P7F5
- SMR:   C3P7F5
- EnsemblBacteria:   EBBACT00000126620
- GeneID:   7852329
- GenomeReviews:   CP001598_GR
- KEGG:   bai:BAA_2038
- GeneTree:   EBGT00050000000874
- ProtClustDB:   PRK01212
- GO:   GO:0005737
- HAMAP:   MF_00384
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR000870
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.230.10
- PIRSF:   PIRSF000676
- PRINTS:   PR00958
- TIGRFAMs:   TIGR00191

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =2.7.1.39

Molecular weight: Translated: 32134; Mature: 32134

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPLSIRVPASTANVGPGFDSVGIALSLYLHVVVKEKSDKWQVIHSFEDSIPTDDKNLIV
CCCEEEECCCCCCCCCCCCCHHHHHHHHHHEEEEECCCCCCHHHHHHHHCCCCCCCHHHH
STACKVCPSLSPHIIEVTSNIPLTRGLGSSASAIVAGIELANQLGKLNLTIDQKVQIATN
HHHHHHCCCCCCEEEEEECCCCEECCCCCCHHHHHHHHHHHHHHCCEEEEECCEEEEEEC
FEGHPDNVAASILGGTVIGALDGKNVSVVRIESKELGVISLIPNEELNTDESRSVLPDVF
CCCCCCHHHHHHHCCEEEEEECCCCEEEEEECCCCCCEEEECCCCCCCCCCCCCCCCCHH
PFHEAVKASAISNVLVAALCQKKWKVVGEMMERDHFHEPYRLELVPLLPSIRKCAKEFGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHCC
YGTALSGAGPSIFILTPYEKRQEIAEQLARVFTSMKVCELEIDHRGITVNKKEHIGL
CCCEECCCCCEEEEECCCHHHHHHHHHHHHHHHCCEEEEEEECCCCEEECCHHCCCC
>Mature Secondary Structure
MIPLSIRVPASTANVGPGFDSVGIALSLYLHVVVKEKSDKWQVIHSFEDSIPTDDKNLIV
CCCEEEECCCCCCCCCCCCCHHHHHHHHHHEEEEECCCCCCHHHHHHHHCCCCCCCHHHH
STACKVCPSLSPHIIEVTSNIPLTRGLGSSASAIVAGIELANQLGKLNLTIDQKVQIATN
HHHHHHCCCCCCEEEEEECCCCEECCCCCCHHHHHHHHHHHHHHCCEEEEECCEEEEEEC
FEGHPDNVAASILGGTVIGALDGKNVSVVRIESKELGVISLIPNEELNTDESRSVLPDVF
CCCCCCHHHHHHHCCEEEEEECCCCEEEEEECCCCCCEEEECCCCCCCCCCCCCCCCCHH
PFHEAVKASAISNVLVAALCQKKWKVVGEMMERDHFHEPYRLELVPLLPSIRKCAKEFGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHCC
YGTALSGAGPSIFILTPYEKRQEIAEQLARVFTSMKVCELEIDHRGITVNKKEHIGL
CCCEECCCCCEEEEECCCHHHHHHHHHHHHHHHCCEEEEEEECCCCEEECCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA