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The map label for this gene is thrC [H]

Identifier: 227815211

GI number: 227815211

Start: 2386121

End: 2387179

Strand: Reverse

Name: thrC [H]

Synonym: BAMEG_2622

Alternate gene names: 227815211

Gene position: 2387179-2386121 (Counterclockwise)

Preceding gene: 227815212

Following gene: 227815210

Centisome position: 45.64

GC content: 39.66

Gene sequence:

>1059_bases
ATGTATAAAGGGCTATTAAACCAATATGCTTCTTATTTACCGGTAAATGAAAACACACCAGATGTGAGCTTAATGGAAGG
AAATACACCCCTTATTCCGTTATTAAACATATCAAAACAATTAGGGATTCAGTTATACGGGAAGTATGAAGGAGCGAATC
CGACAGGTTCTTTTAAAGATCGAGGCATGGTAATGGCTGTTGCGAAGGCGAAAGAAGAAGGTTCGGAGGCAATCATTTGT
GCATCGACAGGTAATACATCAGCATCGGCTGCCGCATACGCGGCACGCCTTGGAATGAAATGTATTATCGTAATACCGGA
AGGAAAGATTGCACATGGAAAATTAGCACAAGCAGTTGCGTATGGTGCTGAAATCATTTCAATAGAAGGAAATTTTGATG
ATGCATTAAAGGCTGTAAGAAATATCGCTGAGGAAGAGCCGATTACGTTAGTAAACTCAGTGAATCCTTATCGAATTGAA
GGGCAAAAAACAGCAGCGTTTGAAATTTGTGATCAGTTGCAACGTGCACCAGATGTTTTAGCGATTCCTGTTGGGAATGC
CGGAAATATTACAGCGTACTGGAAAGGTTTCTGTGAATATGAGAAAGAAAAAGGTTATAAAAAGCCAAGAATTCATGGGT
TTGAAGCGGAAGGAGCAGCTGCAATTGTAAAAGGGCATGTAATTGACGAGCCAGAAACAATTGCAACTGCGATTCGCATC
GGTAACCCAGCAAGTTGGTCATATGCGGTAGAGGCTGCTGAGCAATCTCACGGCGAAATAGATATGGTATCAGATGAAGA
GATTTTACATGCGTATAGATTATTAGCAAAATCGGAAGGGGTTTTCGCTGAGCCAGGATCAAATGCTTCATTAGCCGGTG
TAATGAAACATGTTCAATCTGGAAAAATCAAAAAGGGAGAAACAGTTGTTGCAGTTTTAACTGGAAATGGCTTGAAAGAT
CCTGATATCGCAATTTCTTCTAATACATTAGATATTGCAAGTGTTTCAAATAATATAGAACAAATTAAAGAGCATATTAA
AGGGGTGATTATGTCGTGA

Upstream 100 bases:

>100_bases
CATCAAACTTCAAAGTATCAATTCGAACGAGTTTTAGGGGCAATAGAAGATGTCGCAAGTGAAATAAACAGTTACTACAT
TATCGAGGAGGAAAAACAAT

Downstream 100 bases:

>100_bases
TACCATTAAGTATTCGTGTTCCTGCTAGTACAGCGAATGTTGGACCTGGATTTGATTCAGTAGGAATAGCTTTGTCATTG
TATTTACATGTAGTAGTAAA

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 352; Mature: 352

Protein sequence:

>352_residues
MYKGLLNQYASYLPVNENTPDVSLMEGNTPLIPLLNISKQLGIQLYGKYEGANPTGSFKDRGMVMAVAKAKEEGSEAIIC
ASTGNTSASAAAYAARLGMKCIIVIPEGKIAHGKLAQAVAYGAEIISIEGNFDDALKAVRNIAEEEPITLVNSVNPYRIE
GQKTAAFEICDQLQRAPDVLAIPVGNAGNITAYWKGFCEYEKEKGYKKPRIHGFEAEGAAAIVKGHVIDEPETIATAIRI
GNPASWSYAVEAAEQSHGEIDMVSDEEILHAYRLLAKSEGVFAEPGSNASLAGVMKHVQSGKIKKGETVVAVLTGNGLKD
PDIAISSNTLDIASVSNNIEQIKEHIKGVIMS

Sequences:

>Translated_352_residues
MYKGLLNQYASYLPVNENTPDVSLMEGNTPLIPLLNISKQLGIQLYGKYEGANPTGSFKDRGMVMAVAKAKEEGSEAIIC
ASTGNTSASAAAYAARLGMKCIIVIPEGKIAHGKLAQAVAYGAEIISIEGNFDDALKAVRNIAEEEPITLVNSVNPYRIE
GQKTAAFEICDQLQRAPDVLAIPVGNAGNITAYWKGFCEYEKEKGYKKPRIHGFEAEGAAAIVKGHVIDEPETIATAIRI
GNPASWSYAVEAAEQSHGEIDMVSDEEILHAYRLLAKSEGVFAEPGSNASLAGVMKHVQSGKIKKGETVVAVLTGNGLKD
PDIAISSNTLDIASVSNNIEQIKEHIKGVIMS
>Mature_352_residues
MYKGLLNQYASYLPVNENTPDVSLMEGNTPLIPLLNISKQLGIQLYGKYEGANPTGSFKDRGMVMAVAKAKEEGSEAIIC
ASTGNTSASAAAYAARLGMKCIIVIPEGKIAHGKLAQAVAYGAEIISIEGNFDDALKAVRNIAEEEPITLVNSVNPYRIE
GQKTAAFEICDQLQRAPDVLAIPVGNAGNITAYWKGFCEYEKEKGYKKPRIHGFEAEGAAAIVKGHVIDEPETIATAIRI
GNPASWSYAVEAAEQSHGEIDMVSDEEILHAYRLLAKSEGVFAEPGSNASLAGVMKHVQSGKIKKGETVVAVLTGNGLKD
PDIAISSNTLDIASVSNNIEQIKEHIKGVIMS

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=322, Percent_Identity=28.5714285714286, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI295821200, Length=322, Percent_Identity=28.5714285714286, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI4557415, Length=322, Percent_Identity=28.5714285714286, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI11345492, Length=290, Percent_Identity=29.6551724137931, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI33469958, Length=277, Percent_Identity=25.6317689530686, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1790207, Length=295, Percent_Identity=26.7796610169492, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI2367138, Length=224, Percent_Identity=29.0178571428571, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1789505, Length=246, Percent_Identity=25.609756097561, Blast_Score=62, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI71991565, Length=308, Percent_Identity=27.5974025974026, Blast_Score=69, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6322631, Length=275, Percent_Identity=29.0909090909091, Blast_Score=77, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24643623, Length=189, Percent_Identity=33.8624338624339, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI20129101, Length=189, Percent_Identity=33.8624338624339, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 37519; Mature: 37519

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYKGLLNQYASYLPVNENTPDVSLMEGNTPLIPLLNISKQLGIQLYGKYEGANPTGSFKD
CCHHHHHHHHHHCCCCCCCCCEEEEECCCCEEEEECCCHHCCEEEEEEECCCCCCCCCCC
RGMVMAVAKAKEEGSEAIICASTGNTSASAAAYAARLGMKCIIVIPEGKIAHGKLAQAVA
CCEEEEEEECCCCCCCEEEEEECCCCCHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHH
YGAEIISIEGNFDDALKAVRNIAEEEPITLVNSVNPYRIEGQKTAAFEICDQLQRAPDVL
CCEEEEEEECCHHHHHHHHHHHHCCCCEEEEECCCCEEECCCCHHHHHHHHHHHCCCCEE
AIPVGNAGNITAYWKGFCEYEKEKGYKKPRIHGFEAEGAAAIVKGHVIDEPETIATAIRI
EEECCCCCCEEHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHEEEEEC
GNPASWSYAVEAAEQSHGEIDMVSDEEILHAYRLLAKSEGVFAEPGSNASLAGVMKHVQS
CCCCCCHHEEEHHHHCCCCEEEECCHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHC
GKIKKGETVVAVLTGNGLKDPDIAISSNTLDIASVSNNIEQIKEHIKGVIMS
CCCCCCCEEEEEEECCCCCCCCEEEECCCEEEHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MYKGLLNQYASYLPVNENTPDVSLMEGNTPLIPLLNISKQLGIQLYGKYEGANPTGSFKD
CCHHHHHHHHHHCCCCCCCCCEEEEECCCCEEEEECCCHHCCEEEEEEECCCCCCCCCCC
RGMVMAVAKAKEEGSEAIICASTGNTSASAAAYAARLGMKCIIVIPEGKIAHGKLAQAVA
CCEEEEEEECCCCCCCEEEEEECCCCCHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHH
YGAEIISIEGNFDDALKAVRNIAEEEPITLVNSVNPYRIEGQKTAAFEICDQLQRAPDVL
CCEEEEEEECCHHHHHHHHHHHHCCCCEEEEECCCCEEECCCCHHHHHHHHHHHCCCCEE
AIPVGNAGNITAYWKGFCEYEKEKGYKKPRIHGFEAEGAAAIVKGHVIDEPETIATAIRI
EEECCCCCCEEHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHEEEEEC
GNPASWSYAVEAAEQSHGEIDMVSDEEILHAYRLLAKSEGVFAEPGSNASLAGVMKHVQS
CCCCCCHHEEEHHHHCCCCEEEECCHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHC
GKIKKGETVVAVLTGNGLKDPDIAISSNTLDIASVSNNIEQIKEHIKGVIMS
CCCCCCCEEEEEEECCCCCCCCEEEECCCEEEHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3186450; 8768250 [H]