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The map label for this gene is pdxA [H]

Identifier: 227080655

GI number: 227080655

Start: 457272

End: 458264

Strand: Reverse

Name: pdxA [H]

Synonym: VCM66_0429

Alternate gene names: 227080655

Gene position: 458264-457272 (Counterclockwise)

Preceding gene: 227080656

Following gene: 227080654

Centisome position: 15.84

GC content: 50.25

Gene sequence:

>993_bases
ATGAGCAGTAAACGCATCATTGTCACAGCCGGTGAGCCCGCGGGGATCGGTCCCGATCTGGTGCTCGCCCTCTCCGCGCA
AGATTGGCCACATCAACTGGTGGTGTGTGCCGATAAGGCGTTATTGGCGCAGCGGGCCACGCAACTTGGCATACAGGTTA
AGCTACTGGATTATCAACGCGATAATCCAGTGCAAGCGCAACAAGCAGGAACCTTGTTGGTTGAGCATATTCCTCTCGCG
GAACCCGTCGTCGCCGGTCAACTCAATCCAGCGAATGGACACTATGTGTTAAAAACGCTGGAAAGAGCGGCAAAAGGCTG
TATGAATGGCGAATTTGATGCTATTGTCGCCGGCCCTGTGCACAAGGGGGTGATCAACCGTGCGGGGGTGGCTTTCAGCG
GTCATACCGAATTTTTTGCTGAACAGTCAAAAACTCCCCTCGTCGTGATGATGCTGGCCACAGAAGGCTTACGTACTGCG
TTAGTCACTACACATCTGCCACTCGCAGAAGTGCCGCAAGCGATAACTTGTGAACGTCTAGAACAGATTGTTCATATTCT
CCACAAGGATTTAGTCGAGAAATTTGCCATTGCAGAGCCTAAAATCTACGTATGTGGGTTAAATCCACACGCAGGTGAAG
ACGGTGTATTGGGCATGGATGAGATCGAAACCATCACTCCTACCCTACAGCGTTTGCGTGAGCAATATGGCATGCAATTG
GTTGGTCCTTTACCAGCCGATACTATTTTTAGTGAAAAATACTTGCAACAAGCGGATGCCGTTCTCGGCATGTACCATGA
TCAAGTGCTTCCAGTGCTGAAATACAAAGGCTTTGGCCGCTCAGTCAATATTACGCTCGGGCTGCCTTTTATCCGCACTT
CGGTCGATCACGGTACGGCACTCGATCTGGCTGGAACGGGTCAAGCCGATGCGGGAAGCTTTTGGACTGCATTAGCTTAC
GCAATTGAATTAGTTGATAAAAAAGCGCAATAA

Upstream 100 bases:

>100_bases
TACCGTATCTTGTTCAATCGTAAATTCAATGAAGAAGCCAGTGCTTGGCTGCAAGAGCTGCGTGCCAGCGCCTTTGTTGA
AGTATTGAAGGACGAGAAGG

Downstream 100 bases:

>100_bases
CTTAGAGAAAACTATGAGAAATGATGTCCACTTAGGGCACAAAGCGCGTAAACGCTTTGGTCAGAACTTCCTCAATGATC
CTTACATCATTGATGGTATT

Product: 4-hydroxythreonine-4-phosphate dehydrogenase

Products: NA

Alternate protein names: 4-(phosphohydroxy)-L-threonine dehydrogenase [H]

Number of amino acids: Translated: 330; Mature: 329

Protein sequence:

>330_residues
MSSKRIIVTAGEPAGIGPDLVLALSAQDWPHQLVVCADKALLAQRATQLGIQVKLLDYQRDNPVQAQQAGTLLVEHIPLA
EPVVAGQLNPANGHYVLKTLERAAKGCMNGEFDAIVAGPVHKGVINRAGVAFSGHTEFFAEQSKTPLVVMMLATEGLRTA
LVTTHLPLAEVPQAITCERLEQIVHILHKDLVEKFAIAEPKIYVCGLNPHAGEDGVLGMDEIETITPTLQRLREQYGMQL
VGPLPADTIFSEKYLQQADAVLGMYHDQVLPVLKYKGFGRSVNITLGLPFIRTSVDHGTALDLAGTGQADAGSFWTALAY
AIELVDKKAQ

Sequences:

>Translated_330_residues
MSSKRIIVTAGEPAGIGPDLVLALSAQDWPHQLVVCADKALLAQRATQLGIQVKLLDYQRDNPVQAQQAGTLLVEHIPLA
EPVVAGQLNPANGHYVLKTLERAAKGCMNGEFDAIVAGPVHKGVINRAGVAFSGHTEFFAEQSKTPLVVMMLATEGLRTA
LVTTHLPLAEVPQAITCERLEQIVHILHKDLVEKFAIAEPKIYVCGLNPHAGEDGVLGMDEIETITPTLQRLREQYGMQL
VGPLPADTIFSEKYLQQADAVLGMYHDQVLPVLKYKGFGRSVNITLGLPFIRTSVDHGTALDLAGTGQADAGSFWTALAY
AIELVDKKAQ
>Mature_329_residues
SSKRIIVTAGEPAGIGPDLVLALSAQDWPHQLVVCADKALLAQRATQLGIQVKLLDYQRDNPVQAQQAGTLLVEHIPLAE
PVVAGQLNPANGHYVLKTLERAAKGCMNGEFDAIVAGPVHKGVINRAGVAFSGHTEFFAEQSKTPLVVMMLATEGLRTAL
VTTHLPLAEVPQAITCERLEQIVHILHKDLVEKFAIAEPKIYVCGLNPHAGEDGVLGMDEIETITPTLQRLREQYGMQLV
GPLPADTIFSEKYLQQADAVLGMYHDQVLPVLKYKGFGRSVNITLGLPFIRTSVDHGTALDLAGTGQADAGSFWTALAYA
IELVDKKAQ

Specific function: Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) [H]

COG id: COG1995

COG function: function code H; Pyridoxal phosphate biosynthesis protein

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pdxA family [H]

Homologues:

Organism=Escherichia coli, GI1786237, Length=325, Percent_Identity=62.4615384615385, Blast_Score=413, Evalue=1e-116,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005255 [H]

Pfam domain/function: PF04166 PdxA [H]

EC number: =1.1.1.262 [H]

Molecular weight: Translated: 35576; Mature: 35444

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSKRIIVTAGEPAGIGPDLVLALSAQDWPHQLVVCADKALLAQRATQLGIQVKLLDYQR
CCCCEEEEECCCCCCCCCCEEEEEECCCCCCEEEEEHHHHHHHHHHHHHCEEEEEEECCC
DNPVQAQQAGTLLVEHIPLAEPVVAGQLNPANGHYVLKTLERAAKGCMNGEFDAIVAGPV
CCCCCHHHHCCEEEECCCCCCCHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEECCH
HKGVINRAGVAFSGHTEFFAEQSKTPLVVMMLATEGLRTALVTTHLPLAEVPQAITCERL
HHHHHHHCCEEECCCHHHHHHCCCCCEEEEEEECCCHHHHHHHCCCCHHHCCCHHHHHHH
EQIVHILHKDLVEKFAIAEPKIYVCGLNPHAGEDGVLGMDEIETITPTLQRLREQYGMQL
HHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEE
VGPLPADTIFSEKYLQQADAVLGMYHDQVLPVLKYKGFGRSVNITLGLPFIRTSVDHGTA
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECHHHEECCCCCCE
LDLAGTGQADAGSFWTALAYAIELVDKKAQ
EEECCCCCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SSKRIIVTAGEPAGIGPDLVLALSAQDWPHQLVVCADKALLAQRATQLGIQVKLLDYQR
CCCEEEEECCCCCCCCCCEEEEEECCCCCCEEEEEHHHHHHHHHHHHHCEEEEEEECCC
DNPVQAQQAGTLLVEHIPLAEPVVAGQLNPANGHYVLKTLERAAKGCMNGEFDAIVAGPV
CCCCCHHHHCCEEEECCCCCCCHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEECCH
HKGVINRAGVAFSGHTEFFAEQSKTPLVVMMLATEGLRTALVTTHLPLAEVPQAITCERL
HHHHHHHCCEEECCCHHHHHHCCCCCEEEEEEECCCHHHHHHHCCCCHHHCCCHHHHHHH
EQIVHILHKDLVEKFAIAEPKIYVCGLNPHAGEDGVLGMDEIETITPTLQRLREQYGMQL
HHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEE
VGPLPADTIFSEKYLQQADAVLGMYHDQVLPVLKYKGFGRSVNITLGLPFIRTSVDHGTA
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECHHHEECCCCCCE
LDLAGTGQADAGSFWTALAYAIELVDKKAQ
EEECCCCCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]