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The map label for this gene is recQ [H]

Identifier: 227080417

GI number: 227080417

Start: 187795

End: 189657

Strand: Direct

Name: recQ [H]

Synonym: VCM66_0184

Alternate gene names: 227080417

Gene position: 187795-189657 (Clockwise)

Preceding gene: 227080412

Following gene: 227080418

Centisome position: 6.49

GC content: 53.41

Gene sequence:

>1863_bases
ATGACTCTTACTTTGCACTCTATCGATATGACCGCGACTTTAATGGCTGAATCTTCTGCTCTCTTTGCCACTCCTGAACG
TGTTTTGCACGAGGTGTTTGGCTATCAGCAATTTCGCGTCGGTCAGCAAGAGGTGATTGAGGCGGCGCTGGCTGGGCGTG
ATAGCTTGGTCATTATGCCGACTGGCGGTGGTAAATCGCTCTGTTACCAGATCCCTGCACTGGTGCTGGAAGGGGTCACG
TTAGTGATTTCTCCCCTGATTTCGCTGATGAAAGATCAGGTTGACCAGCTTAAAGCCAACGGTGTGGCGGCAGAGTGCGT
GAATTCCACCTTGGCGCGCGAGGAGTTGATCGCGATTTATAACCGCATGCATGCTGGCCAGCTCAAGCTGCTGTATGTGT
CGCCAGAGCGGGTATTGACCGCCGAGTTTATCGAACGGCTCAGCCATCTGCCGTTAGCCATGATTGCGGTTGATGAAGCG
CACTGTATTTCGCAATGGGGACACGATTTTCGCCCTGAATACGCCTCATTAGGCCAGCTTAAGCAGCGTTTCCCGAATGT
GCCGGTGATGGCGCTGACTGCGACTGCGGATGACGCGACCCGTCACGACATTATGCAGCGTTTGCAGCTCAATGAGCCGC
ATCAGTATCTGGGCAGTTTTGATCGCCCGAACATCCGCTACATGCTGGTGGAAAAACATAAGCCGGTTTCGCAAGTGATT
CGCTATTTGGAAACGCAGCGCGGGCAGTGCGGCATCATCTATTGTGGTAGCCGTAAAAAAGTGGAAATGCTCACCGAAAA
GCTGTGCGGCAACCACATTCGCGCCGCCAGTTACCATGCCGGGATGGATGCCGATGAACGCGCTTGGGTGCAAGAAGCGT
TTCAGCGTGATGACCTGCAAATTGTGGTGGCGACCGTGGCGTTTGGCATGGGGATTAATAAACCCAACGTGCGCTTTGTG
GTGCATTTTGATATTCCACGCAACATTGAATCCTACTATCAGGAAACTGGCCGCGCAGGGCGTGATGGTCTGCCTGCTGA
AGCCATGATGCTGTACGACCCTGCCGACATGAACTGGCTGCGCCGCATGCTGGATGAAAAGCCCGATGGCGCGCAAAAAC
AGGTTGAAAGCCACAAACTCACCGCCATGGGCGCGTTTGCTGAAGCGCAAACTTGTCGCCGCCAAGTGTTGCTCAATTAT
TTTGGCGAATATCGCGATAAGCCATGTGGTAACTGCGATATCTGCCTCGACCCGCCCAAGCGTTTTGATGCCACGGAAGA
GGCACGCAAAGCCTTGTCGTGTGTCTATCGCGTCAATCAAAACTTTGGGATTGGCTATGTGGTGGAAGTGCTGCGCGGCA
TGCAGAATATCCGTATTCGCGAGCATGGCCACGACAAAATCACCACCTACGGCATCGGCCGCGATCACAGCCACGATTAC
TGGGTGAGTATTTTCCGCCAACTGATCCACAAAGGCATGCTCTACCAGAACATCACGCGTAACTCGACATTGCAACTGAC
CGAAGAAGCGCGCCCCTTGCTGCGCGGTGAAATGAATATTGAGCTGGCGGTACCGCGTTTAGATACCGCGGCGCGCGCCG
CGAAATCCGACAAATTGTCGGGCAAAAACTACGACAAAAAGCTGTTTGCCAAACTGCGTAAGCTGCGTAAATCGATCGCC
GATGATGAAGGCTTACCACCGTATGTGGTGTTCAGTGACGCCACCTTGATTGATATGGCGGAGATCATGCCGACCTCTTA
CGGCGAAATGTTGGCGGTGAATGGGGTTGGGCAGCGCAAGCTGGAAAAATACGCCGACCCGTTTTTGGATCTGATTCAGG
AGCATTTGACCTATCATGGCTGA

Upstream 100 bases:

>100_bases
CGGTAGCAGCGAAGTATAACCTGAGAATCGTACACTGTACGTATTTTGCGGTTTTATTCACCGAGTAACCCCTCTACAAT
AGCCAGCTTGTTGGCGACCC

Downstream 100 bases:

>100_bases
GTTTGGTTTAGGTGACTATCTTGCCGCGGAAGGGCGCTTGATTGTGCGCGCCGAAAACTTCGATTTTGAGGCTTTTGCTG
AAACCGCTTTGCGTTTGGTG

Product: ATP-dependent DNA helicase RecQ

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 620; Mature: 619

Protein sequence:

>620_residues
MTLTLHSIDMTATLMAESSALFATPERVLHEVFGYQQFRVGQQEVIEAALAGRDSLVIMPTGGGKSLCYQIPALVLEGVT
LVISPLISLMKDQVDQLKANGVAAECVNSTLAREELIAIYNRMHAGQLKLLYVSPERVLTAEFIERLSHLPLAMIAVDEA
HCISQWGHDFRPEYASLGQLKQRFPNVPVMALTATADDATRHDIMQRLQLNEPHQYLGSFDRPNIRYMLVEKHKPVSQVI
RYLETQRGQCGIIYCGSRKKVEMLTEKLCGNHIRAASYHAGMDADERAWVQEAFQRDDLQIVVATVAFGMGINKPNVRFV
VHFDIPRNIESYYQETGRAGRDGLPAEAMMLYDPADMNWLRRMLDEKPDGAQKQVESHKLTAMGAFAEAQTCRRQVLLNY
FGEYRDKPCGNCDICLDPPKRFDATEEARKALSCVYRVNQNFGIGYVVEVLRGMQNIRIREHGHDKITTYGIGRDHSHDY
WVSIFRQLIHKGMLYQNITRNSTLQLTEEARPLLRGEMNIELAVPRLDTAARAAKSDKLSGKNYDKKLFAKLRKLRKSIA
DDEGLPPYVVFSDATLIDMAEIMPTSYGEMLAVNGVGQRKLEKYADPFLDLIQEHLTYHG

Sequences:

>Translated_620_residues
MTLTLHSIDMTATLMAESSALFATPERVLHEVFGYQQFRVGQQEVIEAALAGRDSLVIMPTGGGKSLCYQIPALVLEGVT
LVISPLISLMKDQVDQLKANGVAAECVNSTLAREELIAIYNRMHAGQLKLLYVSPERVLTAEFIERLSHLPLAMIAVDEA
HCISQWGHDFRPEYASLGQLKQRFPNVPVMALTATADDATRHDIMQRLQLNEPHQYLGSFDRPNIRYMLVEKHKPVSQVI
RYLETQRGQCGIIYCGSRKKVEMLTEKLCGNHIRAASYHAGMDADERAWVQEAFQRDDLQIVVATVAFGMGINKPNVRFV
VHFDIPRNIESYYQETGRAGRDGLPAEAMMLYDPADMNWLRRMLDEKPDGAQKQVESHKLTAMGAFAEAQTCRRQVLLNY
FGEYRDKPCGNCDICLDPPKRFDATEEARKALSCVYRVNQNFGIGYVVEVLRGMQNIRIREHGHDKITTYGIGRDHSHDY
WVSIFRQLIHKGMLYQNITRNSTLQLTEEARPLLRGEMNIELAVPRLDTAARAAKSDKLSGKNYDKKLFAKLRKLRKSIA
DDEGLPPYVVFSDATLIDMAEIMPTSYGEMLAVNGVGQRKLEKYADPFLDLIQEHLTYHG
>Mature_619_residues
TLTLHSIDMTATLMAESSALFATPERVLHEVFGYQQFRVGQQEVIEAALAGRDSLVIMPTGGGKSLCYQIPALVLEGVTL
VISPLISLMKDQVDQLKANGVAAECVNSTLAREELIAIYNRMHAGQLKLLYVSPERVLTAEFIERLSHLPLAMIAVDEAH
CISQWGHDFRPEYASLGQLKQRFPNVPVMALTATADDATRHDIMQRLQLNEPHQYLGSFDRPNIRYMLVEKHKPVSQVIR
YLETQRGQCGIIYCGSRKKVEMLTEKLCGNHIRAASYHAGMDADERAWVQEAFQRDDLQIVVATVAFGMGINKPNVRFVV
HFDIPRNIESYYQETGRAGRDGLPAEAMMLYDPADMNWLRRMLDEKPDGAQKQVESHKLTAMGAFAEAQTCRRQVLLNYF
GEYRDKPCGNCDICLDPPKRFDATEEARKALSCVYRVNQNFGIGYVVEVLRGMQNIRIREHGHDKITTYGIGRDHSHDYW
VSIFRQLIHKGMLYQNITRNSTLQLTEEARPLLRGEMNIELAVPRLDTAARAAKSDKLSGKNYDKKLFAKLRKLRKSIAD
DEGLPPYVVFSDATLIDMAEIMPTSYGEMLAVNGVGQRKLEKYADPFLDLIQEHLTYHG

Specific function: Involved in the recF recombination pathway; its gene expression is under the regulation of the SOS system. It is a DNA helicase [H]

COG id: COG0514

COG function: function code L; Superfamily II DNA helicase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI4557365, Length=637, Percent_Identity=34.0659340659341, Blast_Score=346, Evalue=4e-95,
Organism=Homo sapiens, GI169218196, Length=683, Percent_Identity=32.0644216691069, Blast_Score=323, Evalue=4e-88,
Organism=Homo sapiens, GI110735439, Length=683, Percent_Identity=32.0644216691069, Blast_Score=323, Evalue=4e-88,
Organism=Homo sapiens, GI14591902, Length=528, Percent_Identity=34.280303030303, Blast_Score=304, Evalue=2e-82,
Organism=Homo sapiens, GI14591904, Length=528, Percent_Identity=34.280303030303, Blast_Score=304, Evalue=2e-82,
Organism=Homo sapiens, GI148612816, Length=469, Percent_Identity=35.3944562899787, Blast_Score=276, Evalue=4e-74,
Organism=Homo sapiens, GI51242943, Length=360, Percent_Identity=40.2777777777778, Blast_Score=264, Evalue=2e-70,
Organism=Homo sapiens, GI51242947, Length=360, Percent_Identity=40.2777777777778, Blast_Score=264, Evalue=2e-70,
Organism=Homo sapiens, GI284005309, Length=376, Percent_Identity=38.031914893617, Blast_Score=224, Evalue=2e-58,
Organism=Homo sapiens, GI7661920, Length=400, Percent_Identity=22.75, Blast_Score=80, Evalue=8e-15,
Organism=Homo sapiens, GI148613856, Length=345, Percent_Identity=23.768115942029, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI38201710, Length=345, Percent_Identity=23.768115942029, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI4758138, Length=341, Percent_Identity=23.4604105571848, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI222352149, Length=334, Percent_Identity=24.8502994011976, Blast_Score=71, Evalue=4e-12,
Organism=Homo sapiens, GI164664518, Length=369, Percent_Identity=24.1192411924119, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI48994977, Length=601, Percent_Identity=66.3893510815308, Blast_Score=851, Evalue=0.0,
Organism=Escherichia coli, GI87082221, Length=352, Percent_Identity=23.8636363636364, Blast_Score=70, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI25145561, Length=645, Percent_Identity=33.6434108527132, Blast_Score=347, Evalue=9e-96,
Organism=Caenorhabditis elegans, GI32564293, Length=666, Percent_Identity=32.2822822822823, Blast_Score=305, Evalue=4e-83,
Organism=Caenorhabditis elegans, GI71987993, Length=406, Percent_Identity=39.4088669950739, Blast_Score=293, Evalue=2e-79,
Organism=Caenorhabditis elegans, GI71987997, Length=406, Percent_Identity=39.4088669950739, Blast_Score=293, Evalue=2e-79,
Organism=Caenorhabditis elegans, GI17552866, Length=438, Percent_Identity=36.986301369863, Blast_Score=267, Evalue=1e-71,
Organism=Caenorhabditis elegans, GI17537549, Length=395, Percent_Identity=21.7721518987342, Blast_Score=82, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI71995724, Length=364, Percent_Identity=22.5274725274725, Blast_Score=82, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17507121, Length=364, Percent_Identity=22.2527472527473, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71987143, Length=366, Percent_Identity=24.0437158469945, Blast_Score=79, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17552114, Length=357, Percent_Identity=22.96918767507, Blast_Score=74, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI115533224, Length=352, Percent_Identity=23.0113636363636, Blast_Score=72, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17553716, Length=358, Percent_Identity=22.9050279329609, Blast_Score=72, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI32565321, Length=380, Percent_Identity=23.6842105263158, Blast_Score=72, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6323844, Length=521, Percent_Identity=40.6909788867562, Blast_Score=366, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6324217, Length=378, Percent_Identity=24.8677248677249, Blast_Score=84, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6320224, Length=354, Percent_Identity=23.4463276836158, Blast_Score=82, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6320041, Length=350, Percent_Identity=23.7142857142857, Blast_Score=76, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6325138, Length=140, Percent_Identity=24.2857142857143, Blast_Score=64, Evalue=9e-11,
Organism=Drosophila melanogaster, GI24646066, Length=643, Percent_Identity=35.6143079315708, Blast_Score=376, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24664226, Length=452, Percent_Identity=37.6106194690265, Blast_Score=292, Evalue=5e-79,
Organism=Drosophila melanogaster, GI24664230, Length=459, Percent_Identity=37.4727668845316, Blast_Score=290, Evalue=3e-78,
Organism=Drosophila melanogaster, GI62472181, Length=459, Percent_Identity=37.4727668845316, Blast_Score=290, Evalue=3e-78,
Organism=Drosophila melanogaster, GI21358123, Length=387, Percent_Identity=38.7596899224806, Blast_Score=231, Evalue=9e-61,
Organism=Drosophila melanogaster, GI28574962, Length=368, Percent_Identity=25.5434782608696, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24583281, Length=405, Percent_Identity=22.4691358024691, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24583279, Length=405, Percent_Identity=22.4691358024691, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24645031, Length=364, Percent_Identity=23.0769230769231, Blast_Score=73, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24642822, Length=369, Percent_Identity=22.7642276422764, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI21355075, Length=380, Percent_Identity=20, Blast_Score=66, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR011545
- InterPro:   IPR004589
- InterPro:   IPR006293
- InterPro:   IPR002121
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR010997
- InterPro:   IPR018982 [H]

Pfam domain/function: PF00270 DEAD; PF00271 Helicase_C; PF00570 HRDC; PF09382 RQC [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 70142; Mature: 70010

Theoretical pI: Translated: 7.05; Mature: 7.05

Prosite motif: PS50967 HRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLTLHSIDMTATLMAESSALFATPERVLHEVFGYQQFRVGQQEVIEAALAGRDSLVIMP
CEEEEEECCHHHHHHHCCCCCCCCHHHHHHHHHCCHHHCCCHHHHHHHHHCCCCCEEEEE
TGGGKSLCYQIPALVLEGVTLVISPLISLMKDQVDQLKANGVAAECVNSTLAREELIAIY
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
NRMHAGQLKLLYVSPERVLTAEFIERLSHLPLAMIAVDEAHCISQWGHDFRPEYASLGQL
HHHCCCCEEEEEECCHHHHHHHHHHHHHCCCEEEEEECHHHHHHHCCCCCCCHHHHHHHH
KQRFPNVPVMALTATADDATRHDIMQRLQLNEPHQYLGSFDRPNIRYMLVEKHKPVSQVI
HHHCCCCCEEEEEECCCCHHHHHHHHHHCCCCCHHHHCCCCCCCEEEEEEECCCCHHHHH
RYLETQRGQCGIIYCGSRKKVEMLTEKLCGNHIRAASYHAGMDADERAWVQEAFQRDDLQ
HHHHHCCCCEEEEEECCCCHHHHHHHHHCCCCCCHHHHCCCCCCHHHHHHHHHHCCCCHH
IVVATVAFGMGINKPNVRFVVHFDIPRNIESYYQETGRAGRDGLPAEAMMLYDPADMNWL
HHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHCCCCCCCCCCCEEEEECCCCHHHH
RRMLDEKPDGAQKQVESHKLTAMGAFAEAQTCRRQVLLNYFGEYRDKPCGNCDICLDPPK
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCC
RFDATEEARKALSCVYRVNQNFGIGYVVEVLRGMQNIRIREHGHDKITTYGIGRDHSHDY
CCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCEEHCCCCCEEEEEECCCCCCCHH
WVSIFRQLIHKGMLYQNITRNSTLQLTEEARPLLRGEMNIELAVPRLDTAARAAKSDKLS
HHHHHHHHHHHCHHHHHCCCCCCEEEHHHHHHHHCCCCCEEEECCCCCHHHHHHHCCCCC
GKNYDKKLFAKLRKLRKSIADDEGLPPYVVFSDATLIDMAEIMPTSYGEMLAVNGVGQRK
CCCCCHHHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHCCCCCCCEEEECCCCHHH
LEKYADPFLDLIQEHLTYHG
HHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TLTLHSIDMTATLMAESSALFATPERVLHEVFGYQQFRVGQQEVIEAALAGRDSLVIMP
EEEEEECCHHHHHHHCCCCCCCCHHHHHHHHHCCHHHCCCHHHHHHHHHCCCCCEEEEE
TGGGKSLCYQIPALVLEGVTLVISPLISLMKDQVDQLKANGVAAECVNSTLAREELIAIY
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
NRMHAGQLKLLYVSPERVLTAEFIERLSHLPLAMIAVDEAHCISQWGHDFRPEYASLGQL
HHHCCCCEEEEEECCHHHHHHHHHHHHHCCCEEEEEECHHHHHHHCCCCCCCHHHHHHHH
KQRFPNVPVMALTATADDATRHDIMQRLQLNEPHQYLGSFDRPNIRYMLVEKHKPVSQVI
HHHCCCCCEEEEEECCCCHHHHHHHHHHCCCCCHHHHCCCCCCCEEEEEEECCCCHHHHH
RYLETQRGQCGIIYCGSRKKVEMLTEKLCGNHIRAASYHAGMDADERAWVQEAFQRDDLQ
HHHHHCCCCEEEEEECCCCHHHHHHHHHCCCCCCHHHHCCCCCCHHHHHHHHHHCCCCHH
IVVATVAFGMGINKPNVRFVVHFDIPRNIESYYQETGRAGRDGLPAEAMMLYDPADMNWL
HHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHCCCCCCCCCCCEEEEECCCCHHHH
RRMLDEKPDGAQKQVESHKLTAMGAFAEAQTCRRQVLLNYFGEYRDKPCGNCDICLDPPK
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCC
RFDATEEARKALSCVYRVNQNFGIGYVVEVLRGMQNIRIREHGHDKITTYGIGRDHSHDY
CCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCEEHCCCCCEEEEEECCCCCCCHH
WVSIFRQLIHKGMLYQNITRNSTLQLTEEARPLLRGEMNIELAVPRLDTAARAAKSDKLS
HHHHHHHHHHHCHHHHHCCCCCCEEEHHHHHHHHCCCCCEEEECCCCCHHHHHHHCCCCC
GKNYDKKLFAKLRKLRKSIADDEGLPPYVVFSDATLIDMAEIMPTSYGEMLAVNGVGQRK
CCCCCHHHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHCCCCCCCEEEECCCCHHH
LEKYADPFLDLIQEHLTYHG
HHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3027506; 1379743; 9278503; 2164680 [H]