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The map label for this gene is map [H]

Identifier: 226951030

GI number: 226951030

Start: 4087829

End: 4088704

Strand: Direct

Name: map [H]

Synonym: CLM_4069

Alternate gene names: 226951030

Gene position: 4087829-4088704 (Clockwise)

Preceding gene: 226951029

Following gene: 226951032

Centisome position: 98.38

GC content: 31.74

Gene sequence:

>876_bases
ATGTTTAGTAAATTAGGTAGAAACGATTTATGTTGGTGTGGCAGTGAAAAGAAATATAAAAAATGTCATTTTAACTTTGA
TAAAAAAATAGAACTATATAAGACATATGGTCATATAGTACCTCCTAGAGAAATTATAAAAAAACCAGAAGAAATAGTAG
GTATACGTAAAAGTGGTAAAGTTAATATCGCAATTTTAGATCATATTGAAAAGCACATTAAGGCTGGTATGACAACAGAA
GATATTAATGAACTAATTTATAAAAAAACTATAGAATTAGGAGGTACACCAGCACAATTAGGATTTGAGGGATTTCCCAA
GAGTGTATGTACCTCTATCAATGACCAAGTATGCCATGGAATCCCATCAGAAAACGTAGTTTTAAATGATGGAGATATTA
TAAATGTTGACGTTTCAACTATTTATGAAGGATATTTTTCTGATTCTTCTAGAATGTTCTGTATTGGACATATAGATGAA
AATAAGAAAAGCTTGGTTAATGTGGTAAAGGAATGTGTAAATTTAGGAATAAAACAAGTAAAACCATGGGGCTTTCTCGG
AGATATAGGGCAAGCAATCCATGATCATTCCTTAAAAAATGGATACTCTGTAGTAAAGGAAATTGGTGGTCATGGGATCG
GGTTAGAATTCCACGAAGAACCCTGGATAGGTTATACCTCAAAAAAAAATACAGGTATGCTAATGGTGCCAGGTATGATA
TTTACAATAGAACCAATGATTAATATGGGTACTGATGAAATTTTTTTAGATAAGAAAAATGGGTGGACTTATTATACAAC
TGATGGTAAGCCTTCAGCCCAATGGGAAATCATGATATTAGTAACAAATAACGGTTACGAAATATTGGCATACTAA

Upstream 100 bases:

>100_bases
AGAAAAGATTAACTAATATTGAATTATATATGAAACCTAATATATTTCCGGTATCTGATAATGACAATATTAGTGACTAA
TATATTGAAAGGAAATTAAA

Downstream 100 bases:

>100_bases
CTTCATTATATAAATTTTAATGCTGCAATTAAAAATATTAATCACTATAATTTTTAATTGCAGCATTAAATTTAATATAA
ATATATTCTTTACCACTGTT

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 291; Mature: 291

Protein sequence:

>291_residues
MFSKLGRNDLCWCGSEKKYKKCHFNFDKKIELYKTYGHIVPPREIIKKPEEIVGIRKSGKVNIAILDHIEKHIKAGMTTE
DINELIYKKTIELGGTPAQLGFEGFPKSVCTSINDQVCHGIPSENVVLNDGDIINVDVSTIYEGYFSDSSRMFCIGHIDE
NKKSLVNVVKECVNLGIKQVKPWGFLGDIGQAIHDHSLKNGYSVVKEIGGHGIGLEFHEEPWIGYTSKKNTGMLMVPGMI
FTIEPMINMGTDEIFLDKKNGWTYYTTDGKPSAQWEIMILVTNNGYEILAY

Sequences:

>Translated_291_residues
MFSKLGRNDLCWCGSEKKYKKCHFNFDKKIELYKTYGHIVPPREIIKKPEEIVGIRKSGKVNIAILDHIEKHIKAGMTTE
DINELIYKKTIELGGTPAQLGFEGFPKSVCTSINDQVCHGIPSENVVLNDGDIINVDVSTIYEGYFSDSSRMFCIGHIDE
NKKSLVNVVKECVNLGIKQVKPWGFLGDIGQAIHDHSLKNGYSVVKEIGGHGIGLEFHEEPWIGYTSKKNTGMLMVPGMI
FTIEPMINMGTDEIFLDKKNGWTYYTTDGKPSAQWEIMILVTNNGYEILAY
>Mature_291_residues
MFSKLGRNDLCWCGSEKKYKKCHFNFDKKIELYKTYGHIVPPREIIKKPEEIVGIRKSGKVNIAILDHIEKHIKAGMTTE
DINELIYKKTIELGGTPAQLGFEGFPKSVCTSINDQVCHGIPSENVVLNDGDIINVDVSTIYEGYFSDSSRMFCIGHIDE
NKKSLVNVVKECVNLGIKQVKPWGFLGDIGQAIHDHSLKNGYSVVKEIGGHGIGLEFHEEPWIGYTSKKNTGMLMVPGMI
FTIEPMINMGTDEIFLDKKNGWTYYTTDGKPSAQWEIMILVTNNGYEILAY

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI40385867, Length=244, Percent_Identity=38.5245901639344, Blast_Score=174, Evalue=7e-44,
Organism=Homo sapiens, GI164420681, Length=242, Percent_Identity=40.0826446280992, Blast_Score=173, Evalue=1e-43,
Organism=Escherichia coli, GI1786364, Length=246, Percent_Identity=42.6829268292683, Blast_Score=200, Evalue=8e-53,
Organism=Escherichia coli, GI1788728, Length=260, Percent_Identity=27.3076923076923, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71996291, Length=244, Percent_Identity=40.9836065573771, Blast_Score=174, Evalue=4e-44,
Organism=Saccharomyces cerevisiae, GI6323273, Length=248, Percent_Identity=41.1290322580645, Blast_Score=191, Evalue=8e-50,
Organism=Drosophila melanogaster, GI21355531, Length=242, Percent_Identity=38.8429752066116, Blast_Score=174, Evalue=5e-44,
Organism=Drosophila melanogaster, GI24583427, Length=255, Percent_Identity=38.0392156862745, Blast_Score=166, Evalue=2e-41,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467
- InterPro:   IPR004027 [H]

Pfam domain/function: PF00557 Peptidase_M24; PF02810 SEC-C [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 32761; Mature: 32761

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSKLGRNDLCWCGSEKKYKKCHFNFDKKIELYKTYGHIVPPREIIKKPEEIVGIRKSGK
CCCCCCCCCEEEECCCCCHHEECCCCCCEEEEEEECCCCCCCHHHHCCCHHHCCCCCCCC
VNIAILDHIEKHIKAGMTTEDINELIYKKTIELGGTPAQLGFEGFPKSVCTSINDQVCHG
EEEEEHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHCCCCCCCHHHHHCCCHHHHCC
IPSENVVLNDGDIINVDVSTIYEGYFSDSSRMFCIGHIDENKKSLVNVVKECVNLGIKQV
CCCCCEEECCCCEEEEEHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCHHHC
KPWGFLGDIGQAIHDHSLKNGYSVVKEIGGHGIGLEFHEEPWIGYTSKKNTGMLMVPGMI
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCEEEECCEE
FTIEPMINMGTDEIFLDKKNGWTYYTTDGKPSAQWEIMILVTNNGYEILAY
EEEEHHHCCCCCEEEEECCCCEEEEECCCCCCCEEEEEEEEECCCEEEEEC
>Mature Secondary Structure
MFSKLGRNDLCWCGSEKKYKKCHFNFDKKIELYKTYGHIVPPREIIKKPEEIVGIRKSGK
CCCCCCCCCEEEECCCCCHHEECCCCCCEEEEEEECCCCCCCHHHHCCCHHHCCCCCCCC
VNIAILDHIEKHIKAGMTTEDINELIYKKTIELGGTPAQLGFEGFPKSVCTSINDQVCHG
EEEEEHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHCCCCCCCHHHHHCCCHHHHCC
IPSENVVLNDGDIINVDVSTIYEGYFSDSSRMFCIGHIDENKKSLVNVVKECVNLGIKQV
CCCCCEEECCCCEEEEEHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCHHHC
KPWGFLGDIGQAIHDHSLKNGYSVVKEIGGHGIGLEFHEEPWIGYTSKKNTGMLMVPGMI
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCEEEECCEE
FTIEPMINMGTDEIFLDKKNGWTYYTTDGKPSAQWEIMILVTNNGYEILAY
EEEEHHHCCCCCEEEEECCCCEEEEECCCCCCCEEEEEEEEECCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]