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The map label for this gene is dapA [H]

Identifier: 226950582

GI number: 226950582

Start: 3596839

End: 3597717

Strand: Direct

Name: dapA [H]

Synonym: CLM_3565

Alternate gene names: 226950582

Gene position: 3596839-3597717 (Clockwise)

Preceding gene: 226950581

Following gene: 226950583

Centisome position: 86.56

GC content: 30.72

Gene sequence:

>879_bases
ATGAGTATTTTTAAAGGTTCTGGAGTAGCTATAATAACTCCTTTCACTGAAACAGGAGTAGATTTTGACAAGCTTTCTGA
ACTAATAGAATGGCATATAAAATCCAAAACTGATGCTATAATAGTTTGCGGAACTACTGGTGAAGCAACTACTATGACTG
AAACTGAAAAAAAAGAAACTATAAAGTTTGTAGTAGATAAAGTAAATAAAAGAATTCCTGTTATTGCAGGTACAGGTAGT
AATAATACTGCCGCTTCCATAGCTATGAGTAAATGGGCTGAAAGTATAGGAGTAGATGGACTATTAGTAATAACTCCATA
TTATAATAAGACAACACAAAAAGGATTAGTTAAGCATTTTAAAGCCGTTTCTGATGCTGTTAATGCTCCTATAATCATAT
ATAACGTACCTGGAAGAACAGGACTTAATATAGCTCCTAGCACTTTAAAGGAACTATGTAAAGATAAAAACATAGTAGCT
GTAAAGGAAGCTAGTGGTAATATAAGTCAAATAGCTCAAATTAAAGCTTTATGTGGTGATAAATTAGATATATATTCTGG
GAATGATGATCAAATAATCCCTATATTAGCTCTTGGCGGAATAGGTGTCATCTCTGTATTAGCTAATGTAATTCCAGAAG
ATGTTCACAATATGTGTGAACTATATTTAACTGGGAAGGTTAATGAAGCTCTAAAAATTCAATTAAATTCTTTAGCTCTT
ACTAATGCTCTATTTATAGAGACAAATCCTATACCAGTAAAAACAGCAATGAATCTTATGAACATGAAGGTAGGAGATTT
AAGACTCCCTTTATGTGAAATGAATGAAAATAATTTAGAAATATTAAAGAAAGAATTAAAAGCTTATAACTTAATGTAA

Upstream 100 bases:

>100_bases
GTAGTAGCAGATAATATCAGAAAAGGTGCTGCACTTAACGCAATTCAAATAGCTGAGCATATAATAAAAAGTAAGTAATT
AAAATTTAGGAGGTATTTTT

Downstream 100 bases:

>100_bases
TATAAAGTGTAGAGTTTATCTCTACACTTTACTATTAAGATATCTAATAAAATAAATTTAGTTTATCCGATGACTACCCG
CTCTAATACTCCCATCTTCT

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS [H]

Number of amino acids: Translated: 292; Mature: 291

Protein sequence:

>292_residues
MSIFKGSGVAIITPFTETGVDFDKLSELIEWHIKSKTDAIIVCGTTGEATTMTETEKKETIKFVVDKVNKRIPVIAGTGS
NNTAASIAMSKWAESIGVDGLLVITPYYNKTTQKGLVKHFKAVSDAVNAPIIIYNVPGRTGLNIAPSTLKELCKDKNIVA
VKEASGNISQIAQIKALCGDKLDIYSGNDDQIIPILALGGIGVISVLANVIPEDVHNMCELYLTGKVNEALKIQLNSLAL
TNALFIETNPIPVKTAMNLMNMKVGDLRLPLCEMNENNLEILKKELKAYNLM

Sequences:

>Translated_292_residues
MSIFKGSGVAIITPFTETGVDFDKLSELIEWHIKSKTDAIIVCGTTGEATTMTETEKKETIKFVVDKVNKRIPVIAGTGS
NNTAASIAMSKWAESIGVDGLLVITPYYNKTTQKGLVKHFKAVSDAVNAPIIIYNVPGRTGLNIAPSTLKELCKDKNIVA
VKEASGNISQIAQIKALCGDKLDIYSGNDDQIIPILALGGIGVISVLANVIPEDVHNMCELYLTGKVNEALKIQLNSLAL
TNALFIETNPIPVKTAMNLMNMKVGDLRLPLCEMNENNLEILKKELKAYNLM
>Mature_291_residues
SIFKGSGVAIITPFTETGVDFDKLSELIEWHIKSKTDAIIVCGTTGEATTMTETEKKETIKFVVDKVNKRIPVIAGTGSN
NTAASIAMSKWAESIGVDGLLVITPYYNKTTQKGLVKHFKAVSDAVNAPIIIYNVPGRTGLNIAPSTLKELCKDKNIVAV
KEASGNISQIAQIKALCGDKLDIYSGNDDQIIPILALGGIGVISVLANVIPEDVHNMCELYLTGKVNEALKIQLNSLALT
NALFIETNPIPVKTAMNLMNMKVGDLRLPLCEMNENNLEILKKELKAYNLM

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family [H]

Homologues:

Organism=Homo sapiens, GI31543060, Length=281, Percent_Identity=28.4697508896797, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI13540533, Length=304, Percent_Identity=24.6710526315789, Blast_Score=78, Evalue=9e-15,
Organism=Escherichia coli, GI1788823, Length=292, Percent_Identity=42.4657534246575, Blast_Score=240, Evalue=8e-65,
Organism=Escherichia coli, GI1786463, Length=237, Percent_Identity=31.2236286919831, Blast_Score=135, Evalue=2e-33,
Organism=Escherichia coli, GI87082415, Length=276, Percent_Identity=26.0869565217391, Blast_Score=111, Evalue=4e-26,
Organism=Escherichia coli, GI1789620, Length=273, Percent_Identity=25.6410256410256, Blast_Score=107, Evalue=7e-25,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624 [H]

Pfam domain/function: PF00701 DHDPS [H]

EC number: =4.2.1.52 [H]

Molecular weight: Translated: 31606; Mature: 31475

Theoretical pI: Translated: 6.77; Mature: 6.77

Prosite motif: PS00583 PFKB_KINASES_1 ; PS00665 DHDPS_1 ; PS00666 DHDPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIFKGSGVAIITPFTETGVDFDKLSELIEWHIKSKTDAIIVCGTTGEATTMTETEKKET
CCEECCCCEEEEECCHHCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHH
IKFVVDKVNKRIPVIAGTGSNNTAASIAMSKWAESIGVDGLLVITPYYNKTTQKGLVKHF
HHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHH
KAVSDAVNAPIIIYNVPGRTGLNIAPSTLKELCKDKNIVAVKEASGNISQIAQIKALCGD
HHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHCCC
KLDIYSGNDDQIIPILALGGIGVISVLANVIPEDVHNMCELYLTGKVNEALKIQLNSLAL
CEEEECCCCCCEEEEEEECHHHHHHHHHHHCHHHHHHHHHEEEECCCCCEEEEEEEEEEE
TNALFIETNPIPVKTAMNLMNMKVGDLRLPLCEMNENNLEILKKELKAYNLM
EEEEEEECCCCCHHHHHHHHCCCCCCEECCCCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SIFKGSGVAIITPFTETGVDFDKLSELIEWHIKSKTDAIIVCGTTGEATTMTETEKKET
CEECCCCEEEEECCHHCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHH
IKFVVDKVNKRIPVIAGTGSNNTAASIAMSKWAESIGVDGLLVITPYYNKTTQKGLVKHF
HHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHH
KAVSDAVNAPIIIYNVPGRTGLNIAPSTLKELCKDKNIVAVKEASGNISQIAQIKALCGD
HHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHCCC
KLDIYSGNDDQIIPILALGGIGVISVLANVIPEDVHNMCELYLTGKVNEALKIQLNSLAL
CEEEECCCCCCEEEEEEECHHHHHHHHHHHCHHHHHHHHHEEEECCCCCEEEEEEEEEEE
TNALFIETNPIPVKTAMNLMNMKVGDLRLPLCEMNENNLEILKKELKAYNLM
EEEEEEECCCCCHHHHHHHHCCCCCCEECCCCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12552129 [H]