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The map label for this gene is comEC [H]

Identifier: 226950395

GI number: 226950395

Start: 3396803

End: 3398590

Strand: Reverse

Name: comEC [H]

Synonym: CLM_3364

Alternate gene names: 226950395

Gene position: 3398590-3396803 (Counterclockwise)

Preceding gene: 226950396

Following gene: 226950394

Centisome position: 81.79

GC content: 22.65

Gene sequence:

>1788_bases
ATGGAAAAACCATTAATTTATTATGCTATTTCAGTTTTTTTGGGGTGTATTTCTGTCTTGTTATTATTTAATAATATATT
ATTAGGTGCAGTGTTTACTGCATCTTTTTTAATAATTATTTTTATAAATGAGGATAGCAAAAATTTTATTATAATTTTAT
TATTTTTTATTTTGGCTATGTTTAGTTTTTACAGTTATTTCACTATAGATGTTCCAGATAATATTAAAGTTAGGATTACA
AAAAAAGAAAAATATTATTGTTTTGGAGACTATAAGGGAAGAAATATCTTTATAATAGGGAAGACTAAAGAGTTAAAAGA
AGGGGTGAAAACTACCATAGAGGGCGAATTTACAAGAGATATTAGATATAGGGGTGGATCTTTGGGAAGTTTTAAAGTAA
AAAAAGTAAAAGGAAAAGAAGAAGATATAGTATACAATATATATAATTTTAAATCTATAGCCTATAATGAATTTAAGGAA
CAGTTAGGAGAAAATAAGACTGCTATGGTAATGTCTTTATGCTTTGGAGAAACTAAATATATATCTAATAGTGATAAAGA
TATATTAAAGAAATTAGGTGTTATACATGCAGTTAGTGTATCTGGTTTTCATATGGCTATAATATATAAGCTCCTAGAGA
GGGTGTTAGGTCTTACCTTAGCTATCCCAGTATCTTTTTTATATGTAATCTTAACAGGAATGAAATCATCCGCTATAAGA
GCTTTTATAATGATTATAATATTAAAGCTTTCTAAAAAGGTTTTTAGAAAGTATGATAGTTTATCTTCTATAAGTTTAGC
AGCTATAATAATATTATTAAATAAGCCATATTACATATTGGATATAGGATTTATGTTATCTTTTTTATCTACCATAGGTA
TATTATTATATAATAAAAAAATATCTAGGACTCTTTATAAATTGCCACAGAGAATTAATTCTTGTGTAAGTCTTACGTTG
AGTTCTCAGGTATATACATTCCCCTATATGTGTTTTACCATTCAAAGCTTTGGTTTAGGTTTTATAATAGGAAATTTAGT
GTTAGTACCTCTTTATGCTCCTATAGTATTATTAGGAAATTTAGCAATGCTTTTAATAAAAATACCTTTTGTATTTAAGA
TTATAAATAAAATTATATATATTTTTTTAATAATGATAGAAGGAGCTCAGTATTTACTCTCTAATATAACTCCAGATTGT
ATTTATATAGGAGAGTTTGAGGGGATATGTTTTGTGATTATATATATGAGCTATGTATTATACAAACATGGTTATAAAAA
TGTAAAATATATACCCTTAAGTTGTATAATGTTTTTGATTTTATTCAATTATACTTTTTTCCCAAGTATAGATTTTTATA
GAGAAAAAGATTATAATATTACAGTTGTAAAATATAAGTTTCATACTATAATGCTTTGTAATTATGAAAGTAATGCAGGT
AAAAATATATTAAGGGTAAAACAGCAGGTAAAACCAGATAAAGTAATTACAAATATAAAAAATAATACAAAGATAAATTT
AGATAAAAATTTAAAAGTCTATATTTTAAGTTGTGAAAAAGAACCTAATTTTTATAATGAAATGTCAATGGAAAATGAGA
ATAAATATAGTAAGATAAATATTTTATTAAAAAATAAAAACAAAAATATAGTTTTTACAGAAAAACCTATTAGCTTAAAA
ATTCCTAAAAATAATTATGTTATAATAAATTTAAAAGAAAAAAATTATACAGATATTTTAAATAAAAGATATATAGTAGT
TTTTAATAAAATTTTATGTTTAAAATAA

Upstream 100 bases:

>100_bases
AAAGAAATAAAAAAGATGCTGAAGTTATGAATATAGAATATAATGAATATACGAAAAGTGTTCAAATAGTAGCAAAACTT
CAAAGTTAAGGAGATAGTTT

Downstream 100 bases:

>100_bases
AGGAAATGTTAAATAAGGAGTGAACATTTTGTTAGATATACTAGAGTTTGAACAAAACACAAAGAAATATATAAATAATA
ATTGTTATATTTTTTGTGGA

Product: ComEC/Rec2 family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 595; Mature: 595

Protein sequence:

>595_residues
MEKPLIYYAISVFLGCISVLLLFNNILLGAVFTASFLIIIFINEDSKNFIIILLFFILAMFSFYSYFTIDVPDNIKVRIT
KKEKYYCFGDYKGRNIFIIGKTKELKEGVKTTIEGEFTRDIRYRGGSLGSFKVKKVKGKEEDIVYNIYNFKSIAYNEFKE
QLGENKTAMVMSLCFGETKYISNSDKDILKKLGVIHAVSVSGFHMAIIYKLLERVLGLTLAIPVSFLYVILTGMKSSAIR
AFIMIIILKLSKKVFRKYDSLSSISLAAIIILLNKPYYILDIGFMLSFLSTIGILLYNKKISRTLYKLPQRINSCVSLTL
SSQVYTFPYMCFTIQSFGLGFIIGNLVLVPLYAPIVLLGNLAMLLIKIPFVFKIINKIIYIFLIMIEGAQYLLSNITPDC
IYIGEFEGICFVIIYMSYVLYKHGYKNVKYIPLSCIMFLILFNYTFFPSIDFYREKDYNITVVKYKFHTIMLCNYESNAG
KNILRVKQQVKPDKVITNIKNNTKINLDKNLKVYILSCEKEPNFYNEMSMENENKYSKINILLKNKNKNIVFTEKPISLK
IPKNNYVIINLKEKNYTDILNKRYIVVFNKILCLK

Sequences:

>Translated_595_residues
MEKPLIYYAISVFLGCISVLLLFNNILLGAVFTASFLIIIFINEDSKNFIIILLFFILAMFSFYSYFTIDVPDNIKVRIT
KKEKYYCFGDYKGRNIFIIGKTKELKEGVKTTIEGEFTRDIRYRGGSLGSFKVKKVKGKEEDIVYNIYNFKSIAYNEFKE
QLGENKTAMVMSLCFGETKYISNSDKDILKKLGVIHAVSVSGFHMAIIYKLLERVLGLTLAIPVSFLYVILTGMKSSAIR
AFIMIIILKLSKKVFRKYDSLSSISLAAIIILLNKPYYILDIGFMLSFLSTIGILLYNKKISRTLYKLPQRINSCVSLTL
SSQVYTFPYMCFTIQSFGLGFIIGNLVLVPLYAPIVLLGNLAMLLIKIPFVFKIINKIIYIFLIMIEGAQYLLSNITPDC
IYIGEFEGICFVIIYMSYVLYKHGYKNVKYIPLSCIMFLILFNYTFFPSIDFYREKDYNITVVKYKFHTIMLCNYESNAG
KNILRVKQQVKPDKVITNIKNNTKINLDKNLKVYILSCEKEPNFYNEMSMENENKYSKINILLKNKNKNIVFTEKPISLK
IPKNNYVIINLKEKNYTDILNKRYIVVFNKILCLK
>Mature_595_residues
MEKPLIYYAISVFLGCISVLLLFNNILLGAVFTASFLIIIFINEDSKNFIIILLFFILAMFSFYSYFTIDVPDNIKVRIT
KKEKYYCFGDYKGRNIFIIGKTKELKEGVKTTIEGEFTRDIRYRGGSLGSFKVKKVKGKEEDIVYNIYNFKSIAYNEFKE
QLGENKTAMVMSLCFGETKYISNSDKDILKKLGVIHAVSVSGFHMAIIYKLLERVLGLTLAIPVSFLYVILTGMKSSAIR
AFIMIIILKLSKKVFRKYDSLSSISLAAIIILLNKPYYILDIGFMLSFLSTIGILLYNKKISRTLYKLPQRINSCVSLTL
SSQVYTFPYMCFTIQSFGLGFIIGNLVLVPLYAPIVLLGNLAMLLIKIPFVFKIINKIIYIFLIMIEGAQYLLSNITPDC
IYIGEFEGICFVIIYMSYVLYKHGYKNVKYIPLSCIMFLILFNYTFFPSIDFYREKDYNITVVKYKFHTIMLCNYESNAG
KNILRVKQQVKPDKVITNIKNNTKINLDKNLKVYILSCEKEPNFYNEMSMENENKYSKINILLKNKNKNIVFTEKPISLK
IPKNNYVIINLKEKNYTDILNKRYIVVFNKILCLK

Specific function: The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding [H]

COG id: COG0658

COG function: function code R; Predicted membrane metal-binding protein

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR004477
- InterPro:   IPR004797 [H]

Pfam domain/function: PF03772 Competence; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 68859; Mature: 68859

Theoretical pI: Translated: 9.91; Mature: 9.91

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKPLIYYAISVFLGCISVLLLFNNILLGAVFTASFLIIIFINEDSKNFIIILLFFILAM
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEEECCCCCCHHHHHHHHHHH
FSFYSYFTIDVPDNIKVRITKKEKYYCFGDYKGRNIFIIGKTKELKEGVKTTIEGEFTRD
HHHHCEEEEECCCCEEEEEEECCEEEEEECCCCCEEEEEECCHHHHHHHHCCCCCCEEEE
IRYRGGSLGSFKVKKVKGKEEDIVYNIYNFKSIAYNEFKEQLGENKTAMVMSLCFGETKY
HHCCCCCCCCEEEEEECCCCCCEEEEEECCHHHHHHHHHHHHCCCCHHHHHHHHCCCCCC
ISNSDKDILKKLGVIHAVSVSGFHMAIIYKLLERVLGLTLAIPVSFLYVILTGMKSSAIR
CCCCCHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
AFIMIIILKLSKKVFRKYDSLSSISLAAIIILLNKPYYILDIGFMLSFLSTIGILLYNKK
HHHHHHHHHHHHHHHHHHCCCCHHHHEEEEEEECCCEEEEEHHHHHHHHHHHHHHHCCHH
ISRTLYKLPQRINSCVSLTLSSQVYTFPYMCFTIQSFGLGFIIGNLVLVPLYAPIVLLGN
HHHHHHHHHHHHHHHHEEEECCCEEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
LAMLLIKIPFVFKIINKIIYIFLIMIEGAQYLLSNITPDCIYIGEFEGICFVIIYMSYVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHH
YKHGYKNVKYIPLSCIMFLILFNYTFFPSIDFYREKDYNITVVKYKFHTIMLCNYESNAG
HHCCCCCCEEEHHHHHHHHHHHCCCCCCCCCCEECCCCEEEEEEEEEEEEEEEECCCCCC
KNILRVKQQVKPDKVITNIKNNTKINLDKNLKVYILSCEKEPNFYNEMSMENENKYSKIN
CHHHHHHHHCCCCHHHHCCCCCCEEEECCCEEEEEEEECCCCCCHHHCCCCCCCCEEEEE
ILLKNKNKNIVFTEKPISLKIPKNNYVIINLKEKNYTDILNKRYIVVFNKILCLK
EEEEECCCCEEEECCCEEEEECCCCEEEEEECCCCHHHHHCCCEEEEEEEEHCCC
>Mature Secondary Structure
MEKPLIYYAISVFLGCISVLLLFNNILLGAVFTASFLIIIFINEDSKNFIIILLFFILAM
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEEECCCCCCHHHHHHHHHHH
FSFYSYFTIDVPDNIKVRITKKEKYYCFGDYKGRNIFIIGKTKELKEGVKTTIEGEFTRD
HHHHCEEEEECCCCEEEEEEECCEEEEEECCCCCEEEEEECCHHHHHHHHCCCCCCEEEE
IRYRGGSLGSFKVKKVKGKEEDIVYNIYNFKSIAYNEFKEQLGENKTAMVMSLCFGETKY
HHCCCCCCCCEEEEEECCCCCCEEEEEECCHHHHHHHHHHHHCCCCHHHHHHHHCCCCCC
ISNSDKDILKKLGVIHAVSVSGFHMAIIYKLLERVLGLTLAIPVSFLYVILTGMKSSAIR
CCCCCHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
AFIMIIILKLSKKVFRKYDSLSSISLAAIIILLNKPYYILDIGFMLSFLSTIGILLYNKK
HHHHHHHHHHHHHHHHHHCCCCHHHHEEEEEEECCCEEEEEHHHHHHHHHHHHHHHCCHH
ISRTLYKLPQRINSCVSLTLSSQVYTFPYMCFTIQSFGLGFIIGNLVLVPLYAPIVLLGN
HHHHHHHHHHHHHHHHEEEECCCEEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
LAMLLIKIPFVFKIINKIIYIFLIMIEGAQYLLSNITPDCIYIGEFEGICFVIIYMSYVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHH
YKHGYKNVKYIPLSCIMFLILFNYTFFPSIDFYREKDYNITVVKYKFHTIMLCNYESNAG
HHCCCCCCEEEHHHHHHHHHHHCCCCCCCCCCEECCCCEEEEEEEEEEEEEEEECCCCCC
KNILRVKQQVKPDKVITNIKNNTKINLDKNLKVYILSCEKEPNFYNEMSMENENKYSKIN
CHHHHHHHHCCCCHHHHCCCCCCEEEECCCEEEEEEEECCCCCCHHHCCCCCCCCEEEEE
ILLKNKNKNIVFTEKPISLKIPKNNYVIINLKEKNYTDILNKRYIVVFNKILCLK
EEEEECCCCEEEECCCEEEEECCCCEEEEEECCCCHHHHHCCCEEEEEEEEHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377 [H]