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The map label for this gene is flp [H]

Identifier: 226950277

GI number: 226950277

Start: 3261678

End: 3262775

Strand: Direct

Name: flp [H]

Synonym: CLM_3239

Alternate gene names: 226950277

Gene position: 3261678-3262775 (Clockwise)

Preceding gene: 226950270

Following gene: 226950278

Centisome position: 78.49

GC content: 37.07

Gene sequence:

>1098_bases
GTGCAGCAATTCGACAACCAATTAACGTCACTTTTTGATTCGCTTAAAGTTCCAGGCATAGCTGTACTTGTATTTACCAC
GGATAAAATATTATACAAGAAAGAAATCGGATATGCCAATATTGAAAAGAAAATTCCTTACACGTTGGACACAGTTACCA
ATATTGCTTCTATAAGTAAAACCTTTATTGGGGGATCACTGGCAAAAGCTAAGGAAGATGGCTTACTTAGCCTGGATGAA
GATATCAATGACATACTTCCTTTCAAAGTCGTAAACCCATATTTACCAAATGAGAAAATTACTTTAAAAAATCTTGCTTC
ACATACATCCGGAATAAAGGACGACGACACTAAATATATTAATTCATACAGTGCTTACGGCGCCAAGAATATGACCTTAA
AAGATTTCTTATATAACTATCTGAATCCTGAGGGCAAATGGTATTCAAAGGATAATTTCTCAAACAATAAACCGGGGGCA
AGCTTTTCTTACAGCAATATCGGGTCCGCGCTTGCGGGATACTGCATCGAAGCAAGAAGCAAGATGACGTACGCCGATTA
TGTAAGGAAAAATATATTTGAAAAGCTGTCTATGAGCAGCAGCGGATGGGACAGGAACGAATTCAATCCAGCAAACATAG
CTTTAGATTATTCTAAACTGAGGGTTGATTTTGCCAAACATACGGAATCCATGGGTGCCACCCTTGAGTCAATGCCTGCT
TATGAATTAATTACATATCCCGACGGCGGGGTTATGACAACGGTAAATGATCTGTCGAAATACCTGCAAGCTGTAATGAA
AAGACAAGATACATTTATTACCGCAAAAAGCATTGGTTTAATGCTGCAAAAACAATTTAACGACACTAATATTCCTCCGG
AATGCAAAGAAACTAATGAAAATATAGGATTATTCTGGAGTTATAACGACGAAAAGGCCTGGGGGCATACCGGCAGTGAT
CCTGGAGTAGATACATCTATGTATGTAAATTCAAACAATGTAGGTATAATAACTTTTATAAACACTGACGACTCCAGTTT
AGATGAAGATAAATATGTTGAATTAATGAACCTTCTGATAAATTGCCCTATTAAGTAA

Upstream 100 bases:

>100_bases
TGATTCGTATGTTTCTACTTTCTGGTATTGGATCCGGATGCGTTATGAATTCAACTGAAAACGAAAAAAAGAAACTGCTA
ATGCTACTCTATCTAAAGAA

Downstream 100 bases:

>100_bases
AATTTTATTGTTCATAAAAAAAACTACTTTCGCTCATAATATTTCAAGATAAATAGCATCCTTGGCGGTATGGAAGCGAG
GATGCTATTTTTTTATTGAA

Product: beta-lactamase

Products: A Substituted Beta- Amino Acid. [C]

Alternate protein names: FmtA-like protein [H]

Number of amino acids: Translated: 365; Mature: 365

Protein sequence:

>365_residues
MQQFDNQLTSLFDSLKVPGIAVLVFTTDKILYKKEIGYANIEKKIPYTLDTVTNIASISKTFIGGSLAKAKEDGLLSLDE
DINDILPFKVVNPYLPNEKITLKNLASHTSGIKDDDTKYINSYSAYGAKNMTLKDFLYNYLNPEGKWYSKDNFSNNKPGA
SFSYSNIGSALAGYCIEARSKMTYADYVRKNIFEKLSMSSSGWDRNEFNPANIALDYSKLRVDFAKHTESMGATLESMPA
YELITYPDGGVMTTVNDLSKYLQAVMKRQDTFITAKSIGLMLQKQFNDTNIPPECKETNENIGLFWSYNDEKAWGHTGSD
PGVDTSMYVNSNNVGIITFINTDDSSLDEDKYVELMNLLINCPIK

Sequences:

>Translated_365_residues
MQQFDNQLTSLFDSLKVPGIAVLVFTTDKILYKKEIGYANIEKKIPYTLDTVTNIASISKTFIGGSLAKAKEDGLLSLDE
DINDILPFKVVNPYLPNEKITLKNLASHTSGIKDDDTKYINSYSAYGAKNMTLKDFLYNYLNPEGKWYSKDNFSNNKPGA
SFSYSNIGSALAGYCIEARSKMTYADYVRKNIFEKLSMSSSGWDRNEFNPANIALDYSKLRVDFAKHTESMGATLESMPA
YELITYPDGGVMTTVNDLSKYLQAVMKRQDTFITAKSIGLMLQKQFNDTNIPPECKETNENIGLFWSYNDEKAWGHTGSD
PGVDTSMYVNSNNVGIITFINTDDSSLDEDKYVELMNLLINCPIK
>Mature_365_residues
MQQFDNQLTSLFDSLKVPGIAVLVFTTDKILYKKEIGYANIEKKIPYTLDTVTNIASISKTFIGGSLAKAKEDGLLSLDE
DINDILPFKVVNPYLPNEKITLKNLASHTSGIKDDDTKYINSYSAYGAKNMTLKDFLYNYLNPEGKWYSKDNFSNNKPGA
SFSYSNIGSALAGYCIEARSKMTYADYVRKNIFEKLSMSSSGWDRNEFNPANIALDYSKLRVDFAKHTESMGATLESMPA
YELITYPDGGVMTTVNDLSKYLQAVMKRQDTFITAKSIGLMLQKQFNDTNIPPECKETNENIGLFWSYNDEKAWGHTGSD
PGVDTSMYVNSNNVGIITFINTDDSSLDEDKYVELMNLLINCPIK

Specific function: Its precise function is unknown. Has no penicillin- binding activity and is not involved in methicillin resistance [H]

COG id: COG1680

COG function: function code V; Beta-lactamase class C and other penicillin binding proteins

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI26051231, Length=320, Percent_Identity=25.625, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI26051233, Length=258, Percent_Identity=26.7441860465116, Blast_Score=78, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI115533026, Length=357, Percent_Identity=26.890756302521, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17550934, Length=376, Percent_Identity=24.2021276595745, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001466 [H]

Pfam domain/function: PF00144 Beta-lactamase [H]

EC number: 3.5.2.6 [C]

Molecular weight: Translated: 40953; Mature: 40953

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQQFDNQLTSLFDSLKVPGIAVLVFTTDKILYKKEIGYANIEKKIPYTLDTVTNIASISK
CCHHHHHHHHHHHHHCCCCEEEEEEECCCEEEHHHCCCCCCCCCCCCHHHHHHHHHHHHH
TFIGGSLAKAKEDGLLSLDEDINDILPFKVVNPYLPNEKITLKNLASHTSGIKDDDTKYI
HHHCCHHHHHCCCCCEECCCCHHHHCCHHEECCCCCCCCEEHHHHHHHHCCCCCCCHHHH
NSYSAYGAKNMTLKDFLYNYLNPEGKWYSKDNFSNNKPGASFSYSNIGSALAGYCIEARS
HHHHHCCCCCCCHHHHHHHHCCCCCCEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHC
KMTYADYVRKNIFEKLSMSSSGWDRNEFNPANIALDYSKLRVDFAKHTESMGATLESMPA
CCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCHHHHCCC
YELITYPDGGVMTTVNDLSKYLQAVMKRQDTFITAKSIGLMLQKQFNDTNIPPECKETNE
EEEEECCCCCEEEEHHHHHHHHHHHHHHHHCEEEHHHHHHHHHHHCCCCCCCCCHHCCCC
NIGLFWSYNDEKAWGHTGSDPGVDTSMYVNSNNVGIITFINTDDSSLDEDKYVELMNLLI
CEEEEEEECCCCCCCCCCCCCCCCCEEEEECCCEEEEEEECCCCCCCCHHHHHHHHHHHH
NCPIK
CCCCC
>Mature Secondary Structure
MQQFDNQLTSLFDSLKVPGIAVLVFTTDKILYKKEIGYANIEKKIPYTLDTVTNIASISK
CCHHHHHHHHHHHHHCCCCEEEEEEECCCEEEHHHCCCCCCCCCCCCHHHHHHHHHHHHH
TFIGGSLAKAKEDGLLSLDEDINDILPFKVVNPYLPNEKITLKNLASHTSGIKDDDTKYI
HHHCCHHHHHCCCCCEECCCCHHHHCCHHEECCCCCCCCEEHHHHHHHHCCCCCCCHHHH
NSYSAYGAKNMTLKDFLYNYLNPEGKWYSKDNFSNNKPGASFSYSNIGSALAGYCIEARS
HHHHHCCCCCCCHHHHHHHHCCCCCCEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHC
KMTYADYVRKNIFEKLSMSSSGWDRNEFNPANIALDYSKLRVDFAKHTESMGATLESMPA
CCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCHHHHCCC
YELITYPDGGVMTTVNDLSKYLQAVMKRQDTFITAKSIGLMLQKQFNDTNIPPECKETNE
EEEEECCCCCEEEEHHHHHHHHHHHHHHHHCEEEHHHHHHHHHHHCCCCCCCCCHHCCCC
NIGLFWSYNDEKAWGHTGSDPGVDTSMYVNSNNVGIITFINTDDSSLDEDKYVELMNLLI
CEEEEEEECCCCCCCCCCCCCCCCCEEEEECCCEEEEEEECCCCCCCCHHHHHHHHHHHH
NCPIK
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: A Beta-Lactam; H2O [C]

Specific reaction: A Beta-Lactam + H2O = A Substituted Beta- Amino Acid. [C]

General reaction: Carboxylic acid amide hydrolysis [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA