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The map label for this gene is hcrA [H]

Identifier: 226950266

GI number: 226950266

Start: 3246525

End: 3248855

Strand: Reverse

Name: hcrA [H]

Synonym: CLM_3223

Alternate gene names: 226950266

Gene position: 3248855-3246525 (Counterclockwise)

Preceding gene: 226950267

Following gene: 226950265

Centisome position: 78.19

GC content: 36.29

Gene sequence:

>2331_bases
TTGAGTAATACAATTGGAGTAAGTATACCAAGAAAAGAGGCTTTTGATAAAGTTACAGGTACAGCAAAATATACTGATGA
TACACTTCTTCCTGGTACTTTGCATGCTAAAATGCTCACAAGTCGTTATGCACATGCAAAGATTAAATCACTTGATATAT
CTAAAGCTAAGAAAGCAATAGGCGTTCAAGAGGTAATAACGGGTGATTATTTTCCTATACTTTCTGGATCAGTAATAGAG
GATAGGCCTCCAATAGCAAGAGATAGAGTACGCTACTTTGGAGAACCTATTGCAGTAGTAATTGCAAATAGTGAGCAAGA
AGCAATGAAAGCTGTAAAGCTAATAAATGTAGAATATGAACCATTACCTGTTGTTAATTCAATAAGTGATTCTTTGAAGC
CGGGTGCTACTCTTATACATGAAAATTTGGATCAGTATAATCATGCGGTGAATGATGTATATCCTGAGCTAAATACTAAT
ATTTTAGATCGAATAAAAATAAGAAAAGGTGATATGACAAAGGGATGGGCAGAAAGTGAAGTTATAGTAGAAGGAAATTT
TTCGCTTCCACAATCAGACCATCTTGCAATGGAAACTAGAAGTGCGAAAGCTCAAATTATGCCAGACGGAAAAATAATAA
TTTATACCTCTTCACAAGGGCCTTATTGTGTTAAGAGGCGTTTAAGTAAGATTTATAATATACCAGAAGGAAATATAGTT
GTTAAAGTACCATTTGTAGGTGGGGGATTCGGTGGCAAAGCAGCTGTTCAATTGGAATTTATTGCATACCTGGCCTCTAA
GGCTGTTAATGGTAGATTAGTTACTATAACCAATTCAAGAGAAGAGGATATTAAAACTTCACCCTGTGGAATTGGAGTTG
AGGGAAATTTAAAAATAGGTGCAACAAAAGATGGAATTATTAAAGTACTTGAAGCTAAATATGCGGTTGATAGCGGAGCT
TATGCAGATACTGGTCCACGTATGGCTAAGGCCATGGCAATAGATTGTTCTGGCCCATATAATATTGAAAATATATGGTG
TGATTCAATATGTGTTTATACTAATCATACTTATGTTACTTCTTATCGTGGATTTGGTCATTCAGAGTATACCTTTTGCA
TGGAGAGAATGATGGATAAGTTGGCAACAAAGCTTGGTATGGATCCTCTAGAATTAAGAATTAAGAATGCTATAAAACCT
GGACAATACACACCCACACAAGTAAAAACAACTTTAAGCAATATAGGCAAATTGGAAGATTGTTTGACAAAATTAAAGGA
ATTAGCTAAATGGGATGAAGGACAGGTAATAAAAACAGGAGACGGTATGATAAAGGCAAAGGGAATGGGCTGCTTTTGGA
AAACATCTGATTCGCCTGCAGATGCTGTTTCTGGAGCTTTTCTTACTTTTAATACAGATGGAAGCATAAATCTTAATACT
GGTGCAGTCGAAATTGGACCGTCTACAAAAACTACTTTAGCTCAGATACTTGCTGAAAAATTAAAAATGGATGTAAGTAG
AATTCACGTAGTGATGGGAGTGGATACTCAAGTTTCACCAGAACATTGGAAAACAGTTGCAAGTATGACAACTTTTATGG
CAGGTAGGGCAGTTCTTAGAGCTGCTGAAGATCTTATAAGGCAGCTGAAAAGTTTAGCAGCTACTGTTATGAAATCTCCG
CCAGAAGATTTAGAAGTTGCAGAAGAAAAGGTATATTTAAAGCAAGATCCAGAAATATATGTTTCATTCAAGGATTTAGC
TAGAGGTCATAAAGCGCCTAATGGTCTTGCAATTGACGGACAAATAATTTCACGTGGAACCTTTATAATGAGTCATATTA
CTAATATGGATAAAGAAACAGGAAAAGGTAAACCTGGGCCAGCGTGGACTGTAGGTGCTCAAGCAGTTGAGATTGAATAT
GATCCTAATAAGTTCACATATAGACTTTTAAAAGCAATTACAGTCATAGATGCAGGTAAAGTTATTAATCCCAAAACCTC
AAGAGGATTAATAATGGGAGGTATGAATATGGGCCTTGGTATAGCTACTAGAGAAGCTTTTACATATGATAAGAACGCTA
GGCTACAGACCACTACATTGAGAACTTATAAGTTAATGAGATTCGGCGAAAATCCAGAATACGCGGTTAATTTTGTTGAA
ACTCCCCAAATTGATGCACCTTTCGGGGCTCGTGGATTTGCAGAACATGGAATAATAGCAATTCCAGCTGCATTCGCAAA
TGCTATATCACATGCAGCTGGGCATGAATTTGATAAACTACCTATAACACCTGAAATAATTTGGAAGGTTAAGACTGGAG
GGAAAATATGA

Upstream 100 bases:

>100_bases
CATATTGAATAAATTACCGAAAAGTAGGTAAAAATAAAATTAATTTAAAAATTACATAAATTAATTTTTTAGTCCTGTTT
TTATAAGGAGGTAAGAGCAT

Downstream 100 bases:

>100_bases
TACCCTTTGATTTTGAATATTATAAACCTGAAACTATTGAAGAGGCAGTTCAATTATATGCTCAATTGAATGCTAGGGGA
AAAAAGCCCTTATATTACGG

Product: xanthine dehydrogenase family protein molybdopterin-binding subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 776; Mature: 775

Protein sequence:

>776_residues
MSNTIGVSIPRKEAFDKVTGTAKYTDDTLLPGTLHAKMLTSRYAHAKIKSLDISKAKKAIGVQEVITGDYFPILSGSVIE
DRPPIARDRVRYFGEPIAVVIANSEQEAMKAVKLINVEYEPLPVVNSISDSLKPGATLIHENLDQYNHAVNDVYPELNTN
ILDRIKIRKGDMTKGWAESEVIVEGNFSLPQSDHLAMETRSAKAQIMPDGKIIIYTSSQGPYCVKRRLSKIYNIPEGNIV
VKVPFVGGGFGGKAAVQLEFIAYLASKAVNGRLVTITNSREEDIKTSPCGIGVEGNLKIGATKDGIIKVLEAKYAVDSGA
YADTGPRMAKAMAIDCSGPYNIENIWCDSICVYTNHTYVTSYRGFGHSEYTFCMERMMDKLATKLGMDPLELRIKNAIKP
GQYTPTQVKTTLSNIGKLEDCLTKLKELAKWDEGQVIKTGDGMIKAKGMGCFWKTSDSPADAVSGAFLTFNTDGSINLNT
GAVEIGPSTKTTLAQILAEKLKMDVSRIHVVMGVDTQVSPEHWKTVASMTTFMAGRAVLRAAEDLIRQLKSLAATVMKSP
PEDLEVAEEKVYLKQDPEIYVSFKDLARGHKAPNGLAIDGQIISRGTFIMSHITNMDKETGKGKPGPAWTVGAQAVEIEY
DPNKFTYRLLKAITVIDAGKVINPKTSRGLIMGGMNMGLGIATREAFTYDKNARLQTTTLRTYKLMRFGENPEYAVNFVE
TPQIDAPFGARGFAEHGIIAIPAAFANAISHAAGHEFDKLPITPEIIWKVKTGGKI

Sequences:

>Translated_776_residues
MSNTIGVSIPRKEAFDKVTGTAKYTDDTLLPGTLHAKMLTSRYAHAKIKSLDISKAKKAIGVQEVITGDYFPILSGSVIE
DRPPIARDRVRYFGEPIAVVIANSEQEAMKAVKLINVEYEPLPVVNSISDSLKPGATLIHENLDQYNHAVNDVYPELNTN
ILDRIKIRKGDMTKGWAESEVIVEGNFSLPQSDHLAMETRSAKAQIMPDGKIIIYTSSQGPYCVKRRLSKIYNIPEGNIV
VKVPFVGGGFGGKAAVQLEFIAYLASKAVNGRLVTITNSREEDIKTSPCGIGVEGNLKIGATKDGIIKVLEAKYAVDSGA
YADTGPRMAKAMAIDCSGPYNIENIWCDSICVYTNHTYVTSYRGFGHSEYTFCMERMMDKLATKLGMDPLELRIKNAIKP
GQYTPTQVKTTLSNIGKLEDCLTKLKELAKWDEGQVIKTGDGMIKAKGMGCFWKTSDSPADAVSGAFLTFNTDGSINLNT
GAVEIGPSTKTTLAQILAEKLKMDVSRIHVVMGVDTQVSPEHWKTVASMTTFMAGRAVLRAAEDLIRQLKSLAATVMKSP
PEDLEVAEEKVYLKQDPEIYVSFKDLARGHKAPNGLAIDGQIISRGTFIMSHITNMDKETGKGKPGPAWTVGAQAVEIEY
DPNKFTYRLLKAITVIDAGKVINPKTSRGLIMGGMNMGLGIATREAFTYDKNARLQTTTLRTYKLMRFGENPEYAVNFVE
TPQIDAPFGARGFAEHGIIAIPAAFANAISHAAGHEFDKLPITPEIIWKVKTGGKI
>Mature_775_residues
SNTIGVSIPRKEAFDKVTGTAKYTDDTLLPGTLHAKMLTSRYAHAKIKSLDISKAKKAIGVQEVITGDYFPILSGSVIED
RPPIARDRVRYFGEPIAVVIANSEQEAMKAVKLINVEYEPLPVVNSISDSLKPGATLIHENLDQYNHAVNDVYPELNTNI
LDRIKIRKGDMTKGWAESEVIVEGNFSLPQSDHLAMETRSAKAQIMPDGKIIIYTSSQGPYCVKRRLSKIYNIPEGNIVV
KVPFVGGGFGGKAAVQLEFIAYLASKAVNGRLVTITNSREEDIKTSPCGIGVEGNLKIGATKDGIIKVLEAKYAVDSGAY
ADTGPRMAKAMAIDCSGPYNIENIWCDSICVYTNHTYVTSYRGFGHSEYTFCMERMMDKLATKLGMDPLELRIKNAIKPG
QYTPTQVKTTLSNIGKLEDCLTKLKELAKWDEGQVIKTGDGMIKAKGMGCFWKTSDSPADAVSGAFLTFNTDGSINLNTG
AVEIGPSTKTTLAQILAEKLKMDVSRIHVVMGVDTQVSPEHWKTVASMTTFMAGRAVLRAAEDLIRQLKSLAATVMKSPP
EDLEVAEEKVYLKQDPEIYVSFKDLARGHKAPNGLAIDGQIISRGTFIMSHITNMDKETGKGKPGPAWTVGAQAVEIEYD
PNKFTYRLLKAITVIDAGKVINPKTSRGLIMGGMNMGLGIATREAFTYDKNARLQTTTLRTYKLMRFGENPEYAVNFVET
PQIDAPFGARGFAEHGIIAIPAAFANAISHAAGHEFDKLPITPEIIWKVKTGGKI

Specific function: Catalyzes reductive dehydroxylation of 4-hydroxybenzoyl- CoA. Reaction is not reversible [H]

COG id: COG1529

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To xanthine oxidases [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=797, Percent_Identity=26.8506900878294, Blast_Score=211, Evalue=2e-54,
Organism=Homo sapiens, GI71773480, Length=797, Percent_Identity=25.34504391468, Blast_Score=193, Evalue=4e-49,
Organism=Escherichia coli, GI1789230, Length=780, Percent_Identity=28.0769230769231, Blast_Score=288, Evalue=7e-79,
Organism=Escherichia coli, GI1789246, Length=810, Percent_Identity=27.1604938271605, Blast_Score=254, Evalue=1e-68,
Organism=Escherichia coli, GI1786478, Length=762, Percent_Identity=22.8346456692913, Blast_Score=125, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17540638, Length=682, Percent_Identity=26.2463343108504, Blast_Score=164, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17539860, Length=755, Percent_Identity=23.9735099337748, Blast_Score=132, Evalue=9e-31,
Organism=Caenorhabditis elegans, GI32566215, Length=754, Percent_Identity=22.6790450928382, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI17737937, Length=764, Percent_Identity=24.2146596858639, Blast_Score=158, Evalue=1e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017607
- InterPro:   IPR000674
- InterPro:   IPR008274 [H]

Pfam domain/function: PF01315 Ald_Xan_dh_C; PF02738 Ald_Xan_dh_C2 [H]

EC number: =1.3.99.20 [H]

Molecular weight: Translated: 84754; Mature: 84622

Theoretical pI: Translated: 8.71; Mature: 8.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNTIGVSIPRKEAFDKVTGTAKYTDDTLLPGTLHAKMLTSRYAHAKIKSLDISKAKKAI
CCCCEEEECCCHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHECCCHHHHHHHC
GVQEVITGDYFPILSGSVIEDRPPIARDRVRYFGEPIAVVIANSEQEAMKAVKLINVEYE
CHHHHHCCCCHHHCCCCCCCCCCCCHHHHHHHCCCCEEEEEECCHHHHHHHHHHEECCCC
PLPVVNSISDSLKPGATLIHENLDQYNHAVNDVYPELNTNILDRIKIRKGDMTKGWAESE
CCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHEEEECCCCCCCCCCCE
VIVEGNFSLPQSDHLAMETRSAKAQIMPDGKIIIYTSSQGPYCVKRRLSKIYNIPEGNIV
EEEECCCCCCCCCCEEEECCCCCEEECCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCEE
VKVPFVGGGFGGKAAVQLEFIAYLASKAVNGRLVTITNSREEDIKTSPCGIGVEGNLKIG
EEEEEECCCCCCCEEEEHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCEEEC
ATKDGIIKVLEAKYAVDSGAYADTGPRMAKAMAIDCSGPYNIENIWCDSICVYTNHTYVT
CCCCHHHHHHHHHHHCCCCCCCCCCCHHEEEEEEECCCCCCCCEEEECCEEEEECCEEEE
SYRGFGHSEYTFCMERMMDKLATKLGMDPLELRIKNAIKPGQYTPTQVKTTLSNIGKLED
EECCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
CLTKLKELAKWDEGQVIKTGDGMIKAKGMGCFWKTSDSPADAVSGAFLTFNTDGSINLNT
HHHHHHHHHCCCCCCEEECCCCEEEECCCEEEEECCCCCHHHHCCEEEEEECCCCEEECC
GAVEIGPSTKTTLAQILAEKLKMDVSRIHVVMGVDTQVSPEHWKTVASMTTFMAGRAVLR
CEEEECCCCHHHHHHHHHHHHHCCHHHEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHH
AAEDLIRQLKSLAATVMKSPPEDLEVAEEKVYLKQDPEIYVSFKDLARGHKAPNGLAIDG
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHEEEECCCEEEEEHHHHHCCCCCCCCEEECC
QIISRGTFIMSHITNMDKETGKGKPGPAWTVGAQAVEIEYDPNKFTYRLLKAITVIDAGK
EEECCCHHHHHHHHCCCHHCCCCCCCCCEEECCEEEEEEECCCHHHHHHHHHHHHEECCC
VINPKTSRGLIMGGMNMGLGIATREAFTYDKNARLQTTTLRTYKLMRFGENPEYAVNFVE
EECCCCCCCEEEECCCCCCEEEECHHEEECCCCEEEEEHHHHEEEECCCCCCCEEEEEEE
TPQIDAPFGARGFAEHGIIAIPAAFANAISHAAGHEFDKLPITPEIIWKVKTGGKI
CCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHCCCCCCCCCCHHEEEEECCCCCC
>Mature Secondary Structure 
SNTIGVSIPRKEAFDKVTGTAKYTDDTLLPGTLHAKMLTSRYAHAKIKSLDISKAKKAI
CCCEEEECCCHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHECCCHHHHHHHC
GVQEVITGDYFPILSGSVIEDRPPIARDRVRYFGEPIAVVIANSEQEAMKAVKLINVEYE
CHHHHHCCCCHHHCCCCCCCCCCCCHHHHHHHCCCCEEEEEECCHHHHHHHHHHEECCCC
PLPVVNSISDSLKPGATLIHENLDQYNHAVNDVYPELNTNILDRIKIRKGDMTKGWAESE
CCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHEEEECCCCCCCCCCCE
VIVEGNFSLPQSDHLAMETRSAKAQIMPDGKIIIYTSSQGPYCVKRRLSKIYNIPEGNIV
EEEECCCCCCCCCCEEEECCCCCEEECCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCEE
VKVPFVGGGFGGKAAVQLEFIAYLASKAVNGRLVTITNSREEDIKTSPCGIGVEGNLKIG
EEEEEECCCCCCCEEEEHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCEEEC
ATKDGIIKVLEAKYAVDSGAYADTGPRMAKAMAIDCSGPYNIENIWCDSICVYTNHTYVT
CCCCHHHHHHHHHHHCCCCCCCCCCCHHEEEEEEECCCCCCCCEEEECCEEEEECCEEEE
SYRGFGHSEYTFCMERMMDKLATKLGMDPLELRIKNAIKPGQYTPTQVKTTLSNIGKLED
EECCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
CLTKLKELAKWDEGQVIKTGDGMIKAKGMGCFWKTSDSPADAVSGAFLTFNTDGSINLNT
HHHHHHHHHCCCCCCEEECCCCEEEECCCEEEEECCCCCHHHHCCEEEEEECCCCEEECC
GAVEIGPSTKTTLAQILAEKLKMDVSRIHVVMGVDTQVSPEHWKTVASMTTFMAGRAVLR
CEEEECCCCHHHHHHHHHHHHHCCHHHEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHH
AAEDLIRQLKSLAATVMKSPPEDLEVAEEKVYLKQDPEIYVSFKDLARGHKAPNGLAIDG
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHEEEECCCEEEEEHHHHHCCCCCCCCEEECC
QIISRGTFIMSHITNMDKETGKGKPGPAWTVGAQAVEIEYDPNKFTYRLLKAITVIDAGK
EEECCCHHHHHHHHCCCHHCCCCCCCCCEEECCEEEEEEECCCHHHHHHHHHHHHEECCC
VINPKTSRGLIMGGMNMGLGIATREAFTYDKNARLQTTTLRTYKLMRFGENPEYAVNFVE
EECCCCCCCEEEECCCCCCEEEECHHEEECCCCEEEEEHHHHEEEECCCCCCCEEEEEEE
TPQIDAPFGARGFAEHGIIAIPAAFANAISHAAGHEFDKLPITPEIIWKVKTGGKI
CCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHCCCCCCCCCCHHEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9490068 [H]