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The map label for this gene is pepQ [H]

Identifier: 226949536

GI number: 226949536

Start: 2547149

End: 2548942

Strand: Direct

Name: pepQ [H]

Synonym: CLM_2472

Alternate gene names: 226949536

Gene position: 2547149-2548942 (Clockwise)

Preceding gene: 226949523

Following gene: 226949537

Centisome position: 61.3

GC content: 33.95

Gene sequence:

>1794_bases
ATGAAAGTATCTGAAAGACTTACAAAATTAAGGAACTTGATGACTGAAAAAAATATTGATATGTATATCGTACCTACTGC
TGATTTCCATCAAAGCGAATATGTAGGTGAACATTTCAAAGCTAGAAAATATATCACTGGGTTCTCTGGTTCTGCAGGAA
CTGCTGTTATAACAAAAGATCATGCAGGATTATGGACAGACGGAAGATATTTTCTACAGGCTGGAAACCAATTAAAGGGA
ACCACTGTAGAATTATTTAAAATGGGGGAACCTGGAGTTCCAACTATAGAAGAATATATCATGAACACACTTCCTGATAA
AGGCACTCTTGGATTTGATGGTCGTGTTGTTTCTATGGGAGATGGCCAAACTTATGAAAAAATATTGTTAAGTAAAAATG
CTAACATCAGCTACGATTGTGATTTAATTAATAATATATGGGAAGATCGCCCATCTCTTTCTGAGGAACCAGCTTTTGAA
CTTGATATAAAATACACCGGAGAATCTACTGCTTCTAAATTAAAACGTGTTAGAAAAGCAATGACAGATGCAGGTACAAA
TGTGCATGTTATTACATCTCTAGACGATATTGCGTGGATTCTTAACATACGTGGAAACGATATCGAGTTTTTCCCACTAG
TTTTAAGCTACCTTATTATTACAATGGATGAAGCTCATCTATTCATCAATGAAGATAAATTAAGTGATGAAATCAAATCA
AATCTTAAGAAAAATGGTGTGTCATTTATACATCCATATAATGAAATATACAAAGCAGTAAAAAAATTTAACACTTCTGA
CATTGTTCTAGTTGATCCAGCTAGAATGAATTATGCATTATATAATAATATTCCAAAAGATGTTAAAAAAGTAGAAAAAC
GCAATCCATCTGTTCTGTTTAAAGCTATGAAAAACCCAATTGAAATTGAAAATATTAAAAAAGCTCAAATAAAAGATGGA
GTAGCTCATACTAAATTTATGTACTGGCTTAAACATAATATAGGAAAAGAAACCATCACAGAAATAAGTGCTTCTAATAA
ACTAGATGAATTCCGTGCAGAACAAGGCGGATTTATACGTCCAAGCTTTGAACCTATTTCTTCATTTGCTGAACATGCTG
CTATAGTACACTATGCTCCAACTCCTGAAACAGATGTTGAACTAAAAGAAGGTTCTTTATTCTTAACAGATACTGGTGCT
GGTTTCTATGAAGGTTCTACAGATATTACAAGAACTTATGCATTAGGTGAAATACCGCAGATAATGAAAGATCACTTTAC
TCTAACTGTTAATAGTAACATGCATCTTGCTCATGCAAGATTCCTTTATGGCTGTAATGGTATGAATTTAGATATCCTTG
CACGTGCTCCATTCTGGAATAGAGGCTTAAACTTTAATCATGGTACAGGCCACGGTGTTGGATACTTAATGAACATCCAT
GAAGCACCAACTGGATTTAGATGGCAGTACCGTGCAAACGAAACCCATCCTTTTGAAGAAGGTATGGTTATCACTGATGA
ACCTGGTATCTATATCGCAGGCTCACACGGTGTCCGCATTGAAAATGAACTACTCGTATGCAAAGGAGAAAAGAATGAAT
ACGGTCAATTCATGTACTTTGAACCAATTAGTTATGTGCCTATAGATTTAGACGCAATAAACCCTGACATTATGACTATA
GAAGAAAAAGCATGGTTAAATGAATACCATGAATCTGTATATAATAAACTTTCACCATACCTTACTCAAGAAGAAAAAGA
CTGGTTAAAAGAATATACCAGAAAAATTTCATAA

Upstream 100 bases:

>100_bases
AATTCTTTCATGCACATTCCACTGATTGGGATAGTTTTCCTTCTTCTTTTGTGCTATAATTCTTATGAAAAACAATATTA
ATTGAAGGGGGATTAATACA

Downstream 100 bases:

>100_bases
TTAAGTCCAATTGAAAGAAGGTATGTAACAATGTCACAAGAAAAACAAAAACATCCTATAGGCCTTTCACTGGTAAATAT
CTCTATAGCTCTCCAAAGTT

Product: metallopeptidase, family M24

Products: NA

Alternate protein names: X-Pro dipeptidase; Imidodipeptidase; Proline dipeptidase; Prolidase [H]

Number of amino acids: Translated: 597; Mature: 597

Protein sequence:

>597_residues
MKVSERLTKLRNLMTEKNIDMYIVPTADFHQSEYVGEHFKARKYITGFSGSAGTAVITKDHAGLWTDGRYFLQAGNQLKG
TTVELFKMGEPGVPTIEEYIMNTLPDKGTLGFDGRVVSMGDGQTYEKILLSKNANISYDCDLINNIWEDRPSLSEEPAFE
LDIKYTGESTASKLKRVRKAMTDAGTNVHVITSLDDIAWILNIRGNDIEFFPLVLSYLIITMDEAHLFINEDKLSDEIKS
NLKKNGVSFIHPYNEIYKAVKKFNTSDIVLVDPARMNYALYNNIPKDVKKVEKRNPSVLFKAMKNPIEIENIKKAQIKDG
VAHTKFMYWLKHNIGKETITEISASNKLDEFRAEQGGFIRPSFEPISSFAEHAAIVHYAPTPETDVELKEGSLFLTDTGA
GFYEGSTDITRTYALGEIPQIMKDHFTLTVNSNMHLAHARFLYGCNGMNLDILARAPFWNRGLNFNHGTGHGVGYLMNIH
EAPTGFRWQYRANETHPFEEGMVITDEPGIYIAGSHGVRIENELLVCKGEKNEYGQFMYFEPISYVPIDLDAINPDIMTI
EEKAWLNEYHESVYNKLSPYLTQEEKDWLKEYTRKIS

Sequences:

>Translated_597_residues
MKVSERLTKLRNLMTEKNIDMYIVPTADFHQSEYVGEHFKARKYITGFSGSAGTAVITKDHAGLWTDGRYFLQAGNQLKG
TTVELFKMGEPGVPTIEEYIMNTLPDKGTLGFDGRVVSMGDGQTYEKILLSKNANISYDCDLINNIWEDRPSLSEEPAFE
LDIKYTGESTASKLKRVRKAMTDAGTNVHVITSLDDIAWILNIRGNDIEFFPLVLSYLIITMDEAHLFINEDKLSDEIKS
NLKKNGVSFIHPYNEIYKAVKKFNTSDIVLVDPARMNYALYNNIPKDVKKVEKRNPSVLFKAMKNPIEIENIKKAQIKDG
VAHTKFMYWLKHNIGKETITEISASNKLDEFRAEQGGFIRPSFEPISSFAEHAAIVHYAPTPETDVELKEGSLFLTDTGA
GFYEGSTDITRTYALGEIPQIMKDHFTLTVNSNMHLAHARFLYGCNGMNLDILARAPFWNRGLNFNHGTGHGVGYLMNIH
EAPTGFRWQYRANETHPFEEGMVITDEPGIYIAGSHGVRIENELLVCKGEKNEYGQFMYFEPISYVPIDLDAINPDIMTI
EEKAWLNEYHESVYNKLSPYLTQEEKDWLKEYTRKIS
>Mature_597_residues
MKVSERLTKLRNLMTEKNIDMYIVPTADFHQSEYVGEHFKARKYITGFSGSAGTAVITKDHAGLWTDGRYFLQAGNQLKG
TTVELFKMGEPGVPTIEEYIMNTLPDKGTLGFDGRVVSMGDGQTYEKILLSKNANISYDCDLINNIWEDRPSLSEEPAFE
LDIKYTGESTASKLKRVRKAMTDAGTNVHVITSLDDIAWILNIRGNDIEFFPLVLSYLIITMDEAHLFINEDKLSDEIKS
NLKKNGVSFIHPYNEIYKAVKKFNTSDIVLVDPARMNYALYNNIPKDVKKVEKRNPSVLFKAMKNPIEIENIKKAQIKDG
VAHTKFMYWLKHNIGKETITEISASNKLDEFRAEQGGFIRPSFEPISSFAEHAAIVHYAPTPETDVELKEGSLFLTDTGA
GFYEGSTDITRTYALGEIPQIMKDHFTLTVNSNMHLAHARFLYGCNGMNLDILARAPFWNRGLNFNHGTGHGVGYLMNIH
EAPTGFRWQYRANETHPFEEGMVITDEPGIYIAGSHGVRIENELLVCKGEKNEYGQFMYFEPISYVPIDLDAINPDIMTI
EEKAWLNEYHESVYNKLSPYLTQEEKDWLKEYTRKIS

Specific function: Splits dipeptides with a prolyl in the C-terminal position and a nonpolar amino acid at the N-terminal position [H]

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family. Archaeal-type prolidase subfamily [H]

Homologues:

Organism=Homo sapiens, GI264681563, Length=620, Percent_Identity=37.4193548387097, Blast_Score=403, Evalue=1e-112,
Organism=Homo sapiens, GI264681565, Length=620, Percent_Identity=35.9677419354839, Blast_Score=371, Evalue=1e-103,
Organism=Homo sapiens, GI93141226, Length=604, Percent_Identity=31.953642384106, Blast_Score=359, Evalue=5e-99,
Organism=Escherichia coli, GI1788728, Length=246, Percent_Identity=28.0487804878049, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17509539, Length=626, Percent_Identity=34.3450479233227, Blast_Score=363, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI25149105, Length=591, Percent_Identity=28.9340101522843, Blast_Score=245, Evalue=6e-65,
Organism=Saccharomyces cerevisiae, GI6322999, Length=653, Percent_Identity=33.0781010719755, Blast_Score=324, Evalue=2e-89,
Organism=Drosophila melanogaster, GI17137632, Length=613, Percent_Identity=33.278955954323, Blast_Score=333, Evalue=2e-91,
Organism=Drosophila melanogaster, GI161078230, Length=615, Percent_Identity=26.5040650406504, Blast_Score=233, Evalue=2e-61,
Organism=Drosophila melanogaster, GI21357287, Length=615, Percent_Identity=26.5040650406504, Blast_Score=233, Evalue=2e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.13.9 [H]

Molecular weight: Translated: 67916; Mature: 67916

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVSERLTKLRNLMTEKNIDMYIVPTADFHQSEYVGEHFKARKYITGFSGSAGTAVITKD
CCHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHEEECCCCCCCEEEEEEC
HAGLWTDGRYFLQAGNQLKGTTVELFKMGEPGVPTIEEYIMNTLPDKGTLGFDGRVVSMG
CCCCCCCCEEEEECCCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCCEEEEEC
DGQTYEKILLSKNANISYDCDLINNIWEDRPSLSEEPAFELDIKYTGESTASKLKRVRKA
CCCHHHHHHHCCCCCCEECHHHHHHHHHCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHH
MTDAGTNVHVITSLDDIAWILNIRGNDIEFFPLVLSYLIITMDEAHLFINEDKLSDEIKS
HHHCCCCEEEEEECCCEEEEEEECCCCEEHHHHHHHHHHHEECCCEEEEECHHHHHHHHH
NLKKNGVSFIHPYNEIYKAVKKFNTSDIVLVDPARMNYALYNNIPKDVKKVEKRNPSVLF
HHHHCCCEEECCHHHHHHHHHHCCCCCEEEECCHHHCCHHHCCCHHHHHHHHHCCHHHHH
KAMKNPIEIENIKKAQIKDGVAHTKFMYWLKHNIGKETITEISASNKLDEFRAEQGGFIR
HHHCCCCCCCCCCHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHCCCCCCC
PSFEPISSFAEHAAIVHYAPTPETDVELKEGSLFLTDTGAGFYEGSTDITRTYALGEIPQ
CCHHHHHHHHHHCEEEEECCCCCCCCEEECCEEEEEECCCCCCCCCCCCEEEEECCCCHH
IMKDHFTLTVNSNMHLAHARFLYGCNGMNLDILARAPFWNRGLNFNHGTGHGVGYLMNIH
HHHCCEEEEECCCEEEEEEEEEECCCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEEEEE
EAPTGFRWQYRANETHPFEEGMVITDEPGIYIAGSHGVRIENELLVCKGEKNEYGQFMYF
CCCCCCEEEEECCCCCCHHCCEEEECCCCEEEECCCCEEEECCEEEEECCCCCCCCEEEE
EPISYVPIDLDAINPDIMTIEEKAWLNEYHESVYNKLSPYLTQEEKDWLKEYTRKIS
CCCCCCEEEEECCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MKVSERLTKLRNLMTEKNIDMYIVPTADFHQSEYVGEHFKARKYITGFSGSAGTAVITKD
CCHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHEEECCCCCCCEEEEEEC
HAGLWTDGRYFLQAGNQLKGTTVELFKMGEPGVPTIEEYIMNTLPDKGTLGFDGRVVSMG
CCCCCCCCEEEEECCCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCCEEEEEC
DGQTYEKILLSKNANISYDCDLINNIWEDRPSLSEEPAFELDIKYTGESTASKLKRVRKA
CCCHHHHHHHCCCCCCEECHHHHHHHHHCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHH
MTDAGTNVHVITSLDDIAWILNIRGNDIEFFPLVLSYLIITMDEAHLFINEDKLSDEIKS
HHHCCCCEEEEEECCCEEEEEEECCCCEEHHHHHHHHHHHEECCCEEEEECHHHHHHHHH
NLKKNGVSFIHPYNEIYKAVKKFNTSDIVLVDPARMNYALYNNIPKDVKKVEKRNPSVLF
HHHHCCCEEECCHHHHHHHHHHCCCCCEEEECCHHHCCHHHCCCHHHHHHHHHCCHHHHH
KAMKNPIEIENIKKAQIKDGVAHTKFMYWLKHNIGKETITEISASNKLDEFRAEQGGFIR
HHHCCCCCCCCCCHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHCCCCCCC
PSFEPISSFAEHAAIVHYAPTPETDVELKEGSLFLTDTGAGFYEGSTDITRTYALGEIPQ
CCHHHHHHHHHHCEEEEECCCCCCCCEEECCEEEEEECCCCCCCCCCCCEEEEECCCCHH
IMKDHFTLTVNSNMHLAHARFLYGCNGMNLDILARAPFWNRGLNFNHGTGHGVGYLMNIH
HHHCCEEEEECCCEEEEEEEEEECCCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEEEEE
EAPTGFRWQYRANETHPFEEGMVITDEPGIYIAGSHGVRIENELLVCKGEKNEYGQFMYF
CCCCCCEEEEECCCCCCHHCCEEEECCCCEEEECCCCEEEECCEEEEECCCCCCCCEEEE
EPISYVPIDLDAINPDIMTIEEKAWLNEYHESVYNKLSPYLTQEEKDWLKEYTRKIS
CCCCCCEEEEECCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9733678; 11223522; 11210522 [H]