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The map label for this gene is pdhR [H]

Identifier: 226949411

GI number: 226949411

Start: 2411085

End: 2411774

Strand: Reverse

Name: pdhR [H]

Synonym: CLM_2336

Alternate gene names: 226949411

Gene position: 2411774-2411085 (Counterclockwise)

Preceding gene: 226949413

Following gene: 226949410

Centisome position: 58.04

GC content: 32.75

Gene sequence:

>690_bases
ATGGCTATTCAAAAAATAAATCGTTCAACTTTAGTAGGGCAGGTAACTGCTCAGATTGAAAATATGATAGAAAGTGGCTT
ATGGAAAGTAGGGGAGAAGATTCCTGCAGAACCGGAATTAATGAATAAATTTGATGTTAGTAGAAACACTTTGAGAGAAG
CAATTCAATCTTTAGTTCATGTTGGTATGCTTGAAACTCGACAAGGTATAGGAACTATTGTAAAATCCAACAGTAATTTA
GCAATGGCATTGGAGAAAAAAATTCAAAAAAGCGATCTTCTAGAAACATTAGAAGTTCGTTTGGCGCTTGAAAGGGAAGC
GGCGCAACTAGCTGCTGAGAGAAGAGATGTAGAAGATCTAGAACAAATCGAAAATTGCCTAAAAAAATGCAAGATAGCTG
CTGAAAACAATGACTCACTACAATTCATTAAAATGGATATTGATTTTCATAAGTCTATTGTACAGGCTACACATAATAAG
ATGTTTATTGAGCTTTATGAACATATTACCGATTCATTACAAAATTCCGTTGATAAAGTAATGGAAATAAAAAATACCAC
AAGATTTGAGAGTGAAATTCATTATAACTTGCTTGAAGCAATTAAAACAGGAGATACACAATTAGCTGTTGAGAGTGTTA
ATGAATATTTGAACAAGGCAAAAGAAGCTCTGTATACTATGATAAATTAA

Upstream 100 bases:

>100_bases
ACAATATATAAGTTTTTAGCATACCTTGACAATATCAATTGATTCATGTTATCATACAATAAACCAATCATCCTACGTTT
AGAAAGGGGAATATTATTAT

Downstream 100 bases:

>100_bases
TAAAAAGGAAAAATATACGAAAGACTAGGAGGAAACTCATATGATGTCACTAAATAAATCAGATAAAAAACAAAATAATA
TGGATTTTAAAGTACGTAAA

Product: GntR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 229; Mature: 228

Protein sequence:

>229_residues
MAIQKINRSTLVGQVTAQIENMIESGLWKVGEKIPAEPELMNKFDVSRNTLREAIQSLVHVGMLETRQGIGTIVKSNSNL
AMALEKKIQKSDLLETLEVRLALEREAAQLAAERRDVEDLEQIENCLKKCKIAAENNDSLQFIKMDIDFHKSIVQATHNK
MFIELYEHITDSLQNSVDKVMEIKNTTRFESEIHYNLLEAIKTGDTQLAVESVNEYLNKAKEALYTMIN

Sequences:

>Translated_229_residues
MAIQKINRSTLVGQVTAQIENMIESGLWKVGEKIPAEPELMNKFDVSRNTLREAIQSLVHVGMLETRQGIGTIVKSNSNL
AMALEKKIQKSDLLETLEVRLALEREAAQLAAERRDVEDLEQIENCLKKCKIAAENNDSLQFIKMDIDFHKSIVQATHNK
MFIELYEHITDSLQNSVDKVMEIKNTTRFESEIHYNLLEAIKTGDTQLAVESVNEYLNKAKEALYTMIN
>Mature_228_residues
AIQKINRSTLVGQVTAQIENMIESGLWKVGEKIPAEPELMNKFDVSRNTLREAIQSLVHVGMLETRQGIGTIVKSNSNLA
MALEKKIQKSDLLETLEVRLALEREAAQLAAERRDVEDLEQIENCLKKCKIAAENNDSLQFIKMDIDFHKSIVQATHNKM
FIELYEHITDSLQNSVDKVMEIKNTTRFESEIHYNLLEAIKTGDTQLAVESVNEYLNKAKEALYTMIN

Specific function: Transcriptional repressor for the pyruvate dehydrogenase complex genes aceEF and lpd [H]

COG id: COG2186

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786303, Length=235, Percent_Identity=32.7659574468085, Blast_Score=87, Evalue=6e-19,
Organism=Escherichia coli, GI1789353, Length=177, Percent_Identity=32.7683615819209, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1790032, Length=221, Percent_Identity=29.4117647058824, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI48994955, Length=194, Percent_Identity=29.8969072164948, Blast_Score=70, Evalue=9e-14,
Organism=Escherichia coli, GI1790780, Length=229, Percent_Identity=27.0742358078603, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1789621, Length=228, Percent_Identity=24.5614035087719, Blast_Score=67, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011711
- InterPro:   IPR000524
- InterPro:   IPR011991 [H]

Pfam domain/function: PF07729 FCD; PF00392 GntR [H]

EC number: NA

Molecular weight: Translated: 26064; Mature: 25933

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIQKINRSTLVGQVTAQIENMIESGLWKVGEKIPAEPELMNKFDVSRNTLREAIQSLVH
CCCHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHHH
VGMLETRQGIGTIVKSNSNLAMALEKKIQKSDLLETLEVRLALEREAAQLAAERRDVEDL
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
EQIENCLKKCKIAAENNDSLQFIKMDIDFHKSIVQATHNKMFIELYEHITDSLQNSVDKV
HHHHHHHHHCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MEIKNTTRFESEIHYNLLEAIKTGDTQLAVESVNEYLNKAKEALYTMIN
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AIQKINRSTLVGQVTAQIENMIESGLWKVGEKIPAEPELMNKFDVSRNTLREAIQSLVH
CCHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHHH
VGMLETRQGIGTIVKSNSNLAMALEKKIQKSDLLETLEVRLALEREAAQLAAERRDVEDL
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
EQIENCLKKCKIAAENNDSLQFIKMDIDFHKSIVQATHNKMFIELYEHITDSLQNSVDKV
HHHHHHHHHCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MEIKNTTRFESEIHYNLLEAIKTGDTQLAVESVNEYLNKAKEALYTMIN
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]