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The map label for this gene is tetP [H]

Identifier: 226949385

GI number: 226949385

Start: 2382229

End: 2384184

Strand: Reverse

Name: tetP [H]

Synonym: CLM_2310

Alternate gene names: 226949385

Gene position: 2384184-2382229 (Counterclockwise)

Preceding gene: 226949386

Following gene: 226949384

Centisome position: 57.38

GC content: 28.22

Gene sequence:

>1956_bases
ATGCATAAGACAATAGGAATATTAGCACATGTAGATGCAGGTAAAACCACATTTGCAGAACAAATATTGTATCATACAAA
AAGTATTAAAAATAGAGGAAGAGTGGATCATAAAAATTCTTTTTTAGATAACCATAAAATTGAAAAAGAAAGAGGGATAA
CAGTATTTTCAGAACAAGGAACCTTTAATTATAAAGATTCTACATATTATCTTATAGATACTCCAGGACATATGGATTTT
TCATCTGAAATGGAAAGAGCTATACAGGTTATGGATTACGCTGTAATTATAATAAGTGGAGTTGAAGGGATTCAAGGTCA
TACAGAAACAGTATGGAATCTTTTAAGAAAGCACAATATTCCTGTTCTTTTTTTTATAAATAAAATAGATAGAGTGGGAG
CTAATCCCCAGAATGTAATTGAAGAGATAAAGCTTAATTTTACTAAAAAGACTTTTCTTATTGATAAATCATTAAGTAAT
GAAGAGCTTTCATCTGAGCTTATAGAATTTATCGCAGATCAAGATGAATATCTTTTAGAGAAATATTTAGAAGATGATTA
TGATAAGGATTTATGGTTAAAGTCTATGAAAAAACTTATTAAATCAAGTGAAATTTTTCCTTGTTTTTTAGGCTCTGCAT
TACAGGATATAGGTATAGAAGACTTTCTAGAAAACCTACATATTTTAACCTATACAGAATATAATGAAGAAGAAAAATTT
AGTGGAAGAGTATATAAAATACGCCACGATGAACAAAATAATAGGGTAACTTACATAAAAGCATTAAGTGGCAGCTTAAA
GGTGAAAGATGAAATAGCTTTACCTAATATTGAAAATGATTTTTGTAAGAAAGTTAATGAGATAAGGATATATAATGGTG
ATAAATATATAAATATAGATAAAGCTGAAGCGGGACAGATCTTTGCAGTAACAGGTTTGAATTCTGTTAATGTAGGTGAT
GGAATTGGAATTTTGAAAGATAAAGCTACATATAATATGGTTCCAACTTTAAAATCGAAAGTTATATTTGATGAAACATT
AAATGTAAAAGATGTTTTAAGGTATTTTAAAATATTAGAAGCAGAAGATCCTTCTTTAAATATAATTTGGAATGAAAAAT
TTCAAGAAATTCAAGTTTACATTATGGGTATTATCCAATTAGAAGTTTTAAAGAATTTGATGGAAGAAAGATTTCATATA
TTGATAGATTTTGGACCTTGTGAAATATTATATAAGGAAACTATTTTAGATACAATAATAGGCTATGGCCATTTTGAACC
TTTAGGGCATTATTCTGAAGTTCATCTTAAATTAGAGCCAGGAGAGCGAAATAGTGGTATTACATTTGAAAATTTATGCC
ATACAGATGATTTAACAGTAGGTAATCAAAATTTAGTAAAGACTCATATTTTTGAAAGAGATCATCATGGTATTTTAACA
GGATCTCCTATAACAGATATAAAGATAACGCTTTTAACTGGAAGAGCACATAATAAACATACTAGTGGAGGAGATTTTAG
AGAAGCTACCTTTAGAGCTTTAAGACAAGGATTAGAAAAGGCTAAAAATGTTTTACTAGAACCTTGCTATTCTTTTAAAA
TGGAAGTGCCATTAGATTGTATGGGAAGAGTTTTATCAGATATACAAAAGCTAAAAGGCTCTTTTAATCCTCCAGAAACA
ATTGATAATAAAGCTATTATAAAAGGAAAAGGATCCGTTGCAACATTTATGAACTATAGTGTAGAGTTTATTTCCTTTAC
TAAGGGAAAGGGTAAATTCAATTTCATATTTGATGGATACGATATTTGCCACAATGAAAAAGAAGTTATAGAAAAGATAG
GCTATGATAAAAATGCAGATATTGAATATACTTCAACTTCAATTTTTTGTTCAAAGGGACAAGCATTTTTAGTTAAGTAT
GATGAGGCAGAAAATTATATGCATTGTTTGAAATAA

Upstream 100 bases:

>100_bases
AATAATTTGTTATTATAAAGTTATGTTTCTGGCTTAAGTAGTTTATTTTATGGTAATATAATAGTGTTATTAGAATCAAA
ATTACAATGGGAGATAGATT

Downstream 100 bases:

>100_bases
TAGAGTTTAATAGAATAGTAGAAAGTAGAAAATATTAAATAGAACCTTTAAAATAGTAAGTCCTTTTCGCTGAGTAAAAA
AGAATTGAAATATAAAAGCA

Product: tetracycline resistance protein TetP

Products: NA

Alternate protein names: TetB(P) [H]

Number of amino acids: Translated: 651; Mature: 651

Protein sequence:

>651_residues
MHKTIGILAHVDAGKTTFAEQILYHTKSIKNRGRVDHKNSFLDNHKIEKERGITVFSEQGTFNYKDSTYYLIDTPGHMDF
SSEMERAIQVMDYAVIIISGVEGIQGHTETVWNLLRKHNIPVLFFINKIDRVGANPQNVIEEIKLNFTKKTFLIDKSLSN
EELSSELIEFIADQDEYLLEKYLEDDYDKDLWLKSMKKLIKSSEIFPCFLGSALQDIGIEDFLENLHILTYTEYNEEEKF
SGRVYKIRHDEQNNRVTYIKALSGSLKVKDEIALPNIENDFCKKVNEIRIYNGDKYINIDKAEAGQIFAVTGLNSVNVGD
GIGILKDKATYNMVPTLKSKVIFDETLNVKDVLRYFKILEAEDPSLNIIWNEKFQEIQVYIMGIIQLEVLKNLMEERFHI
LIDFGPCEILYKETILDTIIGYGHFEPLGHYSEVHLKLEPGERNSGITFENLCHTDDLTVGNQNLVKTHIFERDHHGILT
GSPITDIKITLLTGRAHNKHTSGGDFREATFRALRQGLEKAKNVLLEPCYSFKMEVPLDCMGRVLSDIQKLKGSFNPPET
IDNKAIIKGKGSVATFMNYSVEFISFTKGKGKFNFIFDGYDICHNEKEVIEKIGYDKNADIEYTSTSIFCSKGQAFLVKY
DEAENYMHCLK

Sequences:

>Translated_651_residues
MHKTIGILAHVDAGKTTFAEQILYHTKSIKNRGRVDHKNSFLDNHKIEKERGITVFSEQGTFNYKDSTYYLIDTPGHMDF
SSEMERAIQVMDYAVIIISGVEGIQGHTETVWNLLRKHNIPVLFFINKIDRVGANPQNVIEEIKLNFTKKTFLIDKSLSN
EELSSELIEFIADQDEYLLEKYLEDDYDKDLWLKSMKKLIKSSEIFPCFLGSALQDIGIEDFLENLHILTYTEYNEEEKF
SGRVYKIRHDEQNNRVTYIKALSGSLKVKDEIALPNIENDFCKKVNEIRIYNGDKYINIDKAEAGQIFAVTGLNSVNVGD
GIGILKDKATYNMVPTLKSKVIFDETLNVKDVLRYFKILEAEDPSLNIIWNEKFQEIQVYIMGIIQLEVLKNLMEERFHI
LIDFGPCEILYKETILDTIIGYGHFEPLGHYSEVHLKLEPGERNSGITFENLCHTDDLTVGNQNLVKTHIFERDHHGILT
GSPITDIKITLLTGRAHNKHTSGGDFREATFRALRQGLEKAKNVLLEPCYSFKMEVPLDCMGRVLSDIQKLKGSFNPPET
IDNKAIIKGKGSVATFMNYSVEFISFTKGKGKFNFIFDGYDICHNEKEVIEKIGYDKNADIEYTSTSIFCSKGQAFLVKY
DEAENYMHCLK
>Mature_651_residues
MHKTIGILAHVDAGKTTFAEQILYHTKSIKNRGRVDHKNSFLDNHKIEKERGITVFSEQGTFNYKDSTYYLIDTPGHMDF
SSEMERAIQVMDYAVIIISGVEGIQGHTETVWNLLRKHNIPVLFFINKIDRVGANPQNVIEEIKLNFTKKTFLIDKSLSN
EELSSELIEFIADQDEYLLEKYLEDDYDKDLWLKSMKKLIKSSEIFPCFLGSALQDIGIEDFLENLHILTYTEYNEEEKF
SGRVYKIRHDEQNNRVTYIKALSGSLKVKDEIALPNIENDFCKKVNEIRIYNGDKYINIDKAEAGQIFAVTGLNSVNVGD
GIGILKDKATYNMVPTLKSKVIFDETLNVKDVLRYFKILEAEDPSLNIIWNEKFQEIQVYIMGIIQLEVLKNLMEERFHI
LIDFGPCEILYKETILDTIIGYGHFEPLGHYSEVHLKLEPGERNSGITFENLCHTDDLTVGNQNLVKTHIFERDHHGILT
GSPITDIKITLLTGRAHNKHTSGGDFREATFRALRQGLEKAKNVLLEPCYSFKMEVPLDCMGRVLSDIQKLKGSFNPPET
IDNKAIIKGKGSVATFMNYSVEFISFTKGKGKFNFIFDGYDICHNEKEVIEKIGYDKNADIEYTSTSIFCSKGQAFLVKY
DEAENYMHCLK

Specific function: Abolishes the inhibitory effect of tetracyclin on protein synthesis by a non-covalent modification of the ribosomes [H]

COG id: COG0480

COG function: function code J; Translation elongation factors (GTPases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. TetM/tetO subfamily [H]

Homologues:

Organism=Homo sapiens, GI19923640, Length=696, Percent_Identity=25.5747126436782, Blast_Score=217, Evalue=2e-56,
Organism=Homo sapiens, GI18390331, Length=698, Percent_Identity=25.5014326647564, Blast_Score=202, Evalue=1e-51,
Organism=Homo sapiens, GI25306287, Length=661, Percent_Identity=26.3237518910741, Blast_Score=193, Evalue=4e-49,
Organism=Homo sapiens, GI25306283, Length=382, Percent_Identity=28.7958115183246, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI157426893, Length=149, Percent_Identity=34.8993288590604, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI94966754, Length=134, Percent_Identity=36.5671641791045, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI4503483, Length=146, Percent_Identity=32.1917808219178, Blast_Score=73, Evalue=8e-13,
Organism=Homo sapiens, GI310132016, Length=106, Percent_Identity=35.8490566037736, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI310110807, Length=106, Percent_Identity=35.8490566037736, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI310123363, Length=106, Percent_Identity=35.8490566037736, Blast_Score=71, Evalue=3e-12,
Organism=Escherichia coli, GI1789738, Length=685, Percent_Identity=26.5693430656934, Blast_Score=214, Evalue=2e-56,
Organism=Escherichia coli, GI1790835, Length=458, Percent_Identity=23.5807860262009, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI48994988, Length=332, Percent_Identity=23.1927710843373, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1788922, Length=147, Percent_Identity=33.3333333333333, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI1789737, Length=130, Percent_Identity=30.7692307692308, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1790412, Length=130, Percent_Identity=30.7692307692308, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17533571, Length=693, Percent_Identity=24.5310245310245, Blast_Score=184, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17556745, Length=707, Percent_Identity=23.4794908062235, Blast_Score=148, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17557151, Length=142, Percent_Identity=34.5070422535211, Blast_Score=97, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI71988819, Length=130, Percent_Identity=33.8461538461538, Blast_Score=82, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71988811, Length=130, Percent_Identity=33.8461538461538, Blast_Score=82, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17552882, Length=135, Percent_Identity=32.5925925925926, Blast_Score=68, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17556456, Length=137, Percent_Identity=31.3868613138686, Blast_Score=67, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6323098, Length=703, Percent_Identity=27.3115220483642, Blast_Score=216, Evalue=1e-56,
Organism=Saccharomyces cerevisiae, GI6322359, Length=517, Percent_Identity=26.1121856866538, Blast_Score=137, Evalue=7e-33,
Organism=Saccharomyces cerevisiae, GI6323320, Length=171, Percent_Identity=31.5789473684211, Blast_Score=81, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6324707, Length=163, Percent_Identity=31.2883435582822, Blast_Score=76, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6320593, Length=163, Percent_Identity=31.2883435582822, Blast_Score=76, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6324761, Length=133, Percent_Identity=29.3233082706767, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24582462, Length=684, Percent_Identity=24.1228070175439, Blast_Score=198, Evalue=8e-51,
Organism=Drosophila melanogaster, GI221458488, Length=695, Percent_Identity=23.3093525179856, Blast_Score=176, Evalue=4e-44,
Organism=Drosophila melanogaster, GI78706572, Length=149, Percent_Identity=36.9127516778523, Blast_Score=103, Evalue=5e-22,
Organism=Drosophila melanogaster, GI28574573, Length=139, Percent_Identity=34.5323741007194, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24585711, Length=167, Percent_Identity=30.5389221556886, Blast_Score=75, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24585713, Length=167, Percent_Identity=30.5389221556886, Blast_Score=75, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24585709, Length=167, Percent_Identity=30.5389221556886, Blast_Score=75, Evalue=2e-13,
Organism=Drosophila melanogaster, GI19921738, Length=213, Percent_Identity=28.6384976525822, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: 1080 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2520 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 20 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 7984 Molecules/Cell In: Growth Phase, Gl

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009022
- InterPro:   IPR000795
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR005225
- InterPro:   IPR002127
- InterPro:   IPR000640
- InterPro:   IPR005517
- InterPro:   IPR004161
- InterPro:   IPR009000 [H]

Pfam domain/function: PF00679 EFG_C; PF03764 EFG_IV; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2 [H]

EC number: NA

Molecular weight: Translated: 74658; Mature: 74658

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHKTIGILAHVDAGKTTFAEQILYHTKSIKNRGRVDHKNSFLDNHKIEKERGITVFSEQG
CCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHCCCEEEECCC
TFNYKDSTYYLIDTPGHMDFSSEMERAIQVMDYAVIIISGVEGIQGHTETVWNLLRKHNI
EEEECCCEEEEEECCCCCCHHHHHHHHHHHHHEEEEEEECCCCCCCCHHHHHHHHHHCCC
PVLFFINKIDRVGANPQNVIEEIKLNFTKKTFLIDKSLSNEELSSELIEFIADQDEYLLE
CEEEEEECHHHCCCCHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHCCCHHHHHH
KYLEDDYDKDLWLKSMKKLIKSSEIFPCFLGSALQDIGIEDFLENLHILTYTEYNEEEKF
HHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHCCCEEEEEECCCCCCCC
SGRVYKIRHDEQNNRVTYIKALSGSLKVKDEIALPNIENDFCKKVNEIRIYNGDKYINID
CCCEEEEEECCCCCEEEEEEEECCCEEEECCCCCCCCCHHHHHCCCEEEEECCCEEEEEE
KAEAGQIFAVTGLNSVNVGDGIGILKDKATYNMVPTLKSKVIFDETLNVKDVLRYFKILE
CCCCCCEEEEECCCCCCCCCCCCEEECCCCCCCCCCHHHCEEECCCCCHHHHHHHHHHHC
AEDPSLNIIWNEKFQEIQVYIMGIIQLEVLKNLMEERFHILIDFGPCEILYKETILDTII
CCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCHHHHHHHHHHHHHH
GYGHFEPLGHYSEVHLKLEPGERNSGITFENLCHTDDLTVGNQNLVKTHIFERDHHGILT
CCCCCCCCCCCEEEEEEECCCCCCCCCCHHHCCCCCCCCCCCCCHHEEEEEECCCCCEEE
GSPITDIKITLLTGRAHNKHTSGGDFREATFRALRQGLEKAKNVLLEPCYSFKMEVPLDC
CCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCHHH
MGRVLSDIQKLKGSFNPPETIDNKAIIKGKGSVATFMNYSVEFISFTKGKGKFNFIFDGY
HHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCEEEEECCEEEEEEEECCCCEEEEEECCH
DICHNEKEVIEKIGYDKNADIEYTSTSIFCSKGQAFLVKYDEAENYMHCLK
HHHCCHHHHHHHCCCCCCCCEEEEEEEEEEECCCEEEEEECCHHHHHHHCC
>Mature Secondary Structure
MHKTIGILAHVDAGKTTFAEQILYHTKSIKNRGRVDHKNSFLDNHKIEKERGITVFSEQG
CCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHCCCEEEECCC
TFNYKDSTYYLIDTPGHMDFSSEMERAIQVMDYAVIIISGVEGIQGHTETVWNLLRKHNI
EEEECCCEEEEEECCCCCCHHHHHHHHHHHHHEEEEEEECCCCCCCCHHHHHHHHHHCCC
PVLFFINKIDRVGANPQNVIEEIKLNFTKKTFLIDKSLSNEELSSELIEFIADQDEYLLE
CEEEEEECHHHCCCCHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHCCCHHHHHH
KYLEDDYDKDLWLKSMKKLIKSSEIFPCFLGSALQDIGIEDFLENLHILTYTEYNEEEKF
HHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHCCCEEEEEECCCCCCCC
SGRVYKIRHDEQNNRVTYIKALSGSLKVKDEIALPNIENDFCKKVNEIRIYNGDKYINID
CCCEEEEEECCCCCEEEEEEEECCCEEEECCCCCCCCCHHHHHCCCEEEEECCCEEEEEE
KAEAGQIFAVTGLNSVNVGDGIGILKDKATYNMVPTLKSKVIFDETLNVKDVLRYFKILE
CCCCCCEEEEECCCCCCCCCCCCEEECCCCCCCCCCHHHCEEECCCCCHHHHHHHHHHHC
AEDPSLNIIWNEKFQEIQVYIMGIIQLEVLKNLMEERFHILIDFGPCEILYKETILDTII
CCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCHHHHHHHHHHHHHH
GYGHFEPLGHYSEVHLKLEPGERNSGITFENLCHTDDLTVGNQNLVKTHIFERDHHGILT
CCCCCCCCCCCEEEEEEECCCCCCCCCCHHHCCCCCCCCCCCCCHHEEEEEECCCCCEEE
GSPITDIKITLLTGRAHNKHTSGGDFREATFRALRQGLEKAKNVLLEPCYSFKMEVPLDC
CCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCHHH
MGRVLSDIQKLKGSFNPPETIDNKAIIKGKGSVATFMNYSVEFISFTKGKGKFNFIFDGY
HHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCEEEEECCEEEEEEEECCCCEEEEEECCH
DICHNEKEVIEKIGYDKNADIEYTSTSIFCSKGQAFLVKYDEAENYMHCLK
HHHCCHHHHHHHCCCCCCCCEEEEEEEEEEECCCEEEEEECCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8170402 [H]