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The map label for this gene is pdp [H]

Identifier: 226949106

GI number: 226949106

Start: 2090836

End: 2092140

Strand: Reverse

Name: pdp [H]

Synonym: CLM_2024

Alternate gene names: 226949106

Gene position: 2092140-2090836 (Counterclockwise)

Preceding gene: 226949107

Following gene: 226949105

Centisome position: 50.35

GC content: 30.57

Gene sequence:

>1305_bases
ATGAGAATGTATGATTTGATCCTAAAGAAAAGAAATGGCGGAGAGTTAAGCAAAGAAGAAATAGATTATTTTATTTTAGA
ATATACTAATGGCAATGTCCCAGATTATCAAGCTTCAGCTCTTTTAATGGCTATATACTTTCAAAAAATGAAAAGAAGAG
AAACTGTAGATTTGACTATGGCTATGGTTAACTCTGGAGATATATTGGATTTATCAAAAATACAGGGTATAAAAGTTGAT
AAACATAGTACTGGTGGAGTTGGGGATACTACTACCTTAGTTTTGGCGCCTATGGTAGCAGCCTTAGGTATACCTGTAGC
TAAAATGTCTGGTAGAGGTTTAGGTCATACTGGTGGAACTATAGATAAATTAGAATCTTTTAAAGGTTTTTCAGTAAATA
TGACAGAGGATAAATTTATAAATAACGTTAACAATATTAAAATAGCTGTAGGAGCTCAAACAGCAGATTTAGCTCCAGCG
GATAAAAAATTATATGCATTAAGAGATGTTACTGCTACAGTAGACAATATTTCTTTAATAGCTTCTAGTATAATGAGCAA
AAAAATAGCTGCAGGAGCTAATGCCATAATTTTAGATGTAAAGGTTGGAGAAGGAGCCTTCATGAAAACTCCGGAAACTG
CAAAAGAGTTAGCGGAGGAAATGGTTAATATAGGTAAAAGTGTAGGTAGAAATACTGTGGCTATATTATCAGATATGGAT
CAACCTTTAGGTTATGCTATAGGAAATGCTTTAGAAGTAAAAGAAGCTATAGATACACTAAAAGGTAAAGGTCCTAAGGA
TTTATTAGAACTATGTTTAACCTTAGGAAGTAATATGGTTATTTTATCACAAAAAGCAAATACTATAGAGGAAGCAAGAA
AGATGCTTTTAAGTACTATAGAAAAAGGATTAGCTATAGAAAAATTAAAAGAATTTATTAGATCTCAAGGCGGAGATGAT
ACTTTAGTAGACAATACAGAAAAATTACCTAAGGCAGAATATATAATTCCTGTAATTTGTGATAGAAATGGATATATAAA
TAAAATTCATGCCCAAAATATAGGGATAATAGCATCAGAGTTAGGAGCAGGAAGGGTTACAAAGGATAGCATTATAGATT
TAGCAGTAGGTATAGTTTTAAACAAGAAGAGATCAGATAAAGTTAAAAAAGGAGATATAATAGCTTATATTCATGCTAAT
GATAAAATAAAAGAAGAAAAGGCTGCAAAAGATATATTAAATAATTATGTTATAGAAGAAGAGTTAAAAGAAGAATTACC
TTTAATATATGATACAGTAAAATAG

Upstream 100 bases:

>100_bases
ATTTCACTAACAAGTCATAAATGTGTATACATTAAAACTAAATCTATTTGGAGGCAATCCTTATATTATATAATAATTGC
TTTGTAGGGAGGAATAAATT

Downstream 100 bases:

>100_bases
CATAGTTAAAGCATTCATAAAAGCATATTTAATTTTTAAAGTATGTTTAAATTAAAGCTATAATTATAAAAAGTTATAAC
CATATAAACATAGAGGAGGA

Product: pyrimidine-nucleoside phosphorylase

Products: NA

Alternate protein names: PYNP [H]

Number of amino acids: Translated: 434; Mature: 434

Protein sequence:

>434_residues
MRMYDLILKKRNGGELSKEEIDYFILEYTNGNVPDYQASALLMAIYFQKMKRRETVDLTMAMVNSGDILDLSKIQGIKVD
KHSTGGVGDTTTLVLAPMVAALGIPVAKMSGRGLGHTGGTIDKLESFKGFSVNMTEDKFINNVNNIKIAVGAQTADLAPA
DKKLYALRDVTATVDNISLIASSIMSKKIAAGANAIILDVKVGEGAFMKTPETAKELAEEMVNIGKSVGRNTVAILSDMD
QPLGYAIGNALEVKEAIDTLKGKGPKDLLELCLTLGSNMVILSQKANTIEEARKMLLSTIEKGLAIEKLKEFIRSQGGDD
TLVDNTEKLPKAEYIIPVICDRNGYINKIHAQNIGIIASELGAGRVTKDSIIDLAVGIVLNKKRSDKVKKGDIIAYIHAN
DKIKEEKAAKDILNNYVIEEELKEELPLIYDTVK

Sequences:

>Translated_434_residues
MRMYDLILKKRNGGELSKEEIDYFILEYTNGNVPDYQASALLMAIYFQKMKRRETVDLTMAMVNSGDILDLSKIQGIKVD
KHSTGGVGDTTTLVLAPMVAALGIPVAKMSGRGLGHTGGTIDKLESFKGFSVNMTEDKFINNVNNIKIAVGAQTADLAPA
DKKLYALRDVTATVDNISLIASSIMSKKIAAGANAIILDVKVGEGAFMKTPETAKELAEEMVNIGKSVGRNTVAILSDMD
QPLGYAIGNALEVKEAIDTLKGKGPKDLLELCLTLGSNMVILSQKANTIEEARKMLLSTIEKGLAIEKLKEFIRSQGGDD
TLVDNTEKLPKAEYIIPVICDRNGYINKIHAQNIGIIASELGAGRVTKDSIIDLAVGIVLNKKRSDKVKKGDIIAYIHAN
DKIKEEKAAKDILNNYVIEEELKEELPLIYDTVK
>Mature_434_residues
MRMYDLILKKRNGGELSKEEIDYFILEYTNGNVPDYQASALLMAIYFQKMKRRETVDLTMAMVNSGDILDLSKIQGIKVD
KHSTGGVGDTTTLVLAPMVAALGIPVAKMSGRGLGHTGGTIDKLESFKGFSVNMTEDKFINNVNNIKIAVGAQTADLAPA
DKKLYALRDVTATVDNISLIASSIMSKKIAAGANAIILDVKVGEGAFMKTPETAKELAEEMVNIGKSVGRNTVAILSDMD
QPLGYAIGNALEVKEAIDTLKGKGPKDLLELCLTLGSNMVILSQKANTIEEARKMLLSTIEKGLAIEKLKEFIRSQGGDD
TLVDNTEKLPKAEYIIPVICDRNGYINKIHAQNIGIIASELGAGRVTKDSIIDLAVGIVLNKKRSDKVKKGDIIAYIHAN
DKIKEEKAAKDILNNYVIEEELKEELPLIYDTVK

Specific function: The Enzymes Which Catalyze The Reversible Phosphorolysis Of Pyrimidine Nucleosides Are Involved In The Degradation Of These Compounds And In Their Utilization As Carbon And Energy Sources, Or In The Rescue Of Pyrimidine Bases For Nucleotide Synthesis. [C

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI166158925, Length=407, Percent_Identity=38.0835380835381, Blast_Score=270, Evalue=2e-72,
Organism=Homo sapiens, GI4503445, Length=407, Percent_Identity=38.0835380835381, Blast_Score=270, Evalue=2e-72,
Organism=Homo sapiens, GI166158922, Length=407, Percent_Identity=38.0835380835381, Blast_Score=270, Evalue=2e-72,
Organism=Escherichia coli, GI1790842, Length=431, Percent_Identity=40.6032482598608, Blast_Score=305, Evalue=4e-84,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR018090
- InterPro:   IPR000053
- InterPro:   IPR017872 [H]

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C [H]

EC number: =2.4.2.2 [H]

Molecular weight: Translated: 47190; Mature: 47190

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: PS00647 THYMID_PHOSPHORYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRMYDLILKKRNGGELSKEEIDYFILEYTNGNVPDYQASALLMAIYFQKMKRRETVDLTM
CCHHHHHHCCCCCCCCCHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCHHEEEE
AMVNSGDILDLSKIQGIKVDKHSTGGVGDTTTLVLAPMVAALGIPVAKMSGRGLGHTGGT
EEECCCCEEEHHHCCCEEECCCCCCCCCCHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCC
IDKLESFKGFSVNMTEDKFINNVNNIKIAVGAQTADLAPADKKLYALRDVTATVDNISLI
HHHHHHCCCCEEECCHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHH
ASSIMSKKIAAGANAIILDVKVGEGAFMKTPETAKELAEEMVNIGKSVGRNTVAILSDMD
HHHHHHHHHHCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEHHHCC
QPLGYAIGNALEVKEAIDTLKGKGPKDLLELCLTLGSNMVILSQKANTIEEARKMLLSTI
CHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHH
EKGLAIEKLKEFIRSQGGDDTLVDNTEKLPKAEYIIPVICDRNGYINKIHAQNIGIIASE
HHCHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCEEEEEEECCCCCEEEEECCCCCEEECC
LGAGRVTKDSIIDLAVGIVLNKKRSDKVKKGDIIAYIHANDKIKEEKAAKDILNNYVIEE
CCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHH
ELKEELPLIYDTVK
HHHHCCCCEEECCC
>Mature Secondary Structure
MRMYDLILKKRNGGELSKEEIDYFILEYTNGNVPDYQASALLMAIYFQKMKRRETVDLTM
CCHHHHHHCCCCCCCCCHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCHHEEEE
AMVNSGDILDLSKIQGIKVDKHSTGGVGDTTTLVLAPMVAALGIPVAKMSGRGLGHTGGT
EEECCCCEEEHHHCCCEEECCCCCCCCCCHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCC
IDKLESFKGFSVNMTEDKFINNVNNIKIAVGAQTADLAPADKKLYALRDVTATVDNISLI
HHHHHHCCCCEEECCHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHH
ASSIMSKKIAAGANAIILDVKVGEGAFMKTPETAKELAEEMVNIGKSVGRNTVAILSDMD
HHHHHHHHHHCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEHHHCC
QPLGYAIGNALEVKEAIDTLKGKGPKDLLELCLTLGSNMVILSQKANTIEEARKMLLSTI
CHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHH
EKGLAIEKLKEFIRSQGGDDTLVDNTEKLPKAEYIIPVICDRNGYINKIHAQNIGIIASE
HHCHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCEEEEEEECCCCCEEEEECCCCCEEECC
LGAGRVTKDSIIDLAVGIVLNKKRSDKVKKGDIIAYIHANDKIKEEKAAKDILNNYVIEE
CCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHH
ELKEELPLIYDTVK
HHHHCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8550462; 8867804; 9384377; 10568751 [H]