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The map label for this gene is hisC [H]

Identifier: 226948902

GI number: 226948902

Start: 1843051

End: 1844115

Strand: Direct

Name: hisC [H]

Synonym: CLM_1812

Alternate gene names: 226948902

Gene position: 1843051-1844115 (Clockwise)

Preceding gene: 226948901

Following gene: 226948903

Centisome position: 44.35

GC content: 27.23

Gene sequence:

>1065_bases
ATGAGTAAATATTGGAGCAATATAACTAAAGATATAGAACCCTATGTATGTGGAGAGCAACCTAAGAATAAAAAAATTAT
AAAGTTAAATACTAATGAAAATCCATATCCTCCGTCACCTAAGGTATTGCAAGCTATAGAAAATGCTGCCAAGGATGATT
TAAGATTATATCCAGATCCAAATTGCGATGCCTTAAGAAAAACTATAGCTAATTACTACAATTTAAGTAAGGAAGAAGTT
TTTATAGGAAATGGCTCTGATGAGGTTTTATCCCTTTCTTTTTTAACTTTTTTTAATCCAGAAGAGACTATAGTTTTTTC
AGATATTAGTTATAGTTTTTACCCTGTTTATGCAAATTTATATAAATTAGATTATAAGTTAGCAAAACTTAAAGAAGATT
TTTCTATAGATATTAATGACTTTAAAAATGCAAGAGGAGGAGCTGTTATAACAAATCCTAACGCACCAACAGGGGTGTAT
CTTTCCTTAGATTCAATAAAACAAATTTTAGAGGATAATATAAATAATGTGGTTATGGTTGATGAAGCTTATATTGATTT
TGGAGGAGAATCTTCAGTAAGTCTTATAAAGGATTATCCTAATCTTTTAGTAATACAAACCTTATCGAAATCTCGATCTT
TAGCTGGAATGAGAATAGGATTTGCTTTAGGACAAAAGGAGCTTATAGAGGGGTTAAATAGGATAAAAAATTCTTTTAAT
TCCTATACAATAGATAGAATTTCATCTTTAGCAGCTATAGAAGCCATAAAGGATGAAGAATATTTTAAGGAATGTACACT
AAAAGTAATAAAAACACGAAATTGGACTATAAATGAACTAGGAAAAATAGGATTTAAAATCATACCATCTAAAGCTAATT
TTATATTTATTACTCATGATACATATCAAGCTGAAGATATTTTTATAAAGCTAAAGGATGAAAATGTACTTGTTAGATAC
TTTAATAAAGATAGAATAAGTAATTATTTAAGAGTTAGTATAGGTTCTAAAGAAGAAATGGAGATTTTTATGGATAAAAT
AAAGAAGATTATAAATAAATTATAG

Upstream 100 bases:

>100_bases
AAGAAATGGATGTTTATGGAGCTATTGTAGGTAAAGCTATATATTCAGGGAATATTAATTTGAATGAAGCTATTAAAATT
ATAAACAAGGGGAGTTCTAA

Downstream 100 bases:

>100_bases
TTACTATATAAATAAAAATATATAGAAAGTATATATTAGAACATTATATATTTGGAAGATATAGATACAAAGAATAGGTT
TAAAAATATAGTAAGTAAAA

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase [H]

Number of amino acids: Translated: 354; Mature: 353

Protein sequence:

>354_residues
MSKYWSNITKDIEPYVCGEQPKNKKIIKLNTNENPYPPSPKVLQAIENAAKDDLRLYPDPNCDALRKTIANYYNLSKEEV
FIGNGSDEVLSLSFLTFFNPEETIVFSDISYSFYPVYANLYKLDYKLAKLKEDFSIDINDFKNARGGAVITNPNAPTGVY
LSLDSIKQILEDNINNVVMVDEAYIDFGGESSVSLIKDYPNLLVIQTLSKSRSLAGMRIGFALGQKELIEGLNRIKNSFN
SYTIDRISSLAAIEAIKDEEYFKECTLKVIKTRNWTINELGKIGFKIIPSKANFIFITHDTYQAEDIFIKLKDENVLVRY
FNKDRISNYLRVSIGSKEEMEIFMDKIKKIINKL

Sequences:

>Translated_354_residues
MSKYWSNITKDIEPYVCGEQPKNKKIIKLNTNENPYPPSPKVLQAIENAAKDDLRLYPDPNCDALRKTIANYYNLSKEEV
FIGNGSDEVLSLSFLTFFNPEETIVFSDISYSFYPVYANLYKLDYKLAKLKEDFSIDINDFKNARGGAVITNPNAPTGVY
LSLDSIKQILEDNINNVVMVDEAYIDFGGESSVSLIKDYPNLLVIQTLSKSRSLAGMRIGFALGQKELIEGLNRIKNSFN
SYTIDRISSLAAIEAIKDEEYFKECTLKVIKTRNWTINELGKIGFKIIPSKANFIFITHDTYQAEDIFIKLKDENVLVRY
FNKDRISNYLRVSIGSKEEMEIFMDKIKKIINKL
>Mature_353_residues
SKYWSNITKDIEPYVCGEQPKNKKIIKLNTNENPYPPSPKVLQAIENAAKDDLRLYPDPNCDALRKTIANYYNLSKEEVF
IGNGSDEVLSLSFLTFFNPEETIVFSDISYSFYPVYANLYKLDYKLAKLKEDFSIDINDFKNARGGAVITNPNAPTGVYL
SLDSIKQILEDNINNVVMVDEAYIDFGGESSVSLIKDYPNLLVIQTLSKSRSLAGMRIGFALGQKELIEGLNRIKNSFNS
YTIDRISSLAAIEAIKDEEYFKECTLKVIKTRNWTINELGKIGFKIIPSKANFIFITHDTYQAEDIFIKLKDENVLVRYF
NKDRISNYLRVSIGSKEEMEIFMDKIKKIINKL

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=351, Percent_Identity=25.0712250712251, Blast_Score=119, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6322075, Length=378, Percent_Identity=29.1005291005291, Blast_Score=128, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 40495; Mature: 40364

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKYWSNITKDIEPYVCGEQPKNKKIIKLNTNENPYPPSPKVLQAIENAAKDDLRLYPDP
CCCHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHCCCCCEECCCC
NCDALRKTIANYYNLSKEEVFIGNGSDEVLSLSFLTFFNPEETIVFSDISYSFYPVYANL
CHHHHHHHHHHHHCCCCCEEEEECCCCCEEEEEEEEEECCCCEEEEECCCCEEEHHHHHH
YKLDYKLAKLKEDFSIDINDFKNARGGAVITNPNAPTGVYLSLDSIKQILEDNINNVVMV
HHHHHHHHHHCCCCEEEHHHCCCCCCCEEEECCCCCCEEEEEHHHHHHHHHCCCCCEEEE
DEAYIDFGGESSVSLIKDYPNLLVIQTLSKSRSLAGMRIGFALGQKELIEGLNRIKNSFN
EEEEEECCCCCCHHHHHCCCCEEEEEEHHCCCCCCCEEEHHHCCHHHHHHHHHHHHHHHC
SYTIDRISSLAAIEAIKDEEYFKECTLKVIKTRNWTINELGKIGFKIIPSKANFIFITHD
CEEHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHCCCEEEEECCCCEEEEECC
TYQAEDIFIKLKDENVLVRYFNKDRISNYLRVSIGSKEEMEIFMDKIKKIINKL
CEECCEEEEEEECCCEEEEEECHHHHCCEEEEECCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SKYWSNITKDIEPYVCGEQPKNKKIIKLNTNENPYPPSPKVLQAIENAAKDDLRLYPDP
CCHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHCCCCCEECCCC
NCDALRKTIANYYNLSKEEVFIGNGSDEVLSLSFLTFFNPEETIVFSDISYSFYPVYANL
CHHHHHHHHHHHHCCCCCEEEEECCCCCEEEEEEEEEECCCCEEEEECCCCEEEHHHHHH
YKLDYKLAKLKEDFSIDINDFKNARGGAVITNPNAPTGVYLSLDSIKQILEDNINNVVMV
HHHHHHHHHHCCCCEEEHHHCCCCCCCEEEECCCCCCEEEEEHHHHHHHHHCCCCCEEEE
DEAYIDFGGESSVSLIKDYPNLLVIQTLSKSRSLAGMRIGFALGQKELIEGLNRIKNSFN
EEEEEECCCCCCHHHHHCCCCEEEEEEHHCCCCCCCEEEHHHCCHHHHHHHHHHHHHHHC
SYTIDRISSLAAIEAIKDEEYFKECTLKVIKTRNWTINELGKIGFKIIPSKANFIFITHD
CEEHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHCCCEEEEECCCCEEEEECC
TYQAEDIFIKLKDENVLVRYFNKDRISNYLRVSIGSKEEMEIFMDKIKKIINKL
CEECCEEEEEEECCCEEEEEECHHHHCCEEEEECCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA