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The map label for this gene is folE [H]

Identifier: 226948887

GI number: 226948887

Start: 1828841

End: 1829431

Strand: Direct

Name: folE [H]

Synonym: CLM_1797

Alternate gene names: 226948887

Gene position: 1828841-1829431 (Clockwise)

Preceding gene: 226948886

Following gene: 226948888

Centisome position: 44.01

GC content: 32.15

Gene sequence:

>591_bases
ATGGCAATTGATGTTAAAGCAATTGAAGAACACATAAGGGGGATTTTGATAGCTTTAGGAGACGATCCAGAAAGAGAAGG
TCTAAAGAACACACCAAAACGTGTAGCTAAAATGTATGAAGAAGTATTCAAAGGTATGTGTTATAGCAATGATGAAATTG
CAGAAATGTTTAATGTAACCTTTGAAGATGATTTATGTATAAATGATAATGAAAATGATATGGTTTTTATGAAGGAAATA
GAAATATTTAGCCATTGTGAACATCATTTAGCACTTATGTACAATATGAAAGTAGCCATAGCATATATACCTAAGAAAAA
AATTATTGGGTTAAGCAAAATAGCACGAATAGCAGATATGGTAGGACGTAGACTACAGCTTCAAGAGAGGATTGGAAGTG
ATATAGCAGAAATACTTCAGAAGATAACTGGCTCAGAAGATGTAGCTGTTATTATAGAAGGAGAACATGGCTGTATGACC
ACTAGGGGAATAAAAAAGCCAGGTACTAAAACTATAACAACCACATTAAGAGGAAGATTTAATACTGATCCTATTGTAAG
CAATAAATTAATGATGCTTTATACAAAATAA

Upstream 100 bases:

>100_bases
TATTGTAGAATTTATGAAAAATAATAGAATGAATGGAGTTAATTTACAACTGCAGCTTCACAAGATTATATGGGAGCCTA
GTAAGAGAGGAGTATAGTAT

Downstream 100 bases:

>100_bases
AGAAATTTTTAGTTTTAAGTAGAGTTTTATTAAAATAAATATATTAAATTCGTACAAGGTTGAAAAATCTTACACATGAG
TGGAACAGCTTATATAAAGA

Product: GTP cyclohydrolase I

Products: NA

Alternate protein names: GTP cyclohydrolase I; GTP-CH-I [H]

Number of amino acids: Translated: 196; Mature: 195

Protein sequence:

>196_residues
MAIDVKAIEEHIRGILIALGDDPEREGLKNTPKRVAKMYEEVFKGMCYSNDEIAEMFNVTFEDDLCINDNENDMVFMKEI
EIFSHCEHHLALMYNMKVAIAYIPKKKIIGLSKIARIADMVGRRLQLQERIGSDIAEILQKITGSEDVAVIIEGEHGCMT
TRGIKKPGTKTITTTLRGRFNTDPIVSNKLMMLYTK

Sequences:

>Translated_196_residues
MAIDVKAIEEHIRGILIALGDDPEREGLKNTPKRVAKMYEEVFKGMCYSNDEIAEMFNVTFEDDLCINDNENDMVFMKEI
EIFSHCEHHLALMYNMKVAIAYIPKKKIIGLSKIARIADMVGRRLQLQERIGSDIAEILQKITGSEDVAVIIEGEHGCMT
TRGIKKPGTKTITTTLRGRFNTDPIVSNKLMMLYTK
>Mature_195_residues
AIDVKAIEEHIRGILIALGDDPEREGLKNTPKRVAKMYEEVFKGMCYSNDEIAEMFNVTFEDDLCINDNENDMVFMKEIE
IFSHCEHHLALMYNMKVAIAYIPKKKIIGLSKIARIADMVGRRLQLQERIGSDIAEILQKITGSEDVAVIIEGEHGCMTT
RGIKKPGTKTITTTLRGRFNTDPIVSNKLMMLYTK

Specific function: Tetrahydrofolate biosynthesis; first step. [C]

COG id: COG0302

COG function: function code H; GTP cyclohydrolase I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase I family [H]

Homologues:

Organism=Homo sapiens, GI66932968, Length=179, Percent_Identity=37.9888268156425, Blast_Score=130, Evalue=5e-31,
Organism=Homo sapiens, GI4503949, Length=179, Percent_Identity=37.9888268156425, Blast_Score=130, Evalue=5e-31,
Organism=Homo sapiens, GI66932970, Length=150, Percent_Identity=36, Blast_Score=100, Evalue=9e-22,
Organism=Homo sapiens, GI66932972, Length=140, Percent_Identity=37.8571428571429, Blast_Score=99, Evalue=2e-21,
Organism=Escherichia coli, GI1788476, Length=176, Percent_Identity=36.9318181818182, Blast_Score=100, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI17560486, Length=184, Percent_Identity=39.1304347826087, Blast_Score=131, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6321706, Length=177, Percent_Identity=44.0677966101695, Blast_Score=138, Evalue=6e-34,
Organism=Drosophila melanogaster, GI24656782, Length=181, Percent_Identity=40.8839779005525, Blast_Score=122, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24656796, Length=181, Percent_Identity=40.8839779005525, Blast_Score=122, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24656791, Length=181, Percent_Identity=40.8839779005525, Blast_Score=122, Evalue=1e-28,

Paralogues:

None

Copy number: 420 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001474
- InterPro:   IPR020602
- InterPro:   IPR018234 [H]

Pfam domain/function: PF01227 GTP_cyclohydroI [H]

EC number: =3.5.4.16 [H]

Molecular weight: Translated: 22241; Mature: 22110

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: PS00859 GTP_CYCLOHYDROL_1_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
6.1 %Met     (Translated Protein)
8.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
5.6 %Met     (Mature Protein)
7.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIDVKAIEEHIRGILIALGDDPEREGLKNTPKRVAKMYEEVFKGMCYSNDEIAEMFNVT
CCCCHHHHHHHHCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHCCC
FEDDLCINDNENDMVFMKEIEIFSHCEHHLALMYNMKVAIAYIPKKKIIGLSKIARIADM
CCCCEEECCCCCCEEEHHHHHHHHHHHHHHHHHEEEEEEEEECCHHHHHHHHHHHHHHHH
VGRRLQLQERIGSDIAEILQKITGSEDVAVIIEGEHGCMTTRGIKKPGTKTITTTLRGRF
HHHHHHHHHHHCHHHHHHHHHHCCCCCEEEEEECCCCCEECCCCCCCCCCEEEEEECCCC
NTDPIVSNKLMMLYTK
CCCCCCCCCEEEEEEC
>Mature Secondary Structure 
AIDVKAIEEHIRGILIALGDDPEREGLKNTPKRVAKMYEEVFKGMCYSNDEIAEMFNVT
CCCHHHHHHHHCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHCCC
FEDDLCINDNENDMVFMKEIEIFSHCEHHLALMYNMKVAIAYIPKKKIIGLSKIARIADM
CCCCEEECCCCCCEEEHHHHHHHHHHHHHHHHHEEEEEEEEECCHHHHHHHHHHHHHHHH
VGRRLQLQERIGSDIAEILQKITGSEDVAVIIEGEHGCMTTRGIKKPGTKTITTTLRGRF
HHHHHHHHHHHCHHHHHHHHHHCCCCCEEEEEECCCCCEECCCCCCCCCCEEEEEECCCC
NTDPIVSNKLMMLYTK
CCCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA