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The map label for this gene is nadC [H]

Identifier: 226948710

GI number: 226948710

Start: 1681639

End: 1682475

Strand: Reverse

Name: nadC [H]

Synonym: CLM_1610

Alternate gene names: 226948710

Gene position: 1682475-1681639 (Counterclockwise)

Preceding gene: 226948711

Following gene: 226948709

Centisome position: 40.49

GC content: 28.32

Gene sequence:

>837_bases
ATGAATTGGTTAGTTGTTGATGAAATACTTAAATCTGCACTTAAAGAAGATATATCCTTTGAAGACATAACTACAGAATC
TATATTTAAAGAAAATAAAAGAGCAAAAATAGATTTAATTGCAAAAGAAGATGGTATAATTGCTGGCTTAGAAGTTTTTA
GACGAGTGTTTTTACTAATTGGTGATGCAAATGCTCAATTTTATATAAAAGATGGTGAGAAAGTACATAAAGGCGAAAAA
ATAGGAACAGTTTTTGGAAATGTGAAAACTCTCTTAACTGGTGAAAGAGTTGCCTTAAACTTTCTCCAAAGGATGAGTGG
AATAGCTACTTTAACTAGACAATTTGTAGAGGAATTGAAAAGCACAAAAACTAAATTACTAGATACTAGAAAAACTACTC
CAAATCTTAGAATTTTTGAAAAATATGCTGTAAGGATTGGTGGTGGTTTTAATCACAGATTTGGATTAAATGATGGAATT
CTTATAAAGGATAATCACATAAATGCAGCTGGCGGAATAAAAAATGCTATAACTTTAGCAAAAAACAATGCCCCTTTCGT
AAGAAAAATAGAAGTTGAAATTGAAAATTTAGAACAATTAGAAGAAGCTCTAGATTATAAAGCAGATATAATTATGCTTG
ATAATATGTCTTTAGATATGATGAAAAAAGCCATATATATAATAGATGGAAGAGCTGTAACTGAAGCTTCTGGAAATGTA
ACTATAGAAAAAATTAAAGATATAGCAAACTGTGGTGTAGATTATATCTCTACTGGATCACTTACTCATTCTTTTAAAGT
TTTAGATTTAAGCATGAAAAATTTAACATATTTATAA

Upstream 100 bases:

>100_bases
ACAAAGATTTATACATTGAAACATAATGTAGAATATTATAGTTTATTAAATAAAAAAATAATTACAGAATCTCTACTTAA
ACTAAGGAGTGATTTACAAA

Downstream 100 bases:

>100_bases
TTGCAAAATTTCATTTCTCATTTTCCTATAGTTATCTTACAATAAAAATTTAAAATAATTTGTGAAAATTCTATTTTTAT
AAAAATTACTATTACTTTCT

Product: nicotinate-nucleotide diphosphorylase

Products: NA

Alternate protein names: General stress protein 70; GSP70; Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 278; Mature: 278

Protein sequence:

>278_residues
MNWLVVDEILKSALKEDISFEDITTESIFKENKRAKIDLIAKEDGIIAGLEVFRRVFLLIGDANAQFYIKDGEKVHKGEK
IGTVFGNVKTLLTGERVALNFLQRMSGIATLTRQFVEELKSTKTKLLDTRKTTPNLRIFEKYAVRIGGGFNHRFGLNDGI
LIKDNHINAAGGIKNAITLAKNNAPFVRKIEVEIENLEQLEEALDYKADIIMLDNMSLDMMKKAIYIIDGRAVTEASGNV
TIEKIKDIANCGVDYISTGSLTHSFKVLDLSMKNLTYL

Sequences:

>Translated_278_residues
MNWLVVDEILKSALKEDISFEDITTESIFKENKRAKIDLIAKEDGIIAGLEVFRRVFLLIGDANAQFYIKDGEKVHKGEK
IGTVFGNVKTLLTGERVALNFLQRMSGIATLTRQFVEELKSTKTKLLDTRKTTPNLRIFEKYAVRIGGGFNHRFGLNDGI
LIKDNHINAAGGIKNAITLAKNNAPFVRKIEVEIENLEQLEEALDYKADIIMLDNMSLDMMKKAIYIIDGRAVTEASGNV
TIEKIKDIANCGVDYISTGSLTHSFKVLDLSMKNLTYL
>Mature_278_residues
MNWLVVDEILKSALKEDISFEDITTESIFKENKRAKIDLIAKEDGIIAGLEVFRRVFLLIGDANAQFYIKDGEKVHKGEK
IGTVFGNVKTLLTGERVALNFLQRMSGIATLTRQFVEELKSTKTKLLDTRKTTPNLRIFEKYAVRIGGGFNHRFGLNDGI
LIKDNHINAAGGIKNAITLAKNNAPFVRKIEVEIENLEQLEEALDYKADIIMLDNMSLDMMKKAIYIIDGRAVTEASGNV
TIEKIKDIANCGVDYISTGSLTHSFKVLDLSMKNLTYL

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=270, Percent_Identity=31.8518518518519, Blast_Score=151, Evalue=6e-37,
Organism=Escherichia coli, GI1786299, Length=271, Percent_Identity=43.1734317343173, Blast_Score=194, Evalue=6e-51,
Organism=Saccharomyces cerevisiae, GI6321162, Length=274, Percent_Identity=32.1167883211679, Blast_Score=134, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 31149; Mature: 31149

Theoretical pI: Translated: 7.66; Mature: 7.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNWLVVDEILKSALKEDISFEDITTESIFKENKRAKIDLIAKEDGIIAGLEVFRRVFLLI
CCEEEHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCEEEEEECCCCEEHHHHHHHHHHHEE
GDANAQFYIKDGEKVHKGEKIGTVFGNVKTLLTGERVALNFLQRMSGIATLTRQFVEELK
ECCCCEEEECCCCCHHCCCHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
STKTKLLDTRKTTPNLRIFEKYAVRIGGGFNHRFGLNDGILIKDNHINAAGGIKNAITLA
HHHHHHHHCCCCCCCCEEEEEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCEEEEE
KNNAPFVRKIEVEIENLEQLEEALDYKADIIMLDNMSLDMMKKAIYIIDGRAVTEASGNV
CCCCCEEEEEEEEHHHHHHHHHHHCCCCCEEEEECCCHHHHHCEEEEECCCEEEECCCCE
TIEKIKDIANCGVDYISTGSLTHSFKVLDLSMKNLTYL
EHHHHHHHHHCCCCEEECCCCCEEEEEEEEEHHCCCCC
>Mature Secondary Structure
MNWLVVDEILKSALKEDISFEDITTESIFKENKRAKIDLIAKEDGIIAGLEVFRRVFLLI
CCEEEHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCEEEEEECCCCEEHHHHHHHHHHHEE
GDANAQFYIKDGEKVHKGEKIGTVFGNVKTLLTGERVALNFLQRMSGIATLTRQFVEELK
ECCCCEEEECCCCCHHCCCHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
STKTKLLDTRKTTPNLRIFEKYAVRIGGGFNHRFGLNDGILIKDNHINAAGGIKNAITLA
HHHHHHHHCCCCCCCCEEEEEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCEEEEE
KNNAPFVRKIEVEIENLEQLEEALDYKADIIMLDNMSLDMMKKAIYIIDGRAVTEASGNV
CCCCCEEEEEEEEHHHHHHHHHHHCCCCCEEEEECCCHHHHHCEEEEECCCEEEECCCCE
TIEKIKDIANCGVDYISTGSLTHSFKVLDLSMKNLTYL
EHHHHHHHHHCCCCEEECCCCCEEEEEEEEEHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 8444804; 9298659 [H]