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The map label for this gene is yvrG [H]

Identifier: 226948240

GI number: 226948240

Start: 1157172

End: 1158593

Strand: Direct

Name: yvrG [H]

Synonym: CLM_1117

Alternate gene names: 226948240

Gene position: 1157172-1158593 (Clockwise)

Preceding gene: 226948239

Following gene: 226948244

Centisome position: 27.85

GC content: 24.61

Gene sequence:

>1422_bases
ATGAAAAATAATATGAAATGGAGAATAACAGGTAGGTTTTTAATAACAGTTATATGTGTAGTTATAACTGTAGTCATAAT
AAATATTGTATCTTTAATTGGACTCGCAATTTATAGAAATGTTAATGAGATTGGTTCTAAAGAATATAAAATTGAAGACT
TAGTTAGAAATTTTTCTTCGAATATTAAAGAAGCAGATAATAAAATATATATTGATGATAAGGGCAAAGCTATATTAGAT
AGTAACAATGGTTGGATACAGATTATAGATGCTAACAATAATGAAGTTTATAGTTATAAAAAGCCTTCTTATATAAAAAA
TAAACCTACTGCTGCAGAAATAGTAAATTTACATAAATATAAAACTTCTGATAAACGAAATGAAGTGTCTACTAATTTTG
TAGCTGAAAAAAATATAGGAAATAAAAGATTAACTTATATTATGGGACTTCAGAATAATGATATAAATAAATATGTAGTC
ACTACTAGGAACTCAGAAGTAATCCAACTTATAAAATCTGCCACAATAATAATTATTATAGTAGACGGGATTATAGCTTT
AATTTTTGGATATCTTTTTATTAGAAAATTAACTAATCCTTTAGGAGAGATATTATTAGGCATAAAAAAATTAGAAAATG
AGGAATATGATTTATATTATGAAGCTAAAGGAATGTATAATGATTTGTATTATAGCTTAAATAATTTATCAGATAGATTA
CAAGAAAATAAAAGGAATAGAAAAAAGCTAGATAATATGAGAGAAGAATGGATTTCAAACATTTCTCATGATATAAAAAC
TCCATTAGCATCTATCCAAGGGTATGCAGAAATAATAAAAGATGAAGACTATGATTTTACAAAAGAGGAGATAGGAGAGT
ATGCTGAAATCATAGAAAATAAATCTAAATATATTAAAGAATTAGTAGAAGATTTAAATTTATCTACTAGATTAAAAAAT
AATACTTTAACTTTAAATAAGGAAAAAATTAATTTAGCTAATTTAATAAAGGATATTATAATAGATATATTAAATGATAC
CAGATATGAAAATAGGGAAATAGATTTTCACTGTGAGAATGACAATATTGAAATAAATGGAGACAGAATTCTTATAAGAA
GAGCTATAATTAATATTTTATTTAATGCCATTGTGCACAATAGTGAAGATGTAAAGATAAATGTTACACTAAAAAAACAG
GATAAGATAAGTATAATTATTGAAGACAATGGTAGGGGAATAAAAGGAGAAGAGTTAAATAGAATTTTTGATAGATATTA
TAGAGGAACTAATACAGGAGAGAGACATAAAGGTTCTGGATTAGGAATGGCTATATCAAAAGAAACAATTGTTGCCCATG
GAGGGGATATAACTATTGAAAGTGAACTAGGCAAAGGAACCAAAGTAAATATATTAATATAA

Upstream 100 bases:

>100_bases
GTTCATATTAGAAGACTTAGAGAAAAAATTGAAAAAGAACCATCAAAGCCAGAGTATTTAATAAATGTTAAAGGTTTAGG
GTACAAATTGGTGATAAAAA

Downstream 100 bases:

>100_bases
TTAAGAAAATAAATATCTATAAAAATAAATAGAATAATTTATTAAAGTAATAAATTTTTCATTCAACATAAGGACGGTTA
AAACTTATTAAAATAAAAAG

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 473; Mature: 473

Protein sequence:

>473_residues
MKNNMKWRITGRFLITVICVVITVVIINIVSLIGLAIYRNVNEIGSKEYKIEDLVRNFSSNIKEADNKIYIDDKGKAILD
SNNGWIQIIDANNNEVYSYKKPSYIKNKPTAAEIVNLHKYKTSDKRNEVSTNFVAEKNIGNKRLTYIMGLQNNDINKYVV
TTRNSEVIQLIKSATIIIIIVDGIIALIFGYLFIRKLTNPLGEILLGIKKLENEEYDLYYEAKGMYNDLYYSLNNLSDRL
QENKRNRKKLDNMREEWISNISHDIKTPLASIQGYAEIIKDEDYDFTKEEIGEYAEIIENKSKYIKELVEDLNLSTRLKN
NTLTLNKEKINLANLIKDIIIDILNDTRYENREIDFHCENDNIEINGDRILIRRAIINILFNAIVHNSEDVKINVTLKKQ
DKISIIIEDNGRGIKGEELNRIFDRYYRGTNTGERHKGSGLGMAISKETIVAHGGDITIESELGKGTKVNILI

Sequences:

>Translated_473_residues
MKNNMKWRITGRFLITVICVVITVVIINIVSLIGLAIYRNVNEIGSKEYKIEDLVRNFSSNIKEADNKIYIDDKGKAILD
SNNGWIQIIDANNNEVYSYKKPSYIKNKPTAAEIVNLHKYKTSDKRNEVSTNFVAEKNIGNKRLTYIMGLQNNDINKYVV
TTRNSEVIQLIKSATIIIIIVDGIIALIFGYLFIRKLTNPLGEILLGIKKLENEEYDLYYEAKGMYNDLYYSLNNLSDRL
QENKRNRKKLDNMREEWISNISHDIKTPLASIQGYAEIIKDEDYDFTKEEIGEYAEIIENKSKYIKELVEDLNLSTRLKN
NTLTLNKEKINLANLIKDIIIDILNDTRYENREIDFHCENDNIEINGDRILIRRAIINILFNAIVHNSEDVKINVTLKKQ
DKISIIIEDNGRGIKGEELNRIFDRYYRGTNTGERHKGSGLGMAISKETIVAHGGDITIESELGKGTKVNILI
>Mature_473_residues
MKNNMKWRITGRFLITVICVVITVVIINIVSLIGLAIYRNVNEIGSKEYKIEDLVRNFSSNIKEADNKIYIDDKGKAILD
SNNGWIQIIDANNNEVYSYKKPSYIKNKPTAAEIVNLHKYKTSDKRNEVSTNFVAEKNIGNKRLTYIMGLQNNDINKYVV
TTRNSEVIQLIKSATIIIIIVDGIIALIFGYLFIRKLTNPLGEILLGIKKLENEEYDLYYEAKGMYNDLYYSLNNLSDRL
QENKRNRKKLDNMREEWISNISHDIKTPLASIQGYAEIIKDEDYDFTKEEIGEYAEIIENKSKYIKELVEDLNLSTRLKN
NTLTLNKEKINLANLIKDIIIDILNDTRYENREIDFHCENDNIEINGDRILIRRAIINILFNAIVHNSEDVKINVTLKKQ
DKISIIIEDNGRGIKGEELNRIFDRYYRGTNTGERHKGSGLGMAISKETIVAHGGDITIESELGKGTKVNILI

Specific function: Member of the two-component regulatory system YvrG/YvrH that positively regulates 7 transcriptional units (wprA, wapA- yxxG, dltABCDE, sunA, sunT-bdbA-yolJ-bdbB, sigO-rsoA, and sigX- rsiX), and negatively regulates the lytABC operon. Probably activates yv

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=228, Percent_Identity=28.0701754385965, Blast_Score=105, Evalue=8e-24,
Organism=Escherichia coli, GI1786783, Length=308, Percent_Identity=25.6493506493506, Blast_Score=101, Evalue=8e-23,
Organism=Escherichia coli, GI1788549, Length=247, Percent_Identity=27.5303643724696, Blast_Score=93, Evalue=5e-20,
Organism=Escherichia coli, GI1788393, Length=282, Percent_Identity=23.758865248227, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI145693157, Length=242, Percent_Identity=23.1404958677686, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI48994928, Length=254, Percent_Identity=24.8031496062992, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1788713, Length=228, Percent_Identity=25.8771929824561, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1790861, Length=231, Percent_Identity=26.4069264069264, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI1789149, Length=336, Percent_Identity=20.2380952380952, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1790436, Length=235, Percent_Identity=24.6808510638298, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI87082128, Length=292, Percent_Identity=22.9452054794521, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1786912, Length=221, Percent_Identity=25.7918552036199, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1789403, Length=305, Percent_Identity=22.6229508196721, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788279, Length=214, Percent_Identity=28.5046728971963, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1790346, Length=211, Percent_Identity=24.6445497630332, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1790551, Length=293, Percent_Identity=23.5494880546075, Blast_Score=66, Evalue=6e-12,
Organism=Escherichia coli, GI1789808, Length=211, Percent_Identity=25.1184834123223, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 54411; Mature: 54411

Theoretical pI: Translated: 7.63; Mature: 7.63

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNNMKWRITGRFLITVICVVITVVIINIVSLIGLAIYRNVNEIGSKEYKIEDLVRNFSS
CCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCHHHHHHHHHHHH
NIKEADNKIYIDDKGKAILDSNNGWIQIIDANNNEVYSYKKPSYIKNKPTAAEIVNLHKY
HHHHCCCEEEEECCCCEEEECCCCEEEEEECCCCEEEEECCCCCCCCCCCHHHHHHHHHH
KTSDKRNEVSTNFVAEKNIGNKRLTYIMGLQNNDINKYVVTTRNSEVIQLIKSATIIIII
CCCCCCCCCCCCEEEECCCCCCEEEEEEEECCCCCCEEEEEECCHHHHHHHHCCEEEEEE
VDGIIALIFGYLFIRKLTNPLGEILLGIKKLENEEYDLYYEAKGMYNDLYYSLNNLSDRL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHH
QENKRNRKKLDNMREEWISNISHDIKTPLASIQGYAEIIKDEDYDFTKEEIGEYAEIIEN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHC
KSKYIKELVEDLNLSTRLKNNTLTLNKEKINLANLIKDIIIDILNDTRYENREIDFHCEN
HHHHHHHHHHHCCCCEEECCCEEEEEHHHCCHHHHHHHHHHHHHCCCCCCCCCEEEEECC
DNIEINGDRILIRRAIINILFNAIVHNSEDVKINVTLKKQDKISIIIEDNGRGIKGEELN
CCEEECCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCEEEEEECCCCCCCHHHHH
RIFDRYYRGTNTGERHKGSGLGMAISKETIVAHGGDITIESELGKGTKVNILI
HHHHHHHCCCCCCCCCCCCCCEEEEECCEEEEECCCEEEECCCCCCCEEEEEC
>Mature Secondary Structure
MKNNMKWRITGRFLITVICVVITVVIINIVSLIGLAIYRNVNEIGSKEYKIEDLVRNFSS
CCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCHHHHHHHHHHHH
NIKEADNKIYIDDKGKAILDSNNGWIQIIDANNNEVYSYKKPSYIKNKPTAAEIVNLHKY
HHHHCCCEEEEECCCCEEEECCCCEEEEEECCCCEEEEECCCCCCCCCCCHHHHHHHHHH
KTSDKRNEVSTNFVAEKNIGNKRLTYIMGLQNNDINKYVVTTRNSEVIQLIKSATIIIII
CCCCCCCCCCCCEEEECCCCCCEEEEEEEECCCCCCEEEEEECCHHHHHHHHCCEEEEEE
VDGIIALIFGYLFIRKLTNPLGEILLGIKKLENEEYDLYYEAKGMYNDLYYSLNNLSDRL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHH
QENKRNRKKLDNMREEWISNISHDIKTPLASIQGYAEIIKDEDYDFTKEEIGEYAEIIEN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHC
KSKYIKELVEDLNLSTRLKNNTLTLNKEKINLANLIKDIIIDILNDTRYENREIDFHCEN
HHHHHHHHHHHCCCCEEECCCEEEEEHHHCCHHHHHHHHHHHHHCCCCCCCCCEEEEECC
DNIEINGDRILIRRAIINILFNAIVHNSEDVKINVTLKKQDKISIIIEDNGRGIKGEELN
CCEEECCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCEEEEEECCCCCCCHHHHH
RIFDRYYRGTNTGERHKGSGLGMAISKETIVAHGGDITIESELGKGTKVNILI
HHHHHHHCCCCCCCCCCCCCCEEEEECCEEEEECCCEEEECCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9639930; 9384377 [H]