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The map label for this gene is cobD [H]

Identifier: 226948188

GI number: 226948188

Start: 1113874

End: 1114962

Strand: Direct

Name: cobD [H]

Synonym: CLM_1063

Alternate gene names: 226948188

Gene position: 1113874-1114962 (Clockwise)

Preceding gene: 226948187

Following gene: 226948189

Centisome position: 26.81

GC content: 25.9

Gene sequence:

>1089_bases
ATGCATGGTGGAGATATTTATACAGAGGGAATTTTAAAAGGAAAAGAACTCATAGATTTTAGTTCTAATATAAACCCTTT
AGGGTTGCCAGATAGTTTTAAAGATAATTTGGAGGAGGCTCTAAGTTGGGTACAAGTTTATCCAGATATTCAATACAGAA
ATTTAAAAAGAAACTTAATAGACTATTTAAGTTTTTCTCTAGATTATTTTTATAAAGAAAAAGTAGACAAACTTAATATA
AAGGAAGAAAATTTGGTTCTAGGTAATGGAGCAGTAGAAATAATCGATTTAGCCATAAGCAATTTAAAGAGTATATCTAT
TTTAGTACCTTCCTTTGTGGAATATGAATTATGTGCTAAAAAATGGAATGTACAAATAGATTATTGCAATTTAAATGAGG
ATATGACATATAACTATGAAATTATAAAAAAATCCTTAGAAAAAACAGAAGGAATAATATTGGGAAATCCTAATAATCCT
AATGGATCAGTAATAAATAAGGAAGAGTTCATATACATACTAGATTACTGCGACAAAAATAATAAAATTGTAATTTTAGA
TGAAGCTTTTATAGAATTTACAGGAAAGAATTCCTTTAGCTTTTTAAACTTATGCGAAAGATACAAGTGTATTTTTATAA
TAAGGGCTTTAACTAAGTTTTTTTCCATGCCAGGTATAAGATTTGGCTATGGGATAAGTTTTAATAATAAATTTTTAAAT
AAAATAAGAAAAAAACAAAACCCTTGGAATATAAACTGTTTTGCAGAAATTGCAGTTAAATATGTTCTGAAAGATAAAGA
TTTCATAGAGAAATCCATAAGTTACATAGAGAAAGAAAGAACATTTATGTATGAAAATCTAAAAAAATCCTATTTGTTTC
ATGAGGTATATAGTACCTATAGTAATTTTATACTTTGTAAGCTAAAGAGAATTACAGGGGAAGAGCTTAAAGAAAAGCTT
TTAGATAAGGGATTTGTTTTAAGAGTTTGCAAGGATTTCAAAACTTTAAATGATGATTATGTAAGATTTGCAATAAAAAC
TAGAGAATTGAATAAAAATTTAATCCATGCTTTGAAAGAAATAAATTAG

Upstream 100 bases:

>100_bases
AAGTTTTTTCATTTAATAAAAAACTATATCCTCAATTGATTATTAATAATTGTCAACTGATCATTGTTAATTGACAATTG
CTAAATAAGGTGGTGTTTAT

Downstream 100 bases:

>100_bases
AATTAAATTTTATTTTAACCTAAGAATCCTTTAATGAAATGAGGAAATATTTATAAAACTAAATAATTTATTTTATATAA
CTAAGGGAAATCAGCAATGA

Product: aminotransferase family protein

Products: NA

Alternate protein names: L-threonine-O-3-phosphate decarboxylase [H]

Number of amino acids: Translated: 362; Mature: 362

Protein sequence:

>362_residues
MHGGDIYTEGILKGKELIDFSSNINPLGLPDSFKDNLEEALSWVQVYPDIQYRNLKRNLIDYLSFSLDYFYKEKVDKLNI
KEENLVLGNGAVEIIDLAISNLKSISILVPSFVEYELCAKKWNVQIDYCNLNEDMTYNYEIIKKSLEKTEGIILGNPNNP
NGSVINKEEFIYILDYCDKNNKIVILDEAFIEFTGKNSFSFLNLCERYKCIFIIRALTKFFSMPGIRFGYGISFNNKFLN
KIRKKQNPWNINCFAEIAVKYVLKDKDFIEKSISYIEKERTFMYENLKKSYLFHEVYSTYSNFILCKLKRITGEELKEKL
LDKGFVLRVCKDFKTLNDDYVRFAIKTRELNKNLIHALKEIN

Sequences:

>Translated_362_residues
MHGGDIYTEGILKGKELIDFSSNINPLGLPDSFKDNLEEALSWVQVYPDIQYRNLKRNLIDYLSFSLDYFYKEKVDKLNI
KEENLVLGNGAVEIIDLAISNLKSISILVPSFVEYELCAKKWNVQIDYCNLNEDMTYNYEIIKKSLEKTEGIILGNPNNP
NGSVINKEEFIYILDYCDKNNKIVILDEAFIEFTGKNSFSFLNLCERYKCIFIIRALTKFFSMPGIRFGYGISFNNKFLN
KIRKKQNPWNINCFAEIAVKYVLKDKDFIEKSISYIEKERTFMYENLKKSYLFHEVYSTYSNFILCKLKRITGEELKEKL
LDKGFVLRVCKDFKTLNDDYVRFAIKTRELNKNLIHALKEIN
>Mature_362_residues
MHGGDIYTEGILKGKELIDFSSNINPLGLPDSFKDNLEEALSWVQVYPDIQYRNLKRNLIDYLSFSLDYFYKEKVDKLNI
KEENLVLGNGAVEIIDLAISNLKSISILVPSFVEYELCAKKWNVQIDYCNLNEDMTYNYEIIKKSLEKTEGIILGNPNNP
NGSVINKEEFIYILDYCDKNNKIVILDEAFIEFTGKNSFSFLNLCERYKCIFIIRALTKFFSMPGIRFGYGISFNNKFLN
KIRKKQNPWNINCFAEIAVKYVLKDKDFIEKSISYIEKERTFMYENLKKSYLFHEVYSTYSNFILCKLKRITGEELKEKL
LDKGFVLRVCKDFKTLNDDYVRFAIKTRELNKNLIHALKEIN

Specific function: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1- amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin [H]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=289, Percent_Identity=25.2595155709343, Blast_Score=97, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6322075, Length=381, Percent_Identity=25.7217847769029, Blast_Score=75, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005860
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.1.1.81 [H]

Molecular weight: Translated: 42491; Mature: 42491

Theoretical pI: Translated: 7.94; Mature: 7.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHGGDIYTEGILKGKELIDFSSNINPLGLPDSFKDNLEEALSWVQVYPDIQYRNLKRNLI
CCCCCEEHHHHHCCCHHEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
DYLSFSLDYFYKEKVDKLNIKEENLVLGNGAVEIIDLAISNLKSISILVPSFVEYELCAK
HHHHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHCCCCEEEECCHHHHHHHHHH
KWNVQIDYCNLNEDMTYNYEIIKKSLEKTEGIILGNPNNPNGSVINKEEFIYILDYCDKN
HCCEEEEEEECCCCCEEHHHHHHHHHHHHCCEEEECCCCCCCCEECCCCEEEEEEEECCC
NKIVILDEAFIEFTGKNSFSFLNLCERYKCIFIIRALTKFFSMPGIRFGYGISFNNKFLN
CCEEEEEHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHH
KIRKKQNPWNINCFAEIAVKYVLKDKDFIEKSISYIEKERTFMYENLKKSYLFHEVYSTY
HHHHCCCCCCEEHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SNFILCKLKRITGEELKEKLLDKGFVLRVCKDFKTLNDDYVRFAIKTRELNKNLIHALKE
HCEEEEEEHHCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHH
IN
CC
>Mature Secondary Structure
MHGGDIYTEGILKGKELIDFSSNINPLGLPDSFKDNLEEALSWVQVYPDIQYRNLKRNLI
CCCCCEEHHHHHCCCHHEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
DYLSFSLDYFYKEKVDKLNIKEENLVLGNGAVEIIDLAISNLKSISILVPSFVEYELCAK
HHHHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHCCCCEEEECCHHHHHHHHHH
KWNVQIDYCNLNEDMTYNYEIIKKSLEKTEGIILGNPNNPNGSVINKEEFIYILDYCDKN
HCCEEEEEEECCCCCEEHHHHHHHHHHHHCCEEEECCCCCCCCEECCCCEEEEEEEECCC
NKIVILDEAFIEFTGKNSFSFLNLCERYKCIFIIRALTKFFSMPGIRFGYGISFNNKFLN
CCEEEEEHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHH
KIRKKQNPWNINCFAEIAVKYVLKDKDFIEKSISYIEKERTFMYENLKKSYLFHEVYSTY
HHHHCCCCCCEEHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SNFILCKLKRITGEELKEKLLDKGFVLRVCKDFKTLNDDYVRFAIKTRELNKNLIHALKE
HCEEEEEEHHCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHH
IN
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]