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The map label for this gene is tipA [H]

Identifier: 226948110

GI number: 226948110

Start: 1034368

End: 1035657

Strand: Direct

Name: tipA [H]

Synonym: CLM_0975

Alternate gene names: 226948110

Gene position: 1034368-1035657 (Clockwise)

Preceding gene: 226948109

Following gene: 226948111

Centisome position: 24.89

GC content: 26.28

Gene sequence:

>1290_bases
ATGAAGGATACCTCAAAAAAATTATTTACTACAGGAGAATTTGCTAAAAAAGCTGGAGTAACTATAAGGACTTTAAGATA
TTATGACAAAATAGGGTTATTAGTTCCCAGTAGCCATAATGAATTAGGGCATAGATTGTACAGCAAAGAGGATTTTGGTA
AACTACAAAAGATATTAACTCTTAAATTTATAGGGCTTTCCCTAGAGGATATAGCCAATATAATGAAGTATGATTTGAAT
CATAAAGATTTTAAAAAATCTTTAGAAATTCAAAAGGAAATAATGAAGAAAAAAATAAAGCATATACAATCTATTATAAA
AGCTATAGATGAAGCGGCGGATACCATAGATTTTAATAAAGAAATGGATTGGGATAAGTTTATAAATATAATAAGTGCCA
TAAATTCTGATAAAAATTGGACTCAGCAATATGAAAATGCATCAAACTTAAGGGCAAGAATAGCTATTCATGAGCTTTTT
AGTACAAATAAAGAAGGTTGGATGCCCTGGTTTTTTAAAGAACTAAAACAGGAATTGAGTATGATTAGTCCAAACTGTGA
AAATCATAATGAAAAAATAAATAATGAGAATATATCAGAATTAAGTAACTTAGACTTAAAGCAGTCTAATATAAAAATAT
TAGAGCTAGGTTGTGGTGATGCTAGTCTTTGGAATAAAAGTTTTAATCATATACCCTCAAATTGGGAAATAACATTAACA
GATTTTTCAGAGGGCATGCTAAAGGATGCTAAAAAAAATTTAAGAGAAAAAAGAAGTAGATTTAATTTTAAAATTGTAAA
TGCAGAAAATATTCCTTTTGAAGAGGAAAGTTTCAATGTAGTTATAGCAAATCATATGCTTTATCATGTGCCTAATATAA
ATAAAGCTTTAAAAGAAATAAATAGAGTATTGAAAAGTGAGGGGATTTTATTTGCCTCCACTGTTGGTAAAAATCACATG
AAAGAAATAAGAGAAATAATTTCTACATTTGATATATATAATTTAACCAGTGAAAGCTGGGAAATTACAGATAGCTTTCA
ATTAGAAAATGGATTAAAAATTGTATCAGAATATTTTAATATGGTAGAATTGAAAAGATATAAAGACAATTTAAAGGTGA
CAGATCCTGTATATATATTAGACTATATATTTTCTATGCCAGGAAATAATAAAGTAAATTTATCTTCAAAGGATTTAAAA
AAGATTTATGATTATTTAGAAGATAATATAAAGGAAAAAGAAAATATTTACATAACAAAGGATACGGGATATTTTAAAGG
TAAAAAATAA

Upstream 100 bases:

>100_bases
TATACTTATCCAGGTGTGTAGTAAGGCTTAGCTTTTGTCTTGATAAAAAGATTGAAGCTAAGTAAACATGATATGATATA
TTATTGCAGAGGTGATTAAT

Downstream 100 bases:

>100_bases
ATAAAAATTATTTTAAAATAAAAAATCAATTGTTAAATGAAGGGAAGGATTATAATGAAAAAGATACCATTTTCACCACC
AGATATTACAGAAAGAGAGA

Product: MerR family transcriptional regulator/methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 429; Mature: 429

Protein sequence:

>429_residues
MKDTSKKLFTTGEFAKKAGVTIRTLRYYDKIGLLVPSSHNELGHRLYSKEDFGKLQKILTLKFIGLSLEDIANIMKYDLN
HKDFKKSLEIQKEIMKKKIKHIQSIIKAIDEAADTIDFNKEMDWDKFINIISAINSDKNWTQQYENASNLRARIAIHELF
STNKEGWMPWFFKELKQELSMISPNCENHNEKINNENISELSNLDLKQSNIKILELGCGDASLWNKSFNHIPSNWEITLT
DFSEGMLKDAKKNLREKRSRFNFKIVNAENIPFEEESFNVVIANHMLYHVPNINKALKEINRVLKSEGILFASTVGKNHM
KEIREIISTFDIYNLTSESWEITDSFQLENGLKIVSEYFNMVELKRYKDNLKVTDPVYILDYIFSMPGNNKVNLSSKDLK
KIYDYLEDNIKEKENIYITKDTGYFKGKK

Sequences:

>Translated_429_residues
MKDTSKKLFTTGEFAKKAGVTIRTLRYYDKIGLLVPSSHNELGHRLYSKEDFGKLQKILTLKFIGLSLEDIANIMKYDLN
HKDFKKSLEIQKEIMKKKIKHIQSIIKAIDEAADTIDFNKEMDWDKFINIISAINSDKNWTQQYENASNLRARIAIHELF
STNKEGWMPWFFKELKQELSMISPNCENHNEKINNENISELSNLDLKQSNIKILELGCGDASLWNKSFNHIPSNWEITLT
DFSEGMLKDAKKNLREKRSRFNFKIVNAENIPFEEESFNVVIANHMLYHVPNINKALKEINRVLKSEGILFASTVGKNHM
KEIREIISTFDIYNLTSESWEITDSFQLENGLKIVSEYFNMVELKRYKDNLKVTDPVYILDYIFSMPGNNKVNLSSKDLK
KIYDYLEDNIKEKENIYITKDTGYFKGKK
>Mature_429_residues
MKDTSKKLFTTGEFAKKAGVTIRTLRYYDKIGLLVPSSHNELGHRLYSKEDFGKLQKILTLKFIGLSLEDIANIMKYDLN
HKDFKKSLEIQKEIMKKKIKHIQSIIKAIDEAADTIDFNKEMDWDKFINIISAINSDKNWTQQYENASNLRARIAIHELF
STNKEGWMPWFFKELKQELSMISPNCENHNEKINNENISELSNLDLKQSNIKILELGCGDASLWNKSFNHIPSNWEITLT
DFSEGMLKDAKKNLREKRSRFNFKIVNAENIPFEEESFNVVIANHMLYHVPNINKALKEINRVLKSEGILFASTVGKNHM
KEIREIISTFDIYNLTSESWEITDSFQLENGLKIVSEYFNMVELKRYKDNLKVTDPVYILDYIFSMPGNNKVNLSSKDLK
KIYDYLEDNIKEKENIYITKDTGYFKGKK

Specific function: Transcriptional activator. Is activated when bound to the antibiotic thiostrepton [H]

COG id: COG0500

COG function: function code QR; SAM-dependent methyltransferases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR012925
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind; PF07739 TipAS [H]

EC number: NA

Molecular weight: Translated: 50139; Mature: 50139

Theoretical pI: Translated: 8.77; Mature: 8.77

Prosite motif: PS00552 HTH_MERR_1 ; PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDTSKKLFTTGEFAKKAGVTIRTLRYYDKIGLLVPSSHNELGHRLYSKEDFGKLQKILT
CCCCCCHHHCCHHHHHHCCCEEEEHHHHHHHCEEECCCCCHHHHHHHCHHHHHHHHHHHH
LKFIGLSLEDIANIMKYDLNHKDFKKSLEIQKEIMKKKIKHIQSIIKAIDEAADTIDFNK
HHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
EMDWDKFINIISAINSDKNWTQQYENASNLRARIAIHELFSTNKEGWMPWFFKELKQELS
CCCHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
MISPNCENHNEKINNENISELSNLDLKQSNIKILELGCGDASLWNKSFNHIPSNWEITLT
HCCCCCCCCCCCCCCCCHHHHHCCCCCCCCEEEEEECCCCHHHHCCHHHCCCCCCEEEEE
DFSEGMLKDAKKNLREKRSRFNFKIVNAENIPFEEESFNVVIANHMLYHVPNINKALKEI
CCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCEEEECCEEEECCCHHHHHHHH
NRVLKSEGILFASTVGKNHMKEIREIISTFDIYNLTSESWEITDSFQLENGLKIVSEYFN
HHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHHHH
MVELKRYKDNLKVTDPVYILDYIFSMPGNNKVNLSSKDLKKIYDYLEDNIKEKENIYITK
HHHHHHHHCCCCCCCHHHHHHHHHHCCCCCEECCCHHHHHHHHHHHHHCCCCCCCEEEEE
DTGYFKGKK
CCCCCCCCC
>Mature Secondary Structure
MKDTSKKLFTTGEFAKKAGVTIRTLRYYDKIGLLVPSSHNELGHRLYSKEDFGKLQKILT
CCCCCCHHHCCHHHHHHCCCEEEEHHHHHHHCEEECCCCCHHHHHHHCHHHHHHHHHHHH
LKFIGLSLEDIANIMKYDLNHKDFKKSLEIQKEIMKKKIKHIQSIIKAIDEAADTIDFNK
HHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
EMDWDKFINIISAINSDKNWTQQYENASNLRARIAIHELFSTNKEGWMPWFFKELKQELS
CCCHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
MISPNCENHNEKINNENISELSNLDLKQSNIKILELGCGDASLWNKSFNHIPSNWEITLT
HCCCCCCCCCCCCCCCCHHHHHCCCCCCCCEEEEEECCCCHHHHCCHHHCCCCCCEEEEE
DFSEGMLKDAKKNLREKRSRFNFKIVNAENIPFEEESFNVVIANHMLYHVPNINKALKEI
CCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCEEEECCEEEECCCHHHHHHHH
NRVLKSEGILFASTVGKNHMKEIREIISTFDIYNLTSESWEITDSFQLENGLKIVSEYFN
HHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHHHH
MVELKRYKDNLKVTDPVYILDYIFSMPGNNKVNLSSKDLKKIYDYLEDNIKEKENIYITK
HHHHHHHHCCCCCCCHHHHHHHHHHCCCCCEECCCHHHHHHHHHHHHHCCCCCCCEEEEE
DTGYFKGKK
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]