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The map label for this gene is folK [H]

Identifier: 226948108

GI number: 226948108

Start: 1033039

End: 1033494

Strand: Direct

Name: folK [H]

Synonym: CLM_0973

Alternate gene names: 226948108

Gene position: 1033039-1033494 (Clockwise)

Preceding gene: 226948107

Following gene: 226948109

Centisome position: 24.86

GC content: 28.07

Gene sequence:

>456_bases
ATGCATACAGCTTATGTGGCCTTTGGTAGTAATATGGGTGAAAAAGAAAATTACATAAAAAGGGCATTGGAAAAGATAGA
AGAAAGAGGAATGAAAATAATTAAAGTGTCCTCTATATATGAAACAGAACCCTATGGAGTATTAGATCAAGATAGTTTTT
TAAATGGAGTAGTAAAAATAGAAACTAATTTAACTCCAGAAGATTTAATAGGGGAGCTTTTAAACATAGAAAAACAGTTA
GATAGAGTAAGAGAAAGAAGATGGGGACCTAGAACTATAGATTTAGATATTATTTTTTATGATGATTTAATAATAAATGA
AAAAGATTTAGTTATTCCTCATAAGGATATGGAAAACAGAGAGTTTGTACTAAAACCTTTGTGCGATATAGATGAAAATT
TTATACATCCGGTTTTAAAAAAATCAGTAAGACAATTATATGATGAGTTGAAGTAA

Upstream 100 bases:

>100_bases
TAAATATAAATTTCTATTTATTAAAAAGTTTTAAAAAAAATGAGAGTATTGTAAATAAAATATAAACATATATAGAAAAT
CCTTAAGGAAGTGATAATAT

Downstream 100 bases:

>100_bases
ATATTTCTAGTTTATTTTTAATATACTCCTCCAATAATATATATATAAACTAATATTATTAGTTTATATGCAATAAGTAA
AAAATATAAAATAAATAAAG

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase

Products: NA

Alternate protein names: Dihydroneopterin aldolase; DHNA; 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 151; Mature: 151

Protein sequence:

>151_residues
MHTAYVAFGSNMGEKENYIKRALEKIEERGMKIIKVSSIYETEPYGVLDQDSFLNGVVKIETNLTPEDLIGELLNIEKQL
DRVRERRWGPRTIDLDIIFYDDLIINEKDLVIPHKDMENREFVLKPLCDIDENFIHPVLKKSVRQLYDELK

Sequences:

>Translated_151_residues
MHTAYVAFGSNMGEKENYIKRALEKIEERGMKIIKVSSIYETEPYGVLDQDSFLNGVVKIETNLTPEDLIGELLNIEKQL
DRVRERRWGPRTIDLDIIFYDDLIINEKDLVIPHKDMENREFVLKPLCDIDENFIHPVLKKSVRQLYDELK
>Mature_151_residues
MHTAYVAFGSNMGEKENYIKRALEKIEERGMKIIKVSSIYETEPYGVLDQDSFLNGVVKIETNLTPEDLIGELLNIEKQL
DRVRERRWGPRTIDLDIIFYDDLIINEKDLVIPHKDMENREFVLKPLCDIDENFIHPVLKKSVRQLYDELK

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=141, Percent_Identity=44.6808510638298, Blast_Score=118, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6324073, Length=158, Percent_Identity=43.6708860759494, Blast_Score=120, Evalue=7e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006156
- InterPro:   IPR006157
- InterPro:   IPR000550 [H]

Pfam domain/function: PF02152 FolB; PF01288 HPPK [H]

EC number: =4.1.2.25; =2.7.6.3 [H]

Molecular weight: Translated: 17768; Mature: 17768

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS00794 HPPK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHTAYVAFGSNMGEKENYIKRALEKIEERGMKIIKVSSIYETEPYGVLDQDSFLNGVVKI
CCEEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEEECCEECCCCCCCCCCHHHHCCEEEE
ETNLTPEDLIGELLNIEKQLDRVRERRWGPRTIDLDIIFYDDLIINEKDLVIPHKDMENR
ECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCEEECCCCEEECCCCCCCC
EFVLKPLCDIDENFIHPVLKKSVRQLYDELK
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MHTAYVAFGSNMGEKENYIKRALEKIEERGMKIIKVSSIYETEPYGVLDQDSFLNGVVKI
CCEEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEEECCEECCCCCCCCCCHHHHCCEEEE
ETNLTPEDLIGELLNIEKQLDRVRERRWGPRTIDLDIIFYDDLIINEKDLVIPHKDMENR
ECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCEEECCCCEEECCCCCCCC
EFVLKPLCDIDENFIHPVLKKSVRQLYDELK
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2168367; 7798151; 11463916; 8385663 [H]