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The map label for this gene is cobC [H]

Identifier: 226948097

GI number: 226948097

Start: 1022819

End: 1023433

Strand: Direct

Name: cobC [H]

Synonym: CLM_0961

Alternate gene names: 226948097

Gene position: 1022819-1023433 (Clockwise)

Preceding gene: 226948096

Following gene: 226948098

Centisome position: 24.61

GC content: 26.5

Gene sequence:

>615_bases
ATGAATGTATATTTAGTAAGACATGGAGAAACGGAACACAACAAAAGAAAAAATTTTTATGGTAAGTTAGATGTAGGATT
AAATGAAAAGGGAGAAAAGCAAAGCTATAAAGTAGGAGAACTTTTAAAAGATGTAAAGTTCAATAAAATTTATATAAGTG
ATAGAAAAAGAACTAGAGAAACTGCAGAAAGAATCTTAGAGAAAAACAAATTTTATGATAAAGAAAAAAATATTATTTAT
AAAGATGAAAGAATAAATGAAATAGATTTTGGACTTTTTGAAGGGAAATCCTATGAGGAAATAGGCTCTTTATATCCAAA
GGAACAAGAGAAATGGGAAAAGGATTGGAAAAATTTTGCCCCGCCTAAAGGTGAAAGTGCAGTGGTATTTTATAATAGAG
TAGAAAATTTTATGAAACATATACAAAAAGAAGAGGATGGGAACTATTTAATAGTTACTCATGGAGGAGTAATAAGAATG
ATATATAGTTATATACTTCAGAATAATATGGATTTTTACTGGAATTTTGCTTCAAGAAATGGAGATATAACATTAATTAA
ATATGAATATGGAAATTTGTTTATAGATTACATATTGCCTACAAAGTTAATTTGA

Upstream 100 bases:

>100_bases
TATATTAAAGTTAAATCTATTTTGGGATACCTATTAGATATTTAATAATGTTTAAGTTAAAAAATATTTGCATCCAACTA
AATTAGAGTAGGAGAGAAAG

Downstream 100 bases:

>100_bases
GATTAGTACTATGTGAAAGTAGTTTCTTCTTTACAGGTCTTTTGAGTAAAGGTAAAATTATTTATGAGATAATACCGTTT
TTCTTAATTTTTGTTTATAC

Product: alpha-ribazole phosphatase

Products: NA

Alternate protein names: Alpha-ribazole-5'-phosphate phosphatase [H]

Number of amino acids: Translated: 204; Mature: 204

Protein sequence:

>204_residues
MNVYLVRHGETEHNKRKNFYGKLDVGLNEKGEKQSYKVGELLKDVKFNKIYISDRKRTRETAERILEKNKFYDKEKNIIY
KDERINEIDFGLFEGKSYEEIGSLYPKEQEKWEKDWKNFAPPKGESAVVFYNRVENFMKHIQKEEDGNYLIVTHGGVIRM
IYSYILQNNMDFYWNFASRNGDITLIKYEYGNLFIDYILPTKLI

Sequences:

>Translated_204_residues
MNVYLVRHGETEHNKRKNFYGKLDVGLNEKGEKQSYKVGELLKDVKFNKIYISDRKRTRETAERILEKNKFYDKEKNIIY
KDERINEIDFGLFEGKSYEEIGSLYPKEQEKWEKDWKNFAPPKGESAVVFYNRVENFMKHIQKEEDGNYLIVTHGGVIRM
IYSYILQNNMDFYWNFASRNGDITLIKYEYGNLFIDYILPTKLI
>Mature_204_residues
MNVYLVRHGETEHNKRKNFYGKLDVGLNEKGEKQSYKVGELLKDVKFNKIYISDRKRTRETAERILEKNKFYDKEKNIIY
KDERINEIDFGLFEGKSYEEIGSLYPKEQEKWEKDWKNFAPPKGESAVVFYNRVENFMKHIQKEEDGNYLIVTHGGVIRM
IYSYILQNNMDFYWNFASRNGDITLIKYEYGNLFIDYILPTKLI

Specific function: Converts N1-(5-phospho-alpha-D-ribosyl)-5,6- dimethylbenzimidazole into N1-alpha-D-ribosyl-5,6- dimethylbenzimidazole; involved in the assembly of the nucleotide loop of cobalamin [H]

COG id: COG0406

COG function: function code G; Fructose-2,6-bisphosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphoglycerate mutase family [H]

Homologues:

Organism=Homo sapiens, GI118582286, Length=173, Percent_Identity=31.2138728323699, Blast_Score=81, Evalue=5e-16,
Organism=Homo sapiens, GI4758902, Length=168, Percent_Identity=31.547619047619, Blast_Score=78, Evalue=6e-15,
Organism=Homo sapiens, GI9966849, Length=125, Percent_Identity=37.6, Blast_Score=77, Evalue=8e-15,
Organism=Homo sapiens, GI224282149, Length=173, Percent_Identity=30.0578034682081, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI4758900, Length=173, Percent_Identity=30.0578034682081, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI64762445, Length=175, Percent_Identity=29.7142857142857, Blast_Score=71, Evalue=7e-13,
Organism=Homo sapiens, GI64762406, Length=175, Percent_Identity=29.7142857142857, Blast_Score=70, Evalue=1e-12,
Organism=Escherichia coli, GI1790856, Length=194, Percent_Identity=29.8969072164948, Blast_Score=84, Evalue=7e-18,
Organism=Escherichia coli, GI1786857, Length=187, Percent_Identity=26.2032085561497, Blast_Score=82, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI25145314, Length=165, Percent_Identity=27.8787878787879, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71993390, Length=176, Percent_Identity=28.9772727272727, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17510917, Length=176, Percent_Identity=28.9772727272727, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324857, Length=191, Percent_Identity=27.7486910994764, Blast_Score=74, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6322306, Length=167, Percent_Identity=30.5389221556886, Blast_Score=66, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013078
- InterPro:   IPR001345
- InterPro:   IPR017578 [H]

Pfam domain/function: PF00300 PGAM [H]

EC number: =3.1.3.73 [H]

Molecular weight: Translated: 24505; Mature: 24505

Theoretical pI: Translated: 8.93; Mature: 8.93

Prosite motif: PS00175 PG_MUTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVYLVRHGETEHNKRKNFYGKLDVGLNEKGEKQSYKVGELLKDVKFNKIYISDRKRTRE
CEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHCCCCEEEECCCHHHHH
TAERILEKNKFYDKEKNIIYKDERINEIDFGLFEGKSYEEIGSLYPKEQEKWEKDWKNFA
HHHHHHHHHHCCCCCCCEEECCCCCCCCCCEEECCCCHHHHHCCCCCHHHHHHHHHHHCC
PPKGESAVVFYNRVENFMKHIQKEEDGNYLIVTHGGVIRMIYSYILQNNMDFYWNFASRN
CCCCCEEEEEHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHCCCCEEEEEECCC
GDITLIKYEYGNLFIDYILPTKLI
CCEEEEEEECCCEEEEEECCCCCC
>Mature Secondary Structure
MNVYLVRHGETEHNKRKNFYGKLDVGLNEKGEKQSYKVGELLKDVKFNKIYISDRKRTRE
CEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHCCCCEEEECCCHHHHH
TAERILEKNKFYDKEKNIIYKDERINEIDFGLFEGKSYEEIGSLYPKEQEKWEKDWKNFA
HHHHHHHHHHCCCCCCCEEECCCCCCCCCCEEECCCCHHHHHCCCCCHHHHHHHHHHHCC
PPKGESAVVFYNRVENFMKHIQKEEDGNYLIVTHGGVIRMIYSYILQNNMDFYWNFASRN
CCCCCEEEEEHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHCCCCEEEEEECCC
GDITLIKYEYGNLFIDYILPTKLI
CCEEEEEEECCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]