| Definition | Clostridium botulinum A2 str. Kyoto chromosome, complete genome. |
|---|---|
| Accession | NC_012563 |
| Length | 4,155,278 |
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The map label for this gene is uvrA [H]
Identifier: 226947990
GI number: 226947990
Start: 906686
End: 908923
Strand: Direct
Name: uvrA [H]
Synonym: CLM_0851
Alternate gene names: 226947990
Gene position: 906686-908923 (Clockwise)
Preceding gene: 226947989
Following gene: 226947991
Centisome position: 21.82
GC content: 31.99
Gene sequence:
>2238_bases ATGGAACAGGAATTTATAGTTTTAAAAGGATGTAAGGAAAATAATTTAAAAGATATTTCATTAAATATGCCTAAGAGAAA AATAACAATATTTACAGGGGTATCTGGTTCAGGGAAGTCATCAATTGTTTTTGAGACAGTAGCAAAGGAAGCTCAACGTC AATTGAATGAGACATTCACTGCCTTCATAAGAAATTTTTTACCTAAGTATGGTGAGGTTAAAGCTGATCAAATAGAAAAT TTATCAACGCCAATTATTATTGATCAAAGTAGGCTCGGTGGTAATTCAAGGTCAACTTTAGGTACTATTACAGATATAAA TTCATTCCTTAGAGCGCTATATTCAAGGTTTGGAAGTAATTATATCGGTAAGGCCAATATGTTTTCCTTTAATGATATTA ATGGCATGTGTCCGGAATGTCAGGGTCTTGGTAAAAAGTTGGTTCCAAATATGGAGGAGATATTTGATAAAAGTAAATCC CTAAATGAGGGAGCCATTTTACTTTCAGGTTTTGGAGTAGGTTCTTGGCATTGGAAAATATTTGCCCAGTCAGGATACTT TAATAATGATAAGAAAATATGTGATTATTCAGAAGAAGAATTAGATAAGTTTTTATATGGTGGGCCAGATAAAATTAAGA TAGATGAAACAGGTGGAATGAACGTAACCTATGAAGGCTTATTGGTTAAGTTTGATAGGCTATATTTAAAGAAAGAAGGA GAAACCTCTGAAGCTGCAAAGAAAAAACTAAATAAACTACTTATAGAAGACCAGTGCCCTACTTGTAGGGGGAAAAGGCT TCACCAAAGAGTATATGGATCTTTGATTAATGGTTATAATATAGCAGATTTAACTAGCATGCAAATTGATGAATTAGTTG AGGTAGTTAAAGAAATAAATGAGCCAGAAGCAGAACCTTTAGTTAAAGGGATAGTAGAAAAGCTAAATAATATTATAGAT ATAGGTCTTGGATATTTGACTTTAGATAGAGAAACTTCATCATTATCTGGTGGAGAATCTCAACGTATAAAGATGGTAAA GCATTTAAATAGTAATCTTGTAGATTTAATGTATATCTTTGATGAGCCTAGTATAGGTCTTCATCCAAGGGATGTCCATA AATTAAACAATCTATTAAAAAAGCTACGTGATAAAGGTAATACTGTAATAGTTGTTGAGCATGACCCTGATGTTATTAAA ATTGCAGACCATATTATAGATGTAGGCCCAAGGGCAGGTAAGTATGGTGGTGAAATTGTATATGAGGGAACCTATGAAAA TTTACTTGAATCAGGAACCTTAACTGGAAATGCCTTAAATAAAACTCTTTCTATTAAAGAAAAGGTAAGAGATCATAAGG GATATTTAAAGGTTGTAAATTGTAATAAAAATAATTTGAAAAATATATCTGTGACAATACCTAAGGGTGTATTAACAGTA GTAACAGGAGTTGCAGGTTCAGGTAAAAGTACATTAATTAAACATGAATTTTTAAAACAAAATAAAGATGCAATAATAGT AGATCAAAGTCCTGTGTCAGCTAATTCTAGGTCCAGCTTAGCCACTTATAGCGGAATTATGGATAATATAAGAAAGGCTT TTGCTAAGGCAAATGGCGTTAATGCATCATTATTTAGCTCAAATTCAAAAGGAGCCTGCGAAAATTGTAATGGAAGCGGA ATAATAGAAACAAATCTTGCATTTATGGAAAACATAAAAAGTACTTGCCATGTTTGTGAAGGCAAGAAGTATAAAAAAGA AGTTTTAGATTATAAATTACATGACAAAAACATAATAGAAGTTCTTGAAATGTCAGTTTCAGATGCAATTGAATTTTTTA ACTTAAAGTCAGTTAAGGCAAAACTGCAGTCTATAGAAGATATGGGCATTGGATATTTAACCTTAGGGCAAACTCTCGAT ACCTTATCTGGCGGAGAATGTCAAAGATTAAAGCTTGCCAGTGAATTGCATAATGAAAGTTCTATATATATATTGGATGA GCCTACAACAGGTCTTCATATGGCTGATATTGAAAAATTTATCAACATAGTTGAAAATATTGTGGACAGTGGCAATACAG TTATAATAATTGAACACAATGTAGATATAATTAAAAGAGCAGATTGGATTATTGATATGGGGCCTGATGGTGGAACAAAA GGTGGAGAGATAATATTTGAAGGGACTCCAAAACAATTATGTAATTGCCAAGTATCATTAACAGCTAAGTATATTTAG
Upstream 100 bases:
>100_bases AATACTGTAGTGTCTTATGAAAAGTGGGGATATATAAACACTGTATAAGGAAGCGAGAATAGATAAATTAAAAACAAAGG AGTGCCAAGGAGGAATATAG
Downstream 100 bases:
>100_bases TTTATAACTAAGGAGAATCCTAGTTATAGAACTCTCCCTCCACTTTAATTATAACATATGTAAAGCGTGAAATATAGACT ACTAAATTTTGAATCTAACT
Product: putative drug resistance ABC transporter ATP-binding protein
Products: NA
Alternate protein names: UvrA protein; Excinuclease ABC subunit A [H]
Number of amino acids: Translated: 745; Mature: 745
Protein sequence:
>745_residues MEQEFIVLKGCKENNLKDISLNMPKRKITIFTGVSGSGKSSIVFETVAKEAQRQLNETFTAFIRNFLPKYGEVKADQIEN LSTPIIIDQSRLGGNSRSTLGTITDINSFLRALYSRFGSNYIGKANMFSFNDINGMCPECQGLGKKLVPNMEEIFDKSKS LNEGAILLSGFGVGSWHWKIFAQSGYFNNDKKICDYSEEELDKFLYGGPDKIKIDETGGMNVTYEGLLVKFDRLYLKKEG ETSEAAKKKLNKLLIEDQCPTCRGKRLHQRVYGSLINGYNIADLTSMQIDELVEVVKEINEPEAEPLVKGIVEKLNNIID IGLGYLTLDRETSSLSGGESQRIKMVKHLNSNLVDLMYIFDEPSIGLHPRDVHKLNNLLKKLRDKGNTVIVVEHDPDVIK IADHIIDVGPRAGKYGGEIVYEGTYENLLESGTLTGNALNKTLSIKEKVRDHKGYLKVVNCNKNNLKNISVTIPKGVLTV VTGVAGSGKSTLIKHEFLKQNKDAIIVDQSPVSANSRSSLATYSGIMDNIRKAFAKANGVNASLFSSNSKGACENCNGSG IIETNLAFMENIKSTCHVCEGKKYKKEVLDYKLHDKNIIEVLEMSVSDAIEFFNLKSVKAKLQSIEDMGIGYLTLGQTLD TLSGGECQRLKLASELHNESSIYILDEPTTGLHMADIEKFINIVENIVDSGNTVIIIEHNVDIIKRADWIIDMGPDGGTK GGEIIFEGTPKQLCNCQVSLTAKYI
Sequences:
>Translated_745_residues MEQEFIVLKGCKENNLKDISLNMPKRKITIFTGVSGSGKSSIVFETVAKEAQRQLNETFTAFIRNFLPKYGEVKADQIEN LSTPIIIDQSRLGGNSRSTLGTITDINSFLRALYSRFGSNYIGKANMFSFNDINGMCPECQGLGKKLVPNMEEIFDKSKS LNEGAILLSGFGVGSWHWKIFAQSGYFNNDKKICDYSEEELDKFLYGGPDKIKIDETGGMNVTYEGLLVKFDRLYLKKEG ETSEAAKKKLNKLLIEDQCPTCRGKRLHQRVYGSLINGYNIADLTSMQIDELVEVVKEINEPEAEPLVKGIVEKLNNIID IGLGYLTLDRETSSLSGGESQRIKMVKHLNSNLVDLMYIFDEPSIGLHPRDVHKLNNLLKKLRDKGNTVIVVEHDPDVIK IADHIIDVGPRAGKYGGEIVYEGTYENLLESGTLTGNALNKTLSIKEKVRDHKGYLKVVNCNKNNLKNISVTIPKGVLTV VTGVAGSGKSTLIKHEFLKQNKDAIIVDQSPVSANSRSSLATYSGIMDNIRKAFAKANGVNASLFSSNSKGACENCNGSG IIETNLAFMENIKSTCHVCEGKKYKKEVLDYKLHDKNIIEVLEMSVSDAIEFFNLKSVKAKLQSIEDMGIGYLTLGQTLD TLSGGECQRLKLASELHNESSIYILDEPTTGLHMADIEKFINIVENIVDSGNTVIIIEHNVDIIKRADWIIDMGPDGGTK GGEIIFEGTPKQLCNCQVSLTAKYI >Mature_745_residues MEQEFIVLKGCKENNLKDISLNMPKRKITIFTGVSGSGKSSIVFETVAKEAQRQLNETFTAFIRNFLPKYGEVKADQIEN LSTPIIIDQSRLGGNSRSTLGTITDINSFLRALYSRFGSNYIGKANMFSFNDINGMCPECQGLGKKLVPNMEEIFDKSKS LNEGAILLSGFGVGSWHWKIFAQSGYFNNDKKICDYSEEELDKFLYGGPDKIKIDETGGMNVTYEGLLVKFDRLYLKKEG ETSEAAKKKLNKLLIEDQCPTCRGKRLHQRVYGSLINGYNIADLTSMQIDELVEVVKEINEPEAEPLVKGIVEKLNNIID IGLGYLTLDRETSSLSGGESQRIKMVKHLNSNLVDLMYIFDEPSIGLHPRDVHKLNNLLKKLRDKGNTVIVVEHDPDVIK IADHIIDVGPRAGKYGGEIVYEGTYENLLESGTLTGNALNKTLSIKEKVRDHKGYLKVVNCNKNNLKNISVTIPKGVLTV VTGVAGSGKSTLIKHEFLKQNKDAIIVDQSPVSANSRSSLATYSGIMDNIRKAFAKANGVNASLFSSNSKGACENCNGSG IIETNLAFMENIKSTCHVCEGKKYKKEVLDYKLHDKNIIEVLEMSVSDAIEFFNLKSVKAKLQSIEDMGIGYLTLGQTLD TLSGGECQRLKLASELHNESSIYILDEPTTGLHMADIEKFINIVENIVDSGNTVIIIEHNVDIIKRADWIIDMGPDGGTK GGEIIFEGTPKQLCNCQVSLTAKYI
Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion h
COG id: COG0178
COG function: function code L; Excinuclease ATPase subunit
Gene ontology:
Cell location: Cytoplasm [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 2 ABC transporter domains [H]
Homologues:
Organism=Escherichia coli, GI2367343, Length=685, Percent_Identity=37.2262773722628, Blast_Score=432, Evalue=1e-122,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR003439 - InterPro: IPR017871 - InterPro: IPR013815 - InterPro: IPR003593 - InterPro: IPR004602 [H]
Pfam domain/function: PF00005 ABC_tran [H]
EC number: NA
Molecular weight: Translated: 82455; Mature: 82455
Theoretical pI: Translated: 6.63; Mature: 6.63
Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.9 %Cys (Translated Protein) 2.0 %Met (Translated Protein) 3.9 %Cys+Met (Translated Protein) 1.9 %Cys (Mature Protein) 2.0 %Met (Mature Protein) 3.9 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MEQEFIVLKGCKENNLKDISLNMPKRKITIFTGVSGSGKSSIVFETVAKEAQRQLNETFT CCCCEEEEECCCCCCCEEEEECCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHH AFIRNFLPKYGEVKADQIENLSTPIIIDQSRLGGNSRSTLGTITDINSFLRALYSRFGSN HHHHHHCCCCCCCCHHHHHCCCCCEEEEHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCC YIGKANMFSFNDINGMCPECQGLGKKLVPNMEEIFDKSKSLNEGAILLSGFGVGSWHWKI CCCCCCCEEECCCCCCCCHHHCCCHHCCCCHHHHHHHCCCCCCCEEEEEECCCCCEEEEE FAQSGYFNNDKKICDYSEEELDKFLYGGPDKIKIDETGGMNVTYEGLLVKFDRLYLKKEG EEECCEECCCCCCCCCCHHHHHHHHCCCCCEEEEECCCCCEEEEHHHHEEEEHHHEECCC ETSEAAKKKLNKLLIEDQCPTCRGKRLHQRVYGSLINGYNIADLTSMQIDELVEVVKEIN CHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCC EPEAEPLVKGIVEKLNNIIDIGLGYLTLDRETSSLSGGESQRIKMVKHLNSNLVDLMYIF CCCCHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHHHHHCCCCCEEEEEEE DEPSIGLHPRDVHKLNNLLKKLRDKGNTVIVVEHDPDVIKIADHIIDVGPRAGKYGGEIV CCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHCCCCCCCCCCEEE YEGTYENLLESGTLTGNALNKTLSIKEKVRDHKGYLKVVNCNKNNLKNISVTIPKGVLTV ECCCHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEECCCCHHHH VTGVAGSGKSTLIKHEFLKQNKDAIIVDQSPVSANSRSSLATYSGIMDNIRKAFAKANGV HHCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCC NASLFSSNSKGACENCNGSGIIETNLAFMENIKSTCHVCEGKKYKKEVLDYKLHDKNIIE CEEEECCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCHHHHHHHCEECCCCHHHH VLEMSVSDAIEFFNLKSVKAKLQSIEDMGIGYLTLGQTLDTLSGGECQRLKLASELHNES HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHHCCCCCCHHHHHHHHHHCCCC SIYILDEPTTGLHMADIEKFINIVENIVDSGNTVIIIEHNVDIIKRADWIIDMGPDGGTK EEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEECCCEEEEECCCCCCC GGEIIFEGTPKQLCNCQVSLTAKYI CCEEEEECCCHHHHCEEEEEEEECC >Mature Secondary Structure MEQEFIVLKGCKENNLKDISLNMPKRKITIFTGVSGSGKSSIVFETVAKEAQRQLNETFT CCCCEEEEECCCCCCCEEEEECCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHH AFIRNFLPKYGEVKADQIENLSTPIIIDQSRLGGNSRSTLGTITDINSFLRALYSRFGSN HHHHHHCCCCCCCCHHHHHCCCCCEEEEHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCC YIGKANMFSFNDINGMCPECQGLGKKLVPNMEEIFDKSKSLNEGAILLSGFGVGSWHWKI CCCCCCCEEECCCCCCCCHHHCCCHHCCCCHHHHHHHCCCCCCCEEEEEECCCCCEEEEE FAQSGYFNNDKKICDYSEEELDKFLYGGPDKIKIDETGGMNVTYEGLLVKFDRLYLKKEG EEECCEECCCCCCCCCCHHHHHHHHCCCCCEEEEECCCCCEEEEHHHHEEEEHHHEECCC ETSEAAKKKLNKLLIEDQCPTCRGKRLHQRVYGSLINGYNIADLTSMQIDELVEVVKEIN CHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCC EPEAEPLVKGIVEKLNNIIDIGLGYLTLDRETSSLSGGESQRIKMVKHLNSNLVDLMYIF CCCCHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHHHHHCCCCCEEEEEEE DEPSIGLHPRDVHKLNNLLKKLRDKGNTVIVVEHDPDVIKIADHIIDVGPRAGKYGGEIV CCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHCCCCCCCCCCEEE YEGTYENLLESGTLTGNALNKTLSIKEKVRDHKGYLKVVNCNKNNLKNISVTIPKGVLTV ECCCHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEECCCCHHHH VTGVAGSGKSTLIKHEFLKQNKDAIIVDQSPVSANSRSSLATYSGIMDNIRKAFAKANGV HHCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCC NASLFSSNSKGACENCNGSGIIETNLAFMENIKSTCHVCEGKKYKKEVLDYKLHDKNIIE CEEEECCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCHHHHHHHCEECCCCHHHH VLEMSVSDAIEFFNLKSVKAKLQSIEDMGIGYLTLGQTLDTLSGGECQRLKLASELHNES HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHHCCCCCCHHHHHHHHHHCCCC SIYILDEPTTGLHMADIEKFINIVENIVDSGNTVIIIEHNVDIIKRADWIIDMGPDGGTK EEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEECCCEEEEECCCCCCC GGEIIFEGTPKQLCNCQVSLTAKYI CCEEEEECCCHHHHCEEEEEEEECC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: DNA [C]
Specific reaction: Protein + DNA = Protein-DNA [C]
General reaction: Hydrolase; Acting on ester bonds [C]
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 9371463 [H]