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The map label for this gene is mutS2 [H]

Identifier: 226947884

GI number: 226947884

Start: 794694

End: 796589

Strand: Direct

Name: mutS2 [H]

Synonym: CLM_0739

Alternate gene names: 226947884

Gene position: 794694-796589 (Clockwise)

Preceding gene: 226947883

Following gene: 226947885

Centisome position: 19.12

GC content: 27.9

Gene sequence:

>1896_bases
ATGAATAAAGCAGCACTAGAAAAATTACATTATTATGAATTAAAAGAAACGATAAAAGAATATTGCGTCAGCGGATTAGG
AAAAAGATTAATAGATAAATTGGAACCTAGTAGTAATATAAAGATTGTAAATCAAAGACTAGATGAAACATCTGAGGGAA
GAAGATTATTAGATGTCTCTTATAATATACCATTAGAGGGTATTTTTAATATATTGCCCCTTATTGAAAAAATTGAAAAA
GGAGCATCTTTAGAACCCACTGATTTGACTATGATGTCAAATTTTTTAAGAGGATGTAGGAAAGTTAAGTTATTCATAAA
AGACAAAGAGGGATATGCCCCTACATTGAGCGCTTATGGAGAGAATATTTGTGATTTGAGTTATATTGAAGAGGAAATAA
ATAGATCAATTAGAGGTAGTGTAGTTGACTCAAATGCTAGTAAGGAACTTAAAAAAATAAGAAGAAATATTGACATATGT
GAAAGTAGGATAAAGGAAAAATTAGATAAGTTCCTTAGAAATAGTGAAAATAAAGAGTATATTCAAGAATTCTTTATTAG
TCAGCGAGATGGAAAGCATACGATTGCAATTAAGGCAGCGTATAAAAATAAAGTAGAGGGAACTATCGTTGAAACATCTT
CAAAGGGAACAACAGTATTTATGGAGCCAAATGTTATTTCAAAGCATACGAGTGAATTAATAGTATTAAAAGCAGAAGAA
AGTGTAGAAGAATACAAAGTATTAGCCACTTTAACAGGAATGCTTTTTGAAAGAATAAAAGATTTGAAGATGAATGTCGA
TGTTATATCTGAATATGATATGATTTGGGCAAAAGCTAAATATAGTAAAGTAATAAATGGGATTAAACCTAAACTAAATG
ACTATGGATATATAAAAATAATTAAAGGAAAATATCCTCTTATTAAAGATAGTATACCTTTAGACTTTGAAATTGGAAAA
GATTATAGAGGATTAATAATAACAGGACCAAATGCAGGTGGTAAAACAATAGTATTAAAGACAATAGGGCTTCTAACATT
AGCAATACAATCTGGATTCCATATAGAAGCTGAGGAAGGAACAGAACTTTCAGTATTTAAAAAGTTATTTGTTGATATTG
GAGATAATCAAAGTGTTGAAAATGCATTAAGTACATTTTCATCTCATGTAAAAAATCTAGCTGAAATAATTAGAGAAAGT
ACAAAATCAACATTACTATTGTTTGATGAAATCGGTAGTGGAACAGAACCAAATGAGGGATCCGCTTTGGCTATTGCAAT
ATTAGAAGAATTGTATCATAAGGGCTCTATAACTATATCAACTACTCATTATGGAGAAATAAAAAACTTTTCAAAAGAAC
ATCCTGATTTTGAGAATGCAGCTATGGAGTTTGAGAAAGAAACTTTAGAACCATTATATAAACTTAGCATAGGAAAAGTT
GGAGATAGTAATGCTTTATATATTTCTAAAAAGATGGGATTATATGATTCAATTATTGATAGGGCAAGAAAATATATGGA
TACTAAAAGTTATAATTATAATTTAATAGAAGACAGCAAGATTATAAAAAATAAAGAGTTACAAGCAGAGGAAGATTTTT
ATGAATACTCTGTAGGGGATAAAGTTATTCTTTTAGAAAATAATGAATCAGCTATTGTATATAAAGAAAGAGATAGATTA
AATAATGTGACTATACTATACAATAAAGAATTTATTGACGTTAACTATAAAAGAATAAAACTAGAATTAAAGGCAAGTGA
ACTTTATCCAGAGGGGTATGATTTAAATCAGTTATTTATAAGTTATAAGGAAAGAAAGTTAGAAAAAGATATTAAGAGGG
GATCTAAAAAAGCATTAAAAAGAATAAAAAAAGAAACTTTAAAACGTTCTAAATAA

Upstream 100 bases:

>100_bases
GTGGGAGTATCCATAGCTTTTTTTATTATATAAAAATAGAAATCTATCAGGATTTCGTAGATTTGTATTGTAATAAAAAA
TACAGGGAGAGATCATTAAG

Downstream 100 bases:

>100_bases
TATTTATTAAACCTGTAGACAATTTAATTAAAGATATAAAAAGTGTTAGAAAAAATTTATCTAAAGCAAAAATATTAAAT
GAATCAAACAATAATTTTAA

Product: MutS domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 631; Mature: 631

Protein sequence:

>631_residues
MNKAALEKLHYYELKETIKEYCVSGLGKRLIDKLEPSSNIKIVNQRLDETSEGRRLLDVSYNIPLEGIFNILPLIEKIEK
GASLEPTDLTMMSNFLRGCRKVKLFIKDKEGYAPTLSAYGENICDLSYIEEEINRSIRGSVVDSNASKELKKIRRNIDIC
ESRIKEKLDKFLRNSENKEYIQEFFISQRDGKHTIAIKAAYKNKVEGTIVETSSKGTTVFMEPNVISKHTSELIVLKAEE
SVEEYKVLATLTGMLFERIKDLKMNVDVISEYDMIWAKAKYSKVINGIKPKLNDYGYIKIIKGKYPLIKDSIPLDFEIGK
DYRGLIITGPNAGGKTIVLKTIGLLTLAIQSGFHIEAEEGTELSVFKKLFVDIGDNQSVENALSTFSSHVKNLAEIIRES
TKSTLLLFDEIGSGTEPNEGSALAIAILEELYHKGSITISTTHYGEIKNFSKEHPDFENAAMEFEKETLEPLYKLSIGKV
GDSNALYISKKMGLYDSIIDRARKYMDTKSYNYNLIEDSKIIKNKELQAEEDFYEYSVGDKVILLENNESAIVYKERDRL
NNVTILYNKEFIDVNYKRIKLELKASELYPEGYDLNQLFISYKERKLEKDIKRGSKKALKRIKKETLKRSK

Sequences:

>Translated_631_residues
MNKAALEKLHYYELKETIKEYCVSGLGKRLIDKLEPSSNIKIVNQRLDETSEGRRLLDVSYNIPLEGIFNILPLIEKIEK
GASLEPTDLTMMSNFLRGCRKVKLFIKDKEGYAPTLSAYGENICDLSYIEEEINRSIRGSVVDSNASKELKKIRRNIDIC
ESRIKEKLDKFLRNSENKEYIQEFFISQRDGKHTIAIKAAYKNKVEGTIVETSSKGTTVFMEPNVISKHTSELIVLKAEE
SVEEYKVLATLTGMLFERIKDLKMNVDVISEYDMIWAKAKYSKVINGIKPKLNDYGYIKIIKGKYPLIKDSIPLDFEIGK
DYRGLIITGPNAGGKTIVLKTIGLLTLAIQSGFHIEAEEGTELSVFKKLFVDIGDNQSVENALSTFSSHVKNLAEIIRES
TKSTLLLFDEIGSGTEPNEGSALAIAILEELYHKGSITISTTHYGEIKNFSKEHPDFENAAMEFEKETLEPLYKLSIGKV
GDSNALYISKKMGLYDSIIDRARKYMDTKSYNYNLIEDSKIIKNKELQAEEDFYEYSVGDKVILLENNESAIVYKERDRL
NNVTILYNKEFIDVNYKRIKLELKASELYPEGYDLNQLFISYKERKLEKDIKRGSKKALKRIKKETLKRSK
>Mature_631_residues
MNKAALEKLHYYELKETIKEYCVSGLGKRLIDKLEPSSNIKIVNQRLDETSEGRRLLDVSYNIPLEGIFNILPLIEKIEK
GASLEPTDLTMMSNFLRGCRKVKLFIKDKEGYAPTLSAYGENICDLSYIEEEINRSIRGSVVDSNASKELKKIRRNIDIC
ESRIKEKLDKFLRNSENKEYIQEFFISQRDGKHTIAIKAAYKNKVEGTIVETSSKGTTVFMEPNVISKHTSELIVLKAEE
SVEEYKVLATLTGMLFERIKDLKMNVDVISEYDMIWAKAKYSKVINGIKPKLNDYGYIKIIKGKYPLIKDSIPLDFEIGK
DYRGLIITGPNAGGKTIVLKTIGLLTLAIQSGFHIEAEEGTELSVFKKLFVDIGDNQSVENALSTFSSHVKNLAEIIRES
TKSTLLLFDEIGSGTEPNEGSALAIAILEELYHKGSITISTTHYGEIKNFSKEHPDFENAAMEFEKETLEPLYKLSIGKV
GDSNALYISKKMGLYDSIIDRARKYMDTKSYNYNLIEDSKIIKNKELQAEEDFYEYSVGDKVILLENNESAIVYKERDRL
NNVTILYNKEFIDVNYKRIKLELKASELYPEGYDLNQLFISYKERKLEKDIKRGSKKALKRIKKETLKRSK

Specific function: This Protein Is Involved In The Repair Of Mismatches In DNA. It Is Possible That It Carries Out The Mismatch Recognition Step. This Protein Has A Weak Atpase Activity. [C]

COG id: COG1193

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Smr domain [H]

Homologues:

Organism=Homo sapiens, GI284813531, Length=321, Percent_Identity=28.0373831775701, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI36949366, Length=266, Percent_Identity=28.1954887218045, Blast_Score=102, Evalue=8e-22,
Organism=Homo sapiens, GI26638666, Length=311, Percent_Identity=27.0096463022508, Blast_Score=95, Evalue=3e-19,
Organism=Homo sapiens, GI4505253, Length=311, Percent_Identity=27.0096463022508, Blast_Score=95, Evalue=3e-19,
Organism=Homo sapiens, GI4557761, Length=294, Percent_Identity=26.8707482993197, Blast_Score=91, Evalue=4e-18,
Organism=Homo sapiens, GI26638664, Length=312, Percent_Identity=26.9230769230769, Blast_Score=91, Evalue=4e-18,
Organism=Homo sapiens, GI4504191, Length=276, Percent_Identity=25.7246376811594, Blast_Score=89, Evalue=2e-17,
Organism=Homo sapiens, GI262231786, Length=232, Percent_Identity=28.8793103448276, Blast_Score=84, Evalue=4e-16,
Organism=Escherichia coli, GI1789089, Length=261, Percent_Identity=26.0536398467433, Blast_Score=103, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17508445, Length=415, Percent_Identity=25.3012048192771, Blast_Score=95, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17508447, Length=220, Percent_Identity=29.0909090909091, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17534743, Length=187, Percent_Identity=29.9465240641711, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17539736, Length=254, Percent_Identity=24.8031496062992, Blast_Score=76, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6324482, Length=548, Percent_Identity=23.9051094890511, Blast_Score=102, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6319935, Length=382, Percent_Identity=27.4869109947644, Blast_Score=99, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6320302, Length=284, Percent_Identity=26.056338028169, Blast_Score=96, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6321912, Length=228, Percent_Identity=24.1228070175439, Blast_Score=78, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6321109, Length=241, Percent_Identity=26.9709543568465, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24664545, Length=298, Percent_Identity=27.5167785234899, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI24584320, Length=204, Percent_Identity=25.9803921568627, Blast_Score=77, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005747
- InterPro:   IPR000432
- InterPro:   IPR007696
- InterPro:   IPR002625 [H]

Pfam domain/function: PF05192 MutS_III; PF00488 MutS_V; PF01713 Smr [H]

EC number: NA

Molecular weight: Translated: 72123; Mature: 72123

Theoretical pI: Translated: 8.19; Mature: 8.19

Prosite motif: PS00486 DNA_MISMATCH_REPAIR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKAALEKLHYYELKETIKEYCVSGLGKRLIDKLEPSSNIKIVNQRLDETSEGRRLLDVS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHCCCCCCCEEEEEE
YNIPLEGIFNILPLIEKIEKGASLEPTDLTMMSNFLRGCRKVKLFIKDKEGYAPTLSAYG
ECCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHEEEEEEECCCCCCCCHHHCC
ENICDLSYIEEEINRSIRGSVVDSNASKELKKIRRNIDICESRIKEKLDKFLRNSENKEY
CCCCHHHHHHHHHCHHHCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
IQEFFISQRDGKHTIAIKAAYKNKVEGTIVETSSKGTTVFMEPNVISKHTSELIVLKAEE
HHHHHHCCCCCCEEEEEEEECCCCCCCEEEEECCCCCEEEECCCHHCCCCCCEEEEEEHH
SVEEYKVLATLTGMLFERIKDLKMNVDVISEYDMIWAKAKYSKVINGIKPKLNDYGYIKI
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEE
IKGKYPLIKDSIPLDFEIGKDYRGLIITGPNAGGKTIVLKTIGLLTLAIQSGFHIEAEEG
EECCCCCCCCCCCCEEEECCCCCEEEEECCCCCCCEEEEHHHHHHHHHHHCCCEEECCCC
TELSVFKKLFVDIGDNQSVENALSTFSSHVKNLAEIIRESTKSTLLLFDEIGSGTEPNEG
CHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCC
SALAIAILEELYHKGSITISTTHYGEIKNFSKEHPDFENAAMEFEKETLEPLYKLSIGKV
CCHHHHHHHHHHHCCCEEEEEECCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
GDSNALYISKKMGLYDSIIDRARKYMDTKSYNYNLIEDSKIIKNKELQAEEDFYEYSVGD
CCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCEEECCCHHHCCCCCCCHHHHHHCCCCC
KVILLENNESAIVYKERDRLNNVTILYNKEFIDVNYKRIKLELKASELYPEGYDLNQLFI
EEEEEECCCCEEEEECCCCCCCEEEEEECEEEECCEEEEEEEEEHHHCCCCCCCHHHHHH
SYKERKLEKDIKRGSKKALKRIKKETLKRSK
HHHHHHHHHHHHHCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNKAALEKLHYYELKETIKEYCVSGLGKRLIDKLEPSSNIKIVNQRLDETSEGRRLLDVS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHCCCCCCCEEEEEE
YNIPLEGIFNILPLIEKIEKGASLEPTDLTMMSNFLRGCRKVKLFIKDKEGYAPTLSAYG
ECCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHEEEEEEECCCCCCCCHHHCC
ENICDLSYIEEEINRSIRGSVVDSNASKELKKIRRNIDICESRIKEKLDKFLRNSENKEY
CCCCHHHHHHHHHCHHHCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
IQEFFISQRDGKHTIAIKAAYKNKVEGTIVETSSKGTTVFMEPNVISKHTSELIVLKAEE
HHHHHHCCCCCCEEEEEEEECCCCCCCEEEEECCCCCEEEECCCHHCCCCCCEEEEEEHH
SVEEYKVLATLTGMLFERIKDLKMNVDVISEYDMIWAKAKYSKVINGIKPKLNDYGYIKI
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEE
IKGKYPLIKDSIPLDFEIGKDYRGLIITGPNAGGKTIVLKTIGLLTLAIQSGFHIEAEEG
EECCCCCCCCCCCCEEEECCCCCEEEEECCCCCCCEEEEHHHHHHHHHHHCCCEEECCCC
TELSVFKKLFVDIGDNQSVENALSTFSSHVKNLAEIIRESTKSTLLLFDEIGSGTEPNEG
CHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCC
SALAIAILEELYHKGSITISTTHYGEIKNFSKEHPDFENAAMEFEKETLEPLYKLSIGKV
CCHHHHHHHHHHHCCCEEEEEECCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
GDSNALYISKKMGLYDSIIDRARKYMDTKSYNYNLIEDSKIIKNKELQAEEDFYEYSVGD
CCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCEEECCCHHHCCCCCCCHHHHHHCCCCC
KVILLENNESAIVYKERDRLNNVTILYNKEFIDVNYKRIKLELKASELYPEGYDLNQLFI
EEEEEECCCCEEEEECCCCCCCEEEEEECEEEECCEEEEEEEEEHHHCCCCCCCHHHHHH
SYKERKLEKDIKRGSKKALKRIKKETLKRSK
HHHHHHHHHHHHHCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA