Click here to switch to the map view.

The map label for this gene is gloA [H]

Identifier: 226947883

GI number: 226947883

Start: 793963

End: 794349

Strand: Direct

Name: gloA [H]

Synonym: CLM_0738

Alternate gene names: 226947883

Gene position: 793963-794349 (Clockwise)

Preceding gene: 226947881

Following gene: 226947884

Centisome position: 19.11

GC content: 29.46

Gene sequence:

>387_bases
ATGAATATTAAGTTCAATACAATTACTGTGAAAGATTTAGATGAATCATTAAAATTTTATAAAGAAGTTTTAGGATTTAT
GGAGATAAAAAGATTCAATCCTATGGAGGGAATTACTATAGCTTTTTTAAAAGATGAAGATTCAGGATTAATTGAATTAA
TTGAGTATCAAAACACTTCCAAGGATGATAATATTAGAGAATCAATTGTGTCAATCGGTATAGGAGTTGGAGATTTAGAA
AGGACTTTAAATGAACTAAAGGACAAAGGAGTAGAAATCATACGCGGTCCAATAGAAGTTCCAAGTGGAGAAAAGTTTGC
ATTCATAAAAGATCCTAATGGTGTTGAGATAGAATTAATCCAAGGATTCGATATACTTATGTCATAG

Upstream 100 bases:

>100_bases
TAATAGTGTTCTTATTTATTTTAAAGTCAGTTAAAAGGATAATAAAAGAAGTAGTAGAATTGTAGTTAATATAAAAATAA
TTCAATGTGGAGGAGAAATT

Downstream 100 bases:

>100_bases
GAAAATTGACAATTAGACTGGATTTAATGTATATTATATTTAAGATAGATTTCAAAAAAGAAGCGAGGGAATTTTGTGAG
TGTCTAGTATCTAAAATAGT

Product: lactoylglutathione lyase

Products: NA

Alternate protein names: Aldoketomutase; Glyoxalase I; Glx I; Ketone-aldehyde mutase; Methylglyoxalase; S-D-lactoylglutathione methylglyoxal lyase [H]

Number of amino acids: Translated: 128; Mature: 128

Protein sequence:

>128_residues
MNIKFNTITVKDLDESLKFYKEVLGFMEIKRFNPMEGITIAFLKDEDSGLIELIEYQNTSKDDNIRESIVSIGIGVGDLE
RTLNELKDKGVEIIRGPIEVPSGEKFAFIKDPNGVEIELIQGFDILMS

Sequences:

>Translated_128_residues
MNIKFNTITVKDLDESLKFYKEVLGFMEIKRFNPMEGITIAFLKDEDSGLIELIEYQNTSKDDNIRESIVSIGIGVGDLE
RTLNELKDKGVEIIRGPIEVPSGEKFAFIKDPNGVEIELIQGFDILMS
>Mature_128_residues
MNIKFNTITVKDLDESLKFYKEVLGFMEIKRFNPMEGITIAFLKDEDSGLIELIEYQNTSKDDNIRESIVSIGIGVGDLE
RTLNELKDKGVEIIRGPIEVPSGEKFAFIKDPNGVEIELIQGFDILMS

Specific function: Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione [H]

COG id: COG0346

COG function: function code E; Lactoylglutathione lyase and related lyases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glyoxalase I family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004360
- InterPro:   IPR004361
- InterPro:   IPR018146 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: =4.4.1.5 [H]

Molecular weight: Translated: 14473; Mature: 14473

Theoretical pI: Translated: 4.21; Mature: 4.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIKFNTITVKDLDESLKFYKEVLGFMEIKRFNPMEGITIAFLKDEDSGLIELIEYQNTS
CCEEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCEEEEEECCCCC
KDDNIRESIVSIGIGVGDLERTLNELKDKGVEIIRGPIEVPSGEKFAFIKDPNGVEIELI
CCCHHHHHHHHHCCCCCHHHHHHHHHHHCCEEEEECCCCCCCCCEEEEEECCCCCEEEEE
QGFDILMS
CCEEECCC
>Mature Secondary Structure
MNIKFNTITVKDLDESLKFYKEVLGFMEIKRFNPMEGITIAFLKDEDSGLIELIEYQNTS
CCEEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCEEEEEECCCCC
KDDNIRESIVSIGIGVGDLERTLNELKDKGVEIIRGPIEVPSGEKFAFIKDPNGVEIELI
CCCHHHHHHHHHCCCCCHHHHHHHHHHHCCEEEEECCCCCCCCCEEEEEECCCCCEEEEE
QGFDILMS
CCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]