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The map label for this gene is fhuB [H]

Identifier: 226947543

GI number: 226947543

Start: 399795

End: 400823

Strand: Direct

Name: fhuB [H]

Synonym: CLM_0379

Alternate gene names: 226947543

Gene position: 399795-400823 (Clockwise)

Preceding gene: 226947542

Following gene: 226947544

Centisome position: 9.62

GC content: 33.62

Gene sequence:

>1029_bases
ATGGGAAATGAAACTGTAATAACAGATAAAAAAAGTAAATTAAGCTTTACTTTATATATGATTATTGGGCTTATATTTTT
AATTATTGTTATAGTCGGATCTATTTCTTTTGGTGCTGCCAAAATGGATATAGATACAGCATGGAAAGCCATATTAGAAT
TTAATTCAGATATAACAGAGCATCAAATTATTAGAACGCTGCGTTTGCCTCGTACTTTTGGAGATATGGTTGTAGGGGCA
AGTCTTGCAGTAGCAGGTGCAATAATGCAAGGAAGTACAAGAAACCCTTTAGCAGACTCAGGACTAATGGGAGTAAATTC
AGGAGCTACTTTTTTAATAGCTTTATGCCTTGCTTTTTATCCAGGACATACCTATTTTAAACTTAGTATGTTTTCGTTTG
TAGGAGCAGGAATTGGAGTTGGAGTAACTTATTTTATTGCATCATTAAGTAAAAGAGGAATCACACCTCAAAGACTTGTA
CTATCTGGTATATCTATATCTATGCTTTTTAGTGCTATGAGTTCATTTATAGGCATTAAGTATAATATTGGTCAACAGCT
TAGCTATTGGTCAGCAGGGGGTGTTGCTAGCATTTCATGGAGTGAACTTATGGTAGTAATGCCAGCTTTTATAATAGGCA
TAATAGTATCTATTATTATTTCTCCTTCAATTACTATGTTAAGTTTAGGAGAAGAAGTAGCTAAAGGGTTAGGACAGAAA
ACTATAATGATTAAATTTATTGCATCCTTGGTTGTACTTATATTAGCTGGAATTTCTGTTTCCATAGCAGGACCTATAGG
ATTTGTAGGCCTTATTGTACCTCATATAATTAGGTTTTTTGTAGGGGTAGATTATAGATATATTATACCAGCTTCTGCCT
TATATGGTGCTTGTTTTATGGTAGCAGCTGATCTTATGGGAAGGTTAATTAATAGACCATATGAGACTCCACTAGGAATA
ATATTTGCTATTATAGGAGTACCTTTCTTTCTCTATATATCTCGCAGAGAAAGGAGAGCTTTTGAATGA

Upstream 100 bases:

>100_bases
TCTATTTTAATTGAATATTTATTATTATATGTAATTTATATAGATGATTGTATTATCCCTTTTTAAAAAACTTAAAGAAA
CAACTATGAGGAAGGTTAAT

Downstream 100 bases:

>100_bases
AGAAATGTGGCATGTATAAAAAAATAGCAACAATTTTTGCTTTAACTTTACTTTTATTTGTAGCAATTATTATTAGTATG
AATTTAGGTAAGATGAATTT

Product: ferrichrome transport system permease FhuB

Products: ADP; phosphate; iron dicitrate [Cytoplasm] [C]

Alternate protein names: Ferric hydroxamate uptake protein B; Ferrichrome transport system permease protein fhuB; Iron(III)-hydroxamate import system permease protein fhuB [H]

Number of amino acids: Translated: 342; Mature: 341

Protein sequence:

>342_residues
MGNETVITDKKSKLSFTLYMIIGLIFLIIVIVGSISFGAAKMDIDTAWKAILEFNSDITEHQIIRTLRLPRTFGDMVVGA
SLAVAGAIMQGSTRNPLADSGLMGVNSGATFLIALCLAFYPGHTYFKLSMFSFVGAGIGVGVTYFIASLSKRGITPQRLV
LSGISISMLFSAMSSFIGIKYNIGQQLSYWSAGGVASISWSELMVVMPAFIIGIIVSIIISPSITMLSLGEEVAKGLGQK
TIMIKFIASLVVLILAGISVSIAGPIGFVGLIVPHIIRFFVGVDYRYIIPASALYGACFMVAADLMGRLINRPYETPLGI
IFAIIGVPFFLYISRRERRAFE

Sequences:

>Translated_342_residues
MGNETVITDKKSKLSFTLYMIIGLIFLIIVIVGSISFGAAKMDIDTAWKAILEFNSDITEHQIIRTLRLPRTFGDMVVGA
SLAVAGAIMQGSTRNPLADSGLMGVNSGATFLIALCLAFYPGHTYFKLSMFSFVGAGIGVGVTYFIASLSKRGITPQRLV
LSGISISMLFSAMSSFIGIKYNIGQQLSYWSAGGVASISWSELMVVMPAFIIGIIVSIIISPSITMLSLGEEVAKGLGQK
TIMIKFIASLVVLILAGISVSIAGPIGFVGLIVPHIIRFFVGVDYRYIIPASALYGACFMVAADLMGRLINRPYETPLGI
IFAIIGVPFFLYISRRERRAFE
>Mature_341_residues
GNETVITDKKSKLSFTLYMIIGLIFLIIVIVGSISFGAAKMDIDTAWKAILEFNSDITEHQIIRTLRLPRTFGDMVVGAS
LAVAGAIMQGSTRNPLADSGLMGVNSGATFLIALCLAFYPGHTYFKLSMFSFVGAGIGVGVTYFIASLSKRGITPQRLVL
SGISISMLFSAMSSFIGIKYNIGQQLSYWSAGGVASISWSELMVVMPAFIIGIIVSIIISPSITMLSLGEEVAKGLGQKT
IMIKFIASLVVLILAGISVSIAGPIGFVGLIVPHIIRFFVGVDYRYIIPASALYGACFMVAADLMGRLINRPYETPLGII
FAIIGVPFFLYISRRERRAFE

Specific function: Part of the ABC transporter complex fhuBGCD involved in iron(3+)-hydroxamate import. Responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790741, Length=294, Percent_Identity=32.312925170068, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI1790740, Length=317, Percent_Identity=30.2839116719243, Blast_Score=149, Evalue=3e-37,
Organism=Escherichia coli, GI1786805, Length=281, Percent_Identity=33.4519572953737, Blast_Score=149, Evalue=3e-37,
Organism=Escherichia coli, GI1788004, Length=282, Percent_Identity=33.3333333333333, Blast_Score=128, Evalue=4e-31,
Organism=Escherichia coli, GI1786347, Length=343, Percent_Identity=27.6967930029155, Blast_Score=121, Evalue=5e-29,
Organism=Escherichia coli, GI1786804, Length=279, Percent_Identity=27.2401433691756, Blast_Score=91, Evalue=9e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 36847; Mature: 36715

Theoretical pI: Translated: 9.85; Mature: 9.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGNETVITDKKSKLSFTLYMIIGLIFLIIVIVGSISFGAAKMDIDTAWKAILEFNSDITE
CCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCHHHHHHHHHHHCCCCHH
HQIIRTLRLPRTFGDMVVGASLAVAGAIMQGSTRNPLADSGLMGVNSGATFLIALCLAFY
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHC
PGHTYFKLSMFSFVGAGIGVGVTYFIASLSKRGITPQRLVLSGISISMLFSAMSSFIGIK
CCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHCHHHHHHHHHHHHHHCEE
YNIGQQLSYWSAGGVASISWSELMVVMPAFIIGIIVSIIISPSITMLSLGEEVAKGLGQK
ECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCH
TIMIKFIASLVVLILAGISVSIAGPIGFVGLIVPHIIRFFVGVDYRYIIPASALYGACFM
HHHHHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHH
VAADLMGRLINRPYETPLGIIFAIIGVPFFLYISRRERRAFE
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
GNETVITDKKSKLSFTLYMIIGLIFLIIVIVGSISFGAAKMDIDTAWKAILEFNSDITE
CCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCHHHHHHHHHHHCCCCHH
HQIIRTLRLPRTFGDMVVGASLAVAGAIMQGSTRNPLADSGLMGVNSGATFLIALCLAFY
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHC
PGHTYFKLSMFSFVGAGIGVGVTYFIASLSKRGITPQRLVLSGISISMLFSAMSSFIGIK
CCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHCHHHHHHHHHHHHHHCEE
YNIGQQLSYWSAGGVASISWSELMVVMPAFIIGIIVSIIISPSITMLSLGEEVAKGLGQK
ECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCH
TIMIKFIASLVVLILAGISVSIAGPIGFVGLIVPHIIRFFVGVDYRYIIPASALYGACFM
HHHHHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHH
VAADLMGRLINRPYETPLGIIFAIIGVPFFLYISRRERRAFE
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron dicitrate [Periplasm]; H2O [C]

Specific reaction: ATP + iron dicitrate [Periplasm] + H2O = ADP + phosphate + iron dicitrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9639930; 9384377; 8388528 [H]