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The map label for this gene is tpiA [H]

Identifier: 226947449

GI number: 226947449

Start: 264737

End: 265483

Strand: Direct

Name: tpiA [H]

Synonym: CLM_0278

Alternate gene names: 226947449

Gene position: 264737-265483 (Clockwise)

Preceding gene: 226947448

Following gene: 226947450

Centisome position: 6.37

GC content: 32.26

Gene sequence:

>747_bases
ATGAGAACAGCCATAATAGCAGGAAACTGGAAAATGAACAAAACTGTAAAAGAAGCAGTAGAATTGGTTAAAGAATTAAA
ACCACTTGTTAAAGATGCAAAATGTGATGTAGTTGTATGTCCTACTTATGTATGCCTTCCAGCGGTATTAGAAGAAGTTA
AAGGAAGTAATATAAAAGTAGGTGCTCAAAATATGCACTTTGAAGAAAGTGGAGCTTATACAGGTGAAATAGCACCTAAA
ATGTTAGAAGAACTAGGAGTTCATTATGTAATTATAGGACATAGTGAAAGAAGACAATACTTTAATGAAACAGATGAAAC
TGTAAACAAAAAAGTAAAAAAAGCCTTTGAACATAATTTAATTCCAATAGTTTGTTGTGGAGAAAGCTTAGAAGAAAGAG
AAGGAAACATAACAGAAAAAGTTTTAGAAGGACAAATAAAAGTTGGATTAAAAGAATTAAGCAAAGAACAAGTAGAAAAA
TTAGTTATAGCATATGAACCAATTTGGGCTATAGGAACAGGAAAAACTGCTACAGATGAACAAGCAAATGAAACTATAGG
ATATATAAGAACTGTAGTAAAAGATATGTATGGTGAGAGTGTTGCAGATAAAGTAAGGATTCAATACGGTGGATCTGTTA
AGCCTGGCACTATCAAAGCTCAAATGGCTAAAGAAGAGATTGATGGTGCATTAGTAGGGGGCGCAAGCTTAAAAGCAAAA
GATTTTGCTGCTATAGTAAATTATTAA

Upstream 100 bases:

>100_bases
AAAGAACTACCGGGAATAGCGGCTCTTAACGATAAATAAAAGACAGAAAATAAATAGTTACACAGTATTACTTATAAAAT
GTATTGGAGCGTGATTTTAA

Downstream 100 bases:

>100_bases
AAGTGACAAGTGACAAGCTATAAGTTACAAATTGTTTTATATTAGCACTTCTCATTTGTATATTTTCATTTAATGAGATT
TGGAGGTAAAAATGAGTAAA

Product: triosephosphate isomerase

Products: NA

Alternate protein names: TIM; Triose-phosphate isomerase [H]

Number of amino acids: Translated: 248; Mature: 248

Protein sequence:

>248_residues
MRTAIIAGNWKMNKTVKEAVELVKELKPLVKDAKCDVVVCPTYVCLPAVLEEVKGSNIKVGAQNMHFEESGAYTGEIAPK
MLEELGVHYVIIGHSERRQYFNETDETVNKKVKKAFEHNLIPIVCCGESLEEREGNITEKVLEGQIKVGLKELSKEQVEK
LVIAYEPIWAIGTGKTATDEQANETIGYIRTVVKDMYGESVADKVRIQYGGSVKPGTIKAQMAKEEIDGALVGGASLKAK
DFAAIVNY

Sequences:

>Translated_248_residues
MRTAIIAGNWKMNKTVKEAVELVKELKPLVKDAKCDVVVCPTYVCLPAVLEEVKGSNIKVGAQNMHFEESGAYTGEIAPK
MLEELGVHYVIIGHSERRQYFNETDETVNKKVKKAFEHNLIPIVCCGESLEEREGNITEKVLEGQIKVGLKELSKEQVEK
LVIAYEPIWAIGTGKTATDEQANETIGYIRTVVKDMYGESVADKVRIQYGGSVKPGTIKAQMAKEEIDGALVGGASLKAK
DFAAIVNY
>Mature_248_residues
MRTAIIAGNWKMNKTVKEAVELVKELKPLVKDAKCDVVVCPTYVCLPAVLEEVKGSNIKVGAQNMHFEESGAYTGEIAPK
MLEELGVHYVIIGHSERRQYFNETDETVNKKVKKAFEHNLIPIVCCGESLEEREGNITEKVLEGQIKVGLKELSKEQVEK
LVIAYEPIWAIGTGKTATDEQANETIGYIRTVVKDMYGESVADKVRIQYGGSVKPGTIKAQMAKEEIDGALVGGASLKAK
DFAAIVNY

Specific function: Plays an important role in several metabolic pathways. [C]

COG id: COG0149

COG function: function code G; Triosephosphate isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the triosephosphate isomerase family [H]

Homologues:

Organism=Homo sapiens, GI226529917, Length=249, Percent_Identity=42.570281124498, Blast_Score=180, Evalue=1e-45,
Organism=Homo sapiens, GI4507645, Length=249, Percent_Identity=42.570281124498, Blast_Score=179, Evalue=2e-45,
Organism=Escherichia coli, GI1790353, Length=247, Percent_Identity=44.9392712550607, Blast_Score=198, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI17536593, Length=246, Percent_Identity=42.2764227642276, Blast_Score=177, Evalue=3e-45,
Organism=Saccharomyces cerevisiae, GI6320255, Length=246, Percent_Identity=38.6178861788618, Blast_Score=169, Evalue=4e-43,
Organism=Drosophila melanogaster, GI28572008, Length=247, Percent_Identity=40.080971659919, Blast_Score=176, Evalue=1e-44,
Organism=Drosophila melanogaster, GI28572006, Length=247, Percent_Identity=40.080971659919, Blast_Score=176, Evalue=1e-44,
Organism=Drosophila melanogaster, GI28572004, Length=247, Percent_Identity=40.080971659919, Blast_Score=176, Evalue=2e-44,

Paralogues:

None

Copy number: 1120 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR022896
- InterPro:   IPR000652
- InterPro:   IPR020861 [H]

Pfam domain/function: PF00121 TIM [H]

EC number: =5.3.1.1 [H]

Molecular weight: Translated: 27306; Mature: 27306

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS00171 TIM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTAIIAGNWKMNKTVKEAVELVKELKPLVKDAKCDVVVCPTYVCLPAVLEEVKGSNIKV
CCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHCCCCEEE
GAQNMHFEESGAYTGEIAPKMLEELGVHYVIIGHSERRQYFNETDETVNKKVKKAFEHNL
CCCCCCCCCCCCCCCCHHHHHHHHCCCEEEEEECHHHHHHHCHHHHHHHHHHHHHHHCCC
IPIVCCGESLEEREGNITEKVLEGQIKVGLKELSKEQVEKLVIAYEPIWAIGTGKTATDE
EEEEECCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCEEEEECCCCCCCH
QANETIGYIRTVVKDMYGESVADKVRIQYGGSVKPGTIKAQMAKEEIDGALVGGASLKAK
HHHHHHHHHHHHHHHHHCCHHHHHEEEEECCCCCCCCHHHHHHHHHHCCEEECCCCCCHH
DFAAIVNY
HHHHHCCC
>Mature Secondary Structure
MRTAIIAGNWKMNKTVKEAVELVKELKPLVKDAKCDVVVCPTYVCLPAVLEEVKGSNIKV
CCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHCCCCEEE
GAQNMHFEESGAYTGEIAPKMLEELGVHYVIIGHSERRQYFNETDETVNKKVKKAFEHNL
CCCCCCCCCCCCCCCCHHHHHHHHCCCEEEEEECHHHHHHHCHHHHHHHHHHHHHHHCCC
IPIVCCGESLEEREGNITEKVLEGQIKVGLKELSKEQVEKLVIAYEPIWAIGTGKTATDE
EEEEECCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCEEEEECCCCCCCH
QANETIGYIRTVVKDMYGESVADKVRIQYGGSVKPGTIKAQMAKEEIDGALVGGASLKAK
HHHHHHHHHHHHHHHHHCCHHHHHEEEEECCCCCCCCHHHHHHHHHHCCEEECCCCCCHH
DFAAIVNY
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA