Definition | Clostridium botulinum A2 str. Kyoto chromosome, complete genome. |
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Accession | NC_012563 |
Length | 4,155,278 |
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The map label for this gene is metK [H]
Identifier: 226947390
GI number: 226947390
Start: 195232
End: 196407
Strand: Direct
Name: metK [H]
Synonym: CLM_0216
Alternate gene names: 226947390
Gene position: 195232-196407 (Clockwise)
Preceding gene: 226947387
Following gene: 226947391
Centisome position: 4.7
GC content: 33.76
Gene sequence:
>1176_bases GTGAGAAAGTTATTTACATCTGAATCAGTAACAGAAGGGCATCCAGATAAAATATGTGACCAAATTTCAGATGCAGTTTT AGATGCTATATTAGATAAAGATCCTAATGGAAGGGTTGCTTGTGAAACAGCAGTTACAACAGGAATGGTAATGGTAATGG GAGAGATATCAACAAAATGTTATGTTGATATACCAAAGTTAGTTAGAGAAACTATAAGGGGAATAGGATATGATAGAGCT AAATATGGATTTGATTGTGAGACTTGCTCTGTAATAACATCAATAGATGAACAATCAGTAGATATAGCCATGGGTGTTGA TGAAGCCTTAGAATCTAAAAAAGGTGAAATGGATAAATTAGACGCTGTAGGCGCTGGAGATCAAGGTATGATGTTTGGTT TTGCTACAAACGAAACTAAGGAATATATGCCAATGCCTATAGAGATGGCCCACAAATTATCAAGAAGATTATCAGAAGTA AGAAAAAATGGTACATTACCATATTTGAGACCAGATGGAAAAACTCAAGTGACTGTAGAGTATGAGAATGGTAAACCTGT AAGAATAGATGCTATAGTTATTTCAACTCAACATGGTCCAGAAATTTATTTAGAGCAAATAGAAAAGGATATTAAAGAAC ATGTAATAAAAGTTATAGTACCATCAGAGTTATTAGATGAAAATACTAAATATTTTATAAATCCAACAGGAAGATTTGTA GTTGGTGGACCTCAAGGAGATTCAGGATTAACAGGAAGAAAAATAATAGTTGATACTTATGGTGGATATGGAAGACATGG TGGTGGAGCCTTTTCAGGTAAGGATCCAACAAAGGTTGATAGGTCTGCTGCATATGCTGCAAGATGGGTAGCTAAAAATT TAGTTGCAGCAGGGGTTGCTGATAAGCTAGAAATTCAGTTAGCTTATGCTATAGGGGTAGCTAAACCAGTATCTATTTCA GTTGATACATTTGGAACAGGTAAAATGACTGATGAAGAAATAGTTTCAATAGTAAATAAAGTATTTGATTTAAGACCTGG TGCTATAATAAGAGATTTAGACTTAAGAAGACCTATATATAAACAAGTTGCTGCCTATGGTCATTTTGGAAGAACAGATA TAGATGTACCATGGGAAAGATTAGATAAAGTAGAGGAAATAAAAAAGCATATATAA
Upstream 100 bases:
>100_bases GTATTATCTGCAAGATAAGAGAGAGTAGTTAGACAATAACCTCTTCTTATTGAAGAGGTTTTATTTTTTAGACAAAAATT GGTAATTAGGAGGAGTTAAT
Downstream 100 bases:
>100_bases ATTAATATTAGTATTAATATGAAAAGGAATGGACATGATAACATGCCATTCCTTTATATTTTTTCATAATAATATGATAT AATTGTTCTAAATGAATGGC
Product: S-adenosylmethionine synthetase
Products: NA
Alternate protein names: AdoMet synthase; MAT; Methionine adenosyltransferase [H]
Number of amino acids: Translated: 391; Mature: 391
Protein sequence:
>391_residues MRKLFTSESVTEGHPDKICDQISDAVLDAILDKDPNGRVACETAVTTGMVMVMGEISTKCYVDIPKLVRETIRGIGYDRA KYGFDCETCSVITSIDEQSVDIAMGVDEALESKKGEMDKLDAVGAGDQGMMFGFATNETKEYMPMPIEMAHKLSRRLSEV RKNGTLPYLRPDGKTQVTVEYENGKPVRIDAIVISTQHGPEIYLEQIEKDIKEHVIKVIVPSELLDENTKYFINPTGRFV VGGPQGDSGLTGRKIIVDTYGGYGRHGGGAFSGKDPTKVDRSAAYAARWVAKNLVAAGVADKLEIQLAYAIGVAKPVSIS VDTFGTGKMTDEEIVSIVNKVFDLRPGAIIRDLDLRRPIYKQVAAYGHFGRTDIDVPWERLDKVEEIKKHI
Sequences:
>Translated_391_residues MRKLFTSESVTEGHPDKICDQISDAVLDAILDKDPNGRVACETAVTTGMVMVMGEISTKCYVDIPKLVRETIRGIGYDRA KYGFDCETCSVITSIDEQSVDIAMGVDEALESKKGEMDKLDAVGAGDQGMMFGFATNETKEYMPMPIEMAHKLSRRLSEV RKNGTLPYLRPDGKTQVTVEYENGKPVRIDAIVISTQHGPEIYLEQIEKDIKEHVIKVIVPSELLDENTKYFINPTGRFV VGGPQGDSGLTGRKIIVDTYGGYGRHGGGAFSGKDPTKVDRSAAYAARWVAKNLVAAGVADKLEIQLAYAIGVAKPVSIS VDTFGTGKMTDEEIVSIVNKVFDLRPGAIIRDLDLRRPIYKQVAAYGHFGRTDIDVPWERLDKVEEIKKHI >Mature_391_residues MRKLFTSESVTEGHPDKICDQISDAVLDAILDKDPNGRVACETAVTTGMVMVMGEISTKCYVDIPKLVRETIRGIGYDRA KYGFDCETCSVITSIDEQSVDIAMGVDEALESKKGEMDKLDAVGAGDQGMMFGFATNETKEYMPMPIEMAHKLSRRLSEV RKNGTLPYLRPDGKTQVTVEYENGKPVRIDAIVISTQHGPEIYLEQIEKDIKEHVIKVIVPSELLDENTKYFINPTGRFV VGGPQGDSGLTGRKIIVDTYGGYGRHGGGAFSGKDPTKVDRSAAYAARWVAKNLVAAGVADKLEIQLAYAIGVAKPVSIS VDTFGTGKMTDEEIVSIVNKVFDLRPGAIIRDLDLRRPIYKQVAAYGHFGRTDIDVPWERLDKVEEIKKHI
Specific function: Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the e
COG id: COG0192
COG function: function code H; S-adenosylmethionine synthetase
Gene ontology:
Cell location: Cytoplasm [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the AdoMet synthase family [H]
Homologues:
Organism=Homo sapiens, GI4557737, Length=380, Percent_Identity=59.2105263157895, Blast_Score=447, Evalue=1e-126, Organism=Homo sapiens, GI5174529, Length=380, Percent_Identity=58.6842105263158, Blast_Score=445, Evalue=1e-125, Organism=Escherichia coli, GI1789311, Length=387, Percent_Identity=61.4987080103359, Blast_Score=486, Evalue=1e-139, Organism=Caenorhabditis elegans, GI17538498, Length=381, Percent_Identity=57.4803149606299, Blast_Score=437, Evalue=1e-123, Organism=Caenorhabditis elegans, GI17551082, Length=381, Percent_Identity=57.4803149606299, Blast_Score=436, Evalue=1e-122, Organism=Caenorhabditis elegans, GI25145633, Length=387, Percent_Identity=57.6227390180879, Blast_Score=434, Evalue=1e-122, Organism=Caenorhabditis elegans, GI17538494, Length=381, Percent_Identity=57.2178477690289, Blast_Score=434, Evalue=1e-122, Organism=Caenorhabditis elegans, GI32565905, Length=381, Percent_Identity=51.7060367454068, Blast_Score=372, Evalue=1e-103, Organism=Caenorhabditis elegans, GI32565911, Length=336, Percent_Identity=55.0595238095238, Blast_Score=365, Evalue=1e-101, Organism=Caenorhabditis elegans, GI25145635, Length=342, Percent_Identity=55.2631578947368, Blast_Score=362, Evalue=1e-100, Organism=Caenorhabditis elegans, GI32565903, Length=309, Percent_Identity=54.6925566343042, Blast_Score=329, Evalue=1e-90, Organism=Caenorhabditis elegans, GI32565909, Length=81, Percent_Identity=62.962962962963, Blast_Score=110, Evalue=2e-24, Organism=Caenorhabditis elegans, GI32565907, Length=38, Percent_Identity=78.9473684210526, Blast_Score=70, Evalue=2e-12, Organism=Saccharomyces cerevisiae, GI6323209, Length=381, Percent_Identity=58.2677165354331, Blast_Score=450, Evalue=1e-127, Organism=Saccharomyces cerevisiae, GI6320710, Length=386, Percent_Identity=57.2538860103627, Blast_Score=446, Evalue=1e-126, Organism=Drosophila melanogaster, GI45552159, Length=386, Percent_Identity=53.6269430051813, Blast_Score=399, Evalue=1e-111, Organism=Drosophila melanogaster, GI24580529, Length=386, Percent_Identity=53.6269430051813, Blast_Score=399, Evalue=1e-111, Organism=Drosophila melanogaster, GI24580537, Length=386, Percent_Identity=53.6269430051813, Blast_Score=399, Evalue=1e-111, Organism=Drosophila melanogaster, GI24580533, Length=386, Percent_Identity=53.6269430051813, Blast_Score=399, Evalue=1e-111, Organism=Drosophila melanogaster, GI24580535, Length=386, Percent_Identity=53.6269430051813, Blast_Score=399, Evalue=1e-111, Organism=Drosophila melanogaster, GI24580531, Length=386, Percent_Identity=53.6269430051813, Blast_Score=399, Evalue=1e-111, Organism=Drosophila melanogaster, GI24580527, Length=386, Percent_Identity=53.3678756476684, Blast_Score=393, Evalue=1e-110, Organism=Drosophila melanogaster, GI24580525, Length=386, Percent_Identity=53.3678756476684, Blast_Score=393, Evalue=1e-110, Organism=Drosophila melanogaster, GI24580541, Length=374, Percent_Identity=52.1390374331551, Blast_Score=372, Evalue=1e-103, Organism=Drosophila melanogaster, GI24580539, Length=125, Percent_Identity=54.4, Blast_Score=134, Evalue=1e-31,
Paralogues:
None
Copy number: 7,000 Molecules/Cell In: Glucose minimal media [C]
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR022631 - InterPro: IPR022630 - InterPro: IPR022629 - InterPro: IPR022628 - InterPro: IPR002133 - InterPro: IPR022636 [H]
Pfam domain/function: PF02773 S-AdoMet_synt_C; PF02772 S-AdoMet_synt_M; PF00438 S-AdoMet_synt_N [H]
EC number: =2.5.1.6 [H]
Molecular weight: Translated: 43041; Mature: 43041
Theoretical pI: Translated: 5.37; Mature: 5.37
Prosite motif: PS00376 ADOMET_SYNTHETASE_1 ; PS00377 ADOMET_SYNTHETASE_2
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.3 %Cys (Translated Protein) 3.1 %Met (Translated Protein) 4.3 %Cys+Met (Translated Protein) 1.3 %Cys (Mature Protein) 3.1 %Met (Mature Protein) 4.3 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MRKLFTSESVTEGHPDKICDQISDAVLDAILDKDPNGRVACETAVTTGMVMVMGEISTKC CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHCCEEEEECCCCEE YVDIPKLVRETIRGIGYDRAKYGFDCETCSVITSIDEQSVDIAMGVDEALESKKGEMDKL EEECHHHHHHHHHHCCCCCHHCCCCCHHHHHHHHCCCCCCEEEECHHHHHHHCCCCCHHH DAVGAGDQGMMFGFATNETKEYMPMPIEMAHKLSRRLSEVRKNGTLPYLRPDGKTQVTVE HCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEECCCCCEEEEEE YENGKPVRIDAIVISTQHGPEIYLEQIEKDIKEHVIKVIVPSELLDENTKYFINPTGRFV ECCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCEEEECCCCCEE VGGPQGDSGLTGRKIIVDTYGGYGRHGGGAFSGKDPTKVDRSAAYAARWVAKNLVAAGVA EECCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC DKLEIQLAYAIGVAKPVSISVDTFGTGKMTDEEIVSIVNKVFDLRPGAIIRDLDLRRPIY CCEEEEEEEEECCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCEEECCCCCCHHH KQVAAYGHFGRTDIDVPWERLDKVEEIKKHI HHHHHHCCCCCCCCCCCHHHHHHHHHHHHCC >Mature Secondary Structure MRKLFTSESVTEGHPDKICDQISDAVLDAILDKDPNGRVACETAVTTGMVMVMGEISTKC CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHCCEEEEECCCCEE YVDIPKLVRETIRGIGYDRAKYGFDCETCSVITSIDEQSVDIAMGVDEALESKKGEMDKL EEECHHHHHHHHHHCCCCCHHCCCCCHHHHHHHHCCCCCCEEEECHHHHHHHCCCCCHHH DAVGAGDQGMMFGFATNETKEYMPMPIEMAHKLSRRLSEVRKNGTLPYLRPDGKTQVTVE HCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEECCCCCEEEEEE YENGKPVRIDAIVISTQHGPEIYLEQIEKDIKEHVIKVIVPSELLDENTKYFINPTGRFV ECCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCEEEECCCCCEE VGGPQGDSGLTGRKIIVDTYGGYGRHGGGAFSGKDPTKVDRSAAYAARWVAKNLVAAGVA EECCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC DKLEIQLAYAIGVAKPVSISVDTFGTGKMTDEEIVSIVNKVFDLRPGAIIRDLDLRRPIY CCEEEEEEEEECCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCEEECCCCCCHHH KQVAAYGHFGRTDIDVPWERLDKVEEIKKHI HHHHHHCCCCCCCCCCCHHHHHHHHHHHHCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: NA