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The map label for this gene is ywlC [H]

Identifier: 226947365

GI number: 226947365

Start: 172830

End: 173885

Strand: Direct

Name: ywlC [H]

Synonym: CLM_0185

Alternate gene names: 226947365

Gene position: 172830-173885 (Clockwise)

Preceding gene: 226947364

Following gene: 226947366

Centisome position: 4.16

GC content: 32.39

Gene sequence:

>1056_bases
ATGAAAACAAAAGTTATGAGATTAGATGAAAACAATATAGATGAGCATGTCATAAGTGAGGCTGGAGATATATTAAGACA
GGGTGGACTTGTAGTATTTCCTACAGAAACTGTATATGGACTAGGAGCTAATGCTTTGGATAAAAATGCAGTAAAAGGAA
TATTTGAAGCGAAGGGAAGACCACAGGATAATCCTTTAATAGTTCATATTTCTAAGATGAAAGATATAGAGAAATTAGTT
CAAAAGATACCATCTGTAGCCGAAAAATTAATGGATAAATTTTGGCCTGGACCTATGACTATAATATTAAAGAAAAAAGA
TATAATACCAAATGAAACTAGTGCAGGGTTAGATAGTATAGGGATTAGGATGCCATCTAATAAAATAGCAATGAAGCTTA
TTTCTATGGCAGGCGTGCCTATAGCTGCACCTTCAGCAAATTTATCAGGGAAACCTAGTCCAACAGATGTAGAAACTTGC
ATAGAGGATCTAGATGGTAAGGTAAATATAATATTAGGTGGGGATAATTCTGAAGTAGGTGTTGAATCTACTGTAATAGA
TTGTACAATTAATCCCCCTTGCATTTTAAGGCCTGGTGGAATAACATTAGAAATGCTAAAAGAGGTAGATTCCAATATAT
ATATTGATCCAGCTATAATGAAAAAGCCAGATAAAGACTTGAAACCGAAGGCTCCAGGGATGAAATATAGACACTATGCA
CCAAAGGCCCCATTAAAAATAATTAAAGGGGATTTAAATAAAACTATTGAAAAAATTAATGAAATGGTGCAAAATTATAT
AGATGCAGAAAAGAAGGTAGGAATTATTGCTACAGATGAAACTATAGACAATTATAGAAAAGGTGATGTGGTTTCTATAG
GAAGTAGAAAAGATTTAAATACCATTGCCCATAACTTGTTTTATGTTTTAAGAAGCTTTGATGAAAAGAATGTAGATTTG
ATCTTATCTGAAGCATTTGAAGAAAAAGATATGGGAGTAGCTATAATGAATAGGCTAAAAAAGTCAGCTGGCTATGATAT
TATAAATTTAGATTAG

Upstream 100 bases:

>100_bases
ATTTAGGAGATAAGCTTACATCATATTTTTATATGATAGTAGGTATTATAGCTGGATTAGTTATAATAAAACTATTATAA
AACTTAGGATGGTGTTTATT

Downstream 100 bases:

>100_bases
GAGGCACTAATGAATATATTATTTGTTTGTACAGGGAATACTTGTAGAAGTTTTATGGCAGAAGCTATATTTAATTCTTT
AAATAATATGGAAGAGATAA

Product: Sua5/YciO/YrdC/YwlC family protein

Products: NA

Alternate protein names: t(6)A37 threonylcarbamoyladenosine biosynthesis protein YwlC [H]

Number of amino acids: Translated: 351; Mature: 351

Protein sequence:

>351_residues
MKTKVMRLDENNIDEHVISEAGDILRQGGLVVFPTETVYGLGANALDKNAVKGIFEAKGRPQDNPLIVHISKMKDIEKLV
QKIPSVAEKLMDKFWPGPMTIILKKKDIIPNETSAGLDSIGIRMPSNKIAMKLISMAGVPIAAPSANLSGKPSPTDVETC
IEDLDGKVNIILGGDNSEVGVESTVIDCTINPPCILRPGGITLEMLKEVDSNIYIDPAIMKKPDKDLKPKAPGMKYRHYA
PKAPLKIIKGDLNKTIEKINEMVQNYIDAEKKVGIIATDETIDNYRKGDVVSIGSRKDLNTIAHNLFYVLRSFDEKNVDL
ILSEAFEEKDMGVAIMNRLKKSAGYDIINLD

Sequences:

>Translated_351_residues
MKTKVMRLDENNIDEHVISEAGDILRQGGLVVFPTETVYGLGANALDKNAVKGIFEAKGRPQDNPLIVHISKMKDIEKLV
QKIPSVAEKLMDKFWPGPMTIILKKKDIIPNETSAGLDSIGIRMPSNKIAMKLISMAGVPIAAPSANLSGKPSPTDVETC
IEDLDGKVNIILGGDNSEVGVESTVIDCTINPPCILRPGGITLEMLKEVDSNIYIDPAIMKKPDKDLKPKAPGMKYRHYA
PKAPLKIIKGDLNKTIEKINEMVQNYIDAEKKVGIIATDETIDNYRKGDVVSIGSRKDLNTIAHNLFYVLRSFDEKNVDL
ILSEAFEEKDMGVAIMNRLKKSAGYDIINLD
>Mature_351_residues
MKTKVMRLDENNIDEHVISEAGDILRQGGLVVFPTETVYGLGANALDKNAVKGIFEAKGRPQDNPLIVHISKMKDIEKLV
QKIPSVAEKLMDKFWPGPMTIILKKKDIIPNETSAGLDSIGIRMPSNKIAMKLISMAGVPIAAPSANLSGKPSPTDVETC
IEDLDGKVNIILGGDNSEVGVESTVIDCTINPPCILRPGGITLEMLKEVDSNIYIDPAIMKKPDKDLKPKAPGMKYRHYA
PKAPLKIIKGDLNKTIEKINEMVQNYIDAEKKVGIIATDETIDNYRKGDVVSIGSRKDLNTIAHNLFYVLRSFDEKNVDL
ILSEAFEEKDMGVAIMNRLKKSAGYDIINLD

Specific function: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (Probable) [H]

COG id: COG0009

COG function: function code J; Putative translation factor (SUA5)

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 YrdC-like domain [H]

Homologues:

Organism=Homo sapiens, GI58761510, Length=183, Percent_Identity=29.5081967213115, Blast_Score=79, Evalue=6e-15,
Organism=Escherichia coli, GI87081864, Length=200, Percent_Identity=29.5, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI2367210, Length=144, Percent_Identity=28.4722222222222, Blast_Score=79, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17537239, Length=189, Percent_Identity=29.1005291005291, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6321269, Length=381, Percent_Identity=36.2204724409449, Blast_Score=214, Evalue=2e-56,
Organism=Drosophila melanogaster, GI78707274, Length=180, Percent_Identity=27.7777777777778, Blast_Score=75, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR005145
- InterPro:   IPR004388
- InterPro:   IPR006070
- InterPro:   IPR010923 [H]

Pfam domain/function: PF03481 SUA5; PF01300 Sua5_yciO_yrdC [H]

EC number: NA

Molecular weight: Translated: 38594; Mature: 38594

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: PS51163 YRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTKVMRLDENNIDEHVISEAGDILRQGGLVVFPTETVYGLGANALDKNAVKGIFEAKGR
CCCEEEECCCCCCHHHHHHHHHHHHHHCCEEEEECCCEECCCCCHHHHHHHHHHHHCCCC
PQDNPLIVHISKMKDIEKLVQKIPSVAEKLMDKFWPGPMTIILKKKDIIPNETSAGLDSI
CCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCHHC
GIRMPSNKIAMKLISMAGVPIAAPSANLSGKPSPTDVETCIEDLDGKVNIILGGDNSEVG
EEECCCHHHHHHHHHHCCCCEECCCCCCCCCCCCCHHHHHHHHCCCEEEEEECCCCCCCC
VESTVIDCTINPPCILRPGGITLEMLKEVDSNIYIDPAIMKKPDKDLKPKAPGMKYRHYA
CEEEEEEEECCCCEEEECCCCHHHHHHHHCCCEEECHHHHCCCCCCCCCCCCCCCCCCCC
PKAPLKIIKGDLNKTIEKINEMVQNYIDAEKKVGIIATDETIDNYRKGDVVSIGSRKDLN
CCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHCEEEEEECCHHHHCCCCCEEEECCCCHHH
TIAHNLFYVLRSFDEKNVDLILSEAFEEKDMGVAIMNRLKKSAGYDIINLD
HHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEECC
>Mature Secondary Structure
MKTKVMRLDENNIDEHVISEAGDILRQGGLVVFPTETVYGLGANALDKNAVKGIFEAKGR
CCCEEEECCCCCCHHHHHHHHHHHHHHCCEEEEECCCEECCCCCHHHHHHHHHHHHCCCC
PQDNPLIVHISKMKDIEKLVQKIPSVAEKLMDKFWPGPMTIILKKKDIIPNETSAGLDSI
CCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCHHC
GIRMPSNKIAMKLISMAGVPIAAPSANLSGKPSPTDVETCIEDLDGKVNIILGGDNSEVG
EEECCCHHHHHHHHHHCCCCEECCCCCCCCCCCCCHHHHHHHHCCCEEEEEECCCCCCCC
VESTVIDCTINPPCILRPGGITLEMLKEVDSNIYIDPAIMKKPDKDLKPKAPGMKYRHYA
CEEEEEEEECCCCEEEECCCCHHHHHHHHCCCEEECHHHHCCCCCCCCCCCCCCCCCCCC
PKAPLKIIKGDLNKTIEKINEMVQNYIDAEKKVGIIATDETIDNYRKGDVVSIGSRKDLN
CCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHCEEEEEECCHHHHCCCCCEEEECCCCHHH
TIAHNLFYVLRSFDEKNVDLILSEAFEEKDMGVAIMNRLKKSAGYDIINLD
HHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]