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The map label for this gene is serA [H]

Identifier: 226225374

GI number: 226225374

Start: 2879576

End: 2880763

Strand: Reverse

Name: serA [H]

Synonym: Lm4b_02797

Alternate gene names: 226225374

Gene position: 2880763-2879576 (Counterclockwise)

Preceding gene: 226225375

Following gene: 226225373

Centisome position: 98.9

GC content: 39.73

Gene sequence:

>1188_bases
GTGTTTAATATCCAAACGTTTAATGCTATCGCAAAAGAAGGCTTAAAGACATTTGATCTCGAAAAATATGTGATTGATGC
AAATCAGCCAGCAGACGGGATTTTACTACGGAGTTACAACTTACACGATTTTGACTTTCCGGAGACAGTGAAGGCAGTTG
CCCGAGCTGGTGCAGGAGTTAATAATATCCCAGTAGAAAATTGTTCTGAAAAAGGTATTGTTGTATTCAATACACCTGGC
GCGAATGCCAATGCTGTGAAAGAACTAGTTCTTGCGAGTTTATTCGTTTCGGCGCGCCCAATTTTGGAAGGAACGGAATG
GGTCAAAGAATTACCGGCGGAAGATGATGTGGAACAGAAAGTTGAAGCTGGGAAGAAAGCCTTTGCGGGAACAGAACTTG
CTGGCAAAAAACTTGGGATTATCGGTCTAGGCGCAATTGGTGCATTGGTAGCCAATGACGCTTTATCGCTTGGGATGGAT
GTGGTTGGATACGATCCATTCGTTTCAGTAGACACGGCTTGGAGAATTTCTAAAGAAGTGGAACGTGCGATGACGATAGA
AGAAGTTTTGGCCACATGCGATTATTTAACAGTTCATGTGCCTTTAACGGATAAAACACGTGGCATGTTTAACGCAGATA
CACTACAATTAGTGAAGGATAATGCTGTTTTATTAAACTTTTCTCGTGGTGAGTTAGTGGATTCAGCCTCTGTGAAAGAA
GCTTTAGATGATGGACTTTTACGTTTATATATTACAGATTTCGCGACAAAAGAATTACTAAACCACAAAAAAGTGCATGT
ATTTCCTCATTTAGGTGCATCGACGGAAGAAGCCGAAACCAACTGTGCTAAAATGGCTGCGAAAGAACTGCAATCATATC
TTGAAACAGGTAGTATTAAAAACTCGGTTAATTTTCCGAACGTGGAAATGCCGTATAATGGACATCCGCGAATTGGAATT
TGTCACAAAAACATTCCTAATATGGTCGGACAAATTACGACGGAGCTAGGGAAATATTCGTTAAACATTTTAGATATGAT
AAATCGCAGTAAAAATGAATATGCCTACACATTAATTGATATTGATAAGGAAACGCAAGCTAATTTGGAACAACTGAAAA
GTGATTTATTAGCTGTGCAAGGGGTTTTGCGTGTTCGAGTTATTGAACCATTAGGTGTTACGGTTTAA

Upstream 100 bases:

>100_bases
ATGCGAGCAAGTCTTTATAATGCATTTCCAATTGAAGGGGTGGAAGCTCTAATCGCCTTTATGGAAAAATTTGCAAATGC
AAGAAAAGGGGGAGAAGTAC

Downstream 100 bases:

>100_bases
AATTATTACCCGGGAAATAATGAGAGCATGAAACTTTATGGTTATTGCCAGACGGGTTCATGCTCTTTTACTAAAAAGGA
GGATAACAATGGTAAATATA

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 395; Mature: 395

Protein sequence:

>395_residues
MFNIQTFNAIAKEGLKTFDLEKYVIDANQPADGILLRSYNLHDFDFPETVKAVARAGAGVNNIPVENCSEKGIVVFNTPG
ANANAVKELVLASLFVSARPILEGTEWVKELPAEDDVEQKVEAGKKAFAGTELAGKKLGIIGLGAIGALVANDALSLGMD
VVGYDPFVSVDTAWRISKEVERAMTIEEVLATCDYLTVHVPLTDKTRGMFNADTLQLVKDNAVLLNFSRGELVDSASVKE
ALDDGLLRLYITDFATKELLNHKKVHVFPHLGASTEEAETNCAKMAAKELQSYLETGSIKNSVNFPNVEMPYNGHPRIGI
CHKNIPNMVGQITTELGKYSLNILDMINRSKNEYAYTLIDIDKETQANLEQLKSDLLAVQGVLRVRVIEPLGVTV

Sequences:

>Translated_395_residues
MFNIQTFNAIAKEGLKTFDLEKYVIDANQPADGILLRSYNLHDFDFPETVKAVARAGAGVNNIPVENCSEKGIVVFNTPG
ANANAVKELVLASLFVSARPILEGTEWVKELPAEDDVEQKVEAGKKAFAGTELAGKKLGIIGLGAIGALVANDALSLGMD
VVGYDPFVSVDTAWRISKEVERAMTIEEVLATCDYLTVHVPLTDKTRGMFNADTLQLVKDNAVLLNFSRGELVDSASVKE
ALDDGLLRLYITDFATKELLNHKKVHVFPHLGASTEEAETNCAKMAAKELQSYLETGSIKNSVNFPNVEMPYNGHPRIGI
CHKNIPNMVGQITTELGKYSLNILDMINRSKNEYAYTLIDIDKETQANLEQLKSDLLAVQGVLRVRVIEPLGVTV
>Mature_395_residues
MFNIQTFNAIAKEGLKTFDLEKYVIDANQPADGILLRSYNLHDFDFPETVKAVARAGAGVNNIPVENCSEKGIVVFNTPG
ANANAVKELVLASLFVSARPILEGTEWVKELPAEDDVEQKVEAGKKAFAGTELAGKKLGIIGLGAIGALVANDALSLGMD
VVGYDPFVSVDTAWRISKEVERAMTIEEVLATCDYLTVHVPLTDKTRGMFNADTLQLVKDNAVLLNFSRGELVDSASVKE
ALDDGLLRLYITDFATKELLNHKKVHVFPHLGASTEEAETNCAKMAAKELQSYLETGSIKNSVNFPNVEMPYNGHPRIGI
CHKNIPNMVGQITTELGKYSLNILDMINRSKNEYAYTLIDIDKETQANLEQLKSDLLAVQGVLRVRVIEPLGVTV

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=303, Percent_Identity=33.6633663366337, Blast_Score=162, Evalue=6e-40,
Organism=Homo sapiens, GI61743967, Length=310, Percent_Identity=27.0967741935484, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI4557497, Length=314, Percent_Identity=27.0700636942675, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI145580578, Length=310, Percent_Identity=26.7741935483871, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI4557499, Length=310, Percent_Identity=26.7741935483871, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI145580575, Length=319, Percent_Identity=26.6457680250784, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI6912396, Length=261, Percent_Identity=25.6704980842912, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI1789279, Length=341, Percent_Identity=29.6187683284457, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI87082289, Length=271, Percent_Identity=28.0442804428044, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1787645, Length=195, Percent_Identity=26.1538461538462, Blast_Score=72, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17532191, Length=253, Percent_Identity=33.596837944664, Blast_Score=127, Evalue=9e-30,
Organism=Caenorhabditis elegans, GI25147481, Length=222, Percent_Identity=29.2792792792793, Blast_Score=87, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6320925, Length=357, Percent_Identity=28.2913165266106, Blast_Score=133, Evalue=6e-32,
Organism=Saccharomyces cerevisiae, GI6322116, Length=357, Percent_Identity=28.2913165266106, Blast_Score=131, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6324055, Length=287, Percent_Identity=27.5261324041812, Blast_Score=91, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6324964, Length=226, Percent_Identity=26.5486725663717, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI19921140, Length=251, Percent_Identity=36.2549800796813, Blast_Score=145, Evalue=6e-35,
Organism=Drosophila melanogaster, GI24646446, Length=285, Percent_Identity=27.3684210526316, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24646448, Length=285, Percent_Identity=27.3684210526316, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24646452, Length=285, Percent_Identity=27.3684210526316, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24646450, Length=285, Percent_Identity=27.3684210526316, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI62472511, Length=285, Percent_Identity=27.3684210526316, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI28574286, Length=251, Percent_Identity=27.4900398406374, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI28574284, Length=250, Percent_Identity=26.8, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI45552429, Length=250, Percent_Identity=26.8, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24585514, Length=250, Percent_Identity=26.8, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI28574282, Length=250, Percent_Identity=26.8, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI45551003, Length=250, Percent_Identity=26.8, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24585516, Length=253, Percent_Identity=23.7154150197628, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI28571528, Length=262, Percent_Identity=28.2442748091603, Blast_Score=76, Evalue=5e-14,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 43153; Mature: 43153

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFNIQTFNAIAKEGLKTFDLEKYVIDANQPADGILLRSYNLHDFDFPETVKAVARAGAGV
CCCCHHHHHHHHCCCCEECCEEEEEECCCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCC
NNIPVENCSEKGIVVFNTPGANANAVKELVLASLFVSARPILEGTEWVKELPAEDDVEQK
CCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCHHHH
VEAGKKAFAGTELAGKKLGIIGLGAIGALVANDALSLGMDVVGYDPFVSVDTAWRISKEV
HHHHHHHHCCCHHCCCEECEEEHHHHHHHHHHHHHHHCCCEECCCCEEECCHHHHHHHHH
ERAMTIEEVLATCDYLTVHVPLTDKTRGMFNADTLQLVKDNAVLLNFSRGELVDSASVKE
HHHHHHHHHHHHCCEEEEEEEECCCCCCCCCCHHHHEEECCEEEEEECCCCCCCHHHHHH
ALDDGLLRLYITDFATKELLNHKKVHVFPHLGASTEEAETNCAKMAAKELQSYLETGSIK
HHHCCEEEEEHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
NSVNFPNVEMPYNGHPRIGICHKNIPNMVGQITTELGKYSLNILDMINRSKNEYAYTLID
CCCCCCCEECCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEE
IDKETQANLEQLKSDLLAVQGVLRVRVIEPLGVTV
ECCHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCC
>Mature Secondary Structure
MFNIQTFNAIAKEGLKTFDLEKYVIDANQPADGILLRSYNLHDFDFPETVKAVARAGAGV
CCCCHHHHHHHHCCCCEECCEEEEEECCCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCC
NNIPVENCSEKGIVVFNTPGANANAVKELVLASLFVSARPILEGTEWVKELPAEDDVEQK
CCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCHHHH
VEAGKKAFAGTELAGKKLGIIGLGAIGALVANDALSLGMDVVGYDPFVSVDTAWRISKEV
HHHHHHHHCCCHHCCCEECEEEHHHHHHHHHHHHHHHCCCEECCCCEEECCHHHHHHHHH
ERAMTIEEVLATCDYLTVHVPLTDKTRGMFNADTLQLVKDNAVLLNFSRGELVDSASVKE
HHHHHHHHHHHHCCEEEEEEEECCCCCCCCCCHHHHEEECCEEEEEECCCCCCCHHHHHH
ALDDGLLRLYITDFATKELLNHKKVHVFPHLGASTEEAETNCAKMAAKELQSYLETGSIK
HHHCCEEEEEHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
NSVNFPNVEMPYNGHPRIGICHKNIPNMVGQITTELGKYSLNILDMINRSKNEYAYTLID
CCCCCCCEECCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEE
IDKETQANLEQLKSDLLAVQGVLRVRVIEPLGVTV
ECCHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]