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The map label for this gene is serC

Identifier: 226225375

GI number: 226225375

Start: 2880756

End: 2881847

Strand: Reverse

Name: serC

Synonym: Lm4b_02798

Alternate gene names: 226225375

Gene position: 2881847-2880756 (Counterclockwise)

Preceding gene: 226225376

Following gene: 226225374

Centisome position: 98.94

GC content: 41.03

Gene sequence:

>1092_bases
GTGGAACGTGTTTATAATTTTTCGGCAGGTCCGGCAGTTTTACCAGTACCGGTACTTGAAAAGGTTCAAAGGGAGCTACT
CTCTTACAATGGTTCAGGAATGTCAGTAATGGAGCTGAGTCACCGTTCAGAATTATTTCAAAACATCCTAGACGATGCGG
AGAGCTTAATTCGAGAATTGATGGAGATTCCAGAAAATTACAAAGTACTATTTTTGCAAGGTGGCGCGAGTTTGCAATTT
GATATGGTGCCAATGAATCTTGCAAATGGCAAAAAAGCAGCGTATGTAAACACTGGATCTTGGGCGAAGAAAGCAATTTC
CGAAGCTAAGAAAATTCAGGGTGTAGAGGTGGAAGTAATTGCCTCATCGGAAGACCGCAATTTCAGCTATATTCCTGAGA
TTCCTACAGTTTCTAGTGACGCGGCTTACTTACATGTAACTACAAATAATACAATCGAAGGAACAGCAATGTTTGATGTG
CCAGACTCAGCTGTCCCGGTCGTTGCGGATATGTCCTCCAATATTTTATCGAGCGTTTATGATGTGAAAAAATTTGGCTT
AATTTATGCAGGAGCGCAAAAGAACATTGGGCCTGCTGGATTAACGCTTGTCATCGTGCGCGAAGACTTGATAGGGCAAG
TAGAGGGACTTCCTTCTATGTTAGATTTTAAAGTACAAGCCGAGAATGATTCCATGTATAACACACCACCGACATTTGCC
ATTTATGTAGCAAAATTAGTATTTGAATGGATTAAGGAGCAAGGTGGCGTTGCTGGAATTGAAGCGTTGAATCGCAAAAA
AGCGGCCTTATTATATAATTATATTGATCAATCGGATTTCTTTTCTTCACCGGTCGAACCTTCTGCTAGATCGCTCACGA
ATGTTCCTTTTGTGACGAATTCAGCGGAGTTTGATAAAGCTTTTGTTCAAGAAGCTGAAGCAAATGGTTTTAAAAACTTG
AAAGGACATCGCTCAGTGGGCGGTATGCGAGCAAGTCTTTATAATGCATTTCCAATTGAAGGGGTGGAAGCTCTAATCGC
CTTTATGGAAAAATTTGCAAATGCAAGAAAAGGGGGAGAAGTACGTGTTTAA

Upstream 100 bases:

>100_bases
AGTGTAACGAGGAAGGCTCATATCTGGCCAATAAGTATTCGATTATTGGTGAAAATTTTTGTAAGTAATTGGGGAAATTT
GAAGACAGGAGAGATGTTGA

Downstream 100 bases:

>100_bases
TATCCAAACGTTTAATGCTATCGCAAAAGAAGGCTTAAAGACATTTGATCTCGAAAAATATGTGATTGATGCAAATCAGC
CAGCAGACGGGATTTTACTA

Product: phosphoserine aminotransferase

Products: NA

Alternate protein names: Phosphohydroxythreonine aminotransferase; PSAT [H]

Number of amino acids: Translated: 363; Mature: 363

Protein sequence:

>363_residues
MERVYNFSAGPAVLPVPVLEKVQRELLSYNGSGMSVMELSHRSELFQNILDDAESLIRELMEIPENYKVLFLQGGASLQF
DMVPMNLANGKKAAYVNTGSWAKKAISEAKKIQGVEVEVIASSEDRNFSYIPEIPTVSSDAAYLHVTTNNTIEGTAMFDV
PDSAVPVVADMSSNILSSVYDVKKFGLIYAGAQKNIGPAGLTLVIVREDLIGQVEGLPSMLDFKVQAENDSMYNTPPTFA
IYVAKLVFEWIKEQGGVAGIEALNRKKAALLYNYIDQSDFFSSPVEPSARSLTNVPFVTNSAEFDKAFVQEAEANGFKNL
KGHRSVGGMRASLYNAFPIEGVEALIAFMEKFANARKGGEVRV

Sequences:

>Translated_363_residues
MERVYNFSAGPAVLPVPVLEKVQRELLSYNGSGMSVMELSHRSELFQNILDDAESLIRELMEIPENYKVLFLQGGASLQF
DMVPMNLANGKKAAYVNTGSWAKKAISEAKKIQGVEVEVIASSEDRNFSYIPEIPTVSSDAAYLHVTTNNTIEGTAMFDV
PDSAVPVVADMSSNILSSVYDVKKFGLIYAGAQKNIGPAGLTLVIVREDLIGQVEGLPSMLDFKVQAENDSMYNTPPTFA
IYVAKLVFEWIKEQGGVAGIEALNRKKAALLYNYIDQSDFFSSPVEPSARSLTNVPFVTNSAEFDKAFVQEAEANGFKNL
KGHRSVGGMRASLYNAFPIEGVEALIAFMEKFANARKGGEVRV
>Mature_363_residues
MERVYNFSAGPAVLPVPVLEKVQRELLSYNGSGMSVMELSHRSELFQNILDDAESLIRELMEIPENYKVLFLQGGASLQF
DMVPMNLANGKKAAYVNTGSWAKKAISEAKKIQGVEVEVIASSEDRNFSYIPEIPTVSSDAAYLHVTTNNTIEGTAMFDV
PDSAVPVVADMSSNILSSVYDVKKFGLIYAGAQKNIGPAGLTLVIVREDLIGQVEGLPSMLDFKVQAENDSMYNTPPTFA
IYVAKLVFEWIKEQGGVAGIEALNRKKAALLYNYIDQSDFFSSPVEPSARSLTNVPFVTNSAEFDKAFVQEAEANGFKNL
KGHRSVGGMRASLYNAFPIEGVEALIAFMEKFANARKGGEVRV

Specific function: Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine [H]

COG id: COG1932

COG function: function code HE; Phosphoserine aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily [H]

Homologues:

Organism=Homo sapiens, GI17402893, Length=363, Percent_Identity=48.7603305785124, Blast_Score=328, Evalue=7e-90,
Organism=Homo sapiens, GI10863955, Length=358, Percent_Identity=44.1340782122905, Blast_Score=281, Evalue=9e-76,
Organism=Escherichia coli, GI1787136, Length=357, Percent_Identity=49.859943977591, Blast_Score=340, Evalue=9e-95,
Organism=Caenorhabditis elegans, GI17506897, Length=361, Percent_Identity=42.9362880886427, Blast_Score=280, Evalue=6e-76,
Organism=Saccharomyces cerevisiae, GI6324758, Length=387, Percent_Identity=37.984496124031, Blast_Score=262, Evalue=6e-71,
Organism=Drosophila melanogaster, GI21356589, Length=361, Percent_Identity=49.0304709141274, Blast_Score=310, Evalue=7e-85,

Paralogues:

None

Copy number: 2500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR022278
- InterPro:   IPR003248
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.6.1.52 [H]

Molecular weight: Translated: 39697; Mature: 39697

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERVYNFSAGPAVLPVPVLEKVQRELLSYNGSGMSVMELSHRSELFQNILDDAESLIREL
CCCEECCCCCCCEECHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHH
MEIPENYKVLFLQGGASLQFDMVPMNLANGKKAAYVNTGSWAKKAISEAKKIQGVEVEVI
HHCCCCCEEEEEECCCCEEEEEEEEECCCCCEEEEEECCHHHHHHHHHHHHHCCCEEEEE
ASSEDRNFSYIPEIPTVSSDAAYLHVTTNNTIEGTAMFDVPDSAVPVVADMSSNILSSVY
ECCCCCCCEECCCCCCCCCCCEEEEEEECCEECCEEEEECCCCCCCEEHHHHHHHHHHHH
DVKKFGLIYAGAQKNIGPAGLTLVIVREDLIGQVEGLPSMLDFKVQAENDSMYNTPPTFA
HHHHHCEEEECCCCCCCCCCEEEEEEEHHHHHHHHCCCCHHEEEEEECCCCCCCCCCHHH
IYVAKLVFEWIKEQGGVAGIEALNRKKAALLYNYIDQSDFFSSPVEPSARSLTNVPFVTN
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCHHHHCCCCEEEC
SAEFDKAFVQEAEANGFKNLKGHRSVGGMRASLYNAFPIEGVEALIAFMEKFANARKGGE
CHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCC
VRV
CCC
>Mature Secondary Structure
MERVYNFSAGPAVLPVPVLEKVQRELLSYNGSGMSVMELSHRSELFQNILDDAESLIREL
CCCEECCCCCCCEECHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHH
MEIPENYKVLFLQGGASLQFDMVPMNLANGKKAAYVNTGSWAKKAISEAKKIQGVEVEVI
HHCCCCCEEEEEECCCCEEEEEEEEECCCCCEEEEEECCHHHHHHHHHHHHHCCCEEEEE
ASSEDRNFSYIPEIPTVSSDAAYLHVTTNNTIEGTAMFDVPDSAVPVVADMSSNILSSVY
ECCCCCCCEECCCCCCCCCCCEEEEEEECCEECCEEEEECCCCCCCEEHHHHHHHHHHHH
DVKKFGLIYAGAQKNIGPAGLTLVIVREDLIGQVEGLPSMLDFKVQAENDSMYNTPPTFA
HHHHHCEEEECCCCCCCCCCEEEEEEEHHHHHHHHCCCCHHEEEEEECCCCCCCCCCHHH
IYVAKLVFEWIKEQGGVAGIEALNRKKAALLYNYIDQSDFFSSPVEPSARSLTNVPFVTN
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCHHHHCCCCEEEC
SAEFDKAFVQEAEANGFKNLKGHRSVGGMRASLYNAFPIEGVEALIAFMEKFANARKGGE
CHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCC
VRV
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]