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The map label for this gene is mtlA [H]

Identifier: 226225349

GI number: 226225349

Start: 2852669

End: 2854075

Strand: Reverse

Name: mtlA [H]

Synonym: Lm4b_02772

Alternate gene names: 226225349

Gene position: 2854075-2852669 (Counterclockwise)

Preceding gene: 226225350

Following gene: 226225348

Centisome position: 97.99

GC content: 41.15

Gene sequence:

>1407_bases
ATGTCTATTCGGGTACATGTACAAAAGTTTGGGAGTAAGCTAAGTGGTATGGTCATTCCGAATTTGGGAGCTTTTATGGC
TTGGGGTATTTTAACGGCAATTGGGGTGGCTACAGGCTCTGAGATGTTAAAAGGGTTCATCGCACCAATGCTAAATTACT
TGTTACCACTTCTTATTGCCTTTGCTGGAGGTCGAGCGGTTCACGGTTACCGAGGCGGAGTTATTGGTACTGTTGCGACA
ATGGGAGCAATTATTAGTTCGGATATAACCATGTTTATTGGCGCAATGATAATGGGCCCGCTCGCAGCTTGGATACTCAA
AAAATTTGATGAACGTATTGATGGAAAAATTCCAGCTGGATTTGAACTATTAGTTAACAACTTTTCGATTGGGATAATTG
GAGCGGGATTAGCACTATTTTCTTATGTGGCGATTGCTCCAATGGTCGAAGCTGTAACAAAAGTATTAGCAAGTGGCGTG
GATGTATTAATCAATAATCATTTGCTCCCACTAACGGCTTTAATTATTGAGCCGGCCAAGGTCTTATTCTTAAACAATGC
GATCGGTCAAGGTATTCTAAGTCCACTAGCCACCTTGCAACTCGCAGAAACAGGGAAATCAGTGCTTTACTTACTAGAAT
CAAACCCTGGACCAGGACTTGGAATTTTGCTTGGCTATATGTTCTTTGGTAAAGGAAACTCCAAAGCATCTTCCTACGGG
GCAAGTGTTATTCACCTATTTGGTGGTATTCACGAAATTTACTTCCCATTCGTTTTAATGAATCCAATTCTTATTTTACC
GCTAATTCTTGGTGGTATGACAGGAACATTTATTTTAACAATGACAAATGCGGGACTTGTTGGTGTGGCTTCTCCTGGTA
GTATTATCACAATCATGATGATGGCAGCACCCGGCGATCACATTAAGATCCTTATTGCGGTGCTATGTGCGGCACTTGTT
ACATTCATTACTGCCATTCCATTTATTAAACGCATGGGTAACAAAGACTCTGAACTACAAGATGCAGCGAAGAAAATGGA
AAGCCTTAAAGGCAAAAAGAGCAGTATTTCCTCCGTTTTCGAAGCTACAGTAGATGATTTTAATTTTAAAAATGTTAAAA
GAATCGCTTATGCCTGTGATGCGGGACTTGGATCTAGTGCGATGGGCGCGACCGTACTACAGAAAAAAATCAAAAATGCT
GGCTTAGAGGATATTAAAGTGTTCCATATCGCCATCCACGAATTGCCGACCGAATGCGATGTAGTCGTGACGCATAAATC
CCTTATCGACCGAGCCAAAGAAAAGCAACCAGATGCGTATTATGTAGAAATAACGGATTACCTCGGCGCACCAGAATATC
AAGAACTGATAGATAAAATAGTTGCAGACCGAGAACAAAAGAATTAA

Upstream 100 bases:

>100_bases
TGATTCCTTACGAGTAGTAGATGCGATTGAACGTTCGATTTCTGAGGGGAAAGAAGTATCACTATAAAATAGCGCCACAC
ATATGATTGGAGGGGGAAAT

Downstream 100 bases:

>100_bases
CTTATTTGTAAGCGCTTCTTTTTAGGAGCGCTTTGAATAGTAAAATGGGTAGGAGGAAGACAATGTTAAAAGCGATTGTG
ATGGACTTTGACGGAATTGT

Product: phosphotransferase system mannitol-specific enzyme IIBC

Products: NA

Alternate protein names: EIICB-Mtl; EII-Mtl; Mannitol permease IIC component; PTS system mannitol-specific EIIC component; Mannitol-specific phosphotransferase enzyme IIB component; PTS system mannitol-specific EIIB component [H]

Number of amino acids: Translated: 468; Mature: 467

Protein sequence:

>468_residues
MSIRVHVQKFGSKLSGMVIPNLGAFMAWGILTAIGVATGSEMLKGFIAPMLNYLLPLLIAFAGGRAVHGYRGGVIGTVAT
MGAIISSDITMFIGAMIMGPLAAWILKKFDERIDGKIPAGFELLVNNFSIGIIGAGLALFSYVAIAPMVEAVTKVLASGV
DVLINNHLLPLTALIIEPAKVLFLNNAIGQGILSPLATLQLAETGKSVLYLLESNPGPGLGILLGYMFFGKGNSKASSYG
ASVIHLFGGIHEIYFPFVLMNPILILPLILGGMTGTFILTMTNAGLVGVASPGSIITIMMMAAPGDHIKILIAVLCAALV
TFITAIPFIKRMGNKDSELQDAAKKMESLKGKKSSISSVFEATVDDFNFKNVKRIAYACDAGLGSSAMGATVLQKKIKNA
GLEDIKVFHIAIHELPTECDVVVTHKSLIDRAKEKQPDAYYVEITDYLGAPEYQELIDKIVADREQKN

Sequences:

>Translated_468_residues
MSIRVHVQKFGSKLSGMVIPNLGAFMAWGILTAIGVATGSEMLKGFIAPMLNYLLPLLIAFAGGRAVHGYRGGVIGTVAT
MGAIISSDITMFIGAMIMGPLAAWILKKFDERIDGKIPAGFELLVNNFSIGIIGAGLALFSYVAIAPMVEAVTKVLASGV
DVLINNHLLPLTALIIEPAKVLFLNNAIGQGILSPLATLQLAETGKSVLYLLESNPGPGLGILLGYMFFGKGNSKASSYG
ASVIHLFGGIHEIYFPFVLMNPILILPLILGGMTGTFILTMTNAGLVGVASPGSIITIMMMAAPGDHIKILIAVLCAALV
TFITAIPFIKRMGNKDSELQDAAKKMESLKGKKSSISSVFEATVDDFNFKNVKRIAYACDAGLGSSAMGATVLQKKIKNA
GLEDIKVFHIAIHELPTECDVVVTHKSLIDRAKEKQPDAYYVEITDYLGAPEYQELIDKIVADREQKN
>Mature_467_residues
SIRVHVQKFGSKLSGMVIPNLGAFMAWGILTAIGVATGSEMLKGFIAPMLNYLLPLLIAFAGGRAVHGYRGGVIGTVATM
GAIISSDITMFIGAMIMGPLAAWILKKFDERIDGKIPAGFELLVNNFSIGIIGAGLALFSYVAIAPMVEAVTKVLASGVD
VLINNHLLPLTALIIEPAKVLFLNNAIGQGILSPLATLQLAETGKSVLYLLESNPGPGLGILLGYMFFGKGNSKASSYGA
SVIHLFGGIHEIYFPFVLMNPILILPLILGGMTGTFILTMTNAGLVGVASPGSIITIMMMAAPGDHIKILIAVLCAALVT
FITAIPFIKRMGNKDSELQDAAKKMESLKGKKSSISSVFEATVDDFNFKNVKRIAYACDAGLGSSAMGATVLQKKIKNAG
LEDIKVFHIAIHELPTECDVVVTHKSLIDRAKEKQPDAYYVEITDYLGAPEYQELIDKIVADREQKN

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This

COG id: COG2213

COG function: function code G; Phosphotransferase system, mannitol-specific IIBC component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-2 domain [H]

Homologues:

Organism=Escherichia coli, GI1790027, Length=469, Percent_Identity=48.1876332622601, Blast_Score=446, Evalue=1e-126,
Organism=Escherichia coli, GI1789301, Length=469, Percent_Identity=42.4307036247335, Blast_Score=377, Evalue=1e-105,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013011
- InterPro:   IPR003501
- InterPro:   IPR003352
- InterPro:   IPR013014
- InterPro:   IPR004718 [H]

Pfam domain/function: PF02378 PTS_EIIC; PF02302 PTS_IIB [H]

EC number: =2.7.1.69 [H]

Molecular weight: Translated: 49803; Mature: 49672

Theoretical pI: Translated: 8.41; Mature: 8.41

Prosite motif: PS51099 PTS_EIIB_TYPE_2 ; PS51104 PTS_EIIC_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIRVHVQKFGSKLSGMVIPNLGAFMAWGILTAIGVATGSEMLKGFIAPMLNYLLPLLIA
CCEEEEHHHHCCHHCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHH
FAGGRAVHGYRGGVIGTVATMGAIISSDITMFIGAMIMGPLAAWILKKFDERIDGKIPAG
HCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
FELLVNNFSIGIIGAGLALFSYVAIAPMVEAVTKVLASGVDVLINNHLLPLTALIIEPAK
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCHHHHHHHHHCCHH
VLFLNNAIGQGILSPLATLQLAETGKSVLYLLESNPGPGLGILLGYMFFGKGNSKASSYG
HEEECCHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCCCHHHH
ASVIHLFGGIHEIYFPFVLMNPILILPLILGGMTGTFILTMTNAGLVGVASPGSIITIMM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCEEEECCCCCEEEEEE
MAAPGDHIKILIAVLCAALVTFITAIPFIKRMGNKDSELQDAAKKMESLKGKKSSISSVF
EECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHH
EATVDDFNFKNVKRIAYACDAGLGSSAMGATVLQKKIKNAGLEDIKVFHIAIHELPTECD
HHHHCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCC
VVVTHKSLIDRAKEKQPDAYYVEITDYLGAPEYQELIDKIVADREQKN
EEEEHHHHHHHHHHCCCCEEEEEEHHHCCCCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SIRVHVQKFGSKLSGMVIPNLGAFMAWGILTAIGVATGSEMLKGFIAPMLNYLLPLLIA
CEEEEHHHHCCHHCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHH
FAGGRAVHGYRGGVIGTVATMGAIISSDITMFIGAMIMGPLAAWILKKFDERIDGKIPAG
HCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
FELLVNNFSIGIIGAGLALFSYVAIAPMVEAVTKVLASGVDVLINNHLLPLTALIIEPAK
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCHHHHHHHHHCCHH
VLFLNNAIGQGILSPLATLQLAETGKSVLYLLESNPGPGLGILLGYMFFGKGNSKASSYG
HEEECCHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCCCHHHH
ASVIHLFGGIHEIYFPFVLMNPILILPLILGGMTGTFILTMTNAGLVGVASPGSIITIMM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCEEEECCCCCEEEEEE
MAAPGDHIKILIAVLCAALVTFITAIPFIKRMGNKDSELQDAAKKMESLKGKKSSISSVF
EECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHH
EATVDDFNFKNVKRIAYACDAGLGSSAMGATVLQKKIKNAGLEDIKVFHIAIHELPTECD
HHHHCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCC
VVVTHKSLIDRAKEKQPDAYYVEITDYLGAPEYQELIDKIVADREQKN
EEEEHHHHHHHHHHCCCCEEEEEEHHHCCCCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8824601 [H]