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The map label for this gene is pabA [H]

Identifier: 226225300

GI number: 226225300

Start: 2794069

End: 2794641

Strand: Direct

Name: pabA [H]

Synonym: Lm4b_02723

Alternate gene names: 226225300

Gene position: 2794069-2794641 (Clockwise)

Preceding gene: 226225296

Following gene: 226225301

Centisome position: 95.93

GC content: 40.84

Gene sequence:

>573_bases
GTGATTTTAATCATCGACCATAATGATTCATTTACATATAATTTATACCAATATTTTTTAGAGCTTCAAGAGGAGGTACA
GGTTGTTTCTGCTACTAATTTTTCGCTTGAAATATTTCAACAACTCGTTCCCGAAATGGTAGTTCTATCACCAGGGCCAG
GTTCACCGGAAGACTTCCCTGTAAGTTTAGCTCTACTAGATAAAATTCAAGTTCCTATTCTCGGCATTTGCCTCGGTCAT
CAAATGATTGCTCATTTTTTCGGGGCAAAAGTGGTGCCGGCAAAAGTCCCGGTTCACGGAAAAACAAGTATCATTTCGCA
TACTGGGGAAGGGTTGTTTGCAGAGCTTGCACCAAAGTTCCAAGTAACGCGCTACCATTCTTTAGTTATTGATCCTGCCA
CAGTTCCCGCTAATTTAAAAGTAACCGCACTGACAGAAGACGGCGTTATAATGGGACTAGCTCACGTATCAAAACCGATT
CACAGCGTCCAGTTCCACCCAGAAGCAATCCTATCTGAAAACGGACATGCAATACTTGAAAACTTTATACGATTAGGGAG
AAATGTTAAATGA

Upstream 100 bases:

>100_bases
TACCTTTCCACTCGGCTCCCGGCTTTAAACATTCGGGCTTGTTATCTCTCTAGCTATTTGCTATAAAAGAGTATAACCGT
TTTAACTAGGGGGATTTAAA

Downstream 100 bases:

>100_bases
GCTTATTACGATTTGATTTTGAAGGCGACACAAAAATTTTTGAAAATCCACTGTATGAACTAGTTACGCATGATTTAGCA
GAAGTTCTTCCTATAATGAA

Product: glutamine amidotransferase

Products: NA

Alternate protein names: ADC synthase [H]

Number of amino acids: Translated: 190; Mature: 190

Protein sequence:

>190_residues
MILIIDHNDSFTYNLYQYFLELQEEVQVVSATNFSLEIFQQLVPEMVVLSPGPGSPEDFPVSLALLDKIQVPILGICLGH
QMIAHFFGAKVVPAKVPVHGKTSIISHTGEGLFAELAPKFQVTRYHSLVIDPATVPANLKVTALTEDGVIMGLAHVSKPI
HSVQFHPEAILSENGHAILENFIRLGRNVK

Sequences:

>Translated_190_residues
MILIIDHNDSFTYNLYQYFLELQEEVQVVSATNFSLEIFQQLVPEMVVLSPGPGSPEDFPVSLALLDKIQVPILGICLGH
QMIAHFFGAKVVPAKVPVHGKTSIISHTGEGLFAELAPKFQVTRYHSLVIDPATVPANLKVTALTEDGVIMGLAHVSKPI
HSVQFHPEAILSENGHAILENFIRLGRNVK
>Mature_190_residues
MILIIDHNDSFTYNLYQYFLELQEEVQVVSATNFSLEIFQQLVPEMVVLSPGPGSPEDFPVSLALLDKIQVPILGICLGH
QMIAHFFGAKVVPAKVPVHGKTSIISHTGEGLFAELAPKFQVTRYHSLVIDPATVPANLKVTALTEDGVIMGLAHVSKPI
HSVQFHPEAILSENGHAILENFIRLGRNVK

Specific function: Catalyzes the biosynthesis of 4-amino-4-deoxychorismate (ADC) from chorismate and glutamine [H]

COG id: COG0512

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=139, Percent_Identity=35.2517985611511, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI18105007, Length=173, Percent_Identity=29.4797687861272, Blast_Score=64, Evalue=6e-11,
Organism=Escherichia coli, GI1789760, Length=185, Percent_Identity=50.2702702702703, Blast_Score=186, Evalue=1e-48,
Organism=Escherichia coli, GI1787517, Length=187, Percent_Identity=36.3636363636364, Blast_Score=109, Evalue=1e-25,
Organism=Escherichia coli, GI1786215, Length=160, Percent_Identity=31.875, Blast_Score=77, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI193204318, Length=128, Percent_Identity=35.15625, Blast_Score=75, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6322638, Length=187, Percent_Identity=39.572192513369, Blast_Score=146, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6324361, Length=218, Percent_Identity=32.5688073394495, Blast_Score=76, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6323873, Length=185, Percent_Identity=29.1891891891892, Blast_Score=69, Evalue=6e-13,
Organism=Drosophila melanogaster, GI281365319, Length=139, Percent_Identity=33.0935251798561, Blast_Score=74, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR006221 [H]

Pfam domain/function: PF00117 GATase [H]

EC number: =2.6.1.85 [H]

Molecular weight: Translated: 20870; Mature: 20870

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILIIDHNDSFTYNLYQYFLELQEEVQVVSATNFSLEIFQQLVPEMVVLSPGPGSPEDFP
CEEEEECCCCEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCEEEECCCCCCCCCCC
VSLALLDKIQVPILGICLGHQMIAHFFGAKVVPAKVPVHGKTSIISHTGEGLFAELAPKF
EEEEEHHHHCCCHHHHHHHHHHHHHHHCCEECCEECCCCCCCCEEEECCCCCEEHHCCCE
QVTRYHSLVIDPATVPANLKVTALTEDGVIMGLAHVSKPIHSVQFHPEAILSENGHAILE
EEEEEEEEEECCCCCCCCEEEEEEECCCEEEEHHHHCCCHHHEEECCHHHHCCCCHHHHH
NFIRLGRNVK
HHHHHCCCCC
>Mature Secondary Structure
MILIIDHNDSFTYNLYQYFLELQEEVQVVSATNFSLEIFQQLVPEMVVLSPGPGSPEDFP
CEEEEECCCCEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCEEEECCCCCCCCCCC
VSLALLDKIQVPILGICLGHQMIAHFFGAKVVPAKVPVHGKTSIISHTGEGLFAELAPKF
EEEEEHHHHCCCHHHHHHHHHHHHHHHCCEECCEECCCCCCCCEEEECCCCCEEHHCCCE
QVTRYHSLVIDPATVPANLKVTALTEDGVIMGLAHVSKPIHSVQFHPEAILSENGHAILE
EEEEEEEEEECCCCCCCCEEEEEEECCCEEEEHHHHCCCHHHEEECCHHHHCCCCHHHHH
NFIRLGRNVK
HHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3894673; 2403545; 11677609 [H]