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The map label for this gene is pabB [H]

Identifier: 226225301

GI number: 226225301

Start: 2794638

End: 2796344

Strand: Direct

Name: pabB [H]

Synonym: Lm4b_02724

Alternate gene names: 226225301

Gene position: 2794638-2796344 (Clockwise)

Preceding gene: 226225300

Following gene: 226225302

Centisome position: 95.95

GC content: 39.84

Gene sequence:

>1707_bases
ATGAGCTTATTACGATTTGATTTTGAAGGCGACACAAAAATTTTTGAAAATCCACTGTATGAACTAGTTACGCATGATTT
AGCAGAAGTTCTTCCTATAATGAAAGCAGCCGAAGAAGCCCAAAAATCAGGAAAATACGTCGCCGGTTTTGTCAGTTATG
AGGCCGCGCCTGCTTTTCGAAGTAATTTAAAAACAAAAAAACCGAGCGGAAACATGCCCCTCGTCTGGTTTGGCGTATAC
GATAATTTTAACGATACAGCTACCGAAACACCAGATTCCTCGCCGCTCTCTTTTAAAATGAATACTAGTTTCCCTGAATA
CGCCGAGAAAATAGAGCAAATCAAAGCTGAAATTGCAGCTGGAAATACTTACCAAATAAACTACACCGTGCGACTTCAAA
GTGATGTGCCAAACAGCTTTTCTTCTCAAGCGACTTATGAAACGTTACAGCAGATTGGAAAGGCGAATTACACCGCCCTA
CTTTCAACCAGTGACTTTGAGATTATCTCGGCTTCACCCGAGCTCTTTTTTAAATGGAAGGAAAATCTTCTAACGACACG
CCCGATGAAAGGTACTATTCGCCGCGGAATAACGGAGCAAGCGGACTTAGAAGCACATGATTGGCTAAAAAACGATCCTA
AAAACCGTGCAGAAAATGTGATGATTGTCGATTTACTACGGAACGACCTTGGGATGATTGCTGTACCCGGGAGTGTCAAG
GTTCCTAAGTTAATGACGCTAGAACCTTACCCAACTGTTTGGCAAATGACTTCAACCGTTACAGCAGAAACACCTCCTGA
GACTGATTTAACAGCTGTTTTTAAAGCACTCTTCCCATGTGGCTCAATAACTGGTGCGCCTAAAGCACGAACAATGGAAA
TTATTTCAGAACTAGAAGATTCTCCTCGTGGTGTTTACTGCGGAGCAATTGGCTTTTTAGAACCTAACGGAAATGCGATT
TTCAATGTACCGATTCGTACTATTGCTATCGCAGACAACAAGGCAACTTATGGTGTTGGTGGCGGTATCGTCTGGGATTC
GGAAGCCGCTAGCGAATTTTCCGAAATCCACGCAAAATCAGCTATTTTAGAAAAGACGACAAAATTTTCTTTAATTGAAT
GTTTGCGAATTGAAAATGGTGAGCTTTTCCGAACCGAATATCATTTAAAACGACTACAAACAAGCGCAGACTTTTTCGGT
ATTCCTTTTAATAGGGAAGAAACAGAGAAACTATGGACCAAAACTGCGCAAAAAAATACGACCGACACATACAAAATGCG
CTTTTTATTACATCCTGATGGCGCACATGATCTAGAACTAACAAGAATTGATACAAAAAACAAGCGAATAACAGCGCAAC
TTGCTGATAAACCAGTCCCTTCGAATGATTTATTTCTCTATCATAAAACGACTCATCGAAAGGTCTATGAAAACTTAAAA
AATACTCAAACCGAGGAAACACTACTTTGGAATGAACGGGGTGAACTGACAGAATTTATTAACGGGAATATAGTTCTAGG
TATAAATGGCTGTTTTTTCACGCCACCAGTAACTTCAGGTCTTCTTTCAGGGACAATGAGAGCAGAACTATTAGCTAAAA
ATAAGATTTCCGAGAAAACACTAGCAAAAAAAGACCTTTTAGAAGCGGACTATGTGTGGTTAATTAATAGCGTAAGAGGA
TTTATAGAAGTAGAAATCAAACAATAA

Upstream 100 bases:

>100_bases
CAAAACCGATTCACAGCGTCCAGTTCCACCCAGAAGCAATCCTATCTGAAAACGGACATGCAATACTTGAAAACTTTATA
CGATTAGGGAGAAATGTTAA

Downstream 100 bases:

>100_bases
AAGAATAGAAATTTCACAATTTAAAAATGAAATAATTTGTCAAATTCGCCATATTTTCGCCACATTTATAATTTGTGAAA
AAATTACTTGCAAATTTTCA

Product: para-aminobenzoate synthase component I

Products: NA

Alternate protein names: ADC synthase; Para-aminobenzoate synthase component I [H]

Number of amino acids: Translated: 568; Mature: 567

Protein sequence:

>568_residues
MSLLRFDFEGDTKIFENPLYELVTHDLAEVLPIMKAAEEAQKSGKYVAGFVSYEAAPAFRSNLKTKKPSGNMPLVWFGVY
DNFNDTATETPDSSPLSFKMNTSFPEYAEKIEQIKAEIAAGNTYQINYTVRLQSDVPNSFSSQATYETLQQIGKANYTAL
LSTSDFEIISASPELFFKWKENLLTTRPMKGTIRRGITEQADLEAHDWLKNDPKNRAENVMIVDLLRNDLGMIAVPGSVK
VPKLMTLEPYPTVWQMTSTVTAETPPETDLTAVFKALFPCGSITGAPKARTMEIISELEDSPRGVYCGAIGFLEPNGNAI
FNVPIRTIAIADNKATYGVGGGIVWDSEAASEFSEIHAKSAILEKTTKFSLIECLRIENGELFRTEYHLKRLQTSADFFG
IPFNREETEKLWTKTAQKNTTDTYKMRFLLHPDGAHDLELTRIDTKNKRITAQLADKPVPSNDLFLYHKTTHRKVYENLK
NTQTEETLLWNERGELTEFINGNIVLGINGCFFTPPVTSGLLSGTMRAELLAKNKISEKTLAKKDLLEADYVWLINSVRG
FIEVEIKQ

Sequences:

>Translated_568_residues
MSLLRFDFEGDTKIFENPLYELVTHDLAEVLPIMKAAEEAQKSGKYVAGFVSYEAAPAFRSNLKTKKPSGNMPLVWFGVY
DNFNDTATETPDSSPLSFKMNTSFPEYAEKIEQIKAEIAAGNTYQINYTVRLQSDVPNSFSSQATYETLQQIGKANYTAL
LSTSDFEIISASPELFFKWKENLLTTRPMKGTIRRGITEQADLEAHDWLKNDPKNRAENVMIVDLLRNDLGMIAVPGSVK
VPKLMTLEPYPTVWQMTSTVTAETPPETDLTAVFKALFPCGSITGAPKARTMEIISELEDSPRGVYCGAIGFLEPNGNAI
FNVPIRTIAIADNKATYGVGGGIVWDSEAASEFSEIHAKSAILEKTTKFSLIECLRIENGELFRTEYHLKRLQTSADFFG
IPFNREETEKLWTKTAQKNTTDTYKMRFLLHPDGAHDLELTRIDTKNKRITAQLADKPVPSNDLFLYHKTTHRKVYENLK
NTQTEETLLWNERGELTEFINGNIVLGINGCFFTPPVTSGLLSGTMRAELLAKNKISEKTLAKKDLLEADYVWLINSVRG
FIEVEIKQ
>Mature_567_residues
SLLRFDFEGDTKIFENPLYELVTHDLAEVLPIMKAAEEAQKSGKYVAGFVSYEAAPAFRSNLKTKKPSGNMPLVWFGVYD
NFNDTATETPDSSPLSFKMNTSFPEYAEKIEQIKAEIAAGNTYQINYTVRLQSDVPNSFSSQATYETLQQIGKANYTALL
STSDFEIISASPELFFKWKENLLTTRPMKGTIRRGITEQADLEAHDWLKNDPKNRAENVMIVDLLRNDLGMIAVPGSVKV
PKLMTLEPYPTVWQMTSTVTAETPPETDLTAVFKALFPCGSITGAPKARTMEIISELEDSPRGVYCGAIGFLEPNGNAIF
NVPIRTIAIADNKATYGVGGGIVWDSEAASEFSEIHAKSAILEKTTKFSLIECLRIENGELFRTEYHLKRLQTSADFFGI
PFNREETEKLWTKTAQKNTTDTYKMRFLLHPDGAHDLELTRIDTKNKRITAQLADKPVPSNDLFLYHKTTHRKVYENLKN
TQTEETLLWNERGELTEFINGNIVLGINGCFFTPPVTSGLLSGTMRAELLAKNKISEKTLAKKDLLEADYVWLINSVRGF
IEVEIKQ

Specific function: Catalyzes the biosynthesis of 4-amino-4-deoxychorismate (ADC) from chorismate and glutamine [H]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1788114, Length=272, Percent_Identity=39.7058823529412, Blast_Score=199, Evalue=4e-52,
Organism=Escherichia coli, GI1787518, Length=277, Percent_Identity=29.2418772563177, Blast_Score=129, Evalue=6e-31,
Organism=Escherichia coli, GI1786809, Length=196, Percent_Identity=27.0408163265306, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI87082077, Length=195, Percent_Identity=24.6153846153846, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320935, Length=280, Percent_Identity=35.7142857142857, Blast_Score=169, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6324361, Length=282, Percent_Identity=28.3687943262411, Blast_Score=108, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR015890
- InterPro:   IPR005802 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =2.6.1.85 [H]

Molecular weight: Translated: 63794; Mature: 63663

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLLRFDFEGDTKIFENPLYELVTHDLAEVLPIMKAAEEAQKSGKYVAGFVSYEAAPAFR
CCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHH
SNLKTKKPSGNMPLVWFGVYDNFNDTATETPDSSPLSFKMNTSFPEYAEKIEQIKAEIAA
HCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCC
GNTYQINYTVRLQSDVPNSFSSQATYETLQQIGKANYTALLSTSDFEIISASPELFFKWK
CCEEEEEEEEEECCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCEEEECCCHHHHEEH
ENLLTTRPMKGTIRRGITEQADLEAHDWLKNDPKNRAENVMIVDLLRNDLGMIAVPGSVK
HCCCCCCCCCHHHHCCCCCCCCCCHHHHHCCCCCHHHCCEEEEEEHHCCCCEEEECCCCC
VPKLMTLEPYPTVWQMTSTVTAETPPETDLTAVFKALFPCGSITGAPKARTMEIISELED
CCEEEEECCCCCCEEEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCC
SPRGVYCGAIGFLEPNGNAIFNVPIRTIAIADNKATYGVGGGIVWDSEAASEFSEIHAKS
CCCEEEEEEEEEECCCCCEEEECCEEEEEEECCCCEECCCCCEEECCHHHHHHHHHHHHH
AILEKTTKFSLIECLRIENGELFRTEYHLKRLQTSADFFGIPFNREETEKLWTKTAQKNT
HHHHHHHHHHHHHHEECCCCCEEEHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHHCCCC
TDTYKMRFLLHPDGAHDLELTRIDTKNKRITAQLADKPVPSNDLFLYHKTTHRKVYENLK
CCEEEEEEEECCCCCCCEEEEEECCCCCEEEEEECCCCCCCCCEEEEECHHHHHHHHHHH
NTQTEETLLWNERGELTEFINGNIVLGINGCFFTPPVTSGLLSGTMRAELLAKNKISEKT
CCCCCHHEEECCCCCHHHHHCCCEEEEECCEEECCCHHHHHHHHHHHHHHHHHHCCHHHH
LAKKDLLEADYVWLINSVRGFIEVEIKQ
HHHHHHHCHHHHHHHHCCCCEEEEEEEC
>Mature Secondary Structure 
SLLRFDFEGDTKIFENPLYELVTHDLAEVLPIMKAAEEAQKSGKYVAGFVSYEAAPAFR
CEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHH
SNLKTKKPSGNMPLVWFGVYDNFNDTATETPDSSPLSFKMNTSFPEYAEKIEQIKAEIAA
HCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCC
GNTYQINYTVRLQSDVPNSFSSQATYETLQQIGKANYTALLSTSDFEIISASPELFFKWK
CCEEEEEEEEEECCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCEEEECCCHHHHEEH
ENLLTTRPMKGTIRRGITEQADLEAHDWLKNDPKNRAENVMIVDLLRNDLGMIAVPGSVK
HCCCCCCCCCHHHHCCCCCCCCCCHHHHHCCCCCHHHCCEEEEEEHHCCCCEEEECCCCC
VPKLMTLEPYPTVWQMTSTVTAETPPETDLTAVFKALFPCGSITGAPKARTMEIISELED
CCEEEEECCCCCCEEEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCC
SPRGVYCGAIGFLEPNGNAIFNVPIRTIAIADNKATYGVGGGIVWDSEAASEFSEIHAKS
CCCEEEEEEEEEECCCCCEEEECCEEEEEEECCCCEECCCCCEEECCHHHHHHHHHHHHH
AILEKTTKFSLIECLRIENGELFRTEYHLKRLQTSADFFGIPFNREETEKLWTKTAQKNT
HHHHHHHHHHHHHHEECCCCCEEEHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHHCCCC
TDTYKMRFLLHPDGAHDLELTRIDTKNKRITAQLADKPVPSNDLFLYHKTTHRKVYENLK
CCEEEEEEEECCCCCCCEEEEEECCCCCEEEEEECCCCCCCCCEEEEECHHHHHHHHHHH
NTQTEETLLWNERGELTEFINGNIVLGINGCFFTPPVTSGLLSGTMRAELLAKNKISEKT
CCCCCHHEEECCCCCHHHHHCCCEEEEECCEEECCCHHHHHHHHHHHHHHHHHHCCHHHH
LAKKDLLEADYVWLINSVRGFIEVEIKQ
HHHHHHHCHHHHHHHHCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3057324; 11677609; 2251281 [H]