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The map label for this gene is mtlR [H]

Identifier: 226225196

GI number: 226225196

Start: 2689485

End: 2691551

Strand: Reverse

Name: mtlR [H]

Synonym: Lm4b_02618

Alternate gene names: 226225196

Gene position: 2691551-2689485 (Counterclockwise)

Preceding gene: 226225197

Following gene: 226225195

Centisome position: 92.41

GC content: 38.66

Gene sequence:

>2067_bases
GTGGTACAATTTGATGCTCGAAATATGGCGTTGCTCGAATCACTCGTTGTGGCGAATGTATATCTTGCACCCGAGAAATT
ACAAGAAGAACTAGGAATTTCCAAACGAACACTTCAATATGATGTGGAAAAAATTAATAAAGAATTAGATAATATAGGAC
TCGATGGTATTCAATCTGTTCGTGGACAAGGGTATTATTTATTAGAAGATGAAAAATCGACAATTAAAGAAATCCTTGGA
AATAGGGAAGCGAGCCACAAAGTCTTTTCAGCAAGTGAGCGTCGCATCCGTATTTTATTTTTTCTGCTCGTAACAGATGC
GCGAGTAATCATTGATACGATTAATGAATGCAATGAAGTCAGTCGTAATACAAGTTTGCAGGACATTAAACAATTAAAAT
TAGCGCTAAAACAGTTTAATTTAGAACTTGCGTATGACCGTAAAAATGGCAATATGGTTCTCGGTGATGAGCGCAGTATT
CGCCAATTTTTTATTCACTATTGTATGAATAACGAAGAAATCGCAACCGCAGACCAGTTGCTCGATTTAATGAAAATTAA
TCCGATGATAAAAAATCAGGAGTTATTTCACAAATTAGATACGATTTTCGAAATTTTAGCAGTAACGGAGAAAAAAATCG
GAATTCGTTATACTGACGAGGTCCTTGAGCGCATTGGTATTATGATTTTCTTCTTTAAAGAACGAATGAAGCGTAATTGC
TATTTAAATGAACAAGAAGAGCATGAAGTAGAATCTTTTGAGATTGCGCAGGAAATTTATCAGCAATTGCAGCAAAGTGA
GAATTTTAAAATCAATCATGCGGAAATCACTTATTTAGGTAAACTTTTGCTTGGGGCGAGTCGTTTGAATGATGATGCGG
CTGCTGAAGGAAAATTAGATCTCATCGTTGAAAAAATCATCGCCGAATTTGAACGTCTTGCTTGCGTGAATTTTGAAGAC
CATCGCAATTTGAAAAAAGATTTATTGCTTCATTTACAACCAGCCTACTATCGGCTTAAATTCCAAATTGAGTGGATTAA
CCCGCTAAGGACAGACATTAAACAAAGTTACAGTGATGTGTACGAGATTACGAAAAAATCACTCGAACCGCTAGAAGATT
TACTTGGTGAAACAATTCCAGAGGATGAAATAGCGTACGTAACAATCTTGTTCGGTGGCTATCTTTCACGCAAAAATAAT
ACTTTAGTTGAACGAAAAAAACTCTTAATCGTTTGCTCCAAAGGTGTCGGAACGTCGCGGATGATTGAACGGCAATTATC
GCAATTACTTGGTGAGCGAGTAGAGATATTAGAACCAATTTCCATCCGTGAATTTGAAAAAGGGTTATACGCACCAGACT
TTATTGTGTCGACTTTGCCAATTATGGAACCAAAAGCACCAGTTTTTATCGTTAGTCCAATTTTGACAGAAGCGCAGAAA
CAACAACTGATGAAGGCGATTGCCCCGCACATTTTGCAAAAGGACTCGGATGCGCGCATGTTGTCTTCTGTGCTTGATGT
AGTAGATCAATATGCCAAAGTGGAAGACCGCGAGAAATTGGCGGCAAAACTGAAATCGGTATTGTTCCAAGTGCAATCAG
ACAGCCAACTAGAAAAATCTCCAACACTCGAAGAACTTTTACCGAAAGAACGAATTACTTTTAAAGAAAGTGTGGCGGAC
TGGCGTGAAGCTATCCTAGTTGCCTCGAAATCGCTGCAACAAGAAGGCTACATTTCGAGAAATTATCAGCATGCGATGAT
TGAAAATATTGAGAAACTCGGACCATACATCGTTATTGCGCCAGGGATTGCACTGCCACATGCGTCTGTGGATGACGGGG
CATACCGAGTCGGAATGAGCTTACTGCGCTTAAATCAGCCAGTATCATTTTCAAGTAAAGCGAAAGATCAAGTGAAGTTA
ATTATTGTGCTCGCTTCCATTGACTCCTACACACATATTAATGCGCTGAGCCAACTCACTAATTTAATCATGAAACATCA
CTTGCTAGAGCAGATTGAACAAGCGACATCAGCAGCGGAAATTGCCGCAATGTTAACGATACAATAA

Upstream 100 bases:

>100_bases
CCTGAAATAAAAATTAACTTGAAAAATATCACATTTTCGCATAACCTTAAAGTAGACATATCTTTTTACCTTCTAGACCG
AAATCAAGGAGGTAGGCCAA

Downstream 100 bases:

>100_bases
GCAAGAAAGCCAGTGGGGCACCAAGATGCCGCGCTGGCTTTTTGTATGCTCGCTAACAACAAAATGTAACAGTCTATTTT
TTGCACTTTCGAAAAGAAAG

Product: transcriptional antiterminator

Products: NA

Alternate protein names: Mannitol operon transcriptional activator; Mtl operon transcriptional activator; Putative phosphotransferase enzyme IIB component; Putative PTS system EIIB component; Putative phosphotransferase enzyme IIA component; Putative PTS system EIIA component [H]

Number of amino acids: Translated: 688; Mature: 688

Protein sequence:

>688_residues
MVQFDARNMALLESLVVANVYLAPEKLQEELGISKRTLQYDVEKINKELDNIGLDGIQSVRGQGYYLLEDEKSTIKEILG
NREASHKVFSASERRIRILFFLLVTDARVIIDTINECNEVSRNTSLQDIKQLKLALKQFNLELAYDRKNGNMVLGDERSI
RQFFIHYCMNNEEIATADQLLDLMKINPMIKNQELFHKLDTIFEILAVTEKKIGIRYTDEVLERIGIMIFFFKERMKRNC
YLNEQEEHEVESFEIAQEIYQQLQQSENFKINHAEITYLGKLLLGASRLNDDAAAEGKLDLIVEKIIAEFERLACVNFED
HRNLKKDLLLHLQPAYYRLKFQIEWINPLRTDIKQSYSDVYEITKKSLEPLEDLLGETIPEDEIAYVTILFGGYLSRKNN
TLVERKKLLIVCSKGVGTSRMIERQLSQLLGERVEILEPISIREFEKGLYAPDFIVSTLPIMEPKAPVFIVSPILTEAQK
QQLMKAIAPHILQKDSDARMLSSVLDVVDQYAKVEDREKLAAKLKSVLFQVQSDSQLEKSPTLEELLPKERITFKESVAD
WREAILVASKSLQQEGYISRNYQHAMIENIEKLGPYIVIAPGIALPHASVDDGAYRVGMSLLRLNQPVSFSSKAKDQVKL
IIVLASIDSYTHINALSQLTNLIMKHHLLEQIEQATSAAEIAAMLTIQ

Sequences:

>Translated_688_residues
MVQFDARNMALLESLVVANVYLAPEKLQEELGISKRTLQYDVEKINKELDNIGLDGIQSVRGQGYYLLEDEKSTIKEILG
NREASHKVFSASERRIRILFFLLVTDARVIIDTINECNEVSRNTSLQDIKQLKLALKQFNLELAYDRKNGNMVLGDERSI
RQFFIHYCMNNEEIATADQLLDLMKINPMIKNQELFHKLDTIFEILAVTEKKIGIRYTDEVLERIGIMIFFFKERMKRNC
YLNEQEEHEVESFEIAQEIYQQLQQSENFKINHAEITYLGKLLLGASRLNDDAAAEGKLDLIVEKIIAEFERLACVNFED
HRNLKKDLLLHLQPAYYRLKFQIEWINPLRTDIKQSYSDVYEITKKSLEPLEDLLGETIPEDEIAYVTILFGGYLSRKNN
TLVERKKLLIVCSKGVGTSRMIERQLSQLLGERVEILEPISIREFEKGLYAPDFIVSTLPIMEPKAPVFIVSPILTEAQK
QQLMKAIAPHILQKDSDARMLSSVLDVVDQYAKVEDREKLAAKLKSVLFQVQSDSQLEKSPTLEELLPKERITFKESVAD
WREAILVASKSLQQEGYISRNYQHAMIENIEKLGPYIVIAPGIALPHASVDDGAYRVGMSLLRLNQPVSFSSKAKDQVKL
IIVLASIDSYTHINALSQLTNLIMKHHLLEQIEQATSAAEIAAMLTIQ
>Mature_688_residues
MVQFDARNMALLESLVVANVYLAPEKLQEELGISKRTLQYDVEKINKELDNIGLDGIQSVRGQGYYLLEDEKSTIKEILG
NREASHKVFSASERRIRILFFLLVTDARVIIDTINECNEVSRNTSLQDIKQLKLALKQFNLELAYDRKNGNMVLGDERSI
RQFFIHYCMNNEEIATADQLLDLMKINPMIKNQELFHKLDTIFEILAVTEKKIGIRYTDEVLERIGIMIFFFKERMKRNC
YLNEQEEHEVESFEIAQEIYQQLQQSENFKINHAEITYLGKLLLGASRLNDDAAAEGKLDLIVEKIIAEFERLACVNFED
HRNLKKDLLLHLQPAYYRLKFQIEWINPLRTDIKQSYSDVYEITKKSLEPLEDLLGETIPEDEIAYVTILFGGYLSRKNN
TLVERKKLLIVCSKGVGTSRMIERQLSQLLGERVEILEPISIREFEKGLYAPDFIVSTLPIMEPKAPVFIVSPILTEAQK
QQLMKAIAPHILQKDSDARMLSSVLDVVDQYAKVEDREKLAAKLKSVLFQVQSDSQLEKSPTLEELLPKERITFKESVAD
WREAILVASKSLQQEGYISRNYQHAMIENIEKLGPYIVIAPGIALPHASVDDGAYRVGMSLLRLNQPVSFSSKAKDQVKL
IIVLASIDSYTHINALSQLTNLIMKHHLLEQIEQATSAAEIAAMLTIQ

Specific function: Positively regulates the expression of the mtlAFD operon involved in the uptake and catabolism of mannitol [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIB type-2 domain [H]

Homologues:

Organism=Escherichia coli, GI1789302, Length=114, Percent_Identity=39.4736842105263, Blast_Score=86, Evalue=8e-18,
Organism=Escherichia coli, GI2367359, Length=122, Percent_Identity=29.5081967213115, Blast_Score=83, Evalue=6e-17,
Organism=Escherichia coli, GI1790755, Length=132, Percent_Identity=31.0606060606061, Blast_Score=81, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013196
- InterPro:   IPR007737
- InterPro:   IPR011608
- InterPro:   IPR016152
- InterPro:   IPR002178
- InterPro:   IPR013011
- InterPro:   IPR003501
- InterPro:   IPR011991 [H]

Pfam domain/function: PF08279 HTH_11; PF05043 Mga; PF00874 PRD; PF02302 PTS_IIB [H]

EC number: =2.7.1.69 [H]

Molecular weight: Translated: 78855; Mature: 78855

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: PS51094 PTS_EIIA_TYPE_2 ; PS51099 PTS_EIIB_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVQFDARNMALLESLVVANVYLAPEKLQEELGISKRTLQYDVEKINKELDNIGLDGIQSV
CCEECCCHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHH
RGQGYYLLEDEKSTIKEILGNREASHKVFSASERRIRILFFLLVTDARVIIDTINECNEV
CCCCEEEEECCHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
SRNTSLQDIKQLKLALKQFNLELAYDRKNGNMVLGDERSIRQFFIHYCMNNEEIATADQL
HCCCCHHHHHHHHHHHHHHCCEEEEECCCCCEEECCCHHHHHHHHHHHCCCCCHHHHHHH
LDLMKINPMIKNQELFHKLDTIFEILAVTEKKIGIRYTDEVLERIGIMIFFFKERMKRNC
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHCC
YLNEQEEHEVESFEIAQEIYQQLQQSENFKINHAEITYLGKLLLGASRLNDDAAAEGKLD
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHCCCCCCCCCHHH
LIVEKIIAEFERLACVNFEDHRNLKKDLLLHLQPAYYRLKFQIEWINPLRTDIKQSYSDV
HHHHHHHHHHHHHHCCCCHHHHCHHHHHHHHCCCCEEEEEEEEEECCHHHHHHHHHHHHH
YEITKKSLEPLEDLLGETIPEDEIAYVTILFGGYLSRKNNTLVERKKLLIVCSKGVGTSR
HHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEHHHHCCCCCHHHHHCEEEEEECCCCCHHH
MIERQLSQLLGERVEILEPISIREFEKGLYAPDFIVSTLPIMEPKAPVFIVSPILTEAQK
HHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCHHHHHHCCCCCCCCCEEEECHHHHHHHH
QQLMKAIAPHILQKDSDARMLSSVLDVVDQYAKVEDREKLAAKLKSVLFQVQSDSQLEKS
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PTLEELLPKERITFKESVADWREAILVASKSLQQEGYISRNYQHAMIENIEKLGPYIVIA
CCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCEEEEE
PGIALPHASVDDGAYRVGMSLLRLNQPVSFSSKAKDQVKLIIVLASIDSYTHINALSQLT
CCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHH
NLIMKHHLLEQIEQATSAAEIAAMLTIQ
HHHHHHHHHHHHHHHHHHHHHHHHEECC
>Mature Secondary Structure
MVQFDARNMALLESLVVANVYLAPEKLQEELGISKRTLQYDVEKINKELDNIGLDGIQSV
CCEECCCHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHH
RGQGYYLLEDEKSTIKEILGNREASHKVFSASERRIRILFFLLVTDARVIIDTINECNEV
CCCCEEEEECCHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
SRNTSLQDIKQLKLALKQFNLELAYDRKNGNMVLGDERSIRQFFIHYCMNNEEIATADQL
HCCCCHHHHHHHHHHHHHHCCEEEEECCCCCEEECCCHHHHHHHHHHHCCCCCHHHHHHH
LDLMKINPMIKNQELFHKLDTIFEILAVTEKKIGIRYTDEVLERIGIMIFFFKERMKRNC
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHCC
YLNEQEEHEVESFEIAQEIYQQLQQSENFKINHAEITYLGKLLLGASRLNDDAAAEGKLD
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHCCCCCCCCCHHH
LIVEKIIAEFERLACVNFEDHRNLKKDLLLHLQPAYYRLKFQIEWINPLRTDIKQSYSDV
HHHHHHHHHHHHHHCCCCHHHHCHHHHHHHHCCCCEEEEEEEEEECCHHHHHHHHHHHHH
YEITKKSLEPLEDLLGETIPEDEIAYVTILFGGYLSRKNNTLVERKKLLIVCSKGVGTSR
HHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEHHHHCCCCCHHHHHCEEEEEECCCCCHHH
MIERQLSQLLGERVEILEPISIREFEKGLYAPDFIVSTLPIMEPKAPVFIVSPILTEAQK
HHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCHHHHHHCCCCCCCCCEEEECHHHHHHHH
QQLMKAIAPHILQKDSDARMLSSVLDVVDQYAKVEDREKLAAKLKSVLFQVQSDSQLEKS
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PTLEELLPKERITFKESVADWREAILVASKSLQQEGYISRNYQHAMIENIEKLGPYIVIA
CCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCEEEEE
PGIALPHASVDDGAYRVGMSLLRLNQPVSFSSKAKDQVKLIIVLASIDSYTHINALSQLT
CCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHH
NLIMKHHLLEQIEQATSAAEIAAMLTIQ
HHHHHHHHHHHHHHHHHHHHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]