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The map label for this gene is hepT [H]

Identifier: 226225186

GI number: 226225186

Start: 2680471

End: 2681451

Strand: Direct

Name: hepT [H]

Synonym: Lm4b_02608

Alternate gene names: 226225186

Gene position: 2680471-2681451 (Clockwise)

Preceding gene: 226225185

Following gene: 226225187

Centisome position: 92.03

GC content: 38.74

Gene sequence:

>981_bases
ATGCAACTTCATGCTATGTGGGATGAGTATCCTGCACTTTCCAAAGATTTACAAGAAGTCTTACAAACGATTGAAAAAAA
TATTCAAATTCGCGATAAACACGTTGAGCAAAACGTGAAAGATTTGATTCACGCTGGCGGGAAATTACTGCGCCCTGCTT
TTGCGCTTCTTTCTGCGCAAGCTGGTCCTGATTATGATAAAGAACGTGCTGTTTCGATTGCTGCTGCGCTTGAAGTACTT
CATATGGCGACGTTGATTCATGATGATGTCGTTGATGATTCTCCGTTACGCCGCGGGATCCCGACAATTCATTCTAAATA
TGGTCGTAATTATGCTGTTTATACAGGCGATTATTTATTCTGCATCTGTTTCAAAATTTTATCCGCACATGCTTCTTCCG
TGGAGAACATTGAATTTAATAGTAAAAATATCGAAAAAATCTTAATGGGCGAACTAGACCAAATGCGCACAAGCTACAAA
ATGAATGTAACTGTTCGTGAATATTTAACGCGTATTTCTGGTAAAACAGCACAATTATTTGCACTTAGTTGTTACTCTGG
CGCAACTGGCAGTAAAGCAACACGCATGACAGTTGCAAAATGTTATAACATCGGACATTACCTTGGCATGGCTTTCCAAA
TTATTGACGACGTACTGGATTACACAAGTACGGATGAAGGTCTTGGCAAACCCGTTTTAAATGATATGAAACAAGGTATT
TATTCTCTGCCACTTATTTATGCAATGAAAGGTCACTTGGCTGAATTCGAGCCACTTCTTTCTCAAAAACTAGATATGAC
GGATGAAGCTTCCGAACAAGTTTTAGCACTTATTTCTAAGTATAAAGGTGTCGAACAGGCATTCAAACTTGCCAACAAGT
ATACGAATAAAGCGCTTCGTGAAATCAAAAAACTACCAGCTGGCGCATATCGTGATGATATGTACCACTTGACGAAAAAT
ATTTTAGATCGAGATATCTAA

Upstream 100 bases:

>100_bases
AGCAAATTACCTACTGAAAAACGTCCAAACTTTGCGGATGTTCGCTGATGCTAAACAAAGTCAAGCAGCACAAAAATAAC
TTTAAAAAAAGGAGTTCAAT

Downstream 100 bases:

>100_bases
ACCGTTTAGAACATTGCTCCTTCCATATTGAGTTTTGTTCTAAATTTTGGAACTTATTGTGAAAATACAAACATGAAAGC
GTGATTAACGTGATTCGATT

Product: heptaprenyl diphosphate synthase component II

Products: NA

Alternate protein names: HEPPP synthase subunit 2 [H]

Number of amino acids: Translated: 326; Mature: 326

Protein sequence:

>326_residues
MQLHAMWDEYPALSKDLQEVLQTIEKNIQIRDKHVEQNVKDLIHAGGKLLRPAFALLSAQAGPDYDKERAVSIAAALEVL
HMATLIHDDVVDDSPLRRGIPTIHSKYGRNYAVYTGDYLFCICFKILSAHASSVENIEFNSKNIEKILMGELDQMRTSYK
MNVTVREYLTRISGKTAQLFALSCYSGATGSKATRMTVAKCYNIGHYLGMAFQIIDDVLDYTSTDEGLGKPVLNDMKQGI
YSLPLIYAMKGHLAEFEPLLSQKLDMTDEASEQVLALISKYKGVEQAFKLANKYTNKALREIKKLPAGAYRDDMYHLTKN
ILDRDI

Sequences:

>Translated_326_residues
MQLHAMWDEYPALSKDLQEVLQTIEKNIQIRDKHVEQNVKDLIHAGGKLLRPAFALLSAQAGPDYDKERAVSIAAALEVL
HMATLIHDDVVDDSPLRRGIPTIHSKYGRNYAVYTGDYLFCICFKILSAHASSVENIEFNSKNIEKILMGELDQMRTSYK
MNVTVREYLTRISGKTAQLFALSCYSGATGSKATRMTVAKCYNIGHYLGMAFQIIDDVLDYTSTDEGLGKPVLNDMKQGI
YSLPLIYAMKGHLAEFEPLLSQKLDMTDEASEQVLALISKYKGVEQAFKLANKYTNKALREIKKLPAGAYRDDMYHLTKN
ILDRDI
>Mature_326_residues
MQLHAMWDEYPALSKDLQEVLQTIEKNIQIRDKHVEQNVKDLIHAGGKLLRPAFALLSAQAGPDYDKERAVSIAAALEVL
HMATLIHDDVVDDSPLRRGIPTIHSKYGRNYAVYTGDYLFCICFKILSAHASSVENIEFNSKNIEKILMGELDQMRTSYK
MNVTVREYLTRISGKTAQLFALSCYSGATGSKATRMTVAKCYNIGHYLGMAFQIIDDVLDYTSTDEGLGKPVLNDMKQGI
YSLPLIYAMKGHLAEFEPLLSQKLDMTDEASEQVLALISKYKGVEQAFKLANKYTNKALREIKKLPAGAYRDDMYHLTKN
ILDRDI

Specific function: Supplies heptaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinone menaquinone-7 (MQ-7) [H]

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=320, Percent_Identity=30.625, Blast_Score=141, Evalue=8e-34,
Organism=Escherichia coli, GI1789578, Length=286, Percent_Identity=31.4685314685315, Blast_Score=147, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17505681, Length=309, Percent_Identity=29.126213592233, Blast_Score=126, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6319475, Length=311, Percent_Identity=27.9742765273312, Blast_Score=119, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24651612, Length=288, Percent_Identity=28.8194444444444, Blast_Score=129, Evalue=3e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014119
- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.30 [H]

Molecular weight: Translated: 36728; Mature: 36728

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLHAMWDEYPALSKDLQEVLQTIEKNIQIRDKHVEQNVKDLIHAGGKLLRPAFALLSAQ
CCCCCHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHC
AGPDYDKERAVSIAAALEVLHMATLIHDDVVDDSPLRRGIPTIHSKYGRNYAVYTGDYLF
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHHCCCEEEEECHHHH
CICFKILSAHASSVENIEFNSKNIEKILMGELDQMRTSYKMNVTVREYLTRISGKTAQLF
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHE
ALSCYSGATGSKATRMTVAKCYNIGHYLGMAFQIIDDVLDYTSTDEGLGKPVLNDMKQGI
EEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
YSLPLIYAMKGHLAEFEPLLSQKLDMTDEASEQVLALISKYKGVEQAFKLANKYTNKALR
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EIKKLPAGAYRDDMYHLTKNILDRDI
HHHHCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQLHAMWDEYPALSKDLQEVLQTIEKNIQIRDKHVEQNVKDLIHAGGKLLRPAFALLSAQ
CCCCCHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHC
AGPDYDKERAVSIAAALEVLHMATLIHDDVVDDSPLRRGIPTIHSKYGRNYAVYTGDYLF
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHHCCCEEEEECHHHH
CICFKILSAHASSVENIEFNSKNIEKILMGELDQMRTSYKMNVTVREYLTRISGKTAQLF
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHE
ALSCYSGATGSKATRMTVAKCYNIGHYLGMAFQIIDDVLDYTSTDEGLGKPVLNDMKQGI
EEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
YSLPLIYAMKGHLAEFEPLLSQKLDMTDEASEQVLALISKYKGVEQAFKLANKYTNKALR
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EIKKLPAGAYRDDMYHLTKNILDRDI
HHHHCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7629164 [H]