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The map label for this gene is menA [H]

Identifier: 226225180

GI number: 226225180

Start: 2673744

End: 2674703

Strand: Reverse

Name: menA [H]

Synonym: Lm4b_02602

Alternate gene names: 226225180

Gene position: 2674703-2673744 (Counterclockwise)

Preceding gene: 226225181

Following gene: 226225179

Centisome position: 91.83

GC content: 34.69

Gene sequence:

>960_bases
ATGTCAATACCATCGTTTCTGAAGTTGGTTGAAATCCAAACGAAGATAGCTAGTGTTTTTCCGTTTATGTTAGGAACGCT
ATTTGTTGTGTATCAATATGATATGTTCAAACCTGTTAATACGTTGATATTTTTCGGATCTATGCTCATATTCGACTTGA
CTACAACAGCGATTAATAACTATATGGATTACCGCAAAGCAACAGACAATCATGATTACGATTATCGAACTACCAGCAAT
GTAATTGGGCAAGAGCAAATTCCGGTGCGAACAGTTATTATAACTATTTTCTTGATGTTCTTCATTGCTACAGGATTAGG
TGTTTGGTTAGTTTTTCGAACAGATCTTTTAGTGCTCTTAATTGGATTTGTCTGCTTTTGTATAGGCATCTTATATACAT
TCGGTCCTGTACCGCTTTCTCGTATGCCGTTAGGTGAAATTTTTTCAGGCGTAACGATGGGGTTTGGGATTTTCTTCTTA
GCTGTATATGTAAATGCATACGACGCGGGAATAGCGAATTTACTTTGGCAAGGAGAAATGGTGACAATCCAGTTCAATCT
AATAGAAATTATTCGGATAGGTGTGGTATCCTTACCTTGTATTTTCACAATAGCTAATATCATGCTCGCGAATAATCTCT
GTGATTTAGATGAAGATATTCGGAATCATCGTTACACACTTCCGTATTATATAGGAAGAAAAATGGGAGTCTTATTATTT
AATGCTTTATATTATGCTTCATTTTTAGCTGTGGTTGTTTCGGTAGCTATAAACTTCTTACATCCAATCATGTTACTATC
ACTAATAACAATCTATCCAGTGTATCGTAATCTAGTTAAATTCAATAAAGAACAAGTAAAATCAAAAACATTTGTTATTG
GTATTCGTAATTTCGTATTAATTAATGCGACATTGACAATTTTAATGGCGGTGAGCGTGGTACTTCAACAACTGGCGTAA

Upstream 100 bases:

>100_bases
GGACACGCTAAAAAAATAAACTATTATTATAGAAGAAAGTGAGCAGAATTCGCTCTGGATTCTGCTCACAATAAACTAGA
AAAGGGGCTAAAAAGGGGAT

Downstream 100 bases:

>100_bases
AGAAAAGGGGGCTTCTTTGAATGATTGAAAAACTAATATTAGGTCGTTTTGTCCCAGGGGAGTCCTTAATTCATGGTCTG
GATGCGCGAACGAAACTTTT

Product: 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Products: NA

Alternate protein names: DHNA-octaprenyltransferase [H]

Number of amino acids: Translated: 319; Mature: 318

Protein sequence:

>319_residues
MSIPSFLKLVEIQTKIASVFPFMLGTLFVVYQYDMFKPVNTLIFFGSMLIFDLTTTAINNYMDYRKATDNHDYDYRTTSN
VIGQEQIPVRTVIITIFLMFFIATGLGVWLVFRTDLLVLLIGFVCFCIGILYTFGPVPLSRMPLGEIFSGVTMGFGIFFL
AVYVNAYDAGIANLLWQGEMVTIQFNLIEIIRIGVVSLPCIFTIANIMLANNLCDLDEDIRNHRYTLPYYIGRKMGVLLF
NALYYASFLAVVVSVAINFLHPIMLLSLITIYPVYRNLVKFNKEQVKSKTFVIGIRNFVLINATLTILMAVSVVLQQLA

Sequences:

>Translated_319_residues
MSIPSFLKLVEIQTKIASVFPFMLGTLFVVYQYDMFKPVNTLIFFGSMLIFDLTTTAINNYMDYRKATDNHDYDYRTTSN
VIGQEQIPVRTVIITIFLMFFIATGLGVWLVFRTDLLVLLIGFVCFCIGILYTFGPVPLSRMPLGEIFSGVTMGFGIFFL
AVYVNAYDAGIANLLWQGEMVTIQFNLIEIIRIGVVSLPCIFTIANIMLANNLCDLDEDIRNHRYTLPYYIGRKMGVLLF
NALYYASFLAVVVSVAINFLHPIMLLSLITIYPVYRNLVKFNKEQVKSKTFVIGIRNFVLINATLTILMAVSVVLQQLA
>Mature_318_residues
SIPSFLKLVEIQTKIASVFPFMLGTLFVVYQYDMFKPVNTLIFFGSMLIFDLTTTAINNYMDYRKATDNHDYDYRTTSNV
IGQEQIPVRTVIITIFLMFFIATGLGVWLVFRTDLLVLLIGFVCFCIGILYTFGPVPLSRMPLGEIFSGVTMGFGIFFLA
VYVNAYDAGIANLLWQGEMVTIQFNLIEIIRIGVVSLPCIFTIANIMLANNLCDLDEDIRNHRYTLPYYIGRKMGVLLFN
ALYYASFLAVVVSVAINFLHPIMLLSLITIYPVYRNLVKFNKEQVKSKTFVIGIRNFVLINATLTILMAVSVVLQQLA

Specific function: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to dimethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages:the removal of the carboxyl group of DHNA

COG id: COG1575

COG function: function code H; 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the menA family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004657
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: =2.5.1.74 [H]

Molecular weight: Translated: 36186; Mature: 36055

Theoretical pI: Translated: 8.27; Mature: 8.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure 
SIPSFLKLVEIQTKIASVFPFMLGTLFVVYQYDMFKPVNTLIFFGSMLIFDLTTTAINN
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH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HHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7934828; 9384377 [H]