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The map label for this gene is patB [H]

Identifier: 226224920

GI number: 226224920

Start: 2417077

End: 2418243

Strand: Direct

Name: patB [H]

Synonym: Lm4b_02340

Alternate gene names: 226224920

Gene position: 2417077-2418243 (Clockwise)

Preceding gene: 226224914

Following gene: 226224921

Centisome position: 82.98

GC content: 40.45

Gene sequence:

>1167_bases
TTGAGTCAATTTGATGAAGTCATTCCGCGTATTGGAACTAATTCAGAGAAGTGGGATGGGGCAGAAGAATTATTTGGCAG
AAAAAATATTATTCCGATGTGGGTAGCGGATATGGATTTCCGTGCGCCGCAGCCAGTACTTGATGCATTTCAGCGTCAAA
TCGATCATGGGATTTTTGGTTATTCGACCAAGTCAGCGGCACTTGTCGAAGCTATTATCGATTGGAACAAAGAGCAGCAT
CAGTTTGAAATCGATCCGAGCACGTTATTTTTTAATGGAGCGGTTGTTCCGACAATTTCGTTAGCGATTCGCTCTCTCAC
AAATGAAGGCGATGCAGTTCTAATGGTTTCGCCGATTTACCCACCATTTTTCAATGTAACGAAAGCCACTGAGAGAAAAG
TGGTTATGTCGCCACTTATATATGAGAACCGTCAATATCGAATGGATTTTAACGATTTGGAAAAACGGATGAAAGAAGAA
AAGGTAAAATTATTCCTTCTATGTAATCCGCAAAATCCTGGTGGTCGTTGTTTCACCAAGGAAGAACTGGTGGAATTAGC
GAAACTATGTGAAAAATACCAAATTCCGATTGTTTCGGATGAAATTCATGCTGACTTAGTGATGAAAAATCATAAACATG
TGCCAATGATGGTCGCAGCACCGTTTTATCAAGATCAAATTATTACTTTAATGGCGGCTACGAAAACATTTAACTTGGCG
GCGATTAAAGCTTCCTACTATATTATTACGAATAAAGATTATCAGGCCAAATTCGCTGCGGAGCAAAAGTACGCCACAAC
TAATGGGCTCAATGTCTTTGGGATTGTTGGTACAGAAGCAGCGTATCGCCACGGCGTGCCTTGGCTAAAAGAGTTGAAAG
AATATATTTATAGCAACTATGAATATGTCAAAGCAGCACTCGAAAAAGAAGTACCCGAAGTTGGTGTGACCGACTTAGAA
GCAACCTACTTGATGTGGCTTGATTGTCGCGCTCTTCCAAAAGACGAAAAAACGATTTACGCTGATTTAATCGAAGCTGG
TGTTGGTGTTCAAATGGGTTCTGGATTTGGACATTCCGGTAAAGGTTTTGTCCGCCTCAACATTGCATGTCCTAAAGAAA
CTTTAGAAAAAGGGGTAAAACTTCTGATTCAAGGCTTAAAAAAATAG

Upstream 100 bases:

>100_bases
GCGAAACTTTAACAATTATTCTAAATCCTTCTATGGCGAGCTTTAAAGGTGAAATTTATGCTATAATTGAGGCGAATGAA
AGAGAAGGAGCGTGACATAT

Downstream 100 bases:

>100_bases
TTTATTCTGGGAAACTAAGTAGCAAATACTTAGTTTCTTTTTTTAGGAAATTGAATATAGCTTTGGTATACTATTCTTTG
GAAAGTGAAATAATGTTCAT

Product: aminotransferase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 388; Mature: 387

Protein sequence:

>388_residues
MSQFDEVIPRIGTNSEKWDGAEELFGRKNIIPMWVADMDFRAPQPVLDAFQRQIDHGIFGYSTKSAALVEAIIDWNKEQH
QFEIDPSTLFFNGAVVPTISLAIRSLTNEGDAVLMVSPIYPPFFNVTKATERKVVMSPLIYENRQYRMDFNDLEKRMKEE
KVKLFLLCNPQNPGGRCFTKEELVELAKLCEKYQIPIVSDEIHADLVMKNHKHVPMMVAAPFYQDQIITLMAATKTFNLA
AIKASYYIITNKDYQAKFAAEQKYATTNGLNVFGIVGTEAAYRHGVPWLKELKEYIYSNYEYVKAALEKEVPEVGVTDLE
ATYLMWLDCRALPKDEKTIYADLIEAGVGVQMGSGFGHSGKGFVRLNIACPKETLEKGVKLLIQGLKK

Sequences:

>Translated_388_residues
MSQFDEVIPRIGTNSEKWDGAEELFGRKNIIPMWVADMDFRAPQPVLDAFQRQIDHGIFGYSTKSAALVEAIIDWNKEQH
QFEIDPSTLFFNGAVVPTISLAIRSLTNEGDAVLMVSPIYPPFFNVTKATERKVVMSPLIYENRQYRMDFNDLEKRMKEE
KVKLFLLCNPQNPGGRCFTKEELVELAKLCEKYQIPIVSDEIHADLVMKNHKHVPMMVAAPFYQDQIITLMAATKTFNLA
AIKASYYIITNKDYQAKFAAEQKYATTNGLNVFGIVGTEAAYRHGVPWLKELKEYIYSNYEYVKAALEKEVPEVGVTDLE
ATYLMWLDCRALPKDEKTIYADLIEAGVGVQMGSGFGHSGKGFVRLNIACPKETLEKGVKLLIQGLKK
>Mature_387_residues
SQFDEVIPRIGTNSEKWDGAEELFGRKNIIPMWVADMDFRAPQPVLDAFQRQIDHGIFGYSTKSAALVEAIIDWNKEQHQ
FEIDPSTLFFNGAVVPTISLAIRSLTNEGDAVLMVSPIYPPFFNVTKATERKVVMSPLIYENRQYRMDFNDLEKRMKEEK
VKLFLLCNPQNPGGRCFTKEELVELAKLCEKYQIPIVSDEIHADLVMKNHKHVPMMVAAPFYQDQIITLMAATKTFNLAA
IKASYYIITNKDYQAKFAAEQKYATTNGLNVFGIVGTEAAYRHGVPWLKELKEYIYSNYEYVKAALEKEVPEVGVTDLEA
TYLMWLDCRALPKDEKTIYADLIEAGVGVQMGSGFGHSGKGFVRLNIACPKETLEKGVKLLIQGLKK

Specific function: Catalyzes the transformation of cystathionine to homocysteine. Also exhibits cysteine desulfhydrase activity in vitro, producing sulfide from cysteine [H]

COG id: COG1168

COG function: function code E; Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. MalY/PatB cystathionine beta-lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI56713256, Length=158, Percent_Identity=30.379746835443, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI56713254, Length=158, Percent_Identity=30.379746835443, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI95147551, Length=255, Percent_Identity=22.7450980392157, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI169881279, Length=255, Percent_Identity=22.7450980392157, Blast_Score=69, Evalue=8e-12,
Organism=Escherichia coli, GI1787909, Length=392, Percent_Identity=32.9081632653061, Blast_Score=239, Evalue=2e-64,
Organism=Escherichia coli, GI1788722, Length=338, Percent_Identity=25.1479289940828, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788627, Length=189, Percent_Identity=22.7513227513227, Blast_Score=66, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI71994476, Length=188, Percent_Identity=25.531914893617, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71994472, Length=188, Percent_Identity=25.531914893617, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI18859735, Length=240, Percent_Identity=22.9166666666667, Blast_Score=73, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 43979; Mature: 43848

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQFDEVIPRIGTNSEKWDGAEELFGRKNIIPMWVADMDFRAPQPVLDAFQRQIDHGIFG
CCCHHHHHHCCCCCCCCCCCHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCC
YSTKSAALVEAIIDWNKEQHQFEIDPSTLFFNGAVVPTISLAIRSLTNEGDAVLMVSPIY
CCCCHHHHHHHHHHCCCCCCEEEECCCEEEECCCHHHHHHHHHHHHCCCCCEEEEEECCC
PPFFNVTKATERKVVMSPLIYENRQYRMDFNDLEKRMKEEKVKLFLLCNPQNPGGRCFTK
CCCCCCCCCCCCHHHHCHHHCCCCEEEECHHHHHHHHHHCCEEEEEEECCCCCCCCCCCH
EELVELAKLCEKYQIPIVSDEIHADLVMKNHKHVPMMVAAPFYQDQIITLMAATKTFNLA
HHHHHHHHHHHHHCCCEECCHHHHHHHHCCCCCCCEEEECCCCCCHHEEEEEHHCCEEEE
AIKASYYIITNKDYQAKFAAEQKYATTNGLNVFGIVGTEAAYRHGVPWLKELKEYIYSNY
EEEEEEEEEECCCCCCHHHHHHHHCCCCCCEEEEEECCCHHHHCCCHHHHHHHHHHHCCH
EYVKAALEKEVPEVGVTDLEATYLMWLDCRALPKDEKTIYADLIEAGVGVQMGSGFGHSG
HHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHCCCCEEECCCCCCCC
KGFVRLNIACPKETLEKGVKLLIQGLKK
CCEEEEEEECCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SQFDEVIPRIGTNSEKWDGAEELFGRKNIIPMWVADMDFRAPQPVLDAFQRQIDHGIFG
CCHHHHHHCCCCCCCCCCCHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCC
YSTKSAALVEAIIDWNKEQHQFEIDPSTLFFNGAVVPTISLAIRSLTNEGDAVLMVSPIY
CCCCHHHHHHHHHHCCCCCCEEEECCCEEEECCCHHHHHHHHHHHHCCCCCEEEEEECCC
PPFFNVTKATERKVVMSPLIYENRQYRMDFNDLEKRMKEEKVKLFLLCNPQNPGGRCFTK
CCCCCCCCCCCCHHHHCHHHCCCCEEEECHHHHHHHHHHCCEEEEEEECCCCCCCCCCCH
EELVELAKLCEKYQIPIVSDEIHADLVMKNHKHVPMMVAAPFYQDQIITLMAATKTFNLA
HHHHHHHHHHHHHCCCEECCHHHHHHHHCCCCCCCEEEECCCCCCHHEEEEEHHCCEEEE
AIKASYYIITNKDYQAKFAAEQKYATTNGLNVFGIVGTEAAYRHGVPWLKELKEYIYSNY
EEEEEEEEEECCCCCCHHHHHHHHCCCCCCEEEEEECCCHHHHCCCHHHHHHHHHHHCCH
EYVKAALEKEVPEVGVTDLEATYLMWLDCRALPKDEKTIYADLIEAGVGVQMGSGFGHSG
HHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHCCCCEEECCCCCCCC
KGFVRLNIACPKETLEKGVKLLIQGLKK
CCEEEEEEECCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8497199; 9274030; 9384377 [H]