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The map label for this gene is fba [H]

Identifier: 226224740

GI number: 226224740

Start: 2219021

End: 2219920

Strand: Reverse

Name: fba [H]

Synonym: Lm4b_02157

Alternate gene names: 226224740

Gene position: 2219920-2219021 (Counterclockwise)

Preceding gene: 226224741

Following gene: 226224738

Centisome position: 76.22

GC content: 38.44

Gene sequence:

>900_bases
ATGTTAGTAAATATGAAACAATTATTAGAAGTAGCTAAGGAAAACAAATTCGCGGTGGGAGCATTTAATGTTGCAGACAG
TAACTTTTTACGGGTGGTAGTAGAAGAAGCTGAAAAAAACAATGCTCCAGCAATTATTGCAGTGCATCCAACAGAATTAG
ATTTTACGAAAGATGACTTTTTCCAATATGTTCTTGCAAGAATTAAAAATAGTCCTGTTCCATTTGTTCTTCATTTGGAT
CATGGTGACAATATGGGAGATGTGATGCGAGCGGTACGTTGTGGTTTTAGTTCAGTGATGATTGATGGCTCTTTGCTTCC
TTTTGAAGAAAATATTCGTGTTACAAAGGAAGTTGTTGATGTTTGTCATAAACTGGGGGTCTCAGTTGAAGGTGAGCTCG
GGACTATCGGGAAAACCGGTAACAGTATTGAAGGCGGCGTCAGTGAGATTATCTATACAAAACCCGAAGAAGCGGAAGAA
TATATTAGTCGCACGGGTGTAGATACGCTAGCTGTTGCAATCGGGACAGCGCACGGAATTTATCCTAAAGATAAGGAGCC
AAAATTACGTCTAGATATCTTAAAAGAAATAAAAGATTTAGTGAATATTCCACTTGTACTTCACGGTGGTTCTGCAAATC
CAGATGCCGAAATTGCTGCAGCTGTCGAAATTGGAATTCAAAAAGTAAATATTTCCAGCGATTACAAATACGCCTTTTAT
AAGAAATGTCGTGAGATTCTAAGTACAACAGAACTTTGGGATGCCAACGCAATCTACCCAGACTGTATTGATGCGGCGAA
AGAAGTGGTGAAATATAAGATGGAACTTTTTGAGTCTATTGGTCAAGTTGAAAAATACCAACAAGCAAAAACCACAGCTT
GGCGAAGTGAACTAATCTAA

Upstream 100 bases:

>100_bases
TTAATTCATGAAACGATAAAAGCCGGCACAAAAGCTGTTAAAAATTATATTCAACTATCCGGTTCAACCGGAAAATCACT
TTAAAAGGAGAAATGAAAAT

Downstream 100 bases:

>100_bases
CAAAAAAAACTAAGAGCGCAAGTTGGCTCTTAGTTTTTTTGTATCTTTACAAGTGGTACATTCATCTCTATTAACTTTTG
GAGCTTCTGGACATCGTTAA

Product: hypothetical protein

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase [H]

Number of amino acids: Translated: 299; Mature: 299

Protein sequence:

>299_residues
MLVNMKQLLEVAKENKFAVGAFNVADSNFLRVVVEEAEKNNAPAIIAVHPTELDFTKDDFFQYVLARIKNSPVPFVLHLD
HGDNMGDVMRAVRCGFSSVMIDGSLLPFEENIRVTKEVVDVCHKLGVSVEGELGTIGKTGNSIEGGVSEIIYTKPEEAEE
YISRTGVDTLAVAIGTAHGIYPKDKEPKLRLDILKEIKDLVNIPLVLHGGSANPDAEIAAAVEIGIQKVNISSDYKYAFY
KKCREILSTTELWDANAIYPDCIDAAKEVVKYKMELFESIGQVEKYQQAKTTAWRSELI

Sequences:

>Translated_299_residues
MLVNMKQLLEVAKENKFAVGAFNVADSNFLRVVVEEAEKNNAPAIIAVHPTELDFTKDDFFQYVLARIKNSPVPFVLHLD
HGDNMGDVMRAVRCGFSSVMIDGSLLPFEENIRVTKEVVDVCHKLGVSVEGELGTIGKTGNSIEGGVSEIIYTKPEEAEE
YISRTGVDTLAVAIGTAHGIYPKDKEPKLRLDILKEIKDLVNIPLVLHGGSANPDAEIAAAVEIGIQKVNISSDYKYAFY
KKCREILSTTELWDANAIYPDCIDAAKEVVKYKMELFESIGQVEKYQQAKTTAWRSELI
>Mature_299_residues
MLVNMKQLLEVAKENKFAVGAFNVADSNFLRVVVEEAEKNNAPAIIAVHPTELDFTKDDFFQYVLARIKNSPVPFVLHLD
HGDNMGDVMRAVRCGFSSVMIDGSLLPFEENIRVTKEVVDVCHKLGVSVEGELGTIGKTGNSIEGGVSEIIYTKPEEAEE
YISRTGVDTLAVAIGTAHGIYPKDKEPKLRLDILKEIKDLVNIPLVLHGGSANPDAEIAAAVEIGIQKVNISSDYKYAFY
KKCREILSTTELWDANAIYPDCIDAAKEVVKYKMELFESIGQVEKYQQAKTTAWRSELI

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis [H]

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI87082041, Length=248, Percent_Identity=40.3225806451613, Blast_Score=187, Evalue=7e-49,
Organism=Escherichia coli, GI1789526, Length=284, Percent_Identity=35.9154929577465, Blast_Score=186, Evalue=2e-48,
Organism=Escherichia coli, GI1788072, Length=285, Percent_Identity=36.140350877193, Blast_Score=173, Evalue=1e-44,
Organism=Escherichia coli, GI1789293, Length=283, Percent_Identity=27.5618374558304, Blast_Score=86, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR011289
- InterPro:   IPR000771 [H]

Pfam domain/function: PF01116 F_bP_aldolase [H]

EC number: =4.1.2.13 [H]

Molecular weight: Translated: 33112; Mature: 33112

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVNMKQLLEVAKENKFAVGAFNVADSNFLRVVVEEAEKNNAPAIIAVHPTELDFTKDDF
CCCCHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHH
FQYVLARIKNSPVPFVLHLDHGDNMGDVMRAVRCGFSSVMIDGSLLPFEENIRVTKEVVD
HHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHCCHHEEECCCCCCCHHCCHHHHHHHH
VCHKLGVSVEGELGTIGKTGNSIEGGVSEIIYTKPEEAEEYISRTGVDTLAVAIGTAHGI
HHHHHCCCCCCCCCCCCCCCCCCCCCHHHHEECCCHHHHHHHHHCCHHHHHHHHHHHCCC
YPKDKEPKLRLDILKEIKDLVNIPLVLHGGSANPDAEIAAAVEIGIQKVNISSDYKYAFY
CCCCCCCCHHHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHCEEEEECCCCCHHHHH
KKCREILSTTELWDANAIYPDCIDAAKEVVKYKMELFESIGQVEKYQQAKTTAWRSELI
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLVNMKQLLEVAKENKFAVGAFNVADSNFLRVVVEEAEKNNAPAIIAVHPTELDFTKDDF
CCCCHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHH
FQYVLARIKNSPVPFVLHLDHGDNMGDVMRAVRCGFSSVMIDGSLLPFEENIRVTKEVVD
HHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHCCHHEEECCCCCCCHHCCHHHHHHHH
VCHKLGVSVEGELGTIGKTGNSIEGGVSEIIYTKPEEAEEYISRTGVDTLAVAIGTAHGI
HHHHHCCCCCCCCCCCCCCCCCCCCCHHHHEECCCHHHHHHHHHCCHHHHHHHHHHHCCC
YPKDKEPKLRLDILKEIKDLVNIPLVLHGGSANPDAEIAAAVEIGIQKVNISSDYKYAFY
CCCCCCCCHHHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHCEEEEECCCCCHHHHH
KKCREILSTTELWDANAIYPDCIDAAKEVVKYKMELFESIGQVEKYQQAKTTAWRSELI
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA